keyword
https://read.qxmd.com/read/38531915/predictive-value-of-clinical-risk-factors-for-bladder-dysfunction-in-syrian-patients-with-type-2-diabetes-mellitus
#1
JOURNAL ARTICLE
Younes A Khadour, Bashar M Ebrahem, Weaam Alhatem, Engo Ovone Yanne, Fater A Khadour
Diabetes mellitus (DM) is a prevalent disorder that affects the endocrine and metabolic systems. Among the various complications associated with DM, diabetic bladder dysfunction (DBD) is the most frequently occurring genitourinary complication. The presence of DBD can lead to complications that affect the upper urinary tract, significantly impacting the quality of life for individuals with DM. Therefore, it is crucial to identify early risk factors for DBD and predict its onset. Given the absence of studies involving bladder dysfunction in patients with type 2 diabetes mellitus (T2DM) in Syria, this study aims to examine the risk factors associated with bladder dysfunction in T2DM patients and develop a predictive model to identify DBD early...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38529825/diamond-burr-debridement-of-calcific-band-keratopathy-in-24-eyes-of-22-horses
#2
JOURNAL ARTICLE
Sophie Jugant, Alain Regnier, Jean-Yves Douet
PURPOSE: To evaluate the safety and effectiveness of diamond burr debridement (DBD) for the treatment of calcific band keratopathy (CBK) in horses. METHODS: Medical records from horses with CBK were reviewed over a period of 4 years. Diagnosis of CBK was based on slit-lamp examination findings, and DBD was performed on standing sedated horses. Follow-up was obtained by clinical reevaluation of the treated eyes or a telephone survey with the referring veterinarian...
March 26, 2024: Veterinary Ophthalmology
https://read.qxmd.com/read/38522914/behavioral-and-psychological-symptoms-of-dementia-and-mortality-risk-among-people-with-cognitive-impairment-an-8-year-longitudinal-study-from-the-ncgg-stories
#3
JOURNAL ARTICLE
Taiji Noguchi, Takeshi Nakagawa, Taiki Sugimoto, Ayane Komatsu, Yujiro Kuroda, Kazuaki Uchida, Rei Ono, Hidenori Arai, Takashi Sakurai, Tami Saito
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are common among people with dementia from the early stages and can appear even in mild cognitive impairment (MCI). However, the prognostic impact of BPSD is unclear. This study examined the association between BPSD and mortality among people with cognitive impairment. METHODS: This longitudinal study involved 1,065 males and 1,681 females (mean age: males = 77.1 years; females = 78.6 years) with MCI or dementia diagnosis, from the National Center for Geriatrics and Gerontology-Life Stories of People with Dementia (NCGG-STORIES), a single-center memory clinic-based cohort study in Japan that registered first-time outpatients from 2010-2018...
March 23, 2024: Journal of Epidemiology
https://read.qxmd.com/read/38522683/efficient-degradation-and-enhanced-%C3%AE-glucosidase-inhibitory-activity-of-apricot-polysaccharides-through-non-thermal-plasma-assisted-non-metallic-fenton-reaction
#4
JOURNAL ARTICLE
Andi Suo, Gongjian Fan, Caie Wu, Tingting Li, Xiaojing Li, Dandan Zhou, Kaiping Cong, Xin Cheng, Wenjuan Sun
Dielectric barrier discharge (DBD) was a commonly used non-thermal plasma (CP) technology. This paper aimed to enhance the biological activity of apricot polysaccharides (AP) by using dielectric barrier discharge (DBD-CP) assisted H2 O2 -VC Fenton reaction for degradation. The degradation conditions were optimized through response surface methodology. The molecular weight (Mw) of degraded apricot polysaccharides (DAP) was 19.71 kDa, which was 7.25 % of AP. The inhibition rate of DAP (2 mg/mL) was 82...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521350/association-of-procurement-technique-with-organ-yield-and-cost-following-donation-after-circulatory-death
#5
JOURNAL ARTICLE
Syed Shahyan Bakhtiyar, Tiffany E Maksimuk, John Gutowski, Sarah Y Park, Michael T Cain, Jessica Y Rove, T Brett Reece, Joseph C Cleveland, James J Pomposelli, Yanik J Bababekov, Trevor L Nydam, Jesse D Schold, Elizabeth A Pomfret, Jordan R H Hoffman
Donation after circulatory death(DCD) could account for the largest expansion of the donor allograft pool in the contemporary era. However, the organ yield and associated costs of Normothermic Regional Perfusion(NRP) compared to Super-Rapid Recovery(SRR) with ex-situ Normothermic Machine Perfusion(NMP), remain unreported. The Organ Procurement and Transplantation Network (December 2019-June 2023) was analyzed to determine the number of organs recovered per donor. A cost analysis was performed based on our institution's experience since 2022...
