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Hao Ji, Bingqing Hui, Jirong Wang, Ya Zhu, Lingyu Tang, Peng Peng, Tianjun Wang, Lijuan Wang, Shufeng Xu, Juan Li, Keming Wang
Colorectal cancer (CRC) is the third most common malignant in the world, and long noncoding RNA (lncRNA) has become a new gene. Here, we report a novel lncRNA MAPKAPK5-AS1 which acts as a critical oncogene in the CRC. In addition, we attempted to explore the functions of MAPKAPK5-AS1 on tumor progression in vitro and in vivo. qRT-PCR was performed to examine the expression of MAPKAPK5-AS1 in CRC tissues and cells. MAPKAPK5-AS1 expression was significantly up-regulated in 50 colorectal cancer tissues and increased expression of MAPKAPK5-AS1 was found to be associated with greater tumor size and advanced pathological stages in CRC patients...
October 21, 2018: Cancer Science
J W Varni, A M Delamater, K K Hood, J K Raymond, N T Chang, K A Driscoll, J C Wong, J P Yi-Frazier, E K Grishman, M A Faith, S D Corathers, J C Kichler, J L Miller, E M Doskey, V P Aguirre, R W Heffer, D P Wilson
AIM: To test the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module originally developed in Type 1 diabetes in youth with Type 2 diabetes. METHODS: The PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were administered in a field test study to 100 young people aged 9-25 years with Type 2 diabetes. Factor analysis was conducted to determine the factor structure of the items. RESULTS: The 15-item Diabetes Symptoms Summary Score and 12-item Type 2-specific Diabetes Management Summary Score were empirically derived through factor analysis...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Leila Ferguson, Masaki Futamura, Efstratios Vakirlis, Reiji Kojima, Hatoko Sasaki, Amanda Roberts, Rintaro Mori
BACKGROUND: Eczema is a common, chronic, inflammatory skin condition that is frequently associated with atopic conditions, including asthma. Leukotriene receptor antagonists (LTRAs) have a corticosteroid-sparing role in asthma, but their role in eczema remains controversial. Currently available topical therapies for eczema are often poorly tolerated, and use of systemic agents is restricted by their adverse effect profile. A review of alternative treatments was therefore warranted. OBJECTIVES: To assess the possible benefits and harms of leukotriene receptor antagonists for eczema...
October 21, 2018: Cochrane Database of Systematic Reviews
A Corradini, G Campochiaro, M Gialdini, M Rebuzzi, P Baudi
PURPOSE: Glenoid fractures occur as a result of direct impact of the humeral head against the glenoid rim following high-energy trauma. They frequently involve one-third of the glenoid surface with an oblique fracture rim from 2 to 6-7 o'clock, and they must not be confused with bony Bankart lesions. In medium-age patients, they are frequently associated with acute cuff tear while in older patients with chronic cuff tear: These conditions increase the instability of the shoulder if not treated...
October 2018: Musculoskeletal Surgery
Mikhail Mavlikeev, Angelina Titova, Renata Saitburkhanova, Maria Abyzova, Ilyas Sayfutdinov, Nasima Gizzatullina, Ilya Kotov, Igor Plaksa, Artur Isaev, Sayar Abdulkhakov, Andrey Kiyasov, Roman Deev
Herein we present a clinical case of the Caroli syndrome caused by the compound heterozygous mutation in the PKHD1 gene. Histopathological assessment of liver detected biliary cirrhosis, numerous dilated bile ducts of various sizes, hyperplastic cholangiocytes containing a large amount of acid mucopolysaccharides, decreased ß-tubulin expression and increased proliferation of cholangiocytes. A significant proportion of hepatic tissue was composed of giant cysts lined with a single layer of cholangiocytes, containing pus and bile in its lumen and surrounded by granulation tissue...
October 20, 2018: Clinical Journal of Gastroenterology
Jean-Marc Classe, Cecile Loaec, P Gimbergues, S Alran, C Tunon de Lara, P F Dupre, Roman Rouzier, C Faure, N Paillocher, M P Chauvet, G Houvenaeghel, M Gutowski, P De Blay, J L Verhaeghe, E Barranger, C Lefebvre, C Ngo, G Ferron, C Palpacuer, L Campion
PURPOSE: GANEA2 study was designed to assess accuracy and safety of sentinel lymph node (SLN) after neo-adjuvant chemotherapy (NAC) in breast cancer patients. METHODS: Early breast cancer patients treated with NAC were included. Before NAC, patients with cytologically proven node involvement were allocated into the pN1 group, other patient were allocated into the cN0 group. After NAC, pN1 group patients underwent SLN and axillary lymph node dissection (ALND); cN0 group patients underwent SLN and ALND only in case of mapping failure or SLN involvement...
