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https://www.readbyqxmd.com/read/30119617/posttransplant-malignancies-in-adult-renal-and-hepatic-transplant-patients
#1
Samed Rahatli, Ozden Altundag, Ebru Ayvazoglu Soy, Gokhan Moray, Mehmet Haberal
OBJECTIVES: The risk of some cancer types increases after organ transplant compared with that shown in the general population; this has been well documented in clinical studies. With patients having longer survival and with the higher number of transplant procedures, cancer is an increasing health concern at high-volume transplant centers. Malignancy has an important effect on short- and long-term graft and patient survival. In this study, we evaluated cancer frequency during transplant patient follow-up...
August 17, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/30111820/gene-essentiality-landscape-and-druggable-oncogenic-dependencies-in-herpesviral-primary-effusion-lymphoma
#2
Mark Manzano, Ajinkya Patil, Alexander Waldrop, Sandeep S Dave, Amir Behdad, Eva Gottwein
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus. Our understanding of PEL is poor and therefore treatment strategies are lacking. To address this need, we conducted genome-wide CRISPR/Cas9 knockout screens in eight PEL cell lines. Integration with data from unrelated cancers identifies 210 genes as PEL-specific oncogenic dependencies. Genetic requirements of PEL cell lines are largely independent of Epstein-Barr virus co-infection. Genes of the NF-κB pathway are individually non-essential...
August 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/30111565/in-vivo-persistence-of-chimeric-virus-after-substitution-of-the-kshv-lana-dna-binding-domain-with-that-of-muhv-4
#3
Marta Pires de Miranda, Ana Patrícia Quendera, Colin E McVey, Kenneth M Kaye, J Pedro Simas
The latency associated nuclear antigen from Kaposi's sarcoma-associated herpesvirus (KSHV), kLANA, and its homolog from the murine herpesvirus 4 (MuHV-4), mLANA, are essential for viral latency. kLANA is nearly four times the size of mLANA, mainly due to an extensive central repeat region that is absent in mLANA. Both proteins harbor a C-terminal DNA binding domain (DBD). The DBD binds the terminal repeat (TR) DNA sequences of the viral genome to mediate persistence. Despite structural conservation, the kLANA and mLANA DBDs differ in sequence and mode of oligomerization...
August 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30109285/detection-of-human-herpesvirus-8-antigen-in-hiv-infected-patients-in-east-java-indonesia
#4
Devi Oktafiani, Ni Luh Ayu Megasari, Elsa Fitriana, Nasronudin, Maria Inge Lusida, Soetjipto
Background: Co-infection of human herpesvirus-8 (HHV-8) in HIV-positive people might cause Kaposi's sarcoma. Early detection of HHV-8 may prevent the onset of clinical manifestations. In Indonesia, detection of HHV-8 antigen in HIV-positive patients has yet to be reported. The intention of this research was to examine the presence of HHV-8 antigen in HIV-positive patients in East Java, Indonesia. Material and Methods: 103 serum samples were collected from HIV-positive patients in Surabaya and Tulungagung, East Java, Indonesia...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30105990/coexistence-of-kaposi-s-sarcoma-and-psoriasis-is-there-a-hidden-relationship
#5
Lucia Brambilla, Giovanni Genovese, Athanasia Tourlaki, Silvia Della Bella
The relationship between Kaposi's sarcoma (KS) and psoriasis is still controversial. To analyse the association between KS and psoriasis, address the hypothesis of a reciprocal influence between the two conditions relative to clinical presentation and evolution, and consider the best therapeutic approach to be used for the treatment of psoriasis in KS patients in order to avoid the typical induction or worsening of KS during immunosuppression. We retrospectively reviewed clinical records of 37 patients with KS and psoriasis...
