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Jing Chen, Sheng-Zhe Wang, Jun-Yu Chen, Dong-Zhi Chen, Shang-Gui Deng, Bin Xu
BACKGROUND: Atmospheric cold plasma (ACP) has emerged as a potential alternative to traditional methods for non-thermal food decontamination. However, little data are available about ACP treatment for seafood. In this study, dielectric barrier discharge (DBD) was applied to generate CP, and the aim of the study was to investigate the effectiveness of DBD-ACP on improving the quality of chub mackerel on the basis of chemical, microbial, and sensory characteristics. RESULTS: The effect of DBD-ACP on the quality of chub mackerel (Scomber japonicus) during storage was examined...
May 21, 2018: Journal of the Science of Food and Agriculture
Ling Ma, Jinrong Qiu, Yaodong Zhang, Tianzhu Qiu, Biao Wang, Wensen Chen, Xiao Li, Jing Sun, Ke Wang, Xiangcheng Li, Yanhong Gu, Yongqian Shu, Xiaofeng Chen
Background: Biliary tract cancers (BTCs) are uncommon but fatal, with a low 5-year survival rate after surgical resection. This study was designed to investigate the prognostic factors for operable BTC. Methods: Baseline demographics at diagnosis were retrospectively evaluated in 341 BTC patients undergoing radical surgery at The First Affiliated Hospital of Nanjing Medical University from January 2011 to December 2015. The association between prognostic factors and overall survival (OS) was determined by multivariate analysis using the Cox proportional hazards regression model...
2018: OncoTargets and Therapy
Tomoshige Kino
The human genome contains numerous single nucleotide variations (SNVs), and the human GR gene harbors ∼450 of these genetic changes. Among them, extremely rare non-synonymous variants known as pathologic GR gene mutations develop a characteristic pathologic condition, familial/sporadic generalized glucocorticoid resistance syndrome, by replacing the amino acids critical for GR protein structure and functions, whereas others known as pathologic polymorphisms develop mild manifestations recognized mainly at population bases by changing the GR activities slightly...
May 11, 2018: Endocrinology
Annemarie Weissenbacher, Letizia Lo Faro, Olga Boubriak, Maria F Soares, Ian S Roberts, James P Hunter, Daniel Voyce, Nikolay Mikov, Andrew Cook, Rutger J Ploeg, Constantin C Coussios, Peter J Friend
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ utilization and improved transplantation logistics. Eleven clinically-declined kidneys were perfused normothermically, six from donors after brain stem death (DBD, median cold ischemia time 33±36.9 hours) and five from donors after circulatory death (DCD, 36.2±38.3 hours): n=3 kidneys were perfused using Ringer's lactate to replace excreted urine volume, and n=8 using urine recirculation to maintain perfusate volume without fluid replenishment...
May 14, 2018: American Journal of Transplantation
Cameron D Buchman, Sergio C Chai, Taosheng Chen
Pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that play major roles in the expression of various drug metabolism enzymes and are known for their ligand promiscuity. As with other nuclear receptors, PXR and CAR are each composed of a ligand-binding domain (LBD) and a DNA-binding domain (DBD) connected by a hinge region. Areas covered: This review focuses on the information obtained over the last 15+ years from X-ray crystallography studies of the structure of PXR and CAR...
May 14, 2018: Expert Opinion on Drug Metabolism & Toxicology
Patrick Vanraes, Niels Wardenier, Pieter Surmont, Frederic Lynen, Anton Nikiforov, Stijn W H Van Hulle, Christophe Leys, Annemie Bogaerts
A falling film dielectric barrier discharge (DBD) plasma reactor combined with adsorption on activated carbon textile material was optimized to minimize the formation of hazardous oxidation by-products from the treatment of persistent pesticides (alachlor, diuron and isoproturon) in water. The formation of by-products and the reaction mechanism was investigated by HPLC-TOF-MS. The maximum concentration of each by-product was at least two orders of magnitude below the initial pesticide concentration, during the first 10 min of treatment...
May 3, 2018: Journal of Hazardous Materials
Roman Chmel, Marta Novackova, Zlatko Pastor, Jiri Fronek
STUDY OBJECTIVE: The goal of this study was to assess a group of Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) women with surgically created neovaginas in the interest of uterus transplantation (UTx) and to recruit the first group of applicants for a uterus transplant trial. DESIGN: and Setting: This is an original prospective study using semistructured interviews. PARTICIPANTS: A study group of 50 MRKH syndrome women with Vecchietti neovaginas was recruited by letter of invitation...