March 21, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38521169/transplant-benefit-based-offering-of-deceased-donor-livers-in-the-united-kingdom
#6
JOURNAL ARTICLE
Elisa Allen, Rhiannon Taylor, Alex Ander Gimson, Douglas Thorburn, Dave Collett, Elisa Allen, Varuna Aluvihare, Alex Gimson, Ernest Hidalgo, John O'Grady, Tahir Shah, Doug Thorburn, John Crookenden, Alastair MacGilchrist, James O'Beirne, James Powel, Martine Walmsley
BACKGROUND & AIMS: The National Liver Offering Scheme (NLOS) was introduced in the UK in 2018 to offer livers from deceased donors to patients on the national waiting list based, for most patients, on calculated transplant benefit. Before NLOS, livers were offered to transplant centres by geographic donor zones and, within centres, by estimated recipient need for a transplant. METHODS: UK Transplant Registry data on patient registrations and transplants were analysed to build survival on the list (M1) and survival post-transplantation (M2) statistical models...
March 21, 2024: Journal of Hepatology
https://read.qxmd.com/read/38510794/the-dual-angiogenesis-effects-via-nrf2-ho-1-signaling-pathway-of-melatonin-nanocomposite-scaffold-on-promoting-diabetic-bone-defect-repair
#7
JOURNAL ARTICLE
Tingting Chen, Zimei Wu, Qiaodan Hou, Yixin Mei, Kunkun Yang, Jing Xu, Lin Wang
PURPOSE: Given the escalating prevalence of diabetes, the demand for specific bone graft materials is increasing, owing to the greater tendency towards bone defects and more difficult defect repair resulting from diabetic bone disease (DBD). Melatonin (MT), which is known for its potent antioxidant properties, has been shown to stimulate both osteogenesis and angiogenesis. METHODS: MT was formulated into MT@PLGA nanoparticles (NPs), mixed with sodium alginate (SA) hydrogel, and contained within a 3D printing polycaprolactone/β-Tricalcium phosphate (PCL/β-TCP) scaffold...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38502492/dbd-fish-using-specific-chromosomal-region-probes-for-the-study-of-cervical-carcinoma-progression
#8
JOURNAL ARTICLE
Catalina García-Vielma, Elva I Cortés-Gutiérrez, José L Fernández, Martha I Dávila-Rodríguez, Jaime Gosálvez
Genomic instability is an important biomarker in the progression of cervical carcinoma. DBD-FISH (DNA breakage detection-fluorescence in situ hybridization) is a sensitive method that detects strand breaks, alkali-labile sites, and incomplete DNA excision repair in cells of the cervical epithelium. This technique integrates the microgel immersion of cells from a vaginal lesion scraping and the DNA unwinding treatment with the capacity of FISH integrated into digital image analysis. Cells captured within an agarose matrix are lysed and submerged in an alkaline unwinding solution that generates single-stranded DNA motifs at the ends of internal DNA strand breaks...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38489660/age-matters-what-affects-the-cumulative-lifespan-of-a-transplanted-liver
#9
JOURNAL ARTICLE
Chase J Wehrle, Marianna Maspero, Antonio D Pinna, Philipp Dutkowski, Charles Miller, Koji Hashimoto, Pierre-Alain Claviaen, Andrea Schlegel
OBJECTIVE: Assess factors affecting the cumulative lifespan of a transplanted liver. SUMMARY BACKGROUND DATA: Liver ageing is different from other solid organs. It is unknown how old a liver can actually get after liver transplantation (LT). METHODS: Deceased donor liver transplants from 1988-2021 were queried from the United States (US) UNOS registry. Cumulative liver age was calculated as donor age + recipient graft survival. RESULTS: In total, 184,515 livers were included...
March 11, 2024: Annals of Surgery
https://read.qxmd.com/read/38484990/degradation-of-dissolved-sulfide-in-water-using-multi-hole-dielectric-barrier-discharge
#10
JOURNAL ARTICLE
Geonwoo Yang, Heejae Lee, Kangil Kim, Semin Chun, Sangyun Jeong, Jinmu Jung, Yong Cheol Hong
Biogas obtained from livestock manure is used as fuel for solid oxide fuel cells. Although H2 S is a typical biogas, it is a fatal disadvantage for fuel-cell power generation and, thus, must be removed. In this study, we proposed an effective method for sulfide removal from water using a multi-hole dielectric barrier discharge (DBD) system. In this system, active species, such as ozone, ultraviolet rays, hydroxyl radicals, and hydrogen peroxide, were simultaneously generated. Under optimal conditions, dissolved sulfide (initial concentration: 120 mg/L) was completely degraded within 10 min in air plasma and 6 min in oxygen plasma...
