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Chemosensitivity Test

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https://www.readbyqxmd.com/read/30535433/ten-genes-associated-with-mgmt-promoter-methylation-predict-the-prognosis-of-patients-with-glioma
#1
Yang Zhang, Junwei Zhu
Glioma originates from the glial cells of the spine or brain, and promoter methylation of O6‑methylguanine‑DNA methyltransferase (MGMT) can promote the chemosensitivity of glioma. The present study aimed to reveal the key genes implicated in MGMT promoter methylation in patients with glioma. RNA‑sequencing data and methylation data for glioma were extracted from The Cancer Genome Atlas database. Following expression characteristic analysis and differential expression analysis using unsupervised hierarchical clustering and a rank sum test, the feature genes were identified between high and low methylation groups...
December 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30488547/trehalose-inhibits-cell-proliferation-and-amplifies-long-term-temozolomide-and-radiation-induced-cytotoxicity-in-melanoma-cells-a-role-for-autophagy-and-premature-senescence
#2
Giulia Allavena, Barbara Del Bello, Paolo Tini, Nila Volpi, Giuseppe Valacchi, Clelia Miracco, Luigi Pirtoli, Emilia Maellaro
Cutaneous melanomas frequently metastasize to the brain, with temozolomide (TMZ) plus radiotherapy (RT) offering little control of these lesions. We tested whether trehalose, a natural glucose disaccharide proved to induce autophagy, could enhance the effect of TMZ and ionizing radiation (IR). In two melanoma cell lines (A375 and SK-Mel-28), which greatly differ in chemosensitivity and radiosensitivity, trehalose significantly inhibited short-term cell proliferation and also enhanced IR-induced cytostasis. Interestingly, in TMZ-resistant SK-Mel-28 cells, trehalose was more effective than TMZ, and combined trehalose + TMZ further reduced cell proliferation...
November 29, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30486290/nobiletin-enhances-chemosensitivity-to-adriamycin-through-modulation-of-the-akt-gsk3%C3%AE-%C3%AE-%C3%A2-catenin-mycn-mrp1-signaling-pathway-in-a549-human-non-small-cell-lung-cancer-cells
#3
Jeong Yong Moon, Le Van Manh Hung, Tatsuya Unno, Somi Kim Cho
Drug resistance is a major problem in the treatment of non-small-cell lung cancer (NSCLC). In this study, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed to identify the differentially expressed genes in Adriamycin (ADR)-resistant NSCLC A549/ADR cells compared with parental A549 cells. Among the tested phytochemicals, nobiletin (NBT) is able to overcome the ADR resistance of A549/ADR cells. NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3β, and β-catenin...
November 26, 2018: Nutrients
https://www.readbyqxmd.com/read/30468991/a-precision-medicine-test-predicts-clinical-response-after-idarubicin-and-cytarabine-induction-therapy-in-aml-patients
#4
David Martínez-Cuadrón, Cristina Gil, Josefina Serrano, Gabriela Rodríguez, Jaime Pérez-Oteyza, Raimundo García-Boyero, Santiago Jiménez-Bravo, Susana Vives, María Belén Vidriales, Esperanza Lavilla, José A Pérez-Simón, Mar Tormo, Mercedes Colorado, Juan Bergua, Juan A López, Pilar Herrera, Pilar Hernández-Campo, Julián Gorrochategui, Daniel Primo, Jose Luis Rojas, Jesús Villoria, Federico Moscardó, Iñaki Troconiz, María Linares Gómez, Joaquín Martínez-López, Joan Ballesteros, Miguel Sanz, Pau Montesinos
Complete remission (CR) after induction therapy is the first treatment goal in acute myeloid leukemia (AML) patients and has prognostic impact. Our purpose is to determine the correlation between the observed CR/CRi rate after idarubicin (IDA) and cytarabine (CYT) 3 + 7 induction and the leukemic chemosensitivity measured by an ex vivo test of drug activity. Bone marrow samples from adult patients with newly diagnosed AML were included in this study. Whole bone marrow samples were incubated for 48 h in well plates containing IDA, CYT, or their combination...
