keyword
Keywords Outpatient Autologous Stem Cel...

Outpatient Autologous Stem Cell Transplant

https://read.qxmd.com/read/35894853/conducting-hematopoietic-stem-cell-transplantation-in-low-and-middle-income-countries
#21
JOURNAL ARTICLE
Guillermo J Ruiz-Argüelles, Adriana Seber, Guillermo J Ruiz-Delgado
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a well-recognized therapeutic procedure; costs limit its widespread use in low and middle income countries (LMIC). METHODS: Over a 30-year period, we have conducted HSCT in LMIC, making adaptations to the conventional procedures conducted in high-income countries (HIC). RESULTS: These salient observations stem from our practice: (1) Start with autologous transplantations in patients with hematological malignancies, specifically multiple myeloma; cell freezing devices are not necessary...
December 2022: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/35759026/resource-utilization-for-chimeric-antigen-receptor-t-cell-therapy-versus-autologous-hematopoietic-cell-transplantation-in-patients-with-b-cell-lymphoma
#22
JOURNAL ARTICLE
Alexander Ring, Björn Grob, Erik Aerts, Katharina Ritter, Jörk Volbracht, Bettina Schär, Michael Greiling, Antonia M S Müller
CD19-directed chimeric antigen receptor T cells (CAR-T) have emerged as a highly efficacious treatment for patients with relapsed/refractory (r/r) B cell lymphoma (BCL). The value of CAR-T for these patients is indisputable, but one-off production costs are high, and little is known about the ancillary resource consumption associated with CAR-T treatment. Here, we compared the resource use and costs of CAR-T treatment with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) for patients with r/r BCL...
August 2022: Annals of Hematology
https://read.qxmd.com/read/35706759/plasmablastic-lymphoma-presenting-with-rectosigmoid-perforation-in-a-human-immunodeficiency-virus-positive-patient
#23
Muhammad H Zafar, Lola C Gil, Saman Karimi, Saad Arain, Bindu Niravel, Jessica Martinolich, John Galvin, Carlos A Murga-Zamolloa, Gerald Gantt
Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B-cell lymphoma (DLBCL) associated with human immunodeficiency virus (HIV)-positive patients. It accounts for only 2% of all acquired immune deficiency syndrome (AIDS)-related lymphomas (ARLs). We present the case of a 45-year-old male who presented to the emergency department (ED) with a three-month history of abdominal pain, diarrhea, and unintentional 50-lb weight loss. On an earlier presentation to the ED three months prior, the patient was diagnosed with norovirus and Helicobacter pylori infection and received outpatient treatment without resolution of his symptoms...
May 2022: Curēus
https://read.qxmd.com/read/35645640/evaluation-of-patient-preference-and-perception-regarding-the-clinical-use-of-autologous-versus-allogeneic-cell-therapy-in-orthopedic-surgery
#24
JOURNAL ARTICLE
Claire D Eliasberg, Daniel A Nemirov, Samuel J E Green, Stephen G Melancon, Scott A Rodeo
Background: Cell therapy has become a hot topic in orthopedics, with significant research dedicated to improving physicians' understanding of its efficacy. However, little is known about patients' cell therapy knowledge. Questions/Purposes : The aims of this study were to (1) evaluate patients' perceptions of cell therapy in orthopedics, (2) determine whether patients have a preference for autologous or allogeneic cell therapy, and (3) assess patient concerns about cell therapy. Methods : Consecutive outpatients of an orthopedic clinic were surveyed from June 2019 to January 2020...
May 2022: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://read.qxmd.com/read/35549799/lack-of-a-caregiver-is-associated-with-shorter-survival-in-myeloma-patients-undergoing-autologous-stem-cell-transplantation
#25
JOURNAL ARTICLE
Morie A Gertz, Rahma Warsame, Eli Muchtar, Frances Buadi, Angela Dispenzieri, Wilson Gonsalves, David Dingli, Suzanne Hayman, Prashant Kapoor, Taxiarchis Kourelis, Shaji K Kumar, Martha Q Lacy, William Hogan
There is increasing evidence that social infrastructure and a healthy social network can improve cancer survival. Mayo Clinic has an outpatient stem cell transplantation program for myeloma. Safe outpatient transplantation requires a caregiver to be present. Patients lacking a caregiver are transplanted as an inpatient. We reviewed outcomes on over 2000 patients with multiple myeloma, 2103 transplanted as an outpatient compared with 41 hospitalized for transplantation. Although progression-free survival following transplantation was identical between the two groups, overall survival was shorter in those hospitalized...
