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Jesse Pulido, Maria de Cabrera, Adam J Sobczak, Alejandro Amor-Coarasa, Anthony J McGoron, Stanislaw F Wnuk
The conjugation of 4-N-(3-aminopropanyl)-2'-deoxy-2',2'-difluorocytidine with 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (SCN-Bn-NOTA) ligand in 0.1 M Na2 CO3 buffer (pH 11) at ambient temperature provided 4-N-alkylgemcitabine-NOTA chelator. Incubation of latter with excess of gallium(III) chloride (GaCl3 ) (0.6 N AcONa/H2 O, pH = 9.3) over 15 min gave gallium 4-N-alkylgemcitabine-NOTA complex which was characterized by HRMS. Analogous [68 Ga]-complexation of 4-N-alkylgemcitabine-NOTA conjugate proceeded with high labeling efficiency (94%-96%) with the radioligand almost exclusively found in the aqueous layer (∼95%)...
October 12, 2018: Bioorganic & Medicinal Chemistry
Gianluca Serafini, Dorian Lamis, Giovanna Canepa, Andrea Aguglia, Fiammetta Monacelli, Matteo Pardini, Maurizio Pompili, Mario Amore
Major affective conditions including both unipolar (UD) and bipolar disorders (BD) are associated with significant disability throughout the life course. We aimed to investigate the most relevant socio-demographic/clinical differences between UD and BD subjects. Our sample included 180 inpatients, of which 82 (45.5%) participants were diagnosed with UD and 98 (54.5%) with BD. Relative to UD patients, BD individuals were more likely to report prior psychoactive medications, lifetime psychotic symptoms, nicotine abuse, a reduced ability to provide to their needs, gambling behavior, and fewer nonsuicidal self-harm episodes...
June 20, 2018: Psychiatry Research
James Amor Smith, Maor Bar-Peled
The rare branched-chain sugar apiose, once thought to only be present in the plant kingdom, was found in two bacterial species: Geminicoccus roseus and Xanthomonas pisi. Glycans with apiose residues were detected in aqueous methanol-soluble fractions as well as in the insoluble pellet fraction of X. pisi. Genes encoding bacterial uridine diphosphate apiose (UDP-apiose) synthases (bUASs) were characterized in these bacterial species, but the enzyme(s) involved in the incorporation of the apiose into glycans remained unknown...
2018: PloS One
Alexander Mahnert, Rocel Amor Ortega, Christian Berg, Martin Grube, Gabriele Berg
Leaf-inhabiting fungi are an important, but often overlooked component of molecular biodiversity studies. To understand their diversity and function in relation to plant species and climate, the phyllospheres of 14 phylogenetically diverse ornamental plant species were analyzed under different controlled greenhouse conditions. We found unexpectedly high fungal diversity (H' = 2.8-6.5), OTU numbers (449-1050) and abundances (103 -106 CFU cm-2 leaf surface) associated with all plants studied indoors. Despite experimental limitations, the composition of fungal communities were inclined toward a plant species-dependent pattern compared to the ambient climatic variables...
2018: Frontiers in Microbiology
Sophie Lawrie, Yun Dong, Dax Steins, Zhidao Xia, Patrick Esser, Shanbin Sun, Fei Li, James D Amor, Christopher James, Hooshang Izadi, Yi Cao, Derick Wade, Nancy Mayo, Helen Dawes
Background: The majority of stroke patients are inactive outside formal therapy sessions. Tailored activity feedback via a smartwatch has the potential to increase inpatient activity. The aim of the study was to identify the challenges and support needed by ward staff and researchers and to examine the feasibility of conducting a randomised controlled trial (RCT) using smartwatch activity monitors in research-naive rehabilitation wards. Objectives (Phase 1 and 2) were to report any challenges and support needed and determine the recruitment and retention rate, completion of outcome measures, smartwatch adherence rate, (Phase 2 only) readiness to randomise, adherence to protocol (intervention fidelity) and potential for effect...
