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https://www.readbyqxmd.com/read/30514385/oncolytic-virus-immunotherapy-future-prospects-for-oncology
#1
REVIEW
Junaid Raja, Johannes M Ludwig, Scott N Gettinger, Kurt A Schalper, Hyun S Kim
BACKGROUND: Immunotherapy is at the forefront of modern oncologic care. Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerging class in both primary and salvage therapy is oncolytic viruses. This therapy offers a multimodal approach to specifically and effectively target and destroy malignant cells, though a barrier oncoviral therapies have faced is a limited therapeutic response to currently delivery techniques...
December 4, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/30505236/adjuvant-gamma-knife-surgery-and-image-guided-intensity-modulated-radiation-therapy-for-the-treatment-of-sacral-chordomas
#2
Shun Lu, Xinhao Peng, Bingwen Zou, Cheng Zhou, Mei Feng, Jinyi Lang
Aim: The aim of this study was to confirm whether patients with sacral chordoma benefit from adjuvant radiotherapy and to determine the optimal photon radiotherapy module for comprehensive treatment. Background: Chordoma is a rare slow-growing neoplasm arisen from cellular remnants of the notochord. About 50% occur in the sacrococcygeal region. Surgical resection and adjuvant radiation therapy are recommended treatment due to the improving local control rate. Materials and methods: 118 patients treated by surgery and adjuvant radiotherapy from August 2003 to May 2015 were retrospectively analyzed...
January 2019: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/30499597/automated-data-extraction-and-ensemble-methods-for-predictive-modeling-of-breast-cancer-outcomes-after-radiation-therapy
#3
William D Lindsay, Christopher A Ahern, Jacob S Tobias, Christopher G Berlind, Chidambaram Chinniah, Peter E Gabriel, James C Gee, Charles B Simone
PURPOSE: To compare the effectiveness of ensemble methods (e.g. random forests) and single-model methods (e.g. logistic regression and decision trees) in predictive modeling of post-RT treatment failure and adverse events (AEs) for breast cancer patients using automatically extracted EMR data. METHODS: Data from 1,967 consecutive breast radiotherapy (RT) courses at one institution between 2008-2015 was automatically extracted from EMRs and oncology information systems using extraction software...
November 30, 2018: Medical Physics
https://www.readbyqxmd.com/read/30497483/comparative-effectiveness-and-economic-evaluation-of-chuna-manual-therapy-for-chronic-neck-pain-protocol-for-a-multicenter-randomized-controlled-trial
#4
Ho Jeong Do, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jae-Heung Cho, Koh-Woon Kim, In-Hyuk Ha
BACKGROUND: Neck pain is a highly prevalent medical condition that incurs substantial social burden. Although manual therapy is widely used for treatment of neck pain, the body of evidence supporting its effectiveness and safety is not conclusive. The aim of this study is to examine the effect, safety, and cost-effectiveness of Chuna manual therapy, a traditional Korean manual therapy for treatment of various musculoskeletal complaints. METHODS/DESIGN: This study is the protocol for a two-armed parallel, assessor-blinded, multicenter, randomized controlled trial...
November 29, 2018: Trials
https://www.readbyqxmd.com/read/30497431/a-pilot-study-of-stereotactic-body-radiation-therapy-sbrt-after-surgery-for-stage-iii-non-small-cell-lung-cancer
#5
Anurag K Singh, Mark Hennon, Sung Jun Ma, Todd L Demmy, Anthony Picone, Elizabeth U Dexter, Chumy Nwogu, Kristopher Attwood, Wei Tan, Gregory M Hermann, Simon Fung-Kee-Fung, Harish K Malhotra, Sai Yendamuri, Jorge A Gomez-Suescun
BACKGROUND: Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radiation therapy (SBRT) would be a safe alternative. METHODS: Patients with stage IIIA (multistation N2) or IIIB non-small cell lung cancer were enrolled from March 2013 to December 2015. The protocol included transcervical extended mediastinal lymphadenectomy (TEMLA) followed by surgical resection, 10 Gy SBRT directed to the involved mediastinum/hilar stations and/or positive surgical margins, and adjuvant systemic therapy...
