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https://www.readbyqxmd.com/read/30090869/dynamical-networks-finding-measuring-and-tracking-neural-population-activity-using-network-science
#1
Mark D Humphries
Systems neuroscience is in a headlong rush to record from as many neurons at the same time as possible. As the brain computes and codes using neuron populations, it is hoped these data will uncover the fundamentals of neural computation. But with hundreds, thousands, or more simultaneously recorded neurons come the inescapable problems of visualizing, describing, and quantifying their interactions. Here I argue that network science provides a set of scalable, analytical tools that already solve these problems...
2018: Network neuroscience
https://www.readbyqxmd.com/read/30086747/interval-investigation-of-nice-technologies-for-enabling-risk-variable-adjusted-length-dental-recalls-trial-a-multicentre-randomised-controlled-trial-investigating-the-best-dental-recall-interval-for-optimum-cost-effective-maintenance-of-oral-health-in-dentate
#2
Jan E Clarkson, Nigel B Pitts, Debbie Bonetti, Dwayne Boyers, Hazel Braid, Robert Elford, Patrick A Fee, Ruth Floate, Beatriz Goulão, Gerry Humphris, Ian Needleman, John D T Norrie, Fiona Ord, Marjon van der Pol, Craig R Ramsay, David N J Ricketts, Helen V Worthington, Linda Young
BACKGROUND: Traditionally, patients at low risk and high risk of developing dental disease have been encouraged to attend dental recall appointments at regular intervals of six months between appointments. The lack of evidence for the effect that different recall intervals between dental check-ups have on patient outcomes, provider workload and healthcare costs is causing considerable uncertainty for the profession and patients, despite the publication of the NICE Guideline on dental recall...
August 7, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/30056760/annals-express-estimation-of-the-prevalence-of-cholesteryl-ester-storage-disorder-cesd-in-a-cohort-of-patients-with-clinical-features-of-familial-hypercholesterolaemia
#3
Pauline Ashfield-Watt, Kate Haralambos, Rhiannon Edwards, Delyth Townsend, Rob Gingell, Ka Wa Li, Steve Humphries, Ian McDowell
Backgroundandaim. Familial Hypercholesterolaemia (FH) is caused by variants in the LDL-C metabolic pathway involving LDLR, APOB and PCSK9 genes. A national genetic testing service in Wales, UK has observed that no FH variant is found in almost 80% patients with the FH phenotype. It has recently been suggested that some adult patients with an FH phenotype may have Cholesteryl Ester Storage Disease (CESD) which can also present as a mixed hyperlipidaemia. The commonest genetic cause of CESD is an exon 8 splice junction variant in the LIPA gene (rs116928232, c...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/30031341/cardiovascular-comorbidities-in-a-united-states-patient-population-with-hemophilia-a-a-comprehensive-chart-review
#4
Thomas J Humphries, Brittny Rule, Augustina Ogbonnaya, Michael Eaddy, Orsolya Lunacsek, Lois Lamerato, Jennifer Pocoski
PURPOSE: Previous retrospective claims database analyses reported increased prevalence and earlier onset of cardiovascular comorbidities in patients with versus without hemophilia A. A comprehensive chart review was designed to further investigate previous findings. METHODS: This retrospective chart review study was conducted at Henry Ford Health System (Detroit, MI, USA). Baseline demographics, bleeding events, treatment parameters, coexisting diseases, hemophilia-associated events, Charlson Comorbidity Index score, and prevalence of 12 cardiovascular risk factors and associated diseases were compared between hemophilia A and control cohorts...
July 18, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30031289/inhibition-of-prolyl-hydroxylase-domain-proteins-selectively-enhances-venous-thrombus-neovascularisation
#5
S P Grover, P Saha, J Humphries, O T Lyons, A S Patel, J Serneels, B Modarai, M Mazzone, A Smith
BACKGROUND: Hypoxia within acute venous thrombi is thought to drive resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). Prolyl hydroxylase domain (PHD) isoforms are critical regulators of HIF1α stability. Non-selective inhibition of PHD isoforms with l-mimosine has been shown to increase HIF1α stabilisation and promote thrombus resolution. OBJECTIVE: The aim of this study was to investigate the therapeutic potential of PHD inhibition in venous thrombus resolution...