May 8, 2018: Journal of Pediatric and Adolescent Gynecology
Bochuan Tan, Shengtao Zhang, Yujie Qiang, Lei Guo, Li Feng, Chaohui Liao, Yue Xu, Shijin Chen
Diallyl disulfide (DAD), propyl disulfide (PPD) and dibenzyl disulfide (DBD) flavouring agents as copper corrosion inhibitors in 0.5 mol/L H2 SO4 solution were evaluated with multitudinous experiments including electrochemical techniques, morphological characterization measurements, FTIR spectra and theoretical calculations. The electrochemical results indicate that PPD and DBD show mixed-type inhibitors and DAD belongs to cathodic-type inhibitor, and the corrosion inhibition capacity follow order: PPD > DBD > DAD...
April 25, 2018: Journal of Colloid and Interface Science
Yaquan Liu, Kaili Qu, Ying Hai, Chunyan Zhao
Previous research has shown that the major toxicity mechanism for many environment chemicals is binding with estrogen receptor (ER) and blocking endogenous estrogen access, including bisphenol A (BPA). However, the molecular level understanding the global consequence of BPA binding on the full-length architectures of ER is largely unknown, which is a necessary stage to evaluate estrogen-like toxicity of BPA. In the present work, the consequence of BPA on full-length architectures of ER was firstly modeled based on molecular dynamics, focusing on the cross communication between multi-domains including ligand binding domain (LBD) and DNA binding domain (DBD)...
May 8, 2018: Journal of Cellular Biochemistry
Natalia V Zharikova, Timur R Iasakov, Boris K Bumazhkin, Ekaterina O Patutina, Evgeniia I Zhurenko, Vladislav V Korobov, Alina I Sagitova, Boris B Kuznetsov, Tatiana V Markusheva
A small plasmid designated pCS36-4CPA with a size of 5217 base pairs and G-C content of 50.74% was isolated from Citrobacter sp. 36-4CPA. The origin of replication ( ori ) of the plasmid was identified as a region of about 800 bp in length with an identity of 67.1% to the ColE1 plasmid at the nucleotide level. The replication region contained typical elements of ColE1-like plasmids: RNA I and RNA II with their corresponding -10 and -35 boxes, a single-strand initiation site ( ssi ), and a lagging-strand termination site ( terH )...
May 2018: Saudi Journal of Biological Sciences
Fuqiang Ban, Kush Dalal, Eric LeBlanc, Hélène Morin, Paul S Rennie, Artem Cherkasov
Androgen receptor (AR) is a master regulator of prostate cancer (PCa), and therefore is a pivotal drug target for the treatment of PCa including its castration-resistance form (CRPC). The development of acquired resistance is a major challenge in the use of the current antiandrogens. The recent advancements in inhibiting AR activity with small molecules specifically designed to target areas distinct from the receptor's androgen binding site are carefully discussed. Our new classes of AR inhibitors of AF2 and BF3 functional sites and DBD domains designed using cheminformatics techniques are promising to circumvent various AR-dependent resistance mechanisms...
May 7, 2018: Molecular Informatics
Baohua Chen, Yun Zhu, Sheng Ye, Rongguang Zhang
Myelin-gene regulatory factor (MYRF) is a membrane-bound transcription factors, which is responsible for the differentiation of oligodendrocytes and myelination of central nervous system. Followed by a self-cleavage by the intramolecular chaperone auto-processing (ICA) domain, DNA-binding domain (DBD) of MYRF is released from the endoplasmic reticulum (ER) and translocated to the nucleus to regulate gene expression. In present work, we have solved the crystal structure of the human MYRF-DBD to 1.85-Å resolution...
May 2, 2018: Journal of Structural Biology
Laurent Bianchetti, Bianca Wassmer, Audrey Defosset, Anna Smertina, Marion L Tiberti, Roland H Stote, Annick Dejaegere
BACKGROUND: Nuclear hormone receptors (NRs) constitute a large family of multi-domain ligand-activated transcription factors. Dimerization is essential for their regulation, and both DNA binding domain (DBD) and ligand binding domain (LBD) are implicated in dimerization. Intriguingly, the glucocorticoid receptor-α (GRα) presents a DBD dimeric architecture similar to that of the homologous estrogen receptor-α (ERα), but an atypical dimeric architecture for the LBD. The physiological relevance of the proposed GRα LBD dimer is a subject of debate...
April 30, 2018: Biochimica et Biophysica Acta
Christoph Troppmann, Chandrasekar Santhanakrishnan, Ghaneh Fananapazir, Kathrin Troppmann, Richard Perez
En bloc kidney transplants (EBK) from very small pediatric donation after circulatory death (DCD) donors are infrequent owing to the perception that DCD adversely impacts outcomes. We retrospectively studied 130 EBKs from donors ≤10 kg (65 consecutive DCD vs. 65 donation after brain death [DBD] transplants; pair-matched for: donor weight and terminal creatinine; preservation time). For DCD vs. DBD, median donor weight was 5.0 vs. 5.0 kg; median recipient age 57 vs. 48 years (p=0.006). Graft losses from thrombosis (DCD, 5%; DBD, 7%) or primary nonfunction (DCD, 3%; DBD, 0%) were similar in both groups (p=0...