May 12, 2022: Leukemia & Lymphoma
https://read.qxmd.com/read/35329966/feasibility-of-outpatient-stem-cell-transplantation-in-multiple-myeloma-and-risk-factors-predictive-of-hospital-admission
#26
JOURNAL ARTICLE
Kristin Larsen, Horace Spencer, Meera Mohan, Clyde Bailey, Kerri Hill, Mathew Kottarathara, Richa Parikh, Shadiqul Hoque, Amani Erra, Angel A Mitma, Pankaj Mathur, Lakshmi Yarlagadda, Sravani Gundarlapalli, Yetunde Ogunsesan, Munawwar Hussain, Nishanth Thalambedu, Jaskirat Sehti, Samer Al Hadidi, Sharmilan Thanendrarajan, Monica Graziutti, Maurizio Zangari, Bart Barlogie, Frits van Rhee, Guido Tricot, Carolina Schinke
High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for multiple myeloma (MM) patients. Although outpatient ASCT has been shown to be safe and feasible, the procedure is overall rare with most patients in the US undergoing inpatient ASCT. Furthermore, hospitalization rates for patients that undergo outpatient ASCT remain high. Adequate markers that predict hospitalization during outpatient ASCT are lacking, yet would be of great clinical value to select patients that are suited to outpatient ASCT...
March 16, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/34765323/a-novel-wearable-device-for-continuous-temperature-monitoring-fever-detection
#27
JOURNAL ARTICLE
Nishant Verma, Iman Haji-Abolhassani, Suhas Ganesh, Jesus Vera-Aguilera, Jonas Paludo, Roxana Heitz, Svetomir N Markovic, Kimary Kulig, Atiyeh Ghoreyshi
Objective: Continuous temperature monitoring in high-risk patients can enable healthcare providers to remotely track patients' temperatures, promptly detect fevers and timely intervene to improve clinical outcomes. We evaluated if a novel wearable, continuous temperature monitor (Verily Patch) can reliably estimate body temperature and early detect fevers in an outpatient setting in patients at a high risk of febrile neutropenia (FN) who recently underwent chemotherapy and autologous stem cell transplantation (ASCT)...
2021: IEEE Journal of Translational Engineering in Health and Medicine
https://read.qxmd.com/read/34605020/economic-burden-in-non-hodgkin-lymphoma-survivors-the-french-lymphoma-study-association-simonal-cross-sectional-study
#28
JOURNAL ARTICLE
Virginie Nerich, Christophe Guyeux, Michel Henry-Amar, Raphaël Couturier, Catherine Thieblemont, Vincent Ribrag, Hervé Tilly, Corinne Haioun, René-Olivier Casasnovas, Franck Morschhauser, Pierre Feugier, David Sibon, Loic Ysebaert, Emmanuelle Nicolas-Virelizier, Florence Broussais-Guillaumot, Gandhi L Damaj, Jean-Philippe Jais, Gilles Salles, Macha Woronoff-Lemsi, Nicolas Mounier
BACKGROUND: No study has focused on the economic burden in non-Hodgkin lymphoma (NHL) survivors, even though this knowledge is essential. This study reports on health care resource use and associated health care costs as well as related factors in a series of 1671 French long-term NHL survivors. METHODS: Health care costs were measured from the payer perspective. Only direct medical costs (medical consultations, outpatient treatments, hospitalizations, and medical transport) in the past 12 months were included (reference year 2015)...
February 1, 2022: Cancer
https://read.qxmd.com/read/34585327/autologous-atg-free-hematopoietic-stem-cell-transplantation-for-refractory-autoimmune-rheumatic-diseases-a-latin-american-cohort
#29
JOURNAL ARTICLE
José Carlos Jaime-Pérez, Mariana González-Treviño, Jesús D Meléndez-Flores, Eugenia M Ramos-Dávila, Olga G Cantú-Rodriguez, César H Gutiérrez-Aguirre, Dionicio A Galarza-Delgado, David Gómez-Almaguer
Autologous hematopoietic stem cell transplantation (HSCT) has been recognized as treatment alternative for patients with severe, refractory autoimmune rheumatic diseases (ARDs). Usually, anti-thymocyte globulin (ATG)-containing conditioning regimens are employed; however, ATG is unavailable in some developing nations. We report our 15-year clinical experience autografting patients with ARDs with an ATG-free conditioning regimen and a brief assessment of patient-reported outcomes post-HSCT. All patients had active disease and were resistant to multiple lines of treatment...