2018: Pilot and Feasibility Studies
Maria Luisa Martin-Rosello, Maria Reyes Sanz-Amores, Maria Rosa Salvador-Comino
PURPOSE OF THE REVIEW: The growing number of patients with terminal and chronic conditions and co-morbidities constitutes a challenge for any healthcare system, to provide effective and efficient patient-centred care at the end of life. Resources are limited, and complexity is rising within patients' situations and healthcare professionals interventions. This review presents the state of art of the role of complexity in specialist palliative care provision. RECENT FINDINGS: Although studies related to complexity in palliative care are still limited, interesting reviews on complexity frameworks in co-morbidity conditions and palliative care are growing more present in current literature...
October 12, 2018: Current Opinion in Supportive and Palliative Care
Alvaro Juárez Soto, Rocío Caballero Cobos, Ruben Campanario Pérez, Rocío Saiz Marenco, Mercedes Herrera Torres, Rafael Gamaza Martínez, Javier Amores Bermúdez
OBJECTIVES: Prostate cancer is the most frequent neoplasia diagnosed in males. Treatment of metastatic prostate cancer is based on androgen deprivation therapy (ADT) up to its change to the castration resistance state. Recently, new molecules have been developed that significantly increase survival and quality of life of these patients. Abiraterone acetate in combination with prednisone is the first oral hormone therapy that contributed to this change in the approach of the disease. METHODS: Systematic bibliographic review about abiraterone in the treatment of metastatic castration resistant prostate cancer (CPRC), with data on efficacy, safety and quality of life...
September 2018: Archivos Españoles de Urología
Tarek Debs, Niccolo Petrucciani, Radwan Kassir, Eric Sejor, Sami Karam, Imed Ben Amor, Jean Gugenheim
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) is gaining acceptance among bariatric surgeons as a viable option for treating morbidly obese patients. We describe the results of a single center's experience with SG, revealing a low complication rate. OBJECTIVES: The aim of the study was to analyze the short-term results of laparoscopic SG using exclusively black staples with staple-line reinforcement. SETTINGS: University hospital, tertiary referral center for bariatric surgery...
September 12, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Alejandro Amor-Coarasa, James M Kelly, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, John W Babich
Emerging interest in extending the plasma half-life of small molecule radioligands warrants a consideration of the appropriate radionuclide for PET imaging at longer time points (>8 h). Among candidate positron-emitting radionuclides, 66 Ga (t1/2 = 9.5 h, β+ = 57%) has suitable nuclear and chemical properties for the labeling and PET imaging of radioligands of this profile. We investigated the value of 66 Ga to preclinical screening and the evaluation of albumin-binding PSMA-targeting small molecules. 66 Ga was produced by irradiation of a nat Zn target...
October 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
David J Amor
The search for causation is a key component of the assessment of the child with intellectual disability. Historically, a specific diagnosis has been achievable in only a small minority of these children, but over the last decade, this has changed dramatically such that a specific diagnosis is now possible in about half of all children with intellectual disability. This improvement has been driven by major advances in genetic-testing technologies, the most important of which are chromosome microarray and whole exome sequencing...
October 2018: Journal of Paediatrics and Child Health
Cristina Lasmarías, Amor Aradilla-Herrero, Sebastià Santaeugènia, Carles Blay, Sara Delgado, Sara Ela, Núria Terribas, Xavier Gómez-Batiste
OBJECTIVE: Implementation of an advance care planning (ACP) program for people with advanced chronic conditions is a complex process. The aims of this paper are to describe (1) the development of the ACP program in Catalonia, Spain, for patients with advanced chronic conditions and complex needs and (2) the preliminary results of the implementation of this program in health and social services. METHOD: The ACP program was developed and implemented in a four-stage process as follows: (1) design and organization of the project; (2) selection of the professionals to carry out the project; (3) creation of four working groups to develop the conceptual model, guidelines, training program, and perform a qualitative evaluation; and (4) project implementation...