June 1, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/30105217/organ-specific-toxicities-due-to-radiation-therapy-in-cancer-patients-with-or-without-hiv-infection-a-systematic-review-of-the-literature
#6
Melody J Xu, Alison Liewen, Luca Valle, Adam C Olson, Nicola M Zetola, Surbhi Grover
Background: To synthesize published literature on the association between human immunodeficiency virus (HIV) infection and radiation therapy (RT)-related toxicities. Methods: Two electronic databases, MEDLINE and Embase, were searched to identify studies published before November 2016 comparing RT-related toxicities between HIV-infected and HIV-uninfected patients receiving RT or chemoradiation therapy (CRT) for cancer. A qualitative synthesis of included articles and organ-specific toxicities was then performed...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30101071/newly-diagnosed-aids-with-neurosyphilis-kaposi-sarcoma-pancytopenia-oropharyngeal-candidiasis-and-pseudomonal-pneumonia-we-shouldn-t-be-seeing-this-anymore
#7
Daria S Yunina, Natalie Elkayam, Shanti Patel, Fidelis Okoli, Edward Chapnick, Melvyn Hecht
The incidence of new human immunodeficiency virus (HIV) infections is declining and is half of what it was in the mid 1990s. We present a case of newly diagnosed HIV with acquired immune deficiency syndrome (AIDS), Neurosyphilis, Kaposi Sarcoma, and multiple opportunistic infections. Although this type of patient was not uncommon in the pre-antiretroviral era, we do not often see such a constellation of conditions in a single individual. The significance of this case lies not in the diagnosis, but rather in the number of the diagnoses and the thought process used to attain them...
2018: IDCases
https://www.readbyqxmd.com/read/30099376/evolving-paradigms-in-hiv-malignancies-review-of-ongoing-clinical-trials
#8
REVIEW
Rachel Bender Ignacio, Lilie L Lin, Lakshmi Rajdev, Elizabeth Chiao
This review highlights current interventional clinical trials for HIV-associated malignancies (HIVAMs), with emphasis on 4 mechanistic areas: immunomodulatory therapies and gene therapies, including immune checkpoint inhibitors; cytotoxic therapies; novel tumor-targeted and virally targeted therapies in both AIDS-defining and non-AIDS-defining cancers (NADC); and other screening or topical/ablative interventions. A search on ClinicalTrials.gov located 35 trials, including 12 immunomodulatory or gene therapy trials, 6 cytotoxic therapy trials, 10 trials of therapies with tumor or viral molecular targets, and 7 trials evaluating screening interventions or topical or ablative therapies...
August 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/30096191/the-crystal-structure-of-kshv-orf57-reveals-dimeric-active-sites-important-for-protein-stability-and-function
#9
Fei Yuan, Zeng-Qiang Gao, Vladimir Majerciak, Lei Bai, Meng-Lu Hu, Xiao-Xi Lin, Zhi-Ming Zheng, Yu-Hui Dong, Ke Lan
Kaposi's sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus closely associated with Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. Open reading frame 57 (ORF57), a viral early protein of KSHV promotes splicing, stability and translation of viral mRNA and is essential for viral lytic replication. Previous studies demonstrated that dimerization of ORF57 stabilizes the protein, which is critical for its function. However, the detailed structural basis of dimerization was not elucidated...
August 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/30091809/survival-after-the-diagnosis-of-de-novo-malignancy-in-liver-transplant-recipients
#10
Martina Taborelli, Pierluca Piselli, Giuseppe Maria Ettorre, Umberto Baccarani, Patrizia Burra, Augusto Lauro, Laura Galatioto, Maria Rendina, Sarah Shalaby, Raffaella Petrara, Francesco Nudo, Luca Toti, Giovanni Fantola, Claudia Cimaglia, Alessandro Agresta, Giovanni Vennarecci, Antonio Daniele Pinna, Salvatore Gruttadauria, Andrea Risaliti, Alfredo Di Leo, Massimo Rossi, Giuseppe Tisone, Fausto Zamboni, Diego Serraino
In the setting of liver transplant (LT), the survival after the diagnosis of de novo malignancies (DNMs) has been poorly investigated. In this study, we assessed the impact of DNMs on survival of LT recipients as compared to corresponding LT recipients without DNM. A nested case-control study was conducted in a cohort of 2818 LT recipients enrolled in nine Italian centres between 1985 and 2014. Cases were 244 LT recipients who developed DNMs after LT. For each case, 2 controls matched for gender, age, and year at transplant were selected by incidence density sampling among cohort members without DNM...
