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https://www.readbyqxmd.com/read/30524233/lithium-treatment-is-safe-in-children-with-intellectual-disability
#1
Junying Yuan, Juan Song, Dengna Zhu, Erliang Sun, Lei Xia, Xiaoli Zhang, Chao Gao, Galila Agam, Xiaoyang Wang, Klas Blomgren, Changlian Zhu
Lithium is a widely used and effective treatment for individuals with psycho-neurological disorders, and it exhibits protective and regenerative properties in multiple brain injury animal models, but the clinical experience in young children is limited due to potential toxicity. As an interim analysis, this paper reports the safety/tolerability profiles of low-dose lithium treatment in children with intellectual disability (ID) and its possible beneficial effects. In a randomized, single-center clinical trial, 124 children with ID were given either oral lithium carbonate 6 mg/kg twice per day or the same dose of calcium carbonate as a placebo ( n = 62/group) for 3 months...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30509949/corrigendum-spata2-regulates-the-activation-of-ripk1-by-modulating-linear-ubiquitination
#2
Ran Wei, Lily Wen Xu, Jianping Liu, Yanxia Li, Pei Zhang, Bing Shan, Xiaojuan Lu, Lihui Qian, Zheming Wu, Kangyun Dong, Hong Zhu, Lifeng Pan, Junying Yuan, Heling Pan
No abstract text is available yet for this article.
December 1, 2018: Genes & Development
https://www.readbyqxmd.com/read/30489272/condel-detecting-copy-number-variation-and-genotyping-deletion-zygosity-from-single-tumor-samples-using-sequence-data
#3
Xiguo Yuan, Jun Bai, Junying Zhang, Liying Yang, Junbo Duan, Yaoyao Li, Meihong Gao
Characterizing copy number variations (CNVs) from sequenced genomes is a both feasible and cost-effective way to search for driver genes in cancer diagnosis. A number of existing algorithms for CNV detection only explored part of the features underlying sequence data and copy number structures, resulting in limited performance. Here, we describe CONDEL, a method for detecting CNVs from single tumor samples using high-throughput sequence data. CONDEL utilizes a novel statistic in combination with a peel-off scheme to assess the statistical significance of genome bins, and adopts a Bayesian approach to infer copy number gains, losses, and deletion zygosity based on statistical mixture models...
November 26, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/30480515/naturally-derived-pha-l-protein-nanoparticle-as-a-radioprotector-through-activation-of-toll-like-receptor-5
#4
Wei Long, Junying Wang, Jiang Yang, Hongying Wu, Jingya Wang, Xiaoyu Mu, Hua He, Qiang Liu, Yuan-Ming Sun, Haichao Wang, Xiao-Dong Zhang
High energy ray in medical diagnosis and therapy can benefit to patients, but can also cause the significant damages to biomolecules such as DNA, as well as free radical generation, inevitably leading to numerous side effects. Small molecular radioprotectors provide an effective route to preserve the healthy tissue and whole body from ionizing radiation, but always have a short circulation time in body. Inorganic nanoparticles show major protection effect but their heavy metal components considerably jeopardize translational promise due to suboptimal biocompatibility...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30467385/necroptosis-and-ripk1-mediated-neuroinflammation-in-cns-diseases
#5
REVIEW
Junying Yuan, Palak Amin, Dimitry Ofengeim
Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death. However, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (TNF), can sensitize cells in the CNS to apoptosis and a form of regulated necrotic cell death known as necroptosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL)...
November 22, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30341420/abin-1-heterozygosity-sensitizes-to-innate-immune-response-in-both-ripk1-dependent-and-ripk1-independent-manner
#6
Zhenyi Su, Slawomir A Dziedzic, Die Hu, Vica Jean Barrett, Nicole Broekema, Wanjin Li, Lihui Qian, Na Jia, Dimitry Ofengeim, Ayaz Najafov, Hong Zhu, David M Knipe, Junying Yuan
ABIN-1 (encoded by the gene Tnip1) is a ubiquitin-binding protein that can interact with ubiquitin-editing enzyme A20 (encoded by the gene TNFAIP3) to restrain the activation of necroptosis and NF-κB activation. Genetic variants in the genes Tnip1 and TNFAIP3 are both strongly associated with susceptibility to autoimmune chronic inflammatory diseases such as psoriasis vulgaris and systemic lupus erythematosus (SLE) in humans. Here we investigated the mechanism by which ABIN-1 regulated innate immune responses...
October 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/30323337/synthetic-lethality-between-her2-and-transaldolase-in-intrinsically-resistant-her2-positive-breast-cancers
#7
Yi Ding, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H Lin, Gehao Liang, Lifeng Yuan, Handan Xiang, Junying Chen, Tao Yin, Peter B Alexander, Qian-Fei Wang, Er-Wei Song, Qi-Jing Li, Kris C Wood, Xiao-Fan Wang
Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle in the clinic, limiting its efficacy. However, the biological basis for intrinsic resistance is poorly understood. Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade. Suppression of TA increases cell susceptibility to HER2 inhibition in two intrinsically resistant breast cancer cell lines with HER2 amplification...