November 29, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30488323/dosimetry-biodistribution-and-safety-of-flurpiridaz-f-18-in-healthy-subjects-undergoing-rest-and-exercise-or-pharmacological-stress-pet-myocardial-perfusion-imaging
#6
Jamshid Maddahi, Frank Bengel, Johannes Czernin, Paul Crane, Magnus Dahlbom, Heinrich Schelbert, Richard Sparks, Michael Phelps, Joel Lazewatsky
The objectives of this study were to evaluate radiation dosimetry, biodistribution, human safety, and tolerability of 18 F-labeled flurpiridaz (Flurpiridaz) in normal subjects undergoing rest and separate-day exercise or adenosine pharmacological stress PET imaging. METHODS: 12 normal subjects were injected with 58.5 to 121 MBq (1.58 to 3.27 mCi) of Flurpiridaz intravenously at rest on Day 1 and 57 to 171 MBq (1.54 to 4.61 mCi) during stress on Day 2. Sequential whole-body imaging was performed for 5 hours...
November 28, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/30484384/chemoradiation-in-female-patients-with-anal-cancer-patient-reported-outcome-of-acute-and-chronic-side-effects
#7
Stefan A Koerber, Ben Seither, Alla Slynko, Matthias F Haefner, David Krug, Jakob Liermann, Sebastian Adeberg, Klaus Herfarth, Juergen Debus, Florian Sterzing
INTRODUCTION: We evaluated acute and chronic side effects of 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) in female patients with anal carcinoma and accessed correlations between dosimetric parameters and the considered toxicities. METHODS: For 70 women with anal cancer treated at our department, acute and chronic side effects and quality of life (QoL) were evaluated with questionnaires using the Common Terminology Criteria for Adverse Events (CTCAE v...
November 28, 2018: Tumori
https://www.readbyqxmd.com/read/30479044/topical-silymarin-administration-for-prevention-of-acute-radiodermatitis-in-breast-cancer-patients-a-randomized-double-blind-placebo-controlled-clinical-trial
#8
Hedyieh Karbasforooshan, Sare Hosseini, Sepideh Elyasi, Azar Fani Pakdel, Gholamreza Karimi
Radiation-induced dermatitis is one of the most common side effects of radiotherapy. Silymarin, a flavonoid extracted from the Silybum marianum, exhibits antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the efficacy of silymarin gel in prevention of radiodermatitis in patients with breast cancer. During this randomized, double-blinded, placebo-controlled clinical trial, the preventive effect of silymarin 1% gel was assessed in comparison with placebo, on radiodermatitis occurrence...
November 27, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30478695/predictors-of-technical-difficulty-during-endoscopic-submucosal-dissection-of-superficial-esophageal-cancer
#9
Hiromasa Hazama, Masaki Tanaka, Naomi Kakushima, Yohei Yabuuchi, Masao Yoshida, Noboru Kawata, Kohei Takizawa, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Keita Mori, Hiroyuki Ono
BACKGROUND: Endoscopic submucosal dissection (ESD) is the standard treatment for superficial esophageal cancer (SEC); however, it is sometimes technically difficult. Our aim was to identify the predictors of technical difficulty during ESD for SEC. METHODS: We reviewed the records of patients who underwent ESD for superficial esophageal squamous cell carcinomas at a tertiary cancer center between April 2008 and March 2016. Patients undergoing ESD after esophagectomy or for residual/recurrent lesions were excluded...
November 26, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30464150/boron-neutron-capture-therapy-combined-with-early-successive-bevacizumab-treatments-for-recurrent-malignant-gliomas-a-pilot-study
#10
Hiroyuki Shiba, Koji Takeuchi, Ryo Hiramatsu, Motomasa Furuse, Naosuke Nonoguchi, Shinji Kawabata, Toshihiko Kuroiwa, Natsuko Kondo, Yoshinori Sakurai, Minoru Suzuki, Koji Ono, Shiro Oue, Eiichi Ishikawa, Hiroyuki Michiue, Shin-Ichi Miyatake
Recurrent malignant gliomas (RMGs) are difficult to control, and no standard protocol has been established for their treatment. At our institute, we have often treated RMGs by tumor-selective particle radiation called boron neutron capture therapy (BNCT). However, despite the cell-selectivity of BNCT, brain radiation necrosis (BRN) may develop and cause severe neurological complications and sometimes death. This is partly due to the full-dose X-ray treatments usually given earlier in the treatment course. To overcome BRN following BNCT, recent studies have used bevacizumab (BV)...