July 11, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30012755/pharmacodynamics-of-daptomycin-against-enterococcus-faecium-and-enterococcus-faecalis-in-the-murine-thigh-infection-model
#6
James M Kidd, Kamilia Abdelraouf, Tomefa E Asempa, Romney M Humphries, David P Nicolau
The Clinical Laboratory Standards Institute (CLSI) daptomycin MIC susceptibility breakpoint for the treatment of enterococcal infections is ≤4 μg/mL. However, patients receiving daptomycin for enterococci with MICs ≤4 μg/mL may experience treatment failures. We assessed the pharmacodynamics of daptomycin against enterococci in a neutropenic murine thigh infection model and determined exposures necessary for bacteriostasis and 1 log10 CFU reduction against Enterococcus faecalis and Enterococcus faecium We further characterized daptomycin efficacy at clinically achievable exposures...
July 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30010472/sex-differences-in-cardiac-troponin-testing-in-patients-presenting-to-the-emergency-department-with-chest-pain
#7
Karin H Humphries, Min Gao, May K Lee, Mona Izadnegahdar, Daniel T Holmes, Frank X Scheuermeyer, M D MHSc, Martha Mackay, Andre Mattman, Eric Grafstein
BACKGROUND: Elevated cardiac troponin (cTn), with signs/symptoms of ischemia, is a key element in a diagnosis of myocardial infarction (MI). Underdiagnosis of MI in women has been attributed to atypical symptoms, inconsistent ECG findings, and less diagnostic testing. We sought to determine if there are sex differences in cTn testing following presentation to the emergency department (ED) with a chief complaint of ischemic chest pain (CP) and if presentation affects diagnostic assessment...
July 16, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29992038/design-and-development-of-a-complex-narrative-intervention-delivered-by-text-messages-to-reduce-binge-drinking-among-socially-disadvantaged-men
#8
Linda Irvine, Ambrose J Melson, Brian Williams, Falko F Sniehotta, Gerry Humphris, Iain K Crombie
Background: Socially disadvantaged men are at high risk of suffering from alcohol-related harm. Disadvantaged groups are less likely to engage with health promotion. There is a need for interventions that reach large numbers at low cost and which promote high levels of engagement with the behaviour change process. The aim of this study was to design a theoretically and empirically based text message intervention to reduce binge drinking by socially disadvantaged men. Results: Following MRC guidance, the intervention was developed in four stages...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29988116/herpes-simplex-virus-binding-igg-traps-hsv-in-human-cervicovaginal-mucus-across-the-menstrual-cycle-and-diverse-vaginal-microbial-composition
#9
Holly A Schroeder, Kenetta L Nunn, Alison Schaefer, Christine E Henry, Felix Lam, Michael H Pauly, Kevin J Whaley, Larry Zeitlin, Mike S Humphrys, Jacques Ravel, Samuel K Lai
IgG possesses an important yet little recognized effector function in mucus. IgG bound to viral surface can immobilize otherwise readily diffusive viruses to the mucin matrix, excluding them from contacting target cells and facilitating their elimination by natural mucus clearance mechanisms. Cervicovaginal mucus (CVM) is populated by a microbial community, and its viscoelastic and barrier properties can vary substantially not only across the menstrual cycle, but also in women with distinct microbiota. How these variations impact the "muco-trapping" effector function of IgGs remains poorly understood...
July 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29986154/computed-tomographic-biomarkers-in-idiopathic-pulmonary-fibrosis-the-future-of-quantitative-analysis
#10
Xiaoping Wu, Grace H Kim, Margaret L Salisbury, David Barber, Brian J Bartholmai, Kevin K Brown, Craig S Conoscenti, Jan De Backer, Kevin R Flaherty, James F Gruden, Eric A Hoffman, Stephen M Humphries, Joseph Jacob, Toby M Maher, Ganesh Raghu, Luca Richeldi, Brian D Ross, Rozsa Schlenker-Herceg, Nicola Sverzellati, Athol U Wells, Fernando J Martinez, David A Lynch, Jonathan Goldin, Simon L F Walsh
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with great variability in disease severity and rate of progression. The need for a reliable, sensitive, and objective biomarker to track disease progression and response to therapy remains a great challenge in IPF clinical trials. Over the past decade, quantitative computed tomography (QCT) has emerged as an area of intensive research to address this need. We have gathered a group of pulmonologists, radiologists and scientists with expertise in this area to define the current status and future promise of this imaging technique in the evaluation and management of IPF...