November 13, 2018: Leukemia Research
https://www.readbyqxmd.com/read/30466981/modulation-of-multidrug-resistant-in-cancer-cells-by-egcg-tannic-acid-and-curcumin
#5
Hanmei Li, Sonja Krstin, Michael Wink
BACKGROUND: Cancer is one of the most common life-threatening diseases worldwide; many patients develop multidrug resistance after treatment with anticancer drugs. The main mechanism leading to multidrug resistance is the overexpression of ABC transporters in cancer cells. Chemosensitizers are needed to inhibit the activity of ABC transporters, resulting in higer intracellular concentration of anticancer drugs. Some secondary metabolites have been reported to be chemosensitizers by inhibiting ABC transporters...
November 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30455148/seco-4-methyl-dck-derivatives-as-potent-chemosensitizers
#6
Yalan Guo, Ke Wang, Xiaoyu Chen, Haihong Li, Qi Wan, Susan Morris-Natschke, Kuo-Hsiung Lee, Ying Chen
Twenty-five seco-4-methyl-DCK derivatives were designed, synthesized and evaluated for chemoreversal activity when combined with paclitaxel or vincristine in two drug-resistant cancer cell lines (A2780/T and KB-V) respectively. Most of the new compounds displayed moderate to significant MDR reversal activities in the P-gp overexpressing A2780/T and KB-V cells. Especially, compounds 7o and 7y showed the most potent chemosensitization activities with more than 496 and 735 reversal ratios at a concentration of 10 μM...
November 12, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30442453/predictive-factors-of-overall-survival-in-primary-intracranial-pure-choriocarcinoma
#7
REVIEW
Tao Jiang, Raynald, Hongchao Yang, Wenhui Zhang, Chunde Li
The incidence of primary intracranial pure choriocarcinoma (PIPC) is extremely rare. Only several case and case series have been previously reported; therefore, there is still lack of knowledge about the prognosis and its standard treatment. We performed a collective study of all reported cases of PIPC to identify the predictive factors related with OS. A comprehensive search was performed on Pubmed's electronic database using the terms "primary intracranial choriocarcinoma" and "malignant germ cell tumor"...
November 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30425571/identification-of-chemoresistance-associated-mirnas-in-breast-cancer
#8
Weiyang Lou, Jingxing Liu, Bisha Ding, Liang Xu, Weimin Fan
Background: Neoadjuvant chemotherapy (NAC) is an effective therapeutic regimen for patients with breast cancer. However, some individuals cannot benefit from NAC because of drug resistance. To date, valid strategies about enhancing sensitivity of breast cancer to NAC are still scarce. miRNAs have been reported to proverbially be involved in the onset and development of malignancies including drug resistance. Methods: GSE73736 was downloaded from the GEO database...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30415989/e-cadherin-in-colorectal-cancer-relation-to-chemosensitivity
#9
Irina Druzhkova, Nadezhda Ignatova, Natalia Prodanets, Nikolay Kiselev, Iliya Zhukov, Marina Shirmanova, Vladimir Zagainov, Elena Zagaynova
BACKGROUND: The conventional chemotherapy of colorectal cancer with irinotecan, 5-fluorouracil, and oxaliplatin remains one of the front-line treatments worldwide. However, its efficacy is quite low. Recently studies of the epithelial-mesenchymal transition (EMT) have become the focus of investigations into the cause of chemoresistance in several types of cancer, including colorectal cancer. The data about the role of EMT in chemosensitivity are controversial. MATERIALS AND METHODS: Human colon adenocarcinoma cell lines HT29 and HCT116 and 14 primary short-term cultures established from patient tumors were used...
October 16, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/30400960/microrna-31-5p-regulates-chemosensitivity-by-preventing-the-nuclear-location-of-parp1-in-hepatocellular-carcinoma
#10
Ke-Ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-Ping Zhao, Jian-Ping Gong, Zuo-Jin Liu
BACKGROUND: MicroRNAs (miRNAs) posttranscriptionally regulate gene expression and thereby contribute to the modulation of numerous complex and disease-relevant cellular processes, including cell proliferation, cell motility, apoptosis and stress response. miRNA-31-5p is encoded on a genomic fragile site, 9p21.3, which is reportedly lost in many hepatocellular carcinoma (HCC) tumors. Based on previous findings, we hypothesized that miR-31-5p alters chemosensitivity and that miR-31-5p mimics may influence sensitivity to chemotherapeutics in HCC as well as in a variety of other cancers...