March 12, 2024: Chemosphere
https://read.qxmd.com/read/38484545/investigation-into-potential-allergenicity-of-dbd-plasma-treated-casein-digestion-products-based-on-immunoglobulin-e-linear-epitopes-and-the-sensitized-cell-model
#11
JOURNAL ARTICLE
Yongniu Zhang, Er-Fang Ren, Tao Wen, Shijun Lyu, Lili Gai, Siyu Chen, Kai Li, Zhong Han, Fuge Niu, Debao Niu
The study aimed to investigate the allergenicity change in casein treated with dielectric barrier discharge (DBD) plasma during in vitro simulated digestion, focusing on the immunoglobulin E (IgE) linear epitopes and utilizing a sensitized-cell model. Results indicated that prior treatment with DBD plasma treatment (4 min) before simulated digestion led to a 10.5% reduction in the IgE-binding capacity of casein digestion products. Moreover, the release of biologically active substances induced from KU812 cells, including β-HEX release rate, human histamine, IL-4, IL-6, and TNF-α, decreased by 2...
March 5, 2024: Food Chemistry
https://read.qxmd.com/read/38477394/molecular-mechanism-of-the-one-component-regulator-rccr-on-bacterial-metabolism-and-virulence
#12
JOURNAL ARTICLE
Yibo Zhu, Xingyu Mou, Yingjie Song, Qianqian Zhang, Bo Sun, Huanxiang Liu, Hong Tang, Rui Bao
The regulation of carbon metabolism and virulence is critical for the rapid adaptation of pathogenic bacteria to host conditions. In Pseudomonas aeruginosa, RccR is a transcriptional regulator of genes involved in primary carbon metabolism and is associated with bacterial resistance and virulence, although the exact mechanism is unclear. Our study demonstrates that PaRccR is a direct repressor of the transcriptional regulator genes mvaU and algU. Biochemical and structural analyses reveal that PaRccR can switch its DNA recognition mode through conformational changes triggered by KDPG binding or release...
March 13, 2024: Nucleic Acids Research
https://read.qxmd.com/read/38473460/rapid-synthesis-of-noble-metal-colloids-by-plasma-liquid-interactions
#13
JOURNAL ARTICLE
Yuanwen Pang, Hong Li, Yue Hua, Xiuling Zhang, Lanbo Di
The interactions between plasma and liquids cause complex physical and chemical reactions at the gas-liquid contact surface, producing numerous chemically active particles that can rapidly reduce noble metal ions. This study uses atmospheric-pressure surface dielectric barrier discharge (DBD) plasma to treat ethanol aqueous solutions containing noble metal precursors, and stable gold, platinum, and palladium colloids are obtained within a few minutes. To evaluate the mechanism of the reduction of noble metal precursors by atmospheric-pressure surface DBD plasma, the corresponding metal colloids are prepared first by activating an ethanol aqueous solution with plasma and then adding noble metal precursors...
February 21, 2024: Materials
https://read.qxmd.com/read/38462202/degradation-performance-and-mechanism-of-microcystins-in-aquaculture-water-using-low-temperature-plasma-technology
#14
JOURNAL ARTICLE
Jie Wang, Jiahua Zhang, Yuyi Shangguan, Guanyi Yang, Xingguo Liu
The eutrophication of aquaculture water bodies seriously restricts the healthy development of the aquaculture industry. Among them, microcystins are particularly harmful. Therefore, the development of technologies for degrading microcystins is of great significance for maintaining the healthy development of the aquaculture industry. The feasibility and mechanism of removing microcystins-LR by dielectric barrier discharge (DBD) plasma were studied. DBD discharge power of 49.6 W and a treatment time of 40 min were selected as the more suitable DBD parameters, resulting in microcystin-LR removal efficiency of 90...
March 8, 2024: Environmental Pollution
https://read.qxmd.com/read/38460320/modification-of-soy-protein-isolate-and-pea-protein-isolate-by-high-voltage-dielectric-barrier-discharge-dbd-atmospheric-cold-plasma-comparative-study-on-structural-rheological-and-techno-functional-characteristics
#15
JOURNAL ARTICLE
Srutee Rout, Prem Prakash Srivastav
The modification in structural, rheological, and techno-functional characteristics of soy and pea protein isolates (SPI and PPI) due to dielectric barrier discharge cold plasma (DBD-CP) were assessed. The increased carbonyl groups in both samples with cold plasma (CP) treatment led to a reduction in free sulfhydryl groups. Moreover, protein solubility of treated proteins exhibited significant improvements, reaching up to 59.07 % and 41.4 % for SPI and PPI, respectively, at 30 kV for 8 min...
