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"Adverse event" radiation

Giuseppina Laura Masucci
Single fraction radiosurgery (SRS) treatment is an effective and recognized alternative to whole brain radiation for brain metastasis. However, SRS is not always possible, especially in tumors of a larger diameter where the administration of high dose in a single fraction is limited by the possibility of acute and late side effects and the dose to the surrounding organs at risk. Hypofractionated radiation therapy allows the delivery of high doses of radiation per fraction while minimizing adverse events, all the while maintaining good local control of lesions...
2018: Frontiers in Oncology
Weizhi Zhang, Lei Gao, Wancun Jin, Qin Wu, Shijun Hu, Yifeng Yang, Tianli Zhao
To evaluate the feasibility and safety of device closure of patent ductus arteriosus (PDA) using only venous access under echocardiography guidance alone.
 Methods: A total of 102 consecutive pediatric patients underwent transcatheter PDA closure without arterial access, under the guidance of only echocardiography. The patients were followed up by clinical examination, electrocardiogram, and echocardiogram at 1, 3, 6 12, and 24 months.
 Results: Transvenous PDA closure under echocardiographic guidance was successful in 99 (97...
September 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Myxuan Huynh, Loredana Gabriela Marcu, Eileen Giles, Michala Short, Donna Matthews, Eva Bezak
INTRODUCTION: The most common solid tumours that develop in children are cancers of the central nervous system. Due to the increased rate of survival over the past decades, greater focus has been placed on the minimisation of long term side effects. In childhood cancer survivors, over 60% report one or more radiation-related late toxicities while half of these adverse events are graded as life-threatening or severe. Proton therapy enables high conformity with the planning target volume and a reduction in dose to areas beyond the target...
October 9, 2018: Cancer Treatment Reviews
Kelvin Robertson, Laurence A G Marshman, David Plummer, Elena Downs
Importance: Optimal pharmacologic treatment for chronic sciatica (CS) is currently unclear. While gabapentin (GBP) and pregabalin (PGB) are both used to treat CS, equipoise exists. Nevertheless, pharmaceutical regulation authorities typically subsidize one drug over the other. This hinders interchange wherever the favored drug is either ineffective or ill-tolerated. Objective: To assess GBP vs PGB head to head for the treatment of CS. Design, Setting, and Participants: A preplanned interim analysis of a randomized, double-blind, double-dummy crossover trial of PGB vs GBP for management of CS at half the estimated final sample size was performed in a single-center, tertiary referral public hospital...
October 15, 2018: JAMA Neurology
Michael Buchfelder, Aart Jan van der Lely, Beverly M K Biller, Susan M Webb, Thierry Brue, Christian J Strasburger, Ezio Ghigo, Cecilia Camacho-Hubner, Kaijie Pan, Joanne Lavenberg, Peter Jonsson, Juliana H Hey-Hadavi
OBJECTIVES: ACROSTUDY is an international, non-interventional study of acromegaly patients treated with pegvisomant (PEGV), a growth hormone receptor antagonist and has been conducted since 2004 in 15 countries to study the long-term safety and efficacy of PEGV. This report comprises the second interim analysis of 2090 patients as of May 12, 2016. METHODS: Descriptive analyses of safety, pituitary imaging and outcomes on PEGV treatment up to 12 years were performed...
October 1, 2018: European Journal of Endocrinology
Amit Maity, Rosemarie Mick, Alexander C Huang, Sangeeth M George, Michael D Farwell, John N Lukens, Abigail T Berman, Tara C Mitchell, Josh Bauml, Lynn M Schuchter, Mark O'Hara, Lilie L Lin, Angela Demichele, John P Christodouleas, Naomi B Haas, Dana M Patsch, Stephen M Hahn, Andy J Minn, E John Wherry, Robert H Vonderheide
BACKGROUND: We conducted a phase I trial evaluating pembrolizumab+hypofractionated radiotherapy (HFRT) for patients with metastatic cancers. METHODS: There were two strata (12 patients each): (i) NSCLC/melanoma progressing on prior anti-PD-1 therapy, (ii) other cancer types; anti-PD-1-naive. Patients received 6 cycles of pembrolizumab, starting 1 week before HFRT. Patients had ≥2 lesions; only one was irradiated (8 Gy × 3 for first half; 17 Gy × 1 for second half in each stratum) and the other(s) followed for response...
October 15, 2018: British Journal of Cancer
Katsuyuki Karasawa, Sara Hayakawa, Yumiko Machitori, Yukiko Shibata, Hiroaki Ogawa, Kei Ito, Takuya Shimizuguchi, Terufumi Kawamoto, Keiji Nihei
PURPOSE: Although stereotactic body radiation therapy is one of the standard treatments for stage I nonsmall cell lung cancer, in the case of central tumors it carries the risk of severe adverse events for serial organs. Accelerated hypofractionated radiotherapy is considered a reasonable alternative to treat central tumors. We have been treating central tumors with accelerated hypofractionated radiotherapy using a 75 Gy/25 fr/5 weeks regimen, and we compared the results with those of stereotactic body radiation therapy using 48 Gy/4 fr/1 week...