November 6, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30349298/pim1-promotes-cell-proliferation-and-regulates-glycolysis-via-interaction-with-myc-in-ovarian-cancer
#11
Yong Wu, Yu Deng, Jun Zhu, Yachen Duan, WeiWei Weng, Xiaohua Wu
Background: Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignancies. Recent studies have highlighted the role of Pim1, which belongs to a group of constitutively activated serine/threonine kinases, in cancer development. However, the effect of Pim1 in OC is largely unclear. Methods: OC cell lines with Pim1 overexpression or knockdown were constructed with len-tivirus transduction. Cell Counting Kit-8, colony formation, glycolysis stress test and in vivo mice models were carried out to assess the effect of Pim1 on OC biological functions...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30339884/nrf2-inhibition-reverses-resistance-to-gpx4-inhibitor-induced-ferroptosis-in-head-and-neck-cancer
#12
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh
Glutathione peroxidase 4 (GPX4) is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death); its inhibition can render therapy-resistant cancer cells susceptible to ferroptosis. However, some cancer cells develop mechanisms protective against ferroptosis; understanding these mechanisms could help overcome chemoresistance. In this study, we investigated the molecular mechanisms underlying resistance to ferroptosis induced by GPX4 inhibition in head and neck cancer (HNC). The effects of two GPX4 inhibitors, (1S, 3R)-RSL3 and ML-162, and of trigonelline were tested in HNC cell lines, including cisplatin-resistant (HN3R) and acquired RSL3-resistant (HN3-rslR) cells...
December 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30326864/impact-of-cdx2-expression-status-on-the-survival-of-patients-after-curative-resection-for-colorectal-cancer-liver-metastasis
#13
Yasuyuki Shigematsu, Kentaro Inamura, Noriko Yamamoto, Yoshihiro Mise, Akio Saiura, Yuichi Ishikawa, Shunji Takahashi, Hiroaki Kanda
BACKGROUND: The prognostic biomarker for patients undergoing curative liver metastasectomy for colorectal cancer (CRC) is lacking. The purpose was to investigate the prognostic role of a lack of CDX2 expression, which has been proposed as a potential biomarker for high-risk relapse in early-stage CRC, in patients undergoing curative liver metastasectomy. METHODS: A total of 396 consecutive patients with CRC liver metastasis who underwent potentially curative liver metastasectomy at a single center in Japan between 2005 and 2015 were included...
October 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30305596/one-hour-in-vivo-like-phenotypic-screening-system-for-anti-cancer-drugs-using-a-high-precision-surface-plasmon-resonance-device
#14
Junko Johzuka, Toshihiro Ona, Masatoshi Nomura
In anti-cancer drug (candidate) screening, there is the need for evaluation at physiological concentrations similar to in vivo. This is often performed by three-dimensionally (3D) cultured cells; however, it requires a long culture period of 2 - 4 weeks with tedious experimental procedures. Here, we report on a high precision surface plasmon resonance (HP-SPR)-3D system. We developed the system with average fluctuation of 50 ndeg s-1 using two-dimensionally cultured cells attached onto a sensor chip by applying collagen on the top to change their activity into in vivo-like conditions without cell division...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/30292104/tannic-acid-inspired-paclitaxel-nanoparticles-for-enhanced-anticancer-effects-in-breast-cancer-cells
#15
Pallabita Chowdhury, Prashanth K B Nagesh, Elham Hatami, Santosh Wagh, Nirnoy Dan, Manish K Tripathi, Sheema Khan, Bilal B Hafeez, Bernd Meibohm, Subhash C Chauhan, Meena Jaggi, Murali M Yallapu
Paclitaxel (PTX) is a gold standard chemotherapeutic agent for breast, ovarian, pancreatic and non-small cell lung carcinoma. However, in clinical use PTX can have adverse side effects or inadequate pharmacodynamic parameters, limiting its use. Nanotechnology is often employed to reduce the therapeutic dosage required for effective therapy, while also minimizing the systemic side effects of chemotherapy drugs. However, there is no nanoformulation of paclitaxel with chemosensitization motifs built in. With this objective, we screened eleven pharmaceutical excipients to develop an alternative paclitaxel nanoformulation using a self-assembly method...
