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https://www.readbyqxmd.com/read/28550025/mineralocorticoid-receptor-null-mice-informing-cell-type-specific-roles
#1
Timothy James Cole, Morag Young
The mineralocorticoid receptor (MR) mediates the actions of two important adrenal corticosteroid hormones, aldosterone and cortisol. The cell signalling roles of the MR in vivo have expanded enormously since the cloning of human MR gene 30 years ago and the first MR gene knockout in mice nearly 20 years ago. Complete ablation of the MR revealed important roles postnatally for regulation of kidney epithelial functions, with MR-null mice dying 1-2 weeks postnatally from renal salt wasting and hyperkalaemia, with elevated plasma renin and aldosterone...
May 26, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28545434/effects-of-dangguibuxue-decoction-on-rat-glomerular-mesangial-cells-cultured-under-high-glucose-conditions
#2
Xiao-Dan Ren, Ying-Wen Zhang, Xiu-Ping Wang, Ya-Rong Li
BACKGROUND: Dysfunction of glomerular mesangial cells (GMCs) plays an important role in pathogenesis of diabetic nephropathy. Here, we investigated the effects of Dangguibuxue decoction (DBD), an herbal traditional Chinese medicinal (TCM) formula composed of Astragali Radix and Angelicae Sinensis Radix, on GMC proliferation and fibrogenesis under high-glucose (HG) conditions. METHODS: Sixty male Sprague Dawley rats were divided into 5 groups and administered intragastric 0...
May 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28545008/psychiatric-disorders-in-a-cohort-of-individuals-with-prader-willi-syndrome
#3
L Shriki-Tal, H Avrahamy, Y Pollak, V Gross-Tsur, L Genstil, H J Hirsch, F Benarroch
BACKGROUND: Psychiatric manifestations in Prader-Willi Syndrome (PWS) are common and often are the most debilitating problem in these individuals. We present an epidemiological nation-wide survey of psychiatric diagnoses in the PWS population, based on full-range psychiatric interviews. METHODS: We studied the distribution of psychiatric diagnoses (as opposed to a symptom-based approach) in the Israel national cohort of adolescents and adults with PWS. There was a total of 53 (32 males) ages 12 years and older...
April 5, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28534953/proteomic-analysis-of-differentially-expressed-proteins-in-kidneys-of-brain-dead-rabbits
#4
Ling Li, Ning Li, Chongxiang He, Wei Huang, Xiaoli Fan, Zibiao Zhong, Yanfeng Wang, Qifa Ye
A large number of previous clinical studies have reported a delayed graft function for brain dead donors, when compared with living relatives or cadaveric organ transplantations. However, there is no accurate method for the quality evaluation of kidneys from brain‑dead donors. In the present study, two‑dimensional gel electrophoresis and MALDI‑TOF MS‑based comparative proteomic analysis were conducted to profile the differentially‑expressed proteins between brain death and the control group renal tissues...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28528505/enhanced-degradation-of-perfluorooctanoic-acid-using-dielectric-barrier-discharge-with-la-ce-doped-tio2
#5
Shanping Li, Xiaoping Wang, Lijun Liu, Yongbo Guo, Qinglin Mu, Abdelwahid Mellouki
A synergistic system of dielectric barrier discharge (DBD) combined with La/Ce-TiO2 was developed to investigate the decomposition performance of the environmentally persistent perfluorooctanoic acid (PFOA). The La/Ce-TiO2 was modified by sol-gel method and characterized by XRD, SEM, and energy dispersive X-ray. The effects of PFOA concentration, applied voltage, initial pH, liquid conductivity, and additives on the removal rate of PFOA were explored. The results showed that the La/Ce-TiO2 exhibited excellent catalytic effects on PFOA degradation in DBD system...
