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Thymic tumor

Wei-Qiang Yan, Yong-Kang Xin, Yong Jing, Gang-Feng Li, Shu-Mei Wang, Wei-Cheng Rong, Gang Xiao, Xue-Bin Lei, Bo Li, Yu-Chuan Hu, Guang-Bin Cui
The aim of the study was to explore the efficacy of iodine quantification with dual-energy computed tomography (DECT) in differentiating thymoma, thymic carcinoma, and thymic lymphoma. MATERIALS AND METHODS: Fifty-seven patients with pathologically confirmed low-risk thymoma (n = 16), high-risk thymoma (n = 15), thymic carcinoma (n = 14), and thymic lymphoma (n = 12) underwent chest contrast-enhanced DECT scan were enrolled in this study. Tumor DECT parameters including iodine-related Hounsfield unit (IHU), iodine concentration (IC), mixed HU (MHU), and iodine ratio in dual phase, slope of energy spectral HU curve (λ), and virtual noncontrast (VNC) were compared for differences among 4 groups by one-way analysis of variance...
October 18, 2018: Journal of Computer Assisted Tomography
Sylvia L Asa, Ozgur Mete
Thyroid tumors usually present as masses in the thyroid gland. While the majority of these tumors represent neoplasms of thyroid tissues, mainly of follicular epithelial cell differentiation, the differential diagnosis includes other lesions, such as C cell neoplasms (medullary thyroid carcinoma), intrathyroidal parathyroid, or thymic tumors, soft tissue tumors, and hematologic neoplasms as well as metastatic malignancies. Rare tumors are of salivary gland types. This case illustrates an unusual tumor of salivary gland type, an intrathyroidal mammary analog secretory carcinoma (MASC)...
2018: Frontiers in Endocrinology
Qiang Li, Yan-Ling Su, Wei-Xi Shen
PURPOSE: A thymoma is a tumor arising from the epithelium of the thymus, mostly occurring in the anterior mediastinum. The incidence of this disease is low and research progress in this field is slow. Consequently, there is an urgent need to investigate the correlation between molecular regulation and the prediction of survival and prognosis in patients with thymoma. METHODS: We collected thymoma datasets from The Cancer Genome Atlas (TCGA). Differentially expressed genes (DEGs) of TCGA datasets were then determined using R software...
October 17, 2018: Journal of Cancer Research and Clinical Oncology
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Seung-Il Park, Dong Kwan Kim, Yong-Hee Kim, Hyeong Ryul Kim, Eun Kyung Choi
INTRODUCTION: We evaluated the clinical outcome of patients with stage III to IV thymomas (Ts) or stage II to IV thymic carcinomas (TCs) treated with complete thymectomy and local radiation therapy (LRT, targeting the tumor bed and anterior mediastinal areas only) or elective nodal irradiation (ENI, targeting the entire mediastinal and supraclavicular regions). MATERIALS AND METHODS: Data from 47 patients diagnosed with Ts or TCs and treated with surgery and adjuvant RT from May 2002 to May 2015 were analyzed...
September 21, 2018: Clinical Lung Cancer
Michael Peer, Sharbell Azzam, Vladislav Gofman, Mark Kushnir, Benjamin Davidson, Carmel Armon
BACKGROUND: Thymectomy is a reliable surgical method for treating patients with myasthenia gravis (MG) and benign tumors of the thymus. Despite the advantages of minimally invasive surgical approaches for resection of thymic neoplasms, there are still controversies regarding the superiority of one type of surgery over another. OBJECTIVES: To report the results of our initial Israeli experience with robotic thymectomy in 22 patients with MG and suspected benign thymic tumors...
October 2018: Israel Medical Association Journal: IMAJ
Samina Park, In Kyu Park, Young Tae Kim, Geun Dong Lee, Dong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Chang Young Lee, Jin Gu Lee, Chang Hyun Kang
BACKGROUND: The oncological benefit of neoadjuvant chemotherapy in thymic malignancies remains unclear. We compared postoperative oncological outcomes of curative resection following neoadjuvant chemotherapy with those of upfront surgery. METHODS: Based on records from a multi-center database, a total of 1486 patients with surgically resected thymic malignancies between 2000 and 2013 were included in the final study cohort. 110 (7.4%) patients underwent surgical resection following neoadjuvant chemotherapy and 1376 (92...
October 11, 2018: Annals of Thoracic Surgery
Ezel Erşen, Burcu Kılıç, Hasan Volkan Kara, Mehlika İşcan, İsmail Sarbay, Ahmet Demirkaya, Selim Bakan, Melih Tütüncü, Akif Turna, Kamil Kaynak
Introduction: Thymectomy is the preferred standard treatment in younger non-thymoma patients with myasthenia gravis as well as in patients with early stage thymoma. Total thymectomy by median sternotomy has been the surgical approach since resection of the thymus with video-assisted thoracoscopic surgery (VATS). Aim: To compare the clinical outcomes of VATS thymectomy with conventional open thymectomy for neoplastic and non-neoplastic thymic diseases. Material and methods: Forty patients underwent thymectomy between October 2012 and January 2016...
