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G Résimont, R Gadisseur, L Lutteri, J M Krzesinski, E Cavalier, P Delanaye
The measurement of proteinuria is a very simple tool to screen and manage kidney diseases. Its predictive role is also relevant from a cardiovascular point of view. However, the interpretation of the results is not always easy. Indeed, there are several different methods to detect or measure proteinuria (or albuminuria), varying from the measurement on a 24-hour urine collection to the simplest detection with dipsticks or measurement on a random urine sample. Some methods are measuring total proteins, whereas others are measuring more specifically albuminuria...
October 2018: Revue Médicale de Liège
Robert H Press, Chao Zhang, Mudit Chowdhary, Roshan S Prabhu, Matthew J Ferris, Karen M Xu, Jeffrey J Olson, Bree R Eaton, Hui-Kuo G Shu, Walter J Curran, Ian R Crocker, Kirtesh R Patel
BACKGROUND: Brain metastases (BM) treated with surgical resection and focal postoperative radiotherapy have been associated with an increased risk of subsequent leptomeningeal dissemination (LMD). BMs with hemorrhagic and/or cystic features contain less solid components and may therefore be at higher risk for tumor spillage during resection. OBJECTIVE: To investigate the association between hemorrhagic and cystic BMs treated with surgical resection and stereotactic radiosurgery and the risk of LMD...
October 17, 2018: Neurosurgery
Nikolas Plevris, Mathew Lyons, Philip W Jenkinson, Cher S Chuah, Lynne M Merchant, Rebecca J Pattenden, Eleanor F Watson, Gwo-Tzer Ho, Colin L Noble, Alan G Shand, Shahida Din, Ian D Arnott, Gareth R Jones, Charlie W Lees
Background: Adalimumab is an established treatment for Crohn's disease. Limited data are available regarding the relationship between adalimumab drug levels and serum/fecal markers of gut inflammation. We therefore aimed to characterize the relationship between adalimumab levels and biologic remission during maintenance therapy. Methods: A single-center prospective cross-sectional study was undertaken on Crohn's disease patients who had received adalimumab therapy for a minimum of 12 weeks after induction...
October 17, 2018: Inflammatory Bowel Diseases
S Loibl, K E Weber, K M Timms, E P Elkin, E Hahnen, P A Fasching, B Lederer, C Denkert, A Schneeweiss, S Braun, C T Salat, M Rezai, J U Blohmer, D M Zahm, C Jackisch, B Gerber, P Klare, S Kümmel, C Schem, S Paepke, R Schmutzler, K Rhiem, S Penn, J Reid, V Nekljudova, A-R Hartman, G von Minckwitz, M Untch
Background: In the neoadjuvant GeparSixto study, adding carboplatin to taxane- and anthracycline-based chemotherapy improved pathological complete response (pCR) rates in patients with triple-negative breast cancer (TNBC). Here, we present survival data and the potential prognostic and predictive role of homologous recombination deficiency (HRD). Patients and Methods: Patients were randomized to paclitaxel plus non-pegylated liposomal doxorubicin (Myocet®) (PM) or PM plus carboplatin (PMCb)...
October 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
I R Weir, G D Marshall, J I Schneider, J A Sherer, E M Lord, B Gyawali, M K Paasche-Orlow, E J Benjamin, L Trinquart
Background: Multiple features in the presentation of randomized controlled trial (RCT) results are known to influence comprehension and interpretation. We aimed to compare interpretation of cancer RCTs with time-to-event outcomes when the reported treatment effect measure is the hazard ratio (HR), difference in restricted mean survival times (RMSTD), or both (HR+RMSTD). We also assessed the prevalence of misinterpretation of the HR. Patients and methods: We performed a randomized experiment...