March 2022: Clinical Rheumatology
https://read.qxmd.com/read/34383780/hospital-and-outpatient-models-for-hematopoietic-stem-cell-transplantation-a-systematic-review-of-comparative-studies-for-health-outcomes-experience-of-care-and-costs
#30
JOURNAL ARTICLE
Marino J González, Elena Urizar, Maider Urtaran-Laresgoiti, Roberto Nuño-Solinís, Esther Lázaro-Pérez, Lourdes Vázquez, Maria Jesús Pascual-Cascón, Carlos Solano, Mi Kwon, Cristina Gallego, Francesc Fernández-Avilés
The number of Hematopoietic Stem Cell Transplantations has risen in the past 20 years. The practice of outpatient Hematopoietic Stem Cell Transplantation programs is increasing in an attempt to improve the quality of patient care and reduce the demand for hospital admission. A systematic review of 29 comparative studies between in-hospital and outpatient treatment of Hematopoietic Stem Cell Transplantation, with no restriction by outpatient regime was conducted. This study aims to analyse the current evidence on the effects of the outpatient model on patient-centred outcomes, comparing both in-hospital and outpatient models for autologous and allogeneic HSCT using the Triple Aim framework: health outcomes, costs and experience of care...
2021: PloS One
https://read.qxmd.com/read/34363493/implementation-and-evaluation-of-a-nurse-allied-health-clinic-for-patients-after-haematopoietic-stem-cell-transplantation
#31
JOURNAL ARTICLE
Midori Nakagaki, Nicole C Gavin, Therese Hayes, Rebecca Fichera, Caroline Stewart, Leonie Naumann, Justine Brennan, Natasha Perry, Emma Foley, Erin Crofton, Christie Brown, Jenni Leutenegger, Glen A Kennedy
PURPOSE: Patients who undergo haematopoietic stem cell transplantation (HSCT) often have multiple health issues following hospital discharge. In many centres, outpatient follow-up is solely conducted by specialist physicians. We aimed to implement and describe the outcomes of a nurse-allied health multidisciplinary clinic. METHODS: The clinic consisted of six disciplines-nursing, pharmacy, dietetics, physiotherapy, occupational therapy and social work. All allogeneic and high risk autologous HSCT patients were reviewed at 2 weeks after discharge and on day 100 post HSCT, with additional reviews as needed...
January 2022: Supportive Care in Cancer
https://read.qxmd.com/read/34297879/safety-of-outpatient-stem-cell-mobilization-with-low-or-intermediate-dose-cyclophosphamide-in-newly-diagnosed-multiple-myeloma-patients
#32
JOURNAL ARTICLE
Alessandra Pompa, Loredana Pettine, Diana Giannarelli, Laura Paris, Lorella Torretta, Francesca Cavallaro, Giorgia Virginia Levati, Paola Stefanoni, Cristina Mocellin, Monica Galli, Luca Baldini
OBJECTIVES: Autologous stem cell transplantation is the gold standard for eligible newly diagnosed multiple myeloma patients. Patients are usually hospitalized for administration of mobilization chemotherapy. We aimed to assess safety and efficacy of mobilization therapy with low-dose (2 g/m2 ) and intermediate-dose (3-4 g/m2 ) cyclophosphamide administered as outpatient. METHODS: A total of 176 consecutive newly diagnosed transplant-eligible myeloma patients receiving outpatient mobilization were retrospectively evaluated...