October 20, 2018: Breast Cancer Research and Treatment
Anna M Mazor, Alina M Mateo, Lyudmila Demora, Elin R Sigurdson, Elizabeth Handorf, John M Daly, Allison A Aggon, Penny R Anderson, Stephanie E Weiss, Richard J Bleicher
PURPOSE: Breast conservation therapy (BCT) is standard for T1-T2 tumors, but early trials excluded breast cancers > 5 cm. This study was performed to assess patterns and outcomes of BCT for T3 tumors. METHODS: We reviewed the National Cancer Database (NCDB) for noninflammatory breast cancers > 5 cm, between 2004 and 2011 who underwent BCT or mastectomy (Mtx) with nodal evaluation. Patients with skin or chest wall involvement were excluded. Patients having clinical T3 tumors were analyzed to determine outcomes based upon presentation, with those having pathologic T3 tumors, subsequently assessed, irrespective of presentation...
October 20, 2018: Breast Cancer Research and Treatment
Carlos Blanco, John C Markowitz, David J Hellerstein, Arthur M Nezu, Melanie Wall, Mark Olfson, Ying Chen, Jon Levenson, Maika Onishi, Cindy Varona, Mayumi Okuda, Dawn L Hershman
PURPOSE: Breast cancer (BC) is a risk factor for major depressive disorder (MDD), yet little research has tested the efficacy of different psychotherapies for depressed women with BC. This study, the largest to date, compared outcomes of three evidence-based, 12-week therapies in treating major depressive disorder among women with breast cancer. METHODS: This randomized trial compared interpersonal psychotherapy (IPT), problem solving therapy (PST), and brief supportive psychotherapy (BSP)...
October 20, 2018: Breast Cancer Research and Treatment
Sandro Huenchuguala, Birgitta Sjödin, Bengt Mannervik, Juan Segura-Aguilar
Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson's disease. Oxidative stress produces aminochrome from dopamine, but conjugation with glutathione catalyzed by glutathione transferase M2-2 significantly decreases aminochrome-induced toxicity and alpha-synuclein oligomer formation. Notably, in the presence of the aminochrome-glutathione conjugate, previously unknown species of alpha-synuclein oligomers are formed. These aminochrome-glutathione oligomers of alpha-synuclein differ from formerly characterized oligomers and (i) have high molecular weight, and are stable and SDS-resistant, as determined by the Western blot method, (ii) show positive NBT-quinone-protein staining, which indicates the formation of alpha-synuclein adducts containing aminochrome...
October 20, 2018: Neurotoxicity Research
G Nic Rider, Barbara J McMorris, Amy L Gower, Eli Coleman, Marla E Eisenberg
Most gambling research utilizes general youth samples and focuses on binary gender categories; few studies examine and compare gambling behaviors between transgender and gender diverse (TGD) youth and their cisgender peers. The current study used population-based data from the 2016 Minnesota Student Survey to compare the prevalence of gambling behaviors and problem gambling among TGD versus cisgender adolescents, in addition to examining differences by birth-assigned sex. The analytic sample consisted of 80,929 students (including, n = 2168 [2...
October 20, 2018: Journal of Gambling Studies
Yadav Gyawali, Wei Zhang, Shiaoman Chao, Steven Xu, Xiwen Cai
We detected the deletion breakpoints of wheat ph1b mutant and the actual size of the deletion. Also, we developed ph1b deletion-specific markers useful for ph1b-mediated gene introgression and genome studies. The Ph1 (pairing homoeologous) locus has been considered a major genetic system for the diploidized meiotic behavior of the allopolyploid genome in wheat. It functions as a defense system against meiotic homoeologous pairing and recombination in polyploid wheat. A large deletion of the genomic region harboring Ph1 on the long arm of chromosome 5B (5BL) led to the ph1b mutant in hexaploid wheat 'Chinese Spring,' which has been widely used to induce meiotic homoeologous recombination for gene introgression from wild grasses into wheat...
October 20, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Qianqian Huang, Yun Hu, Guangying He, Chunjing Lin, Chaohai Wei
A series of anatase TiO2 nanosheets with different percentage of {001} facets ({001}TiO2 ) were synthesized through a hydrothermal route using tetrabutyltitanate as a titanium precursor and HF as a shape controlling agent. The amount of HF exhibits an obvious influence on the structures and activities of TiO2 samples. The adsorbed surface F- ions on the {001} facets of the anatase TiO2 were removed by washing them with NaOH solution. The as-prepared catalysts were characterized by X-ray diffraction, Brunner-Emmet-Teller measurements, ultraviolet-visible diffuse reflectance spectroscopy, scanning electron microscopy, transmission electron microscopy techniques, and X-ray photoelectron spectroscopy analysis...
October 20, 2018: Environmental Science and Pollution Research International
Georgia Wingfield, Frank E Marino, Melissa Skein
Pacing during exercise performance is well-established; however, little is known about the neural responses associated with changes in power output and the effect of exercise end-point knowledge. Therefore, the aim of this study was to examine the effect of deception of cycling distance on pacing, cerebral oxy- (O2 Hb) and deoxy-haemoglobin concentrations, and alpha (α) wave activity. Ten well-trained male cyclists (23.7 ± 6.6 years) completed three cycling time trials (TT) on a stationary air-braked cycle ergometer and were informed the study was to examine the reliability of 3 × 30-km TT...