October 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/30299526/paediatric-cerebral-palsy-prevalence-and-high-risk-factors-in-henan-province-central-china
#8
Junying Yuan, Jun Wang, Jieqiong Ma, Dengna Zhu, Zhenhuan Zhang, Jianan Li
OBJECTIVE: To evaluate the prevalence of, and risk factors for, cerebral palsy in Henan province, China. METHODS: The prevalence of cerebral palsy in children aged 0-6 years between September 2011 and September 2012 was investigated using a stratified-clustered-random sampling method. An age-, sex- , and residence-matched control group of typically developing children was recruited. Univariate analysis and multinomial logistic regression analysis were used to identify risk factors associated with cerebral palsy...
October 9, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/30221056/s100a4-promotes-colon-inflammation-and-colitis-associated-colon-tumorigenesis
#9
Jinhua Zhang, Shasha Hou, Jianchun Gu, Tian Tian, Qi Yuan, Junying Jia, Zhihai Qin, Zhinan Chen
S100A4 plays important roles in tumor development and metastasis, but its role in regulating inflammation and colitis-associated tumorigenesis has not been well characterized. Here, we report that S100A4 expression was increased in azoxymethane (AOM) and dextran sulfate sodium (DSS) induced colorectal cancer (CRC) in mice. After AOM/DSS treatment, both S100A4-TK mice with the selective depletion of S100A4-expressing cells and S100A4-deficient (S100A4-/- ) mice developed fewer and smaller tumors than wild-type (WT) control littermates...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/30181285/inhibition-of-ciap1-as-a-strategy-for-targeting-c-myc-driven-oncogenic-activity
#10
Haoyan Li, Yanjia Fang, Chunyi Niu, Hengyi Cao, Ting Mi, Hong Zhu, Junying Yuan, Jidong Zhu
Protooncogene c-MYC , a master transcription factor, is a major driver of human tumorigenesis. Development of pharmacological agents for inhibiting c-MYC as an anticancer therapy has been a longstanding but elusive goal in the cancer field. E3 ubiquitin ligase cIAP1 has been shown to mediate the activation of c-MYC by destabilizing MAD1, a key antagonist of c-MYC. Here we developed a high-throughput assay for cIAP1 ubiquitination and identified D19, a small-molecule inhibitor of E3 ligase activity of cIAP1...
October 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30146158/tbk1-suppresses-ripk1-driven-apoptosis-and-inflammation-during-development-and-in-aging
#11
Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z Levin, Bruce A Yankner, Junying Yuan
Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders. However, it is unclear how aging interacts with genetic predispositions to promote neurodegeneration. Here, we investigate how partial loss of function of TBK1, a major genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comorbidity, leads to age-dependent neurodegeneration. We show that TBK1 is an endogenous inhibitor of RIPK1 and the embryonic lethality of Tbk1-/- mice is dependent on RIPK1 kinase activity...
September 6, 2018: Cell
https://www.readbyqxmd.com/read/30141613/novel-sanger-s-reagent-like-styrene-polymer-for-the-immobilization-of-burkholderia-cepacia-lipase
#12
Junying Fu, Zhiyuan Wang, Wen Luo, Shiyou Xing, Pengmei Lv, Zhongming Wang, Zhenhong Yuan
Sanger's reaction, which was originally developed for amino acid detection, was utilized for enzyme immobilization. The newly synthesized polymer support, which was called polymer NO2 -4-fluorostyrene-divinylbenzene (pNFD), was embedded with a Sanger's reagent-like functional group for immobilizing enzymes covalently under mild reaction conditions. Using Burkholderia cepacia lipase (BCL) as the target enzyme, the immobilization efficiency and activity of pNFD-BCL reached as high as 1.2 mg·g-1 and 33.21 U·g-1 (a specific activity of 27 675 U·g-1 ), respectively, realizing 90% activity recovery...
September 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30050954/obesity-related-asthma-immune-regulation-and-potential-targeted-therapies
#13
REVIEW
Yuze Yuan, Nan Ran, Lingxin Xiong, Guoqiang Wang, Xuewa Guan, Ziyan Wang, Yingqiao Guo, Zhiqiang Pang, Keyong Fang, Junying Lu, Chao Zhang, Ruipeng Zheng, Jingtong Zheng, Jie Ma, Fang Wang
Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29955050/parkin-regulates-nf-%C3%AE%C2%BAb-by-mediating-site-specific-ubiquitination-of-ripk1
#14
Yu Wang, Bing Shan, Yaosi Liang, Huiting Wei, Junying Yuan
Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations in Parkin are associated with Parkinson's disease. Here we investigated the interaction of Parkin with Receptor-interacting protein kinase 1 (RIPK1) kinase, a key mediator of multiple signaling pathways activated by TNFR1 including NF-κB pathway. We report that Parkin interacts with RIPK1 and mediates K63 ubiquitination of RIPK1 on K376 in TNFR1-signaling pathway. The expression of Parkin promotes the recruitment of transforming growth factor β (TGF-β)-activated kinase 1 (TAK1), nuclear factor-κB (NF-κB) essential molecule (NEMO), Sharpin and A20 in complex I associated with TNFR1 upon TNFα stimulation...