May 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28506057/liquid-spray-dielectric-barrier-discharge-induced-plasma-chemical-vapor-generation-for-the-determination-of-lead-by-icpms
#6
Xing Liu, Zhenli Zhu, Huilai Li, Dong He, Yatai Li, Hongtao Zheng, Yiqun Gan, Yanxiang Li, Nicholas Stanley Belshaw, Shenghong Hu
In the present study, a novel and sensitive liquid spray dielectric barrier discharge induced plasma-chemical vapor generation technique (LSDBD-CVG) is developed for the determination of lead concentration by inductively coupled plasma mass spectrometry (ICPMS). The dissolved Pb(2+) is readily converted to volatile species by LSDBD plasma induced chemical processes in the presence of 5% (v/v) formic acid in a supporting electrolyte (HCl, 0.01 mol L(-1)). In this LSDBD approach, the sample solution is converted to aerosol and simultaneously mixed with the DBD plasma generated at the nozzle of a pneumatic nebulizer, which greatly facilitates Pb vapor generation because of the enhanced interaction of sprayed analytes and the plasma...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28505153/gene-duplication-and-co-evolution-of-g1-s-transcription-factor-specificity-in-fungi-are-essential-for-optimizing-cell-fitness
#7
Adi Hendler, Edgar M Medina, Anastasiya Kishkevich, Mehtap Abu-Qarn, Steffi Klier, Nicolas E Buchler, Robertus A M de Bruin, Amir Aharoni
Transcriptional regulatory networks play a central role in optimizing cell survival. How DNA binding domains and cis-regulatory DNA binding sequences have co-evolved to allow the expansion of transcriptional networks and how this contributes to cellular fitness remains unclear. Here we experimentally explore how the complex G1/S transcriptional network evolved in the budding yeast Saccharomyces cerevisiae by examining different chimeric transcription factor (TF) complexes. Over 200 G1/S genes are regulated by either one of the two TF complexes, SBF and MBF, which bind to specific DNA binding sequences, SCB and MCB, respectively...
May 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28497668/potential-brain-dead-organ-donation-in-neurocritical-care-mortality
#8
Vera Spatenkova, Ondrej Bradac, Petr Suchomel
BACKGROUND: Mortality is a marker of quality in neurocritical care, but it also provides potential for donors after brain death (DBD) following irreversible acute brain damage. The aim of this study was to analyse the neurointensive care unit (NICU) mortality rate and recovery of potential DBD. METHODS: We performed a 10-year prospective observational cohort computer database analysis of 6138 acute neurological and neurosurgical patients (pts, 58.2% male, mean: age 55...
May 11, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28493145/influence-of-the-recipient-body-mass-index-on-the-outcomes-after-kidney-transplantation
#9
Juliane Liese, Nils Bottner, Stefan Büttner, Alexander Reinisch, Guido Woeste, Markus Wortmann, Ingeborg A Hauser, Wolf Otto Bechstein, Frank Ulrich
PURPOSE: The relationship between the body mass index (BMI) of kidney transplant recipients and outcomes after kidney transplantation (KT) is not fully understood and remains controversial. We studied the influence of BMI on clinically relevant outcomes in kidney transplant recipients. METHODS: In this retrospective single-centre study, all patients who underwent kidney transplantation at our institution between January 2007 and December 2012 were included. Demographic data and BMI were correlated with the clinical course of the disease, rejection rates, delayed graft function rates, and graft and patient survival...
May 10, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28490106/inactivation-of-soybean-trypsin-inhibitor-by-dielectric-barrier-discharge-dbd-plasma
#10
Junguang Li, Qisen Xiang, Xiufang Liu, Tian Ding, Xiangsheng Zhang, Yafei Zhai, Yanhong Bai
Soybean trypsin inhibitor (STI) is considered as one of the most important anti-nutritional factors in soybeans. The objective of this study was to investigate the impacts and underling mechanisms of dielectric-barrier discharge (DBD) plasma on STI activities. The results shown that DBD plasma treatment significantly induced the inactivation of STI in soymilk and Kunitz-type trypsin inhibitor from soybean (SKTI) in a model system. After exposure to DBD plasma at 51.4W for 21min, the STI activities of soymilk were reduced by 86...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28474127/conformational-stabilization-of-fox-dna-complex-architecture-to-sensitize-prostate-cancer-chemotherapy
#11
Bin Chen, Huiqiang Wang, Zhun Wu, Bo Duan, Peide Bai, Kaiyan Zhang, Wei Li, Jiaxin Zheng, Jinchun Xing
The forkhead box (FOX) transcription factor is a family of tumor suppressors that negatively regulates the tumorigenesis activity of prostate cancer; stabilization of FOX-DNA complex architecture has been recognized as a new and promising strategy for sensitizing cancer chemotherapy. Here, we described a systematic method that combined in silico analysis and in vitro assay to investigate the intermolecular interaction between FOX DNA-binding domain (DBD) and its cognate DNA partner. The structural and energetic information harvested from the molecular investigation were used to guide high-throughput virtual screening against a structurally diverse, nonredundant library of natural product compounds, aiming at discovery of novel small-molecule medicines that can conformationally stabilize and promote FOX-DNA recognition and interaction...