October 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
G R Tabeeva
Alzheimer's disease and vascular dementia are two most common causes of dementia in late life. The combination of Alzheimer's type dementia and vascular dementia is the third most common form of dementia, especially in the elderly. Most clinical forms of dementia are characterized by the presence of 'overlap' symptoms of both neurodegenerative and vascular pathology, which makes it expedient to consider mixed dementia as a separate entity characterized by clinical presentations, course and the rate of progression of cognitive decline...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
R N Mustafin, R F Enikeeva, S B Malykh, R G Valinurov, E K Khusnutdinova
Molecular genetic studies of attention deficit hyperactivity disorder (ADHD) have demonstrated the involvement of multiple genes in the etiology of ADHD. A polygenic hypothesis of the etiopathogenesis was formulated without clear knowledge of common mechanisms of ADHD development. Twin, family and adoption studies have established the heritability of 70-80% for ADHD. Association studies have shown the relationship between ADHD and genes of dopaminergic (DRD4, DRD5, SLC6A3), serotoninergic (HTR1B, 5-HTTLPR), glutamatergic (mGluR, NDRG2) systems, metabolic pathways (SLC2A3, SLC6A4, CDH13, CFOD1, GFOD1), membrane proteins (KChIP1, ITGA1, SNAP-25) as well as tumour-suppressor (NDRG2, NF1) and cytokine genes...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Benjamin K Potter, Robert G Sheu, Daniel Stinner, John Fergason, Joseph R Hsu, Kevin Kuhn, Johnny G Owens, Jessica Rivera, Scott B Shawen, Jason M Wilken, Jennifer DeSanto, Yanjie Huang, Daniel O Scharfstein, Ellen J MacKenzie
BACKGROUND: The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is a custom energy-storing carbon fiber ankle-foot orthosis developed for lower-extremity trauma patients. Studies conducted at the military treatment facility where the IDEO was developed demonstrated benefits of the IDEO when used with the Return to Run Physical Therapy (RTR PT) program. The current study was designed to determine if results could be replicated at other military treatment facilities and to examine whether early performance gains in patient-reported functional outcomes remained at 12 months...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
V P Mantripragada, W A Bova, C Boehm, N S Piuzzi, N A Obuchowski, R J Midura, G F Muschler
BACKGROUND: Current decisions on cellular therapies for osteoarthritis are based primarily on clinical experience or on assumptions about preferred cell sourcing. They have not been informed by rigorous standardized measurements of the chondrogenic connective-tissue progenitors (CTP-Cs) or their intrinsic diversity of chondrogenic potential. The goal of this study was to quantitatively define the CTP-Cs resident in cartilage of different grades of osteoarthritis and to compare their concentration, prevalence, and biological potential...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
Yuankai Huo, Zhoubing Xu, Hyeonsoo Moon, Shunxing Bao, Albert Assad, Tamara K Moyo, Michael R Savona, Richard G Abramson, Bennett A Landman
A key limitation of deep convolutional neural networks (DCNN) based image segmentation methods is the lack of generalizability. Manually traced training images are typically required when segmenting organs in a new imaging modality or from distinct disease cohort. The manual efforts can be alleviated if the manually traced images in one imaging modality (e.g., MRI) are able to train a segmentation network for another imaging modality (e.g., CT). In this paper, we propose an end-to-end synthetic segmentation network (SynSeg-Net) to train a segmentation network for a target imaging modality without having manual labels...
October 17, 2018: IEEE Transactions on Medical Imaging
David G Hendrickson, Ilya Soifer, Bernd J Wranik, Griffin Kim, Michael Robles, Patrick A Gibney, R Scott McIsaac
Replicative aging of Saccharomyces cerevisiae is an established model system for eukaryotic cellular aging. A limitation in yeast lifespan studies has been the difficulty of separating old cells from young cells in large quantities. We engineered a new platform, the Miniature-chemostat Aging Device (MAD), that enables purification of aged cells at sufficient quantities for genomic and biochemical characterization of aging yeast populations. Using MAD, we measured DNA accessibility and gene expression changes in aging cells...
October 18, 2018: ELife
Jay E Gee, Mindy G Elrod, Christopher A Gulvik, Dirk T Haselow, Catherine Waters, Lindy Liu, Alex R Hoffmaster
The bacterium Burkholderia thailandensis, a member of the Burkholderia pseudomallei complex, is generally considered nonpathogenic; however, on rare occasions, B. thailandensis infections have been reported. We describe a clinical isolate of B. thailandensis, BtAR2017, recovered from a patient with an infected wound in Arkansas, USA, in 2017.
November 2018: Emerging Infectious Diseases
Alessia Pepe, Antonella Meloni, Laura Pistoia, Liana Cuccia, Maria R Gamberini, Roberto Lisi, Domenico G D'Ascola, Rosamaria Rosso, Massimo Allò, Anna Spasiano, Gennaro Restaino, Riccardo Righi, Maurizio Mangione, Vincenzo Positano, Paolo Ricchi
We prospectively assessed the efficacy of deferasirox versus deferiprone or desferrioxamine as monotherapy in thalassaemia major (TM) patients by magnetic resonance imaging (MRI). We selected the patients enrolled in the Myocardial Iron Overload in Thalassaemia network who received only one chelator between two MRIs (deferasirox = 235, deferiprone = 142, desferrioxamine = 162). Iron overload was measured by T2* technique and biventricular function by cine images. Among the patients with baseline myocardial iron, in all three groups there was a significant improvement in global heart T2* values...
