Pauline Henrot, Léo Blervaque, Isabelle Dupin, Maéva Zysman, Pauline Esteves, Fares Gouzi, Maurice Hayot, Pascal Pomiès, Patrick Berger
Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality. However, cellular basis responsible for increased catabolism in myocytes often remains unclear. Although myocytes represent the vast majority of skeletal muscle cellular population, they are surrounded by numerous cells with various functions. Animal models, mostly rodents, can help to decipher the mechanisms behind this highly dynamic process, by allowing access to every muscle as well as time-course studies...
April 2023: Journal of Cachexia, Sarcopenia and Muscle