Eleonora Aimaretti, Elisa Porchietto, Giacomo Mantegazza, Giorgio Gargari, Debora Collotta, Giacomo Einaudi, Gustavo Ferreira Alves, Enrica Marzani, Alessandro Algeri, Federica Dal Bello, Manuela Aragno, Carlo Cifani, Simone Guglielmetti, Raffaella Mastrocola, Massimo Collino
Advanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga Arthrospira platensis (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements. Thirty male C57Bl6 mice were fed a standard diet (SD) or a high-fat high-sugar diet (HFHS) for 12 weeks, and a subgroup of HFHS mice received 350 mg/kg Zn-SP three times a week...
February 17, 2024: Nutrients