October 18, 2018: British Journal of Haematology
Hitomi Sudo, Atsushi B Tsuji, Aya Sugyo, Maki Okada, Koichi Kato, Ming-Rong Zhang, Tsuneo Saga, Tatsuya Higashi
The non‑natural amino acid positron emission tomography tracers, 2‑amino[3‑11C]isobutyric acid ([3‑11C]AIB) and 2‑amino[11C]methyl‑isobutyric acid ([11C]MeAIB), are metabolically stable in vivo and accumulate in tumors. [3‑11C]AIB is transported into cells mainly via the amino acid transport system A and partially via systems L and ASC, whereas [11C]MeAIB is transported into cells specifically via system A. How transport via the different systems affects the tumor uptake of these tracers, however, is unclear...
October 16, 2018: International Journal of Oncology
N V Mitiushkina, M M Holmatov, A R Venina, V I Tiurin, G A Yanus, T N Sokolova, O S Yatsuk, O A Zaitseva, A O Ivantsov, E Sh Kuligina, A V Togo, E N Imyanitov
In contrast to other countries with predominantly White population, Russian smoking-related lung cancers (LC) are represented mainly by squamous cell carcinomas, while approximately a half of lung adenocarcinomas (AdCa) observed in this country are not related to tobacco consumption. Given that smoking significantly influences the probability of the presence of actionable mutations in LC, one would expect that Russian lung AdCa patients would differ from other Whites with respect to distribution of EGFR, ALK, KRAS and BRAF mutations...
September 4, 2018: Neoplasma
A Furdova, P Babal, D Kobzova, P Zahorjanova, K Kapitanova, M Sramka, G Kralik, R Furda, V Krasnik
This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001 - 2016. There were 81males (47.7%) and 89 females 89 (52.3%). The median overall follow-up time was three years. The median tumor volume at baseline was 0...
September 4, 2018: Neoplasma
Nikolaos Gardikas, Myrofora Vikentiou, Evgenia Konsta, Christos K Kontos, Sotirios G Papageorgiou, Aris Spathis, Efthimia Bazani, Anthi Bouchla, Violetta Kapsimali, Katherina Psarra, Periklis Foukas, George Dimitriadis, Vasiliki Pappa
BACKGROUND: Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders with unknown aetiology. Multiparameter flow cytometry (MFC) is being evaluated for the diagnosis and prognosis of MDS. METHODS: In the present study, five-color MFC was performed on bone marrow aspirates of 50 untreated patients, newly diagnosed with MDS and 27 age matched control samples. Patients were classified according to World Health Organization 2016, International Prognostic Scoring System (IPSS), and Revised IPSS (IPSS-R)...
October 17, 2018: Cytometry. Part B, Clinical Cytometry
Jared Ehrhart, Paul R Sanberg, Svitlana Garbuzova-Davis
Limited efficacy of current therapeutic approaches for neurodegenerative disease has led to increased interest in alternative therapies. Cord blood plasma (CBP) derived from human umbilical cord blood (hUCB) may be a potential therapeutic. Benefits of CBP injection into rodent models of aging or ischaemic stroke have been demonstrated, though how benefits are elicited is still unclear. The present study evaluated various factors within the same samples of CBP and human adult blood plasma/sera (ABP/S). Also, autologous CBP effects vs...
October 18, 2018: Journal of Cellular and Molecular Medicine
Rohit Abraham John, Natalia Yantara, Yan Fong Ng, Govind Narasimman, Edoardo Mosconi, Daniele Meggiolaro, Mohit R Kulkarni, Pradeep Kumar Gopalakrishnan, Chien A Nguyen, Filippo De Angelis, Subodh G Mhaisalkar, Arindam Basu, Nripan Mathews
Emulation of brain-like signal processing is the foundation for development of efficient learning circuitry, but few devices offer the tunable conductance range necessary for mimicking spatiotemporal plasticity in biological synapses. An ionic semiconductor which couples electronic transitions with drift-diffusive ionic kinetics would enable energy-efficient analog-like switching of metastable conductance states. Here, ionic-electronic coupling in halide perovskite semiconductors is utilized to create memristive synapses with a dynamic continuous transition of conductance states...
October 17, 2018: Advanced Materials
R Hartman, P Patil, R Tisherman, C St Croix, L J Niedernhofer, P D Robbins, F Ambrosio, B Van Houten, G Sowa, N Vo
Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbation observed in intervertebral disc degeneration. The present study aimed to measure how ageing impacted disc cell mitochondria and bioenergetics. Age-related changes measured included matrix content and cellularity in disc tissue, as well as matrix synthesis, cell proliferation and senescence markers in cell cultures derived from annulus fibrosus (AF) and nucleus pulposus (NP) isolated from the discs of young (6-9 months) and older (36-50 months) New Zealand White rabbits...
October 18, 2018: European Cells & Materials
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