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Dorra Amor, Sébastien Goutal, Solène Marie, Fabien Caillé, Martin Bauer, Oliver Langer, Sylvain Auvity, Nicolas Tournier
BACKGROUND: Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear uptake transport of erlotinib into the liver, suggesting carrier-mediated system(s) to mediate its hepatobiliary clearance. Erlotinib has been identified in vitro as a substrate of organic anion-transporting polypeptide (OATP) transporters which expression does not restrict to hepatocytes and may impact the tissue uptake of erlotinib in vivo...
August 16, 2018: EJNMMI Research
Leonardo Joaquim van Zyl, Yoonus Abrahams, Emily Amor Stander, Bronwyn Kirby-McCollough, Roland Jourdain, Cécile Clavaud, Lionel Breton, Marla Trindade
Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been investigated. While skin metagenome and -metavirome studies have indicated that the skin virome is highly site specific and shows marked interpersonal variation, they have not assessed the presence/absence of individual phages...
August 16, 2018: Scientific Reports
P Solano, E Pizzorno, M Pompili, G Serafini, M Amore
OBJECTIVES: Suicide is a complex phenomenon determined by the interplay of an articulated network of factors including socio-economic factors which have a decisive role. This paper investigates the development of the modern conceptualization of suicide in Europe, its sociological understandings and its intertwinement with economic cycles throughout time. METHODS: MEDLINE, SCHOLAR, EMBASE using the keywords 'socioeconomic factors AND suicide'; 'economic cycles AND suicide'; 'history AND suicide' without timeframe limitations...
March 2018: Irish Journal of Psychological Medicine
Nádia Ghinelli Amôr, Carine Ervolino de Oliveira, Thaís Helena Gasparoto, Vanessa Garcia Vilas Boas, Graziela Perri, Ramon Kaneno, Vanessa Soares Lara, Gustavo Pompermaier Garlet, João Santana da Silva, Gislâine A Martins, Cory Hogaboam, Karen A Cavassani, Ana Paula Campanelli
Squamous cell carcinoma (SCC) is the second most common form of skin cancer and the mechanism(s) involved in the progression of this tumor are unknown. Increases in the expression of IL-33/ST2 axis components have been demonstrated to contribute to neoplastic transformation in several tumor models and interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Based on these observations, we sought to determine the role of the IL-33/ST2 pathway during the development of SCC...
July 20, 2018: Oncotarget
Gianluca Serafini, Giulia Adavastro, Giovanna Canepa, Domenico De Berardis, Alessandro Valchera, Maurizio Pompili, Henry Nasrallah, Mario Amore
Although several pharmacological options to treat depression are currently available, approximately one third of patients who receive antidepressant medications do not respond adequately or achieve a complete remission. Thus, novel strategies are needed to successfully address those who did not respond, or partially respond, to available antidepressant pharmacotherapy. Research findings revealed that the opioid system is significantly involved in the regulation of mood and incentives salience and may be an appropriate target for novel therapeutic agents...
August 15, 2018: International Journal of Molecular Sciences
Maurizio Pompili, Luana Lionetto, Martina Curto, Alberto Forte, Denise Erbuto, Franco Montebovi, Maria Elena Seretti, Isabella Berardelli, Gianluca Serafini, Marco Innamorati, Mario Amore, Ross J Baldessarini, Paolo Girardi, Maurizio Simmaco
BACKGROUND: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased L-kynurenine (KYN), or its metabolites, in the body fluids of subjects with major depressive disorder (MDD), sometimes in association with suicidal behavior. Such changes might indicate a shift of TRY away from serotonin production, possibly via the effects of inflammatory peptides which activate indoleamine-2,3-dioxygenase. However, these findings have been inconsistent and require replication...
August 15, 2018: Neuropsychobiology
Ricard V Solé, Raúl Montañez, Salva Duran-Nebreda, Daniel Rodriguez-Amor, Blai Vidiella, Josep Sardanyés
Ecosystems are complex systems, currently experiencing several threats associated with global warming, intensive exploitation and human-driven habitat degradation. Because of a general presence of multiple stable states, including states involving population extinction, and due to the intrinsic nonlinearities associated with feedback loops, collapse in ecosystems could occur in a catastrophic manner. It has been recently suggested that a potential path to prevent or modify the outcome of these transitions would involve designing synthetic organisms and synthetic ecological interactions that could push these endangered systems out of the critical boundaries...