January 1, 2018: Technology in Cancer Research & Treatment
Mack Roach, Jennifer Moughan, Colleen A F Lawton, Adam P Dicker, Kenneth L Zeitzer, Elizabeth M Gore, Young Kwok, Michael J Seider, I-Chow Hsu, Alan C Hartford, Eric M Horwitz, Kosj Yamoah, Christopher U Jones, Jeff M Michalski, W Robert Lee, Thomas M Pisansky, Rachel Rabinovitch, Marvin Rotman, Rodger M Pryzant, Harold E Kim, Charles R Thomas, William U Shipley, Howard M Sandler
BACKGROUND: The NRG/RTOG 9413 study showed that whole pelvic radiotherapy (WPRT) plus neoadjuvant hormonal therapy (NHT) improved progression-free survival in patients with intermediate-risk or high-risk localised prostate cancer compared with prostate only radiotherapy (PORT) plus NHT, WPRT plus adjuvant hormonal therapy (AHT), and PORT plus AHT. We provide a long-term update after no years of follow-up of the primary endpoint (progression-free survival) and report on the late toxicities of treatment...
October 10, 2018: Lancet Oncology
Lucas C Mendez, Pencilla Lang, Chirag Patel, David D'Souza, Adam Gladwish, Laura D'Alimonte, Amandeep Taggar, Elizabeth Barnes, Lisa Barbera, Eric Leung
PURPOSE: Perineal interstitial brachytherapy (P-ISBT) is an important component in the treatment of locally advanced gynecological cancers. However, there are concerns about potential acute complications from catheter needles. The goal is to evaluate the safety of P-ISBT by studying acute complications and radiological organ needle intrusions. MATERIALS AND METHODS: Forty-eight patients with gynecological cancers treated with P-ISBT at a single institution from September 2014 to April 2016 were included in a prospective registry trial...
October 10, 2018: Brachytherapy
Paul Lesueur, Alexandre Escande, Juliette Thariat, Enora Vauléon, Isabelle Monnet, Alexis Cortot, Delphine Lerouge, Serge Danhier, Pascal Dô, Catherine Dubos-Arvis, Christos Chouaïd, Radj Gervais
INTRODUCTION: Randomized prospective studies on patients with metastatic non-small-cell lung cancers (NSCLCs) showed that anti-programmed death-1 (PD-1) agents notably improved 2-year overall survival (OS) rates, compared to docetaxel. NSCLC patients now receive nivolumab and irradiation, concurrently or not. However, little is known about the safety of this combination, even though the preclinical model suggested a possible synergic effect. We analyzed NSCLC patients treated with radiotherapy and nivolumab according to former's timing...
October 11, 2018: Cancer Medicine
Kazumasa Orihashi
Transesophageal echocardiography (TEE) provides real-time information on both morphology and hemodynamics without radiation exposure or contrast media, interruption of surgical procedures, or need for transferring the patient to other division, and thus can be used as intraoperative monitoring as well as diagnostic imaging. TEE is helpful for confirming the adequacy of routine surgical procedures, ruling out an occurrence of unexpected adverse events, or even navigating the manipulations of cannulae and catheters...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Koichiro Nakajima, Hiromitsu Iwata, Hiroyuki Ogino, Yukiko Hattori, Shingo Hashimoto, Toshiyuki Toshito, Kensuke Hayashi, Kenji Akita, Fumiya Baba, Katsumi Nakamae, Jun-Etsu Mizoe, Yuta Shibamoto
BACKGROUND: Two prospective phase II trials were designed to assess the efficacy and safety of image-guided proton therapy (IGPT) for either medically inoperable or operable stage I non-small cell lung cancer (NSCLC). The present study reports the interim results of these trials. METHODS: Fifty-five patients with histologically confirmed stage I NSCLC (IA in 33 patients and IB in 22 patients; inoperable in 21 patients and operable in 34 patients) who received IGPT between July 2013 and February 2017 were analyzed...
October 11, 2018: Radiation Oncology
J White, G Carolan-Rees, M Dale, H E Morgan, H E Patrick, T C See, E L Beeton, D E B Swinson, J K Bell, D M Manas, A Crellin, N J Slevin, R A Sharma
AIMS: Patients with chemotherapy-refractory colorectal cancer liver metastases have limited therapeutic options. Selective internal radiation therapy (SIRT) delivers yttrium 90 microspheres as a minimally invasive procedure. This prospective, single-arm, observational, service-evaluation study was part of National Health Service England Commissioning through Evaluation. METHODS: Patients eligible for treatment had histologically confirmed carcinoma with liver-only/liver-dominant metastases with clinical progression during or following oxaliplatin-based and irinotecan-based chemotherapy...