October 20, 2018: Pflügers Archiv: European Journal of Physiology
Xiao Chen, Jihua Liu, Yongle Xu, Yanan Wang, Xiaojun Yan
A Gram-negative, motile, rod-shaped, aerobic bacterial strain with tufty polar flagella, JLT1363T , was isolated from the South China Sea. The bacteria formed yellow colonies on rich organic medium. The major cellular fatty acids present in JLT1363T were C18:1 ω7c and/or C18:1 ω6c (36.06%), C17:1 ω6c (17.04%), C14:0 2-OH (9.85%), and C16:0 (8.09%). The genome size was ~3.12 Mbps with a G+C content of 64.9%. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain JLT1363T fell within the genus Erythrobacter...
October 20, 2018: Current Microbiology
Lin Che, Weiping Xu, Jingjing Zhan, Lei Zhang, Lifen Liu, Hao Zhou
Metallic selenides nanomaterials are widely used in many fields, especially for photothermal therapy and thermoelectric devices. However, the traditional chemogenic methods are energy-intensive and environmentally unfriendly. In this study, the first complete genome data of a metallic selenides producing bacterium Bacillus cereus CC-1 was reported. This strain can not only reduce selenite and selenate into elemental selenium nanoparticles (SeNPs), but also synthesize several metallic selenides nanoparticles when adding metal ions (Pb2+ , Ag+ and Bi3+ ) and selenite simultaneously...
October 20, 2018: Current Microbiology
Ke Ding, Jianyang Jiang, Liang Chen, Xiaohua Xu
BACKGROUND Non-small cell lung cancer (NSCLC) accounts for about 85% of all types of lung cancer. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is involved in DNA methylation, and DNA methylation is related to tumorigenesis. The role of MTHFD1 in NSCLC was examined in our study. MATERIAL AND METHODS The correlation between the expression of MTHFD1 and the clinicopathological features of patients diagnosed with lung cancer was investigated using the chi-square test. The viability and apoptosis of NCI-H1299 cells was respectively detected using cell counting kit-8 and flow cytometry assays...
October 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ana Dionísio, Isabel Catarina Duarte, Miguel Patrício, Miguel Castelo-Branco
BACKGROUND: Following a stroke event, patients often are severely affected by disabilities that hinder their quality-of-life. There are currently several rehabilitative options and strategies, and it is crucial to find the most effective interventions. The applicability of transcranial magnetic stimulation (TMS) to the recovery of nonmotor functions such as communication skills, swallowing ability and spatial attention after stroke remains important clinical questions. SUMMARY: We searched PubMed and ISI Web of Science for articles that used repetitive TMS protocols to rehabilitate post-stroke deficits...
October 19, 2018: Cerebrovascular Diseases
Tal Sadeh-Vered, Nurit Rosenberg, Iris Morag, Asaf A Berg, Gili Kenet, Tzipora Strauss
BACKGROUND: We evaluated the effect of surfactant on platelet function as a potential contributing mechanism to the pathogenesis of pulmonary hemorrhage (PHEM) in term and preterm infants. METHODS: Cord blood samples were collected from neonates following delivery. Complete blood count and platelet function were measured using a cone and platelet analyzer (CPA). Increasing surfactant concentrations were added to platelets in vitro, and the adhesion molecule P-selectin and the monoclonal antibody PAC-1 were evaluated following platelet activation by flow cytometry...
October 19, 2018: Acta Haematologica
Ruggero Rossi, David Jones, Jaewook Myung, Emily Zikmund, Wulin Yang, Yolanda Alvarez Gallego, Deepak Pant, Patrick J Evans, Martin A Page, Donald M Cropek, Bruce E Logan
To scale up microbial fuel cells (MFCs), larger cathodes need to be developed that can use air directly, rather than dissolved oxygen, and have good electrochemical performance. A new type of cathode design was examined here that uses a "window-pane" approach with fifteen smaller cathodes welded to a single conductive metal sheet to maintain good electrical conductivity across the cathode with an increase in total area. Abiotic electrochemical tests were conducted to evaluate the impact of the cathode size (exposed areas of 7 cm2 , 33 cm2 , and 6200 cm2 ) on performance for all cathodes having the same active catalyst material...
October 10, 2018: Water Research
Feride Kural Rahatli, Fuldem Yildirim Donmez, Cagri Kesim, Kemal Murat Haberal, Hale Turnaoglu, Ahmet Muhtesem Agildere
PURPOSE: We hypothesized that unenhanced brain MRI can be used in follow up of patients with intracranial meningioma to avoid gadolinium deposition in the brain and allow measurement of meningioma dimensions from pre-contrast T2-weighted images. METHODS: Dimensions of meningiomas were measured on pre-contrast T2, post-contrast T1 weighted images. RESULTS: The sizes of meningiomas in post-contrast axial T1-weighted images were similar with that in pre-contrast axial T2-weighted images...
October 13, 2018: Clinical Imaging
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