May 2, 2018: American Journal of Transplantation
Xiaojuan Liu, Aihong Li, Yuanyuan Ju, Wangrui Liu, Hui Shi, Renyue Hu, Zijian Zhou, Xiaolei Sun
The inflammatory activation of microglia has double-edged effects in central nervous system (CNS) diseases. The ligand-activated transcriptional factor peroxisome proliferator-activated receptor γ (PPARγ) inhibits the inflammatory response. β-1,4-Galactosyltransferase Ι (β1, 4GalT1) mediates N-glycosylation. In this study, the N-glycosylation of PPARγ, as well as two N-linked glycosylation sites in its DNA binding domain (DBD), was identified. Disruption of both sites by site-directed mutagenesis completely abrogated the N-glycosylation of PPARγ...
May 1, 2018: Inflammation
Maria Carmen Mulero, Shandy Shahabi, Myung Soo Ko, Jamie M Schiffer, Debin Huang, Vivien Ya-Fan Wang, Rommie E Amaro, Tom Huxford, Gourisankar Ghosh
Transcription activator proteins typically contain two functional domains: a DNA binding domain (DBD) that binds to DNA with sequence specificity, and an activation domain (AD) whose established function is to recruit RNA polymerase. In this report, we show that purified recombinant nuclear factor κB (NF-κB) RelA dimers bind specific κB DNA sites with significantly lower affinity than the same dimers from nuclear extracts of activated cells suggesting that additional nuclear co-factors might facilitate DNA binding by the RelA dimers...
April 30, 2018: Biochemistry
Andrei A Puiu, Olga Wudarczyk, Katharina S Goerlich, Mikhail Votinov, Kerstin Konrad, Bruce Turetsky, Beate Herpertz-Dahlmann
BACKGROUND: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms. AIMS AND METHODS: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder-specific and shared IA and RI aberrant neural mechanisms. RESULTS: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA...
April 21, 2018: Neuroscience and Biobehavioral Reviews
Yuehan Qi, Xuefei Mao, Jixin Liu, Xing Na, Guoying Chen, Meitong Liu, Chuangmu Zheng, Yongzhong Qian
The mechanisms of arsenic gas phase enrichment (GPE) by dielectric barrier discharge (DBD) was investigated via X-ray photoelectron spectroscopy (XPS), in-situ fiber optic spectrometer (FOS), etc. It proved for the first time that the arsenic species during DBD trapping, release, and transportation to the atomic fluorescence spectrometer (AFS) are probably oxides, free atoms and atom clusters, respectively. Accordingly, a novel in-situ DBD trap as a GPE approach was re-designed using three-concentric quartz tube design and a modified gas line system...
April 24, 2018: Analytical Chemistry
Xiaoxiang Peng, Yuntao Zhou, Yanli Sun, Wei Song, Xiangying Meng, Chunling Zhao, Ronglan Zhao
Association studies suggest that TRβ1 functions as a tumor suppressor. Thyroid hormone receptors (TRs) mediate transcriptional responses through a highly conserved DNA-binding domain (DBD). We previously constructed an artificially modified human TRβ1 (m-TRβ1) via the introduction of a 108-bp exon sequence into the corresponding position of the wild-type human TRβ1 (TRβ1) DBD. Studies confirmed that m-TRβ1 was functional and could inhibit the proliferation of breast cancer MDA-MB-468 cells in vitro. To understand the role of m-TRβ1 in liver tumor development, we adopted a gain-of-function approach by stably expressing TRβ (m-TRβ1 and TRβ1) genes in a human hepatocarcinoma cell line, SK-hep1 (without endogenous TRβ), and then evaluated the effects of the expressed TRβ on cancer cell proliferation, migration, and tumor growth in cell-based studies and xenograft models...
April 20, 2018: Molecular and Cellular Biochemistry
Hyeon Jin Seo, Ki-Hwan Hwang, Young Hoon Na, Jin-Hyo Boo
This study focused on the photocatalytic degradation effect of the μ-dielectric barrier discharge (μ-DBD) plasma treated titanium dioxide (TiO2) nanoparticles on environmental contaminant such as formaldehyde. TiO2 nanoparticles were treated by a μ-DBD plasma source with nitrogen gas. We analyzed the degradation of formaldehyde with the plasma treated TiO2 nanoparticles by UV-visible spectrophotometer (UV-VIS), and demonstrated that the photocatalytic activity of the μ-DBD plasma-treated TiO2 nanoparticles showed significantly high catalytic efficiency rather than without plasma treated TiO2 nanoparticles...
September 1, 2018: Journal of Nanoscience and Nanotechnology
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