October 5, 2018: Palliative & Supportive Care
Jianfeng Zhang, Paola Magioncalda, Zirui Huang, Zhonglin Tan, Xiwen Hu, Zhiguo Hu, Benedetta Conio, Mario Amore, Matilde Inglese, Matteo Martino, Georg Northoff
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dominant symptom swings across different phases (manic, depressive, and euthymic). Different symptoms in BD such as abnormal episodic memory recall and psychomotor activity have been related to alterations in different regions, ie, hippocampus and motor cortex. How the abnormal regional distribution of neuronal activity relates to specific symptoms remains unclear, however. One possible neuronal mechanism of the relationship is the alteration of the global distribution of neuronal activity manifested in specific local regions; this can be measured as the correlation between the global signal (GS) and local regions...
October 3, 2018: Schizophrenia Bulletin
Ali Harchani, Damian Trzybiński, Sylwia Pawlędzio, Krzysztof Woźniak, Amor Haddad
A detailed description of the crystal structure and a Hirshfeld surface analysis of the new heteropolyoxometalate compound (C6 H8 N)5 [HAs2 Mo6 O26 (H2 O)]·3H2 O are reported. The title compound was synthesized using solution methods and its structure was characterized by single-crystal X-ray diffraction. The investigated compound contains a new [HAs2 Mo6 O26 (H2 O)]5- polyanion and crystallizes in the monoclinic space group P21 /c. The crystallographic analysis provided an understanding of the architecture and structural features of the complex crystal lattice and the Hirshfeld surface analysis shed more light on the intermolecular interactions occurring in the crystal...
October 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Yevgeniy Khariton, Krishna K Patel, Paul S Chan, Yashashwi Pokharel, Jingyan Wang, John A Spertus, David M Safley, William R Hiatt, Kim G Smolderen
AIMS: The ACC/AHA cholesterol guidelines recommend patients with peripheral artery disease (PAD) be treated with a moderate to high-intensity statin. The extent to which patients with new or worsening PAD symptoms are offered guideline therapy is unknown. METHODS AND RESULTS: In the PORTRAIT registry, patterns of statin therapy were assessed in 1144 patients at 16 PAD specialty clinics between June 2011-December 2015 before and after an evaluation for new or worsening claudication symptoms...
October 4, 2018: Clinical Cardiology
Anis Kacem, Mohamed Daoudi, Boulbaba Ben Amor, Stefano Berretti, Juan Carlos Alvarez-Paiva
In this paper, we propose a novel space-time geometric representation of human landmark configurations and derive tools for comparison and classification. We model the temporal evolution of landmarks as parametrized trajectories on the Riemannian manifold of positive semidefinite matrices of fixed-rank. Our representation has the benefit to bring naturally a second desirable quantity when comparing shapes - the spatial covariance - in addition to the conventional affine-shape representation. We derived then geometric and computational tools for rate-invariant analysis and adaptive re-sampling of trajectories, grounding on the Riemannian geometry of the underlying manifold...
September 28, 2018: IEEE Transactions on Pattern Analysis and Machine Intelligence
Roberto Amore, Domenico Amuso, Vincenza Leonardi, Francesco Leva, Andrea Carnovale Sibaud, Antonio Guida, Ezio Costa, Ferdinando Terranova, Vincenzo Amodeo, Konstantinos Gkritzalas
Background: The use of deoxycholic acid to reduce localized fat deposits is a procedure that has been in use for about 30 years. Its effectiveness as treatment is due to emulsification of phospholipids and therefore, solubilization of the biological membranes with resulting fat necrosis. The purpose of the study was to assess the effectiveness and the safety of an injectable solution containing sodium deoxycholtate 1.25% (DB125), used as intralipotherapy. Methods: The effectiveness and safety of DB125 solution have been assessed with a multicentre observational prospective study carried out between February and October 2017...
June 2018: Plastic and Reconstructive Surgery. Global Open
Christina Dai, Shawn Shih, Amor Khachemoune
BACKGROUND: Skin substitutes are designed to accelerate wound healing by providing replacement of extracellular matrix and can be used to promote healing of both acute and chronic wounds. AIM: To describe advantages, disadvantages, and indications for different skin substitutes with the intention of providing a systematic framework that clinicians can easily utilize in clinical practice. MATERIALS AND METHOD: We conducted a PubMed, Cochrane Library, and company website search for publications using various search terms associated with skin substitutes...