May 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28470870/a-multicenter-study-on-long-term-outcomes-after-lung-transplantation-comparing-donation-after-circulatory-death-and-donation-after-brain-death
#12
V van Suylen, B Luijk, R A S Hoek, E A van de Graaf, E A Verschuuren, C Van De Wauwer, J A Bekkers, R C A Meijer, W van der Bij, M E Erasmus
The implementation of donation after circulatory death category 3 (DCD3) was one of the attempts to reduce the gap between supply and demand of donor lungs. In the Netherlands, the total number of potential lung donors was greatly increased by the availability of DCD3 lungs in addition to the initial standard usage of donation after brain death (DBD) lungs. From the three lung transplant centers in the Netherlands, 130 DCD3 recipients were one-to-one nearest neighbor propensity score matched with 130 DBD recipients...
May 4, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28467380/nanosecond-pulsed-dbd-plasma-generated-reactive-oxygen-species-trigger-immunogenic-cell-death-in-a549-lung-carcinoma-cells-through-intracellular-oxidative-stress
#13
Abraham Lin, Billy Truong, Sohil Patel, Nagendra Kaushik, Eun Ha Choi, Gregory Fridman, Alexander Fridman, Vandana Miller
A novel application for non-thermal plasma is the induction of immunogenic cancer cell death for cancer immunotherapy. Cells undergoing immunogenic death emit danger signals which facilitate anti-tumor immune responses. Although pathways leading to immunogenic cell death are not fully understood; oxidative stress is considered to be part of the underlying mechanism. Here; we studied the interaction between dielectric barrier discharge plasma and cancer cells for oxidative stress-mediated immunogenic cell death...
May 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28456226/experimental-investigation-on-electrical-characteristics-and-dose-measurement-of-dielectric-barrier-discharge-plasma-device-used-for-therapeutic-application
#14
Zahra Shahbazi Rad, Fereydoun Abbasi Davani
In this research, a Dielectric Barrier Discharge (DBD) plasma device operating in air has been made. The electrical characteristics of this device like instantaneous power, dissipated power, and discharge capacitance have been measured. Also, the effects of applied voltage on the dissipated power and discharge capacitance of the device have been investigated. The determination of electrical parameters is important in DBD plasma device used in living tissue treatment for choosing the proper treatment doses and preventing the destructive effects...