November 21, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/30464040/first-in-human-phase-i-study-of-ctt1057-a-novel-18-f-labeled-imaging-agent-with-phosphoramidate-core-targeting-prostate-specific-membrane-antigen-in-prostate-cancer
#11
Spencer C Behr, Rahul Aggarwal, Henry F Van Brocklin, Robert R Flavell, Kenneth Geo, Eric J Small, Joseph Blecha, Salma Jivan, Thomas A Hope, Jeffrey P Simko, John Kurhanewicz, Susan M Noworolski, Natalie J Korn, Romelyn De Los Santos, Matthew R Cooperberg, Peter R Carroll, Hao G Nguyen, Kirsten L Greene, Beatrice Langton-Webster, Clifford E Berkman, Youngho Seo
Prostate-specific membrane antigen (PSMA) targeting agents comprise a rapidly emerging class of radiopharmaceuticals for prostate cancer diagnostic imaging. Unlike most other PSMA agents with a urea-backbone, CTT1057 is based on a phosphoramidate scaffold that irreversibly binds to PSMA. We conducted a first-in-human Phase I study of CTT1057 in patients with localized and metastatic prostate cancer. Methods: Two patient cohorts were recruited. Cohort A were patients with biopsy-proven localized prostate cancer preceding radical prostatectomy, and cohort B were patients with metastatic castrate resistant prostate cancer...
November 21, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30460505/a-phase-i-study-of-the-safety-and-tolerability-of-vlx600-an-iron-chelator-in-patients-with-refractory-advanced-solid-tumors
#12
Kabir Mody, Aaron S Mansfield, Lalitha Vemireddy, Peter Nygren, Joachim Gulbo, Mitesh Borad
Introduction VLX600 is a novel iron chelator designed to interfere with intracellular iron metabolism, leading to inhibition of mitochondrial respiration and bioenergetic catastrophe and resultant tumor cell death. Methods We conducted a multicenter, phase 1, dose escalation study to determine the safety and adverse event profile and the maximum tolerated dose and recommended phase 2 dose of VLX600. Other endpoints included pharmacokinetics, and preliminary evidence of anti-cancer efficacy as assessed according to RECIST 1...
November 21, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/30460449/intrathecal-administration-of-nusinersen-in-adolescent-and-adult-sma-type-2-and-3-patients
#13
Claudia D Wurster, Benedikt Winter, Kurt Wollinsky, Albert C Ludolph, Zeljko Uzelac, Simon Witzel, Michael Schocke, Ralf Schneider, Tugrul Kocak
Spinal muscular atrophy is a genetic motor neuron disease that leads to progressive muscular atrophy and muscle weakness. In December 2016, the Food and Drug Administration, and in June 2017, the European Medicines Agency approved the antisense oligonucleotide nusinersen for treatment of spinal muscular atrophy. Nusinersen has to be repeatedly administered intrathecally. Due to the clinical features of SMA, the application of the ASO by lumbar puncture can be challenging in symptomatic patients considering the frequently observed scoliosis, previous spine fusion surgeries, joint contractures, and respiratory insufficiency...
November 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30455944/sacral-insufficiency-fracture-after-stereotactic-body-radiation-therapy-for-sacral-metastasis
#14
Terufumi Kawamoto, Kei Ito, Tomohisa Furuya, Keisuke Sasai, Katsuyuki Karasawa
Stereotactic body radiation therapy (SBRT) allows the targeting of high doses of radiation with steep dose gradients. Vertebral fracture is increasingly recognized as an adverse event after SBRT; however, no sacral fractures have been observed after SBRT. We report an extremely rare case of sacral insufficiency fracture after SBRT.
November 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/30452687/nivolumab-and-stereotactic-radiation-therapy-for-the-treatment-of-patients-with-stage-iv-non-small-cell-lung-cancer
#15
Shingo Miyamoto, Ryutaro Nomura, Kengo Sato, Nobuyasu Awano, Naoyuki Kuse, Minoru Inomata, Takehiro Izumo, Yuriko Terada, Yoshiaki Furuhata, Yuan Bae, Hideo Kunitoh
Background: Radiation therapy might modify the cancer immune environment to enhance the antitumor effect of immune checkpoint inhibitors. We performed a feasibility study of nivolumab following stereotactic radiation therapy for chemotherapy pretreated advanced non-small-cell lung cancer. Patients and methods: Pretreated advanced/recurrent non-small-cell lung cancer patients received stereotactic radiation therapy to one of the disease sites. Nivolumab at a dose of 3 mg/kg was given within 2 weeks after the completion of stereotactic radiation therapy and continued every 2 weeks thereafter until disease progression or unacceptable toxicities...