October 5, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Julie E Bauman, Umamaheswar Duvvuri, Sufi Thomas, William E Gooding, David A Clump, Brian Karlovits, Ahmad Wehbe, Frank R Miller, Seungwon Kim, Malabika Sen, Dwight E Heron, Jennifer R Grandis, Athanassios Argiris
BACKGROUND: Cetuximab combined with radiation therapy (RT) is an evidence-based treatment for locally advanced head and neck squamous cell carcinoma (HNSCC); however, locoregional failure remains the primary cause of cancer-related death in this disease. Intratumoral injection of epidermal growth factor receptor (EGFR)-antisense plasmid DNA (EGFR-AS) is safe and has been associated with promising lesional responses in patients who have recurrent/metastatic HNSCC. For the current study, the authors investigated the antitumor effects of cetuximab and EGFR-AS in preclinical HNSCC models and reported their phase 1 experience adding intratumoral EGFR-AS to cetuximab RT...
October 6, 2018: Cancer
Markus Schosserer, Gareth Banks, Soner Dogan, Peter Dungel, Adelaide Fernandes, Darja Marolt Presen, Ander Matheu, Marcin Osuchowski, Paul Potter, Coral Sanfeliu, Bilge Guvenc Tuna, Isabel Varela-Nieto, Ilaria Bellantuono
Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Frailty is the result of an accumulation of deficits, which occurs with age and reduces the ability to respond to adverse events (physical resilience)...
October 2, 2018: Mechanisms of Ageing and Development
Jin Huang, Tianyu He, Ronghui Yang, Tianlong Ji, Guang Li
Purpose: The purpose of this study was to estimate the relation between acute esophagitis (AE) and clinical, dosimetric, and position factors in patients with locally advanced non-small-cell lung cancer (NSCLC) receiving intensity-modulated (chemo)radiotherapy. Materials and methods: A retrospective cohort analysis was performed to identify factors associated with Common Toxicity Criteria for Adverse Events grade 2 or worse AE (AE2+). A multivariable model was established including patient- and treatment-related variables and esophageal dose-volume histogram parameters...
2018: OncoTargets and Therapy
Pierluigi Bove, Valerio Iacovelli, Maria Cristina Tirindelli, Daniele Bianchi, Gerardo Paolo Flammia, Chiara Cipriani, Angelo Salvatore Ferraro, Matteo Ferro, William Arcese, Gianluca Ingrosso, Giuseppe Vespasiani, Enrico Finazzi Agrò
Objective To evaluate the clinical value of endoscopic fibrin glue (FG) application therapy in treating hemorrhagic radiation cystitis (HRC). Patients and Methods This is a single cohort, prospective pilot study. We collected data from patients with HRC who were treated at our urology unit during the period May 2014 to December 2016. Patients with grade >=2 HRC for whom conventional therapy and trans-urethral endoscopic electrocoagulation had failed were treated with endoscopic intravesical FG. The mean follow-up was 26...
October 3, 2018: Journal of Endourology
Hiroaki Ogawa, Kei Ito, Takuya Shimizuguchi, Tomohisa Furuya, Keiji Nihei, Katsuyuki Karasawa
PURPOSE: Stereotactic body radiotherapy (SBRT) is expected to achieve safe and effective re-irradiation for painful bone metastases. This study aimed to clarify the efficacy of re-irradiation using SBRT for painful bone metastases. METHODS: Prospective database at our institution for the period between September 2013 and December 2017 were retrospectively reviewed for patients with: (1) painful bone metastases; (2) history of radiotherapy to the metastasis; and (3) SBRT performed as re-irradiation...
October 3, 2018: Acta Oncologica
Shahnawaz M Amdani, Robert D Ross, Paul A Webster, Daniel R Turner, Thomas J Forbes, Daisuke Kobayashi
INTRODUCTION: Reduction of radiation dosage in the pediatric cardiac catheterization laboratory (PCL) is important to reduce the risk of its stochastic effect in children with congenital heart disease. Lowering the frame rate would reduce radiation dosage possibly at the expense of image quality, potentially resulting in higher fluoroscopic time and procedural complication rate. METHODS: The data were retrospectively analyzed in three eras: era 1 (n = 234), cineangiography 30 frames/sec (f/s) and fluoroscopy 15 pulse/sec (p/s); era 2 (n = 381), cineangiography 30 f/s and fluoroscopy 6 p/s; and era 3 (n = 328), cineangiography 15 f/s and fluoroscopy 6 p/s...
October 2, 2018: Congenital Heart Disease
Yukihiro Hama, Tatsumi Kaji
BACKGROUND/AIM: To examine whether CT-guided daily adaptive radiation therapy (ART) can be safely administered against localized prostate cancer. PATIENTS AND METHODS: Twenty-six patients with localized prostate adenocarcinoma were irradiated through opposed AP/PA fields up to 46 Gy, then CT-guided daily ART was performed through opposed lateral fields until 76 Gy at 2 Gy/fraction. RESULTS: Biochemical relapse-free survival was 89% at 3 years and 85% at 5 years and 76% at 7 years after ART, respectively...
October 2018: Anticancer Research
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