August 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30085887/frequent-hiv-and-young-age-among-individuals-with-diverse-cancers-at-a-national-teaching-hospital-in-malawi
#11
Marie-Josèphe Horner, Ande Salima, Chrissie Chilima, Matthews Mukatipa, Wiza Kumwenda, Coxcilly Kampani, Fred Chimzimu, Bal Mukunda, Tamiwe Tomoka, Maurice Mulenga, Richard Nyasosela, Steady Chasimpha, Charles Dzamalala, Satish Gopal
Purpose Cancer surveillance provides a critical evidence base to guide cancer control efforts, yet population-based coverage in Africa is sparse. Hospital-based registries may help fill this need by providing local epidemiologic data to guide policy and forecast local health care needs. We report the epidemiology of patients with cancer recorded by a de novo hospital-based cancer registry at Kamuzu Central Hospital, Malawi, the sole provider of comprehensive oncology services for half the country and location of a high-volume pathology laboratory...
July 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30084838/mast-cell-activation-and-kshv-infection-in-kaposi-sarcoma
#12
Leona W Ayers, Arturo Barbachano-Guerrero, Shane C McAllister, Julie A Ritchie, Elizabeth Asiago-Reddy, Linda C Bartlett, Ethel Cesarman, Dongliang Wang, Rosemary Rochford, Jeffrey N Martin, Christine A King
PURPOSE: Kaposi sarcoma (KS) is a vascular tumor initiated by infection of endothelial cells (ECs) with KS-associated herpesvirus (KSHV). KS is dependent on sustained pro-inflammatory signals provided by intra-lesional leukocytes and continued infection of new ECs. However, the sources of these cytokines and infectious virus within lesions are not fully understood. Here, mast cells (MCs) are identified as pro-inflammatory cells within KS lesions that are permissive for, and activated by, infection with KSHV...
July 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30080759/endobronchial-kaposi-sarcoma
#13
Ramon G Valentin, Peter A Drew, Lauryn A Benninger, Pichapong Tunsupon
No abstract text is available yet for this article.
August 4, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/30076864/ll-37-disrupts-the-kaposi-s-sarcoma-associated-herpesvirus-envelope-and-inhibits-infection-in-oral-epithelial-cells
#14
David C Brice, Zsolt Toth, Gill Diamond
Oral epithelial cells (OECs) represent the first line of defense against viruses that are spread via saliva, including Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of humans by KSHV and viral pathogenesis begins by infecting OECs. One method OECs use to limit viral infections in the oral cavity is the production of antimicrobial peptides (AMPs), or host defense peptides (HDPs). However, no studies have investigated the antiviral activities of any HDP against KSHV. The goal of this study was to determine the antiviral activity of one HDP, LL-37, against KSHV in the context of infecting OECs...
August 1, 2018: Antiviral Research
https://www.readbyqxmd.com/read/30066758/kaposi-s-sarcoma-in-persons-living-with-hiv-aids-a-case-series-in-a-tertiary-referral-hospital
#15
Carla Andréa Avelar Pires, Marcos Antonio Neves Noronha, Julius Caesar Mendes Soares Monteiro, Albert Luiz Costa da Costa, José Maria de Castro Abreu Júnior
BACKGROUND: Kaposi's sarcoma (KS) is a rare neoplasm with indolent progression. Since 1981, the Kaposi's sarcoma epidemic has increased as co-infection with HIV. OBJECTIVES: The study aimed to identify the clinical and demographic characteristics and therapeutic approaches in HIV/AIDS patients in a regional referral hospital. METHODS: We analyzed the medical records of 51 patients with histopathological diagnosis of Kaposi's sarcoma hospitalized at Hospital Universitário João de Barros Barreto (HUJBB) from 2004 to 2015...