July 2018: Royal Society Open Science
Mounia Rahmani, Maria Benabdeljlil, Fouad Bellakhdar, Mustapha El Alaoui Faris, Mohamed Jiddane, Khalil El Bayad, Fatima Boutbib, Rachid Razine, Rachid Gana, Moulay R El Hassani, Nizar El Fatemi, Meryem Fikri, Siham Sanhaji, Hennou Tassine, Imane El Alaoui Balrhiti, Souad El Hadri, Najwa Ech-Cherif Kettani, Najia El Abbadi, Mourad Amor, Abdelmjid Moussaoui, Afifa Semlali, Saadia Aidi, El Hachmia Ait Benhaddou, Ali Benomar, Ahmed Bouhouche, Mohamed Yahyaoui, Abdeslam El Khamlichi, Abdessamad El Ouahabi, Rachid El Maaqili, Houyam Tibar, Yasser Arkha, Adyl Melhaoui, Abdelhamid Benazzouz, Wafa Regragui
Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients. Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL)...
2018: Frontiers in Neurology
Andrés Díaz-López, Nancy Babio, Miguel A Martínez-González, Dolores Corella, Antonio J Amor, Montse Fitó, Ramon Estruch, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Josep Basora, F Javier Basterra-Gortari, Vicente Zanon-Moreno, Miguel Ángel Muñoz, Jordi Salas-Salvadó
No abstract text is available yet for this article.
August 13, 2018: Diabetes Care
Takwa Missaoui, Moêz Smiri, Hajer Chemingui, Elyes Jbira, Amor Hafiane
In the present study, the interactions between nanoparticle (NP) exposure, root application and plants were examined. NPs are potentially responsible for conformational changes in polysaccharides, lipids, proteins, pectin, suberin and lignin molecules. 4 days of treatment with metal oxide caused a statistically significant increase in nicotinamide adénine dinucléotide oxidase activity in mitochondria and cytosol. Following exposure to TiO2 NP, even lipid peroxidation levels decreased in the mitochondria (leaves, stem and root) and in the cytosol (leaves and root), although it increased in the cytosol of the stem...
August 11, 2018: Bulletin of Environmental Contamination and Toxicology
Claudine M Kraan, David E Godler, David J Amor
The fragile X mental retardation 1 gene (FMR1)-related disorder fragile X syndrome (FXS) is the most common heritable form of cognitive impairment and the second most common cause of comorbid autism. FXS usually results when a premutation trinucleotide CGG repeat in the 5' untranslated region of the FMR1 gene (CGG 55-200) expands over generations to a full mutation allele (CGG >200). This expansion is associated with silencing of the FMR1 promoter via an epigenetic mechanism that involves DNA methylation of the CGG repeat and the surrounding regulatory regions...
August 7, 2018: Developmental Medicine and Child Neurology
Emma K Baker, David E Godler, Minh Bui, Chriselle Hickerton, Carolyn Rogers, Mike Field, David J Amor, Lesley Bretherton
BACKGROUND: Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are neurodevelopmental disorders that are caused by abnormal expression of imprinted genes in the 15q11-13 region. Dysregulation of genes located in this region has been proposed as a susceptibility factor for autism spectrum disorder (ASD) in both disorders. METHODS: This study aimed to explore symptoms of ASD in 25 PWS and 19 AS individuals aged between 1 and 39 years via objective assessment...
August 6, 2018: Journal of Neurodevelopmental Disorders
Batya Engel-Yeger, Boaz Bloch, Xenia Gonda, Giovanna Canepa, Maurizio Pompili, Leo Sher, Zoltan Rihmer, Mario Amore, Gianluca Serafini
INTRODUCTION: Sensory processing patterns have been proposed as a stable dimension able to characterize individuals with major affective disorders, but to what extent specific impairments in sensory processing may be involved in the pathophysiology of these conditions is poorly understood. We aimed to explore which sensory profiles may better respond to psychoactive medications, with particular regard to antidepressants, according to depression, alexithymia, and hopelessness levels. METHODS: A total of 402 outpatients who received maintenance treatment and were in stable psychopathological conditions were recruited and completed the Adolescent/Adult Sensory Profile (AASP), Toronto Alexithymia Scale (TAS-20), second version of the Beck Depression Inventory (BDI-II), and Beck Hopelessness Scale (BHS) according to a longitudinal prospective study design including three time points of measurements...