September 22, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30257412/mir-1284-enhances-sensitivity-of-cervical-cancer-cells-to-cisplatin-via-downregulating-hmgb1
#16
Jia Chen, Gaojun Li
BACKGROUND: Chemotherapy is one of the commonest therapeutic method for cervical cancer. There are some common chemotherapy drugs, such as cisplatin, docetaxel, paclitaxel and selenium nanoparticle. microRNAs (miRNAs) have been verified to be regulators in various human cancers. This study aims to investigate the effects of miR-1284 on the cisplatin sensitivity of cervical cancer cells. METHODS: The levels of miR-1284 in different tissues and cell lines were detected through using qRT-PCR analysis...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30247965/integrative-treatment-for-colorectal-cancer-a-comprehensive-approach
#17
REVIEW
Keith I Block, Penny B Block, Charlotte Gyllenhaal
A comprehensive approach to integrative treatment of colorectal cancer (CRC) patients involves three spheres of intervention: lifestyle, biology, and conventional treatment. Individualization of treatment is emphasized. The lifestyle sphere includes nutritional therapies, biobehavioral strategies with circadian interventions, and physical care modalities. The biology sphere comprises six host factors in the patient's internal biochemical environment or "terrain": inflammation, glycemia, oxidative stress, immune dysregulation, coagulopathy, and stress chemistries...
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/30166422/the-effect-of-acute-morphine-on-obstructive-sleep-apnoea-a-randomised-double-blind-placebo-controlled-crossover-trial
#18
Luke Rowsell, Keith K H Wong, Brendon J Yee, Danny J Eckert, Andrew A Somogyi, James Duffin, Ronald R Grunstein, David Wang
OBJECTIVE: Anaesthesiology guidelines suggest that opioids worsen obstructive sleep apnoea (OSA) despite no randomised controlled trial evidence. We therefore conducted a randomised controlled trial to evaluate the effects of a common clinical dose of morphine on OSA, and to identify clinical phenotype and genotype vulnerability to opioid-respiratory depression. METHODS: Under a double-blind, randomised, crossover design, 60 male patients with OSA attended two visits to the hospital sleep laboratory, at least 1 week apart...
August 30, 2018: Thorax
https://www.readbyqxmd.com/read/30106121/cip2a-depletion-potentiates-the-chemosensitivity-of-cisplatin-by-inducing-increased-apoptosis-in-bladder-cancer-cells
#19
Fengbin Gao, Xiaojing Wang, Shanwen Chen, Tianyuan Xu, Xianjin Wang, Yifan Shen, Fan Dong, Shan Zhong, Zhoujun Shen
Poor response and chemotherapy resistance to cisplatin (DDP)‑based therapy frequently lead to treatment failure in advanced bladder cancer; however the underlying mechanism is extremely complex and unclear. Furthermore, cancerous inhibitor of protein phosphatase 2A (CIP2A), a recently identified human oncoprotein, has been shown to play important regulatory roles in cancer cell survival. The present study aimed to investigate the correlation of CIP2A with sensitivity to DDP in bladder cancer cells. In the present study, knockdown of CIP2A was performed using short hairpin‑RNA...
November 2018: Oncology Reports
https://www.readbyqxmd.com/read/30083105/ascorbic-acid-chemosensitizes-colorectal-cancer-cells-and-synergistically-inhibits-tumor-growth
#20
Ana S Pires, Cláudia R Marques, João C Encarnação, Ana M Abrantes, Inês A Marques, Mafalda Laranjo, Rui Oliveira, João E Casalta-Lopes, Ana C Gonçalves, Ana B Sarmento-Ribeiro, Maria F Botelho
Colorectal cancer (CRC) is continuously classified as one of the most incidental and mortal types of cancer worldwide. The positive outcomes of the conventional chemotherapy are frequently associated with high toxicity, which often leads to the suspension of the treatment. Growing evidences consider the use of pharmacological concentrations of ascorbic acid (AA), better known as vitamin C, in the treatment of cancer. The use of AA in a clinical context is essentially related to the adoption of new therapeutic strategies based on combination regimens, where AA plays a chemosensitizing role...
2018: Frontiers in Physiology
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