March 6, 2024: Food Chemistry
https://read.qxmd.com/read/38460018/untargeted-nmr-based-metabolomics-analysis-of-kidney-allograft-perfusates-identifies-a-signature-of-delayed-graft-function
#16
JOURNAL ARTICLE
A Cirillo, M Vandermeulen, P Erpicum, T Pinto Coelho, N Meurisse, O Detry, F Jouret, P de Tullio
INTRODUCTION: Kidney transplantation (KTx) necessarily conveys an ischemia/reperfusion (I/R) process, which impacts on allograft outcomes. Delayed graft function (DGF) is defined as a non-decrease of serum creatinine by at least 10% daily on 3 consecutive days during the first 7 days post-KTx. DGF significantly conditions both short- and long-term graft outcomes. Still there is a lack of DGF predictive biomarkers. OBJECTIVES: This study aimed to explore the potential of kidney graft perfusate metabolomics to predict DGF occurrence...
March 9, 2024: Metabolomics: Official Journal of the Metabolomic Society
https://read.qxmd.com/read/38455485/using-extracorporeal-membrane-oxygenation-in-donations-after-cardiac-death-or-brain-death-a-single-center-experience-and-long-term-outcome
#17
JOURNAL ARTICLE
Chia-En Hsieh, Ya-Lan Hsu, Yao-Li Chen, Hsin-Rou Liang, Kuo-Hua Lin, Wen-Yuan Chen, Hsiu-Man Wu, Sin-Bao Hunang, Yu-Ju Hung
AIMS: The use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death. METHODS: We performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants. The patients were divided into three groups: the donation after brain death (DBD) group ( n  = 58, 64.4%), the DBD with ECMO group ( n  = 11, 12...
March 2024: Annals of Gastroenterological Surgery
https://read.qxmd.com/read/38454610/implications-of-drug-intoxication-on-donor-utilization-and-outcomes-in-liver-transplantation
#18
JOURNAL ARTICLE
Michie Adjei, Steven A Wisel, Ju Dong Yang, Nicholas N Nissen, Irene K Kim, Justin A Steggerda
INTRODUCTION: This study evaluates the implications of drug intoxication (DI) on donor utilization and outcomes in liver transplantation (LT). METHODS: The UNOS STAR database was evaluated for all potential donors and adult, first-time, whole LT between 2005 and 2019. Logistic regression analyses evaluated liver utilization; proportional hazards modeling assessed risk of 1-year graft loss. RESULTS: A total of 132 783 potential donors (10 205, 7...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38452839/surface-air-gas-discharge-plasma-an-ecofriendly-virus-inactivation-approach-to-enhance-cprrs-mediated-antiviral-genes-expression-against-airborne-bio-contaminant-human-coronavirus-229e
#19
JOURNAL ARTICLE
Paritosh Patel, Neha Kaushik, Tirtha Raj Acharya, Eun Ha Choi, Nagendra Kumar Kaushik
Emerging bio-contaminants (airborne viruses) exploits and manipulate host (human) metabolism to produce new viral particles, evading the host's immune defences and leading to infections. Non-thermal plasma, operating at atmospheric pressure and ambient temperature, is explored for virus inactivation, generating RONS that interact and denatures viral proteins. However, various factors affecting virus survival influence the efficacy of non-thermal plasma. Glucose analogue 2-DG, a metabolic modifier used in this study, disrupts the glycolysis pathway viruses rely on, creating an unfavourable environment for replication...
March 5, 2024: Environmental Pollution
https://read.qxmd.com/read/38451917/new-insights-into-the-all-testis-differentiation-in-zebrafish-with-compromised-endogenous-androgen-and-estrogen-synthesis
#20
JOURNAL ARTICLE
Yonglin Ruan, Xuehui Li, Xinyi Wang, Gang Zhai, Qiyong Lou, Xia Jin, Jiangyan He, Jie Mei, Wuhan Xiao, Jianfang Gui, Zhan Yin
The regulatory mechanism of gonadal sex differentiation, which is complex and regulated by multiple factors, remains poorly understood in teleosts. Recently, we have shown that compromised androgen and estrogen synthesis with increased progestin leads to all-male differentiation with proper testis development and spermatogenesis in cytochrome P450 17a1 (cyp17a1)-/- zebrafish. In the present study, the phenotypes of female-biased sex ratio were positively correlated with higher Fanconi anemia complementation group L (fancl) expression in the gonads of doublesex and mab-3 related transcription factor 1 (dmrt1)-/- and cyp17a1-/-;dmrt1-/- fish...
March 2024: PLoS Genetics
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