September 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
David Suster, Howard D Epstein, Daryl Pearlstein, Saul Suster
Thymic epithelial neoplasms with foci of rhabdomyomatous differentiation are rare. A case is presented of a primary thymic epithelial neoplasm showing the features of an atypical spindle cell thymoma that contained foci of bland-appearing rhabdomyomatous cells. The histologic and immunohistochemical features of this tumor are discussed along with a review of the literature and the comments from the AMR members to the case.
October 8, 2018: Advances in Anatomic Pathology
Junmiao Wen, Jiayan Chen, Donglai Chen, Di Liu, Xinyan Xu, Lv Huang, Jianzhao Cao, Junhua Zhang, Yu Gu, Min Fan, Yongbing Chen
BACKGROUND: The prognostic value of surgery and postoperative radiotherapy (PORT) for primary thymic neuroendocrine tumors (TNETs) was estimated using the SEER database. METHODS: This retrospective study used SEER data of TNET patients between 1998 and 2015. Propensity score matching (PSM) was performed according to whether surgery was performed. The prognostic effects on overall survival (OS) and cancer-specific survival (CSS) were evaluated using multivariate Cox regression...
October 1, 2018: Thoracic Cancer
Richard Benedict Supan Roxas, Marie Christine Fajatin Bernardo, Araceli Pacis Jacoba, Janet Lim-Dy, Anarose Cariaga Alvarado, Jasna Metovic, Laura Annaratone, Mauro Papotti
We describe the first case of primary thymic adenocarcinoma with signet ring cell features. The patient was a 39-year-old Filipino male who presented with a huge anterior mediastinal mass extending to the left supraclavicular fossa, which underwent an incisional biopsy. Extensive clinicoradiological work-up showed no evidence of any primary tumor in other organs, and radiological imaging confirmed a primary tumor location in the thymic area. He later developed bilateral pleural and pericardial effusions and eventually died of his tumor...
September 27, 2018: International Journal of Surgical Pathology
Takahiko Nakazono, Ken Yamaguchi, Ryoko Egashira, Yukari Takase, Junichi Nojiri, Masanobu Mizuguchi, Hiroyuki Irie
Division of the mediastinum into compartments is used to help narrow down the differential diagnosis of mediastinal tumors, assess tumor growth, and plan biopsies and surgical procedures. There are several traditional mediastinal compartment classification systems based upon anatomical landmarks and lateral chest radiograph. Recently, the Japanese Association of Research of the Thymus (JART) and the International Thymic Malignancy Interest Group (ITMIG) proposed new mediastinal compartment classification systems based on transverse CT images...
September 20, 2018: Japanese Journal of Radiology
Luis Cabezón-Gutiérrez, Parham Khosravi-Shahi, Sara Custodio-Cabello, Maria García-Martos, Magda Palka-Kotlowska, Ana Isabel Franco-Moreno
Thymic carcinomas are the most aggressive histological subtype of thymic tumors with limited data to guide correct management. No standard treatments are available for patients with advanced thymic carcinoma after progressing while on platinum-based chemotherapy. We present a case of a patient with metastatic thymic carcinoma with an unusual response and favorable evolution after receiving treatment with sunitinib, obtaining a progression-free survival of 23 months, much higher than reported to date. We review the literature on the efficacy of sunitinib in metastatic thymic carcinoma after progression to first-line treatment with platinum combinations...
July 14, 2018: Curēus
Yuzuru Inoue, Shiro Kohi, Masato Gobara, Fumi Joden, Kei Yabuki, Takayuki Tanoue, Nagahiro Sato, Takefumi Katsuki, Takahisa Nagata, Kazunori Shibao, Masanori Hisaoka, Keiji Hirata
The case presented herein was a 70-year-old woman who had no compliant, but had a mass in the lower part of the right lobe of the thyroid detected by ultrasound (US). The US image of the tumor, measuring 13 mm in diameter, showed a low and heterogeneous internal echo level with calcification and an irregular margin. The tumor appeared to extend to the adjacent sternothyroid muscle, and cervical lymph node swelling was detected in a computer tomography (CT) image, but no metastatic lesion was found by positron emission tomography (PET)-CT...