July 9, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29977337/development-of-an-emergency-general-surgery-process-improvement-program
#11
Matthew J Bradley, Angela T Kindvall, Ashley E Humphries, Elliot M Jessie, John S Oh, Debra M Malone, Jeffrey A Bailey, Philip W Perdue, Eric A Elster, Carlos J Rodriguez
Background: The Joint Trauma System has demonstrated improved outcomes through coordinated research and process improvement programs. With fewer combat trauma patients, our military American College of Surgeons level 2 trauma center's ability to maintain a strong trauma Process Improvement (PI) program has become difficult. As emergency general surgery (EGS) patients are similar to trauma patients, our Trauma and Acute Care Surgery (TACS) service developed an EGS PI program analogous to what is done in trauma...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29976595/risk-factors-for-developing-colistin-resistance-among-gram-negative-rods-and-klebsiella-pneumoniae
#12
Stefan E Richter, Loren Miller, Daniel Z Uslan, Douglas Bell, Karol Watson, Romney Humphries, James A McKinnell
Infections due to colistin-resistant Gram-negative rods (ColR-GNR), and colistin-resistant Klebsiella pneumoniae (ColR-KP) in particular result in high associated mortality and poor treatment options. To determine risk factors for recovery on culture of ColR-GNR and ColR-KP, analyses were chosen to aid decisions at two separate time points, the first when only Gram stain results are available without any bacterial species information (corresponding to the ColR-GNR model), and the second when organism identification was performed, but prior to reporting of antimicrobial susceptibility results (corresponding to the ColR-KP model)...
July 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29976590/multicenter-evaluation-of-the-etest%C3%A2-gradient-diffusion-method-for-ceftolozane-tazobactam-susceptibility-testing-of-enterobacteriaceae-and-pseudomonas-aeruginosa
#13
Adam L Bailey, Tom Armstrong, Hari-Prakash Dwivedi, Gerald A Denys, Janet Hindler, Shelley Campeau, Maria Traczewski, Romney Humphries, C A Burnham
Ceftolozane-tazobactam (C/T) is a novel beta-lactam/beta-lactamase inhibitor combination antibiotic approved by the USA Food and Drug Administration in 2014 for the treatment of complicated intra-abdominal infections (in combination with metronidazole) and complicated urinary tract infections. Here, we evaluated the performance of the C/T ETEST®, a gradient diffusion method. C/T ETEST® was compared to broth microdilution (BMD) for 51 Enterobacteriaceae challenge isolates and 39 Pseudomonas aeruginosa challenge isolates at three clinical sites...
July 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29975730/environmental-factors-effecting-the-germination-and-seedling-emergence-of-two-populations-of-an-aggressive-agricultural-weed-nassella-trichotoma
#14
Talia Humphries, Bhagirath S Chauhan, Singarayer K Florentine
Nassella trichotoma (Nees) Hack. ex Arechav. (Serrated tussock) is an aggressive globally significant weed to agricultural and natural ecosystems. Herbicide resistant populations of this C3 perennial weed have emerged, increasing the need for effective wide-scale cultural control strategies. A thorough seed ecology study on two spatially distinct populations of N. trichotoma was conducted on this weed to identify differences in important environmental factors (drought, salinity, alternating temperature, photoperiod, burial depth, soil pH, artificial seed aging, and radiant heat) which influence seed dormancy...
2018: PloS One
https://www.readbyqxmd.com/read/29967995/review-of-an-emergency-general-surgery-process-improvement-program-at-a-verified-military-trauma-center
#15
Joseph Bozzay, Matthew Bradley, Angela Kindvall, Ashley Humphries, Elliot Jessie, Judy Logeman, Jeffrey Bailey, Eric Elster, Carlos Rodriguez
INTRODUCTION: Decreasing combat-based admissions to our military facility have made it difficult to maintain a robust trauma process improvement (PI) program. Since emergency general surgery (EGS) and trauma patients share similarities, we merged the care of our EGS and trauma patients into one acute care surgery (ACS) team. An EGS PI program was developed based on trauma PI principles to facilitate continued identification of opportunities for improvement despite our decline in trauma admissions...