September 28, 2018: Journal of Dermatological Treatment
Maria Chiara Scali, Quirino Ciampi, Eugenio Picano, Eduardo Bossone, Francesco Ferrara, Rodolfo Citro, Paolo Colonna, Marco Fabio Costantino, Lauro Cortigiani, Antonello D' Andrea, Sergio Severino, Claudio Dodi, Nicola Gaibazzi, Maurizio Galderisi, Andrea Barbieri, Ines Monte, Fabio Mori, Barbara Reisenhofer, Federica Re, Fausto Rigo, Paolo Trambaiolo, Miguel Amor, Jorge Lowenstein, Pablo Martin Merlo, Clarissa Borguezan Daros, José Luis de Castro E Silva Pretto, Marcelo Haertel Miglioranza, Marco A R Torres, Clarissa Carmona de Azevedo Bellagamba, Daniel Quesada Chaves, Iana Simova, Albert Varga, Jelena Čelutkienė, Jaroslaw D Kasprzak, Karina Wierzbowska-Drabik, Piotr Lipiec, Paulina Weiner-Mik, Eva Szymczyk, Katarzyna Wdowiak-Okrojek, Ana Djordjevic-Dikic, Milica Dekleva, Ivan Stankovic, Aleksandar N Neskovic, Angela Zagatina, Giovanni Di Salvo, Julio E Perez, Ana Cristina Camarozano, Anca Irina Corciu, Alla Boshchenko, Fabio Lattanzi, Carlos Cotrim, Paula Fazendas, Maciej Haberka, Bozena Sobkowic, Wojciech Kosmala, Tomasz Witkowski, Piotr Gosciniak, Alessandro Salustri, Hugo Rodriguez-Zanella, Luis Ignacio Martin Leal, Alexandra Nikolic, Suzana Gligorova, Madalina-Loredana Urluescu, Maria Fiorino, Giuseppina Novo, Tamara Preradovic-Kovacevic, Miodrag Ostojic, Branko Beleslin, Bruno Villari, Michele De Nes, Marco Paterni, Clara Carpeggiani
BACKGROUND: The effectiveness trial "Stress echo (SE) 2020" evaluates novel applications of SE in and beyond coronary artery disease. The core protocol also includes 4-site simplified scan of B-lines by lung ultrasound, useful to assess pulmonary congestion. PURPOSE: To provide web-based upstream quality control and harmonization of B-lines reading criteria. METHODS: 60 readers (all previously accredited for regional wall motion, 53 B-lines naive) from 52 centers of 16 countries of SE 2020 network read a set of 20 lung ultrasound video-clips selected by the Pisa lab serving as reference standard, after taking an obligatory web-based learning 2-h module ( http://se2020...
September 25, 2018: Cardiovascular Ultrasound
Maristela Carpintero Hensen, Malva Isabel Medina Hernández, Pedro Giovâni da Silva, Valentina Amore, Jorge M Lobo
Subspecies is a debated taxonomic rank that, in some cases, could indicate that a speciation process is taking place. Studying the degree of co-occurrence among subspecies along environmental gradients may help to determine its taxonomic status. In this study, we explore the distribution of two subspecies of Canthon rutilans along spatio-temporal and temperature gradients in the Atlantic Forest of southern Brazil in order to reinforce their current subspecies status or to support their consideration as two different species...
September 21, 2018: Insects
D Sánchez-Fabra, R Marinas Sanz, E Tarí Ferrer, A Gracia Gutiérrez, S López Garrido, M Morando Pérez, B Amores Arriaga, J Cebollada Del Hoyo
OBJECTIVES: To describe the characteristics of hypertensive urgencies at the emergency department, as well as the variables associated with early re-admission (<7 days) and re-admission at one month (<30 days). METHODS: We conducted a descriptive, retrospective study of all patients who were admitted to the emergency department of a third level hospital during 2013. Subsequently, a case-control analysis was performed to analyze the group of patients with readmission...
September 20, 2018: Hipertensión y Riesgo Vascular
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