2018: Journal of UOEH
Neda Kalhor, Cesar A Moran
Seven primary thymic epithelial neoplasms, three thymomas, and four thymic carcinomas with rhabdomyomatous component are herein described. The patients are two women and 5 men between the ages of 42 and 62years (average: 52years). Clinically, the patients presented with non-specific symptoms of cough, chest pain, and dyspnea. None of the patients had history of myasthenia gravis or of previous malignancy. Diagnostic imaging revealed the presence of an anterior mediastinal mass in all the patients. Surgical resection was accomplished in all the cases...
September 11, 2018: Human Pathology
Yoohwa Hwang, Chang Hyun Kang, Samina Park, Hyun Joo Lee, In Kyu Park, Young Tae Kim, Geun Dong Lee, Hyeong Ryul Kim, Se Hoon Choi, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Sumin Shin, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Il Zo, Young Mog Shim, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik, Kyung Young Chung
INTRODUCTION: Surgical resection is a standard treatment for thymic malignancies. However, prognostic significance of nodal metastases and lymph node dissection remains unclear. The aim of this study is to determine prognostic significance of nodal metastases and role of lymph node dissection (LND) in thymic malignancies. METHODS: Between 2000 and 2013, 1,597 patients who underwent thymectomy due to thymic malignancy were included. Predictive factors for nodal metastasis and prognostic significance of LND were evaluated...
September 11, 2018: Journal of Thoracic Oncology
Barbara Vizio, Monica Boita, Carmen Cristiano, Jasenka Mazibrada, Ornella Bosco, Anna Novarino, Adriana Prati, Savino Sciascia, Giovanni Rolla, Libero Ciuffreda, Giuseppe Montrucchio, Graziella Bellone
Thymic stromal lymphopoietin (TSLP) has emerged as an important, but contradictory, player conditioning tumor growth. In certain contexts, by driving T helper (h) 2 responses via tumor-associated OX40 Ligand (OX40L)+ dendritic cells (DCs), TSLP may play a pro-tumorigenic role. The study elucidates the importance of TSPL in pancreatic ductal adenocarcinoma (PDAC), by analyzing: i) TSLP levels in PDAC cell-line supernatants and plasma from patients with locally-advanced/metastatic PDAC, pre- and post-treatment with different chemotherapeutic protocols, in comparison with healthy donors; ii) TSLP and OX40L expression in PDAC and normal pancreatic tissues, by immunohistochemistry; iii) OX40L expression on ex vivo -generated normal DCs in the presence of tumor-derived TSLP, by flow cytometry; iv) clinical relevance in terms of diagnostic and prognostic value and influence on treatment modality and response...
August 28, 2018: Oncotarget
Tatsuaki Watanabe, Hideo Shimomura, Tatsushi Mutoh, Ryoko Saito, Ryoi Goto, Takehiro Yamada, Hirotsugu Notsuda, Yasushi Matsuda, Masafumi Noda, Akira Sakurada, Yasuyuki Taki, Yoshinori Okada
PURPOSE: The purpose of this study was to assess the usefulness of positron emission tomography/computed tomography (PET/CT) in the differential diagnosis of anterior mediastinal tumors. METHODS: A total of 94 patients with anterior mediastinal masses or nodules (male, n = 41; female, n = 53; age, 17-84 years) were retrospectively evaluated. All patients were evaluated by PET/CT and the masses or nodules were histologically diagnosed in our institution...
September 10, 2018: Surgery Today
Shuchun Zhao, Arturo Molina, Abigail Yu, Jeff Hanson, Harry Cheung, Xiaofan Li, Yasodha Natkunam
CD74 is a type II transmembrane glycoprotein that functions as an MHC class II chaperone and displays diverse roles in immune responses. Recently, anti-CD74 immunotherapy has shown promise as an effective treatment strategy for lymphoid neoplasms in preclinical models. Using a humanized anti-CD74 antibody (SP7219), we defined the expression of CD74 protein in both normal and over 790 neoplastic hematolymphoid tissue samples. We found that CD74 is expressed broadly in normal B-cell compartments including primary and secondary lymphoid follicles and in the thymic medulla...
September 7, 2018: Journal of Pathology. Clinical Research
Na-Ra Han, Phil-Dong Moon, Hyung-Min Kim, Hyun-Ja Jeong
OBJECTIVES: Atopic dermatitis (AD) is an allergic and inflammatory skin disorder caused by a combination of itching and skin sensitization by allergens. This article investigated whether cordycepin modulates AD symptoms by using an AD murine model. MATERIAL AND METHODS: We evaluated a regulatory effect and specific molecular mechanism of cordycepin on AD induced by the repeated local exposure of 2,4-dinitrochlorobenzene to dorsal skin of mice. Blood or AD-like skin lesions samples were removed for histopathologic analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot analyses...
September 5, 2018: Immunopharmacology and Immunotoxicology
Mohammed Amine Achhal El Kadmiri, Arun Rajan
No abstract text is available yet for this article.
March 2018: Mediastinum
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