April 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28456023/paternal-psychopathological-risk-and-psychological-functioning-in-children-with-eating-disorders-and-disruptive-behavior-disorder
#15
Luca Cerniglia, Pietro Muratori, Annarita Milone, Marinella Paciello, Laura Ruglioni, Silvia Cimino, Valentina Levantini, Renata Tambelli
Several studies demonstrated that maternal psychopathological risk is related to child's maladjustment, but until recently research has relatively neglected fathers. Disruptive Behavior Disorder (DBD) and Eating disorders (ED) have a large prevalence during childhood but a few studies have focused on their association with paternal psychopathological risk. One-hundred and thirty-nine children and their fathers were recruited from pediatric hospitals and outpatient clinics and paired with a healthy control group (CG)...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28432354/structural-and-functional-analysis-of-lysozyme-after-treatment-with-dielectric-barrier-discharge-plasma-and-atmospheric-pressure-plasma-jet
#16
Sooho Choi, Pankaj Attri, Inhwan Lee, Jeongmin Oh, Ji-Hye Yun, Ji Hoon Park, Eun Ha Choi, Weontae Lee
The variation in the biological function of proteins plays an important role in plasma medicine and sterilization. Several non-thermal plasma sources with different feeding gases are used worldwide for plasma treatment, including dielectric barrier discharge (DBD) and atmospheric-pressure plasma jet (APPJ) as the most commonly used sources. Therefore, in the present work, we used both DBD and APPJ plasma sources with N2 and air as feeding gases to evaluate the effects on the structural, thermodynamic, and activity changes of enzymes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432336/structure-function-analysis-of-the-dna-binding-domain-of-a-transmembrane-transcriptional-activator
#17
Andreas Schlundt, Sophie Buchner, Robert Janowski, Thomas Heydenreich, Ralf Heermann, Jürgen Lassak, Arie Geerlof, Ralf Stehle, Dierk Niessing, Kirsten Jung, Michael Sattler
The transmembrane DNA-binding protein CadC of E. coli, a representative of the ToxR-like receptor family, combines input and effector domains for signal sensing and transcriptional activation, respectively, in a single protein, thus representing one of the simplest signalling systems. At acidic pH in a lysine-rich environment, CadC activates the transcription of the cadBA operon through recruitment of the RNA polymerase (RNAP) to the two cadBA promoter sites, Cad1 and Cad2, which are directly bound by CadC...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427034/taxometric-analyses-and-predictive-accuracy-of-callous-unemotional-traits-regarding-quality-of-life-and-behavior-problems-in-non-conduct-disorder-diagnoses
#18
Pierre C M Herpers, Helen Klip, Nanda N J Rommelse, Mark J Taylor, Corina U Greven, Jan K Buitelaar
Callous-unemotional (CU) traits have mainly been studied in relation to conduct disorder (CD), but can also occur in other disorder groups. However, it is unclear whether there is a clinically relevant cut-off value of levels of CU traits in predicting reduced quality of life (QoL) and clinical symptoms, and whether CU traits better fit a categorical (taxonic) or dimensional model. Parents of 979 youths referred to a child and adolescent psychiatric clinic rated their child's CU traits on the Inventory of Callous-Unemotional traits (ICU), QoL on the Kidscreen-27, and clinical symptoms on the Child Behavior Checklist...
April 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28426684/long-term-results-after-transplantation-of-pediatric-liver-grafts-from-donation-after-circulatory-death-donors
#19
Rianne van Rijn, Pieter E R Hoogland, Frank Lehner, Ernest L W van Heurn, Robert J Porte
BACKGROUND: Liver grafts from donation after circulatory death (DCD) donors are increasingly accepted as an extension of the organ pool for transplantation. There is little data on the outcome of liver transplantation with DCD grafts from a pediatric donor. The objective of this study was to assess the outcome of liver transplantation with pediatric DCD grafts and to compare this with the outcome after transplantation of livers from pediatric donation after brain death (DBD) donors. METHOD: All transplantations performed with a liver from a pediatric donor (≤16 years) in the Netherlands between 2002 and 2015 were included...
2017: PloS One
https://www.readbyqxmd.com/read/28416437/the-computed-tomography-based-fractal-analysis-of-trabecular-bone-structure-may-help-in-detecting-decreased-quality-of-bone-before-urgent-spinal-procedures
#20
Marcin Czyz, Arion Kapinas, James Holton, Renata Pyzik, Bronek M Boszczyk, Nasir A Quraishi
BACKGROUND CONTEXT: To date, no reliable method is available to determine the parameters of bone density based on the routine spinal computed tomography (CT) in the emergency setup. We propose the use of fractal analysis to detect patients with poor quality of bone before urgent or semi-urgent spinal procedures. PURPOSE: This study aimed to validate the hypothesis that the CT-based fractal analysis of the trabecular bone structure may help in detecting patients with poor quality of bone before urgent spinal procedures...
April 14, 2017: Spine Journal: Official Journal of the North American Spine Society
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