July 2, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29965906/bridging-the-gap-a-20-year-experience-with-vein-grafts-for-free-flap-reconstruction-the-odds-for-success
#16
Amir Inbal, Amanda K Silva, Laura S Humphries, Chad M Teven, Lawrence J Gottlieb
BACKGROUND: Successful free tissue transfer requires tension-free microvascular anastomoses. Vein grafts are utilized when this cannot be obtained, which increases microsurgical complexity and the chance of vessel thrombosis. Previous studies on vein grafts are limited to low numbers and selected techniques, making it difficult to draw conclusions. METHODS: A retrospective chart review was performed for all patients who underwent vein grafts in free flap reconstruction from 1995 to 2015...
June 22, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29964204/integrin-%C3%AE-5-down-regulation-by-mir-205-suppresses-triple-negative-breast-cancer-stemness-and-metastasis-by-inhibiting-the-src-vav2-rac1-pathway
#17
Yajuan Xiao, Yunfei Li, Hua Tao, Brock Humphries, Aimin Li, Yiguo Jiang, Chengfeng Yang, Rongcheng Luo, Zhishan Wang
Triple negative breast cancer (TNBC) usually displays more aggressive metastasis, the underlying mechanism is unclear. Previous studies showed that microRNA-205 (miR-205) has controversial roles in cancer, however, its role in TNBC metastasis and the underlying mechanism have not been well-understood. In this study we found that miR-205 expression level is extremely low in basal mesenchymal-like highly migratory and invasive TNBC cells. Stably re-expressing miR-205 in TNBC cells significantly reduced their migration, invasion capability and cancer stem cell (CSC)-like property...
October 1, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29963217/the-nonmarket-benefits-of-education-and-ability
#18
James J Heckman, John Eric Humphries, Gregory Veramendi
This paper analyzes the non-market benefits of education and ability. Using a dynamic model of educational choice we estimate returns to education that account for selection bias and sorting on gains. We investigate a range of non-market outcomes including incarceration, mental health, voter participation, trust, and participation in welfare. We find distinct patterns of returns that depend on the levels of schooling and ability. Unlike the monetary benefits of education, the benefits to education for many non-market outcomes are greater for low-ability persons...
2018: Journal of Human Capital
https://www.readbyqxmd.com/read/29961479/mental-and-physical-health-impairments-at-the-transition-to-college-early-patterns-in-the-education-health-gradient
#19
Jamie M Carroll, Melissa Humphries, Chandra Muller
Part of the education-health gradient may be related to inequalities in the transition from high school to college by health impairment status. In this paper, we use the National Longitudinal Survey of Youth 1997 to investigate the link between health impairments beginning prior to high school completion and college-going, distinguishing between individuals with mental, physical, or multiple health impairments and between enrollment in 2-year and 4-year postsecondary institutions. We find that individuals with mental impairments or multiple impairments are less likely to initially enroll in 4-year postsecondary institutions than individuals without health impairments, controlling on background and high school preparation...
August 2018: Social Science Research
https://www.readbyqxmd.com/read/29957711/cerebral-concussion-primes-the-lungs-for-subsequent-neutrophil-mediated-injury
#20
Duncan C Humphries, Stephen O'Neill, Emma Scholefield, David A Dorward, Alison C Mackinnon, Adriano G Rossi, Christopher Haslett, Peter J D Andrews, Jonathan Rhodes, Kevin Dhaliwal
OBJECTIVES: Mild traumatic brain injury in the form of concussion is extremely common, and the potential effects on pulmonary priming have been underestimated. The aim of this study was to characterize the pulmonary response following mild traumatic brain injury and assess the pulmonary susceptibility to lung injury after a subsequent innocuous pulmonary insult. DESIGN: Experimental in vivo study. SETTING: University research laboratory. SUBJECTS: Male CD1 mice...
June 27, 2018: Critical Care Medicine
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