November 17, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30449067/a-multi-institutional-retrospective-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-malignant-tumors-of-the-nasopharynx-subanalysis-of-japan-carbon-ion-radiation-oncology-study-group-study-1402-hn
#16
Takanori Abe, Tatsuya Ohno, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Jun-Ichi Saitoh, Katsuyuki Shirai, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
BACKGROUND: This multi-institutional retrospective study focused on the clinical outcome of carbon-ion radiotherapy (C-ion RT) for non-squamous cell malignant tumors of the nasopharynx. METHODS: The Japan Carbon-ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non-squamous cell malignant tumors of the nasopharynx treated with C-ion RT at four institutions in Japan. RESULTS: Twenty-nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies...
November 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30448098/development-of-a-positron-emission-tomography-risks-map
#17
A Rodríguez Fernández, E M Triviño Ibáñez, M Gómez Río, J J Pérez Lázaro, I Fernández Ruiz, Á Ramírez Navarro, Y García Rivero, E Córdoba Cañete, C Romero Fernández, J M Llamas-Elvira
Patient safety is an essential component of quality of care, especially when the complexity of care has reached extreme levels. Currently achieving this safety is considered a basic strategy of the National Health System. Nuclear Medicine departments have certain peculiarities that make them special in terms of patient safety, with situations that go beyond the common healthcare practice of other departments. Namely, that both encapsulated and non-encapsulated ionizing radiation is used in daily practice, and numerous groups of professionals must be coordinated to undertake positron emission tomography (PET) specifically, from the clinical management unit itself, and from other departments of the hospital (as well as companies outside the hospital itself and the Public Health System)...
November 14, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/30445171/imrt-and-image-guided-adapted-brachytherapy-for-cervix-cancer
#18
Alexander J Lin, Elizabeth Kidd, Farrokh Dehdashti, Barry A Siegel, Sasa Mutic, Premal H Thaker, Leslie S Massad, Matthew A Powell, David G Mutch, Stephanie Markovina, Julie Schwarz, Perry W Grigsby
PURPOSE: To report long-term outcomes of cervical cancer patients treated with intensity-modulated radiation therapy and 3D image-guided adapted brachytherapy (IMRT/3D-IGABT) compared to 2D external irradiation and 2D brachytherapy (2D EBRT/BT). METHODS AND MATERIALS: This study included patients with newly diagnosed cervical cancer and pre-treatment FDG-PET treated with curative-intent irradiation from 1997-2013. Treatment policy changed from 2D EBRT/BT to IMRT/3D-IGABT in 2005...
November 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30445001/eus-guided-fiducial-placement-for-gi-malignancies-a-systematic-review-and-meta-analysis
#19
REVIEW
Emmanuel Coronel, Irina Mihaela Cazacu, Atsushi Sakuraba, Adriana Alexandra Luzuriaga Chavez, Angad Uberoi, Yimin Geng, Yutaka Tomizawa, Adrian Saftoiu, Eun Ji Shin, Cullen M Taniguchi, Albert C Koong, Joseph M Herman, Manoop S Bhutani
BACKGROUND AND AIMS: Image-guided radiotherapy (IGRT) allows the delivery of radiation with high precision to a target lesion while minimizing toxicity to surrounding tissues. Endoscopic ultrasound (EUS) provides excellent visualization of GI tumors and consequently is being used for fiducial placement with increased frequency. Our goal was to perform a systematic review and meta-analysis of studies evaluating the technical aspects, safety and efficacy of EUS fiducial placement for IGRT in GI malignancies...
November 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30428462/confocal-laser-endomicroscopy-as-a-guidance-tool-for-transbronchial-lung-cryobiopsies-in-interstitial-lung-disorder
#20
Lizzy Wijmans, Peter I Bonta, Rita Rocha-Pinto, Daniel M de Bruin, Paul Brinkman, René E Jonkers, Joris J T H Roelofs, Venerino Poletti, Jürgen Hetzel, Jouke T Annema
BACKGROUND: Transbronchial cryobiopsy (TBCB) of the lung parenchyma is a minimally invasive alternative for surgical lung biopsy in interstitial lung disease (ILD) patients. Drawbacks are the nondiagnostic rate and complication risk of pneumothorax and bleeding. Fluoroscopy is the current guidance tool for TBCB, which is limited by 2D imaging and a radiation dose for the patient. Confocal laser endomicroscopy (CLE) is a high-resolution imaging technique that provides immediate feedback during bronchoscopy about the elastin fiber network of peripheral lung areas...
November 14, 2018: Respiration; International Review of Thoracic Diseases
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