July 23, 2018: Journal of Affective Disorders
Melina Amor, Bianca K Itariu, Veronica Moreno-Viedma, Magdalena Keindl, Alexander Jürets, Gerhard Prager, Felix Langer, Viktor Grablowitz, Maximilian Zeyda, Thomas M Stulnig
Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment concepts need to be identified. Myostatin, a myokine known for restraining skeletal muscle growth, has been associated with the development of insulin resistance and type 2 diabetes mellitus. Yet, little is known about the regulation of myostatin in human obesity and insulin resistance. We aimed to investigate the regulation of myostatin in obesity and uncover potential associations between myostatin, metabolic markers and insulin resistance/sensitivity indices...
August 3, 2018: Experimental and Clinical Endocrinology & Diabetes
Marco Amores, Peter J Baker, Edmund J Cussen, Serena A Corr
Increasing demand for lithium batteries for automotive applications, coupled with the necessity to move to large-scale energy storage systems, is driving a push towards new technologies and has seen Na-ion batteries emerge as a leading alternative to Li-ion. Amongst these, all solid-state configurations represent a promising route to achieving higher energy densities and increased safety. Remaining challenges include the need for Na+ solid electrolytes with the requisite ionic conductivities crucial for use in a solid-state cell...
August 3, 2018: Chemical Communications: Chem Comm
Olha Zhenyukh, Maria González-Amor, Raul R Rodrigues-Diez, Vanesa Esteban, Marta Ruiz-Ortega, Mercedes Salaices, Sebastian Mas, Ana M Briones, Jesus Egido
Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are essential amino acids implicated in glucose metabolism and maintenance of correct brain function. Elevated BCAA levels can promote an inflammatory response in peripheral blood mononuclear cells. However, there are no studies analysing the direct effects of BCAA on endothelial cells (ECs) and its possible modulation of vascular function. In vitro and ex vivo studies were performed in human ECs and aorta from male C57BL/6J mice, respectively...
July 31, 2018: Journal of Cellular and Molecular Medicine
Jacques Pliquett, Souheila Amor, Miguel Ponce-Vargas, Myriam Laly, Cindy Racoeur, Yoann Rousselin, Franck Denat, Ali Bettaïeb, Paul Fleurat-Lessard, Catherine Paul, Christine Goze, Ewen Bodio
A simple trifunctional BODIPY platform was designed. The high potential of this platform was validated via the elaboration of twelve optical theranostics. More specifically, we reported on the synthesis, the characterization, the photophysical properties, and the evaluation of the hydrophilicity properties of the different BODIPY derivatives, as well as a theoretical rationalization of the intriguing chemical behavior of some of them. The antiproliferative evaluation and confocal imaging of the different compounds in three human and murine cancer cell lines were performed and analysed, along with the measurement of gold(i) uptake in one cancer cell line via ICP-MS...
August 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
M Ng, H Ho, J Skelton, M Guerrieri, M Guiney, M Chao, D Blakey, C Macleod, H Amor, B Subramanian, L Melven
AIMS: Intensity-modulated radiotherapy (IMRT) is increasingly used in the treatment delivery of chemoradiotherapy in anal cancer with the ability to reduce toxicity. We report on 4 year outcomes since the introduction of IMRT and identify the most predictive bowel organ at risk that correlates with acute diarrhoea. MATERIALS AND METHODS: Fifty-eight patients receiving definitive chemoradiotherapy for squamous or basaloid cell anal carcinoma (T1-4NanyM0) were reviewed...
July 23, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Donald Livingstone Iii, Conrad Stack, Guiliana M Mustiga, Dayana C Rodezno, Carmen Suarez, Freddy Amores, Frank A Feltus, Keithanne Mockaitis, Omar E Cornejo, Juan C Motamayor
[This corrects the article on p. 2008 in vol. 8, PMID: 29259608.].
2018: Frontiers in Plant Science
Claudia Erika Amor M Buco, Keith Anthony C Buenviaje, Rialin Bettina C Bulan, Reineir James L Cabaña, Maria Karlene S Cabuhat, Maria Victoria V Bongar, John Rey B Macindo
PURPOSE: Although healthy ageing aims for better quality of life, the inability of older adults to adequately care for themselves and their health impair the realization of such objective. Moreover, in a collectivist community like the Philippines, the family, community, and Transcendent are inseparable in promoting quality of life. This study developed and tested a model of quality of life (QoL) among chronically-ill, community-dwelling older adults. MATERIALS AND METHODS: From August to November 2017, a cross-sectional study of 304 chronically-ill, community-dwelling older adults from selected rural communities in the Philippines was conducted...
September 2018: Archives of Gerontology and Geriatrics
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