July 23, 2021: European Journal of Haematology
https://read.qxmd.com/read/34294574/symptom-prevalence-and-health-related-quality-of-life-in-patients-undergoing-autologous-stem-cell-transplantation-a-longitudinal-observational-study
#33
JOURNAL ARTICLE
Simone Lena Stamm, Elisabeth Spichiger, Thomas Pabst, Stefanie Bachnick, Marie-Madlen Jeitziner
PURPOSE: The aims of this study are to assess symptoms, health-related quality of life (HRQoL) and associations between symptoms and HRQoL in adult patients with myeloma or lymphoma undergoing autologous stem-cell transplantation (ASCT) during the pre- and post-transplantation phases in the outpatient setting. METHODS: This longitudinal, observational study conducted at a Swiss tertiary care hospital assesses the prevalence, frequency, severity and distress of symptoms, as well as HRQoL prior to hospital admission (T1), within two weeks after hospital discharge (T2) and three months after hospital discharge (T3)...
August 2021: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/34255180/a-hybrid-method-of-healthcare-delivery-research-and-human-centered-design-to-develop-technology-enabled-support-for-caregivers-of-hematopoietic-stem-cell-transplant-recipients
#34
JOURNAL ARTICLE
Lauren R Bangerter, Monica Looze, Barbara Barry, Kathleen Harder, Joan Griffin, Meredith Dezutter, Nandita Khera, Sikander Ailawadhi, Karen Schaepe, Kristin Fischer
Health information technology (HIT) is a widely recognized strategy to encourage cancer patients and caregivers to participate in healthcare delivery in a sustainable and cost-effective way. In the context of autologous hematopoietic cell transplant (HSCT), HIT-enabled tools have the potential to effectively engage, educate, support, and optimize outcomes of patients and caregivers in the outpatient setting. This study sought to leverage human-centered design to develop a high-fidelity prototype of a HIT-enabled psychoeducational tool for HSCT caregivers...
January 2022: Supportive Care in Cancer
https://read.qxmd.com/read/34204102/prospective-spect-ct-organ-dosimetry-driven-radiation-absorbed-dose-escalation-using-the-in-111-111-in-yttrium-90-90-y-ibritumomab-tiuxetan-zevalin-%C3%A2-theranostic-pair-in-patients-with-lymphoma-at-myeloablative-dose-levels
#35
JOURNAL ARTICLE
Richard L Wahl, Eric C Frey, Heather A Jacene, Brad S Kahl, Steven Piantadosi, Jesus A Bianco, Richard J Hammes, Miah Jung, Wayne Kasecamp, Bin He, George Sgouros, Ian W Flinn, Lode J Swinnen
PURPOSE: We prospectively evaluated the feasibility of SPECT-CT/planar organ dosimetry-based radiation dose escalation radioimmunotherapy in patients with recurrent non-Hodgkin's lymphoma using the theranostic pair of 111 In and 90 Y anti-CD20 ibritumomab tiuxetan (Zevalin® ) at myeloablative radiation-absorbed doses with autologous stem cell support. We also assessed acute non-hematopoietic toxicity and early tumor response in this two-center outpatient study. METHODS: 24 patients with CD20-positive relapsed or refractory rituximab-sensitive, low-grade, mantle cell, or diffuse large-cell NHL, with normal organ function, platelet counts > 75,000/mm3 , and <35% tumor involvement in the marrow were treated with Rituximab (375 mg/m2 ) weekly for 4 consecutive weeks, then one dose of cyclophosphamide 2...
June 6, 2021: Cancers
https://read.qxmd.com/read/34099429/trajectory-of-symptoms-in-patients-undergoing-autologous-stem-cell-transplant-for-multiple-myeloma-a-population-based-cohort-study-of-patient-reported-outcomes
#36
JOURNAL ARTICLE
Mohammed S Ebraheem, Hsien Seow, Amaris K Balitsky, Gregory R Pond, Tanya M Wildes, Branavan Sivapathasundaram, Jonathan Sussman, Hira Mian
BACKGROUND: Autologous stem cell transplant (ASCT) is an established treatment for patients with newly diagnosed multiple myeloma (NDMM). Understanding the symptom burden associated with ASCT may be an important consideration for patients with NDMM when selecting treatment options. PATIENTS AND METHODS: We conducted a population-based study of patients who underwent an ASCT for NDMM in Ontario, Canada, between 2007 and 2018. The patient-reported outcome, Edmonton Symptom Assessment System (ESAS) score, which captures nine common cancer-associated symptoms and is routinely collected at all outpatient visits, was linked to provincial administrative healthcare data...