June 28, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29891719/regulation-of-a-distinct-activated-ripk1-intermediate-bridging-complex-i-and-complex-ii-in-tnf%C3%AE-mediated-apoptosis
#15
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J LaVoie, Junying Yuan
Stimulation of cells with TNFα can promote distinct cell death pathways, including RIPK1-independent apoptosis, necroptosis, and RIPK1-dependent apoptosis (RDA)-the latter of which we still know little about. Here we show that RDA involves the rapid formation of a distinct detergent-insoluble, highly ubiquitinated, and activated RIPK1 pool, termed "iuRIPK1." iuRIPK1 forms after RIPK1 activation in TNF-receptor-associated complex I, and before cytosolic complex II formation and caspase activation...
June 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29725272/the-role-of-regulatory-t-cell-in-nontypeable-haemophilus-influenzae-induced-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#16
Xuewa Guan, Yanjiao Lu, Guoqiang Wang, Peter Gibson, Fang Chen, Keyong Fang, Ziyan Wang, Zhiqiang Pang, Yingqiao Guo, Junying Lu, Yuze Yuan, Nan Ran, Fang Wang
Chronic obstructive pulmonary disease (COPD) is associated with irreversible persistent airflow limitation and enhanced inflammation. The episodes of acute exacerbation (AECOPD) largely depend on the colonized pathogens such as nontypeable Haemophilus influenzae (NTHi), one of the most commonly isolated bacteria. Regulatory T cells (Tregs) are critical in controlling inflammatory immune responses and maintaining tolerance; however, their role in AECOPD is poorly understood. In this study, we hypothesized a regulatory role of Tregs, as NTHi participated in the progress of COPD...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29703889/necroptosis-promotes-cell-autonomous-activation-of-proinflammatory-cytokine-gene-expression
#17
Kezhou Zhu, Wei Liang, Zaijun Ma, Daichao Xu, Shuangyi Cao, Xiaojuan Lu, Nan Liu, Bing Shan, Lihui Qian, Junying Yuan
Necroptosis, a form of regulated necrotic cell death, is mediated by receptor interacting protein 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). However, the mechanism by which necroptosis promotes inflammation is still unclear. Here we report that the expression of cytokines is robustly upregulated in a cell-autonomous manner during necroptosis induced by tumor necrosis factor alpha (TNFα). We demonstrate that TNFα-induced necroptosis leads to two waves of cytokine production. The first wave, more transient and weaker than the second, is in response to TNFα alone; whereas the second wave depends upon the necroptotic signaling...
May 1, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29693254/microrna-224-suppresses-osteoblast-differentiation-by-inhibiting-smad4
#18
Yuan Luo, Xiaodong Cao, Junfeng Chen, Jianwei Gu, Jitong Zhao, Junying Sun
Osteoblast differentiation was found to be regulated by a variety of cell signaling and intracellular regulatory factors. In this study, we aimed at investigating the regulatory effect of microRNA-224 on osteoblast differentiation and its molecular mechanism. Expression of miR-224 in the osteoblasts, adipose-derived mesenchymal stem cells (MSC-A), bone marrow-derived mesenchymal stem cells (MSC-B) and mbilical cord-derived mesenchymal stem cells (MSC-U) were detected using RT-PCR. Expression of miR-224 was lower in osteoblast than in the three mesenchymal stem cells and it revealed a decreasing time-dependent trend from 0 day to 28 days during osteoblast differentiation...
October 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29662181/author-correction-niche-harmony-search-algorithm-for-detecting-complex-disease-associated-high-order-snp-combinations
#19
Shouheng Tuo, Junying Zhang, Xiguo Yuan, Zongzhen He, Yajun Liu, Zhaowen Liu
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29593066/necroptosis-in-development-and-diseases
#20
REVIEW
Bing Shan, Heling Pan, Ayaz Najafov, Junying Yuan
Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like pseudokinase), can be activated under apoptosis-deficient conditions. Modulating the activation of RIPK1 by ubiquitination and phosphorylation is critical to control both necroptosis and apoptosis. Mutant mice with kinase-dead RIPK1 or RIPK3 and MLKL deficiency show no detrimental phenotype in regard to development and adult homeostasis...
March 1, 2018: Genes & Development
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