July 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/30061278/sensitivity-of-the-c-terminal-nuclease-domain-of-kaposi-s-sarcoma-associated-herpesvirus-orf29-to-two-classes-of-active-site-ligands
#16
Jennifer T Miller, Haiyan Zhao, Takashi Masaoka, Brittany Varnado, Elena M Cornejo Castro, Vickie A Marshall, Kaivon Kouhestani, Anna Y Lynn, Keith E Aron, Anqi Xia, John A Beutler, Danielle R Hirsch, Liang Tang, Denise Whitby, Ryan P Murelli, Stuart F J Le Grice
Kaposi's sarcoma-associated herpesvirus (KSHV), the etiological agent of Kaposi's sarcoma, belongs to the Herpesviridae family, whose members employ a multicomponent terminase to resolve nonparametric viral DNA into genome-length units prior to their packaging. Homology modeling of ORF29 C-terminal nuclease domain (pORF29C) and bacteriophage Sf6 gp2 have suggested an active site clustered with four acidic residues, D476 , E550 , D661 and D662 that collectively sequester the catalytic divalent metal (Mn++ ), and also provided important insight into a potential inhibitor binding mode...
July 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30055902/bilateral-eyelid-kaposi-s-sarcoma-in-an-hiv-negative-patient
#17
L Fernández-Montalvo, N Ibáñez-Flores, P Cifuentes-Canorea, J Castellar-Cerpa, X Graell-Martín, V Cuadrado-Claramonte
CASE REPORT: We report a case of 70-year-old male from Sicily, who presented with a bilateral eyelid mass involving the tarsal conjunctiva, found to be Kaposi's sarcoma on histologic examination. Cutaneous and pulmonary Kaposi's sarcoma involvement was documented. The patient had no prior diagnosis of human immunodeficiency virus infection. This case was managed successfully after the completion of five cycles of chemotherapy with liposomal doxorubicin, and his eyelid, skin and pulmonary lesions disappeared...
July 25, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/30044684/kaposi-s-sarcoma-after-autologous-stem-cell-transplantation-and-rituximab-treatment
#18
Shamir Geller, Mark A Dickson, Klaus J Busam, Patricia L Myskowski
No abstract text is available yet for this article.
July 25, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/30042376/fatal-disseminated-kaposi-s-sarcoma-in-two-patients-with-human-immunodeficiency-virus-hiv-infectionfatal-disseminated-kaposi-s-sarcoma-in-two-patients-with-human-immunodeficiency-virus-hiv-infection
#19
Rafaela Barbirato Fardin, Luiz Arhur Calheiros Leite, Luanna Mayara Dos Santos Bezerra, Priscilla Maris Pereira Alves, Layanne Lima Dos Santos, Marília de Andrade Salvá, Antônio Luiz Soares Moura Rezende Filho, Gilberto Salustiano Lima, Juliana de Amorim Matos, Sônia Maria Soares Ferreira, Ducy Lily Joazeiro de Farias Costa
BACKGROUND Kaposi's sarcoma (KS) is a common condition in patients with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). In these patients, the occurrence of KS is reduced by treatment with highly active antiretroviral therapy (HAART). Fatal and disseminated KS is presented in two patients with HIV/AIDS. CASE REPORT A 25-year-old man and a 30-year-old man with HIV/AIDS presented with KS affecting the skin, oral cavity, gastrointestinal tract, liver, lungs, kidneys, adrenal glands, and bone...
July 25, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/30039355/primary-nasopharyngeal-kaposi-sarcoma-as-index-diagnosis-of-aids-in-a-previously-healthy-man
#20
Gwyneth S T Soon, Fredrik Petersson, Mark K T Thong, Char Loo Tan
A 38-year-old, previously healthy man presented with blood-stained saliva and epistaxis. A 3 mm nasopharyngeal lesion was found. A biopsy was performed and microscopic examination revealed a Kaposi sarcoma. The patient was subsequently found to be positive for human immunodeficiency virus (HIV). The diagnosis of Kaposi sarcoma in the presence of HIV infection advanced his disease to Acquired Immunodeficiency Syndrome (AIDS). Primary manifestation of Kaposi sarcoma in the nasopharynx is extremely rare. The histologic differential diagnosis of Kaposi sarcoma in this unusual site, especially without the clinical history of immunosuppression, is broad...
July 23, 2018: Head and Neck Pathology
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