September 2021: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/33964038/extracorporeal-photopheresis-vs-standard-therapies-for-steroid-refractory-chronic-graft-vs-host-disease-pharmacoeconomic-assessment-of-hospital-resource-use-in-spain
#37
COMPARATIVE STUDY
Blanca Boluda, Antonio Solana-Altabella, Isabel Cano, Evelyn Acuña-Cruz, Rebeca Rodríguez-Veiga, Octavio Ballesta-López, Juan Eduardo Megías-Vericat, David Martínez-Cuadrón, Ines Gómez, Pilar Solves, Ignacio Lorenzo, Jose Luis Piñana, Jaime Sanz, Manuel Guerreiro, Juan Montoro Gómez, Alvaro Díaz-González, Javier Marco, Albert Blanco, Miguel Á Sanz, Pau Montesinos
BACKGROUND: This study assessed pharmacoeconomic costs associated with extracorporeal photopheresis (ECP) compared with other available second-line therapies for chronic graft-vs-host disease (cGvHD) in a tertiary Spanish institution. METHODS: Patients (≥18 years) diagnosed with steroid-refractory cGvHD were eligible. Data were collected retrospectively from index date until 1 year or relapse. Patients were distributed in two cohorts (ECP vs non-ECP), matched by age (≤ or > 40), hematopoietic stem cell transplant (HLA-identical sibling donor or other) and number of previous immunosuppressive lines (1, 2, or ≥ 3)...
August 2021: Journal of Clinical Apheresis
https://read.qxmd.com/read/33949777/outpatient-autologous-stem-cell-transplantation-in-royal-hobart-hospital-tasmania-a-single-centre-retrospective-review-in-the-australian-setting
#38
JOURNAL ARTICLE
Xuan Ni Tan, Chang Yang Yew, Scott J Ragg, Rosemary A Harrup, Anna M Johnston
BACKGROUND: Several international centres have published their experiences with outpatient autologous stem cell transplantation (ASCT) as treatment of haematological malignancies. AIM: In this single-centre retrospective review, we aim to examine the outcomes of outpatient autograft and review healthcare resource utilization in the pre-cytopenic period. METHODS: Patients undergoing ASCT in Royal Hobart Hospital, Tasmania between 2008 and 2018 had their records reviewed and key outcomes data collected based upon whether they received inpatient/outpatient ASCT...
May 5, 2021: Internal Medicine Journal
https://read.qxmd.com/read/33908282/economic-burden-of-acute-steroid-refractory-graft-versus-host-disease-in-commercially-insured-pediatric-patients
#39
JOURNAL ARTICLE
Michael Grabner, Eric Strati, Karen Sandman, Anna Forsythe
BACKGROUND: Acute graft-versus-host disease (aGVHD), a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT), often occurs within 100 days of HSCT. While steroids are typically used as first-line treatment, there is no consensus on second-line steroid-refractory (SR) treatments. SR aGVHD is associated with significantly worse pediatric health outcomes, but less is known about its economic impact. OBJECTIVE: To evaluate the economic burden of SR pediatric aGVHD in a commercially insured US patient population...
May 2021: Journal of Managed Care & Specialty Pharmacy
https://read.qxmd.com/read/33728732/healthcare-resource-utilisation-and-sickness-absence-in-newly-diagnosed-multiple-myeloma-patients-who-did-not-undergo-autologous-stem-cell-transplantation-trends-in-sweden-with-the-changing-treatment-landscape
#40
JOURNAL ARTICLE
Fredrik Borgsten, Xenia Gatopoulou, Marta Pisini, Magnus Tambour, Frida Schain, Christina V Jones, Kelvin Ho Man Kwok, Nurgul Batyrbekova, Magnus Björkholm
OBJECTIVES: The introduction of novel drugs has significantly improved outcomes for multiple myeloma (MM) patients. This study describes survival, healthcare resource utilisation and sickness absence in association with the changing MM treatment landscape over time, focussing on patients who did not undergo autologous stem cell transplantation (ASCT). METHODS: Population-based, retrospective registry study in Sweden, where 7012 non-ASCT patients diagnosed between 2001 and 2015 were stratified into diagnosis periods 2001-2005 (n = 2053), 2006-2010 (n = 2372) and 2011-2015 (n = 2587)...
July 2021: European Journal of Haematology
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