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Thymic tumor

Kyung Hwa Lee, Jae Myoung Noh, Yong Chan Ahn, Dongryul Oh, Jhingook Kim, Young Mog Shim, Jung-Ho Han
PURPOSE: To report failure pattern in Masaoka-Koga stage II-IV type C thymic epithelial tumor (TET) following postoperative radiation therapy (PORT) and to evaluate suitability of PORT target volume confined to "tumor bed only with margin". METHODS AND MATERIALS: Retrospective review of 53 patients with stage II-IV type C TET was done. The clinical outcomes, failure pattern in relation to PORT target volume, and prognostic factors were analyzed. RESULTS: During the median follow-up of 69 months, 14 deaths and 25 recurrences were observed...
August 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Christine L Hann, Patrick M Forde
Carcinoids of the lung and thymus are rare thoracic cancers. In general, lung carcinoid tumors have a favorable prognosis, particularly when diagnosed at an early stage and treated with surgical resection. Thymic neuroendocrine tumors may be associated with multiple endocrine neoplasia-1 syndrome, tend to have a more aggressive natural history, and relatively frequently secrete ectopic adrenocorticotropic hormone.
September 2018: Endocrinology and Metabolism Clinics of North America
Khalil Saleh, Nadine Khalifeh-Saleh, Hampig Raphael Kourie
No abstract text is available yet for this article.
August 2018: Immunotherapy
Marco De Simone, Grazisa Rossetti, Massimiliano Pagani
The peculiarity of T cell is their ability to recognize an infinite range of self and foreign antigens. This ability is achieved during thymic development through a complex molecular mechanism based on somatic recombination that leads to the expression of a very heterogeneous population of surface antigen receptors, the T Cell Receptors (TCRs). TCRs are cell specific and represent a sort of "molecular tag" of T cells and have been widely studied to monitor the dynamics of T cells in terms of clonality and diversity in several contexts including lymphoid malignancies, infectious diseases, autoimmune diseases, and tumor immunology...
2018: Frontiers in Immunology
Katherine V Clark-Knowles, Danielle Dewar-Darch, Karen E Jardine, Josée Coulombe, Manijeh Daneshmand, Xiaohong He, Michael W McBurney
SIRT1 is a protein deacetylase with a broad range of biological functions, many of which are known to be important in carcinogenesis, however much of the literature regarding the role of SIRT1 in cancer remains conflicting. In this study we assessed the effect of SIRT1 on the initiation and progression of thymic T cell lymphomas. We employed mouse strains in which SIRT1 activity was absent or could be reversibly modulated in conjunction with thymic lymphoma induction using either the N-nitroso-N-methylurea (NMU) carcinogenesis or the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) transgene...
July 27, 2018: Experimental Cell Research
Aiko Kato, Akifumi Takaori-Kondo, Nagahiro Minato, Yoko Hamazaki
Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomized mice showing accelerated HP has an increased capacity for TCR-mediated interferon-γ and tumor necrosis factor α production, which is attributed to an increase in CXCR3+ cells in the NP CD8+ T cell population...
July 30, 2018: European Journal of Immunology
Xuefei Zhang, Chunyu Ji, Zhitao Gu, Wentao Fang
BACKGROUND: So far there's no tumor maker applied in diagnosis and treatment of thymic epithelial tumors. This study is to assess the correlation between serum cytokine 19 fragment (Cyfra 21-1) and clinicopathological features and prognosis of thymic epithelial tumors (TETs). METHODS: The clinical data of 159 patients with TETs in Shanghai Chest Hospital was retrospectively analysed. Patients were divided into groups according to different tumor stages and histotypes...
July 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Xuefei Zhang, Zhitao Gu, Wentao Fang
Surgery is the most important therapy for thymic malignancies. The last decade has seen increasing adoption of minimally invasive thymectomy (MIT) for thymic tumors. MIT for early stage diseases has been shown to yield similar oncological results while being helpful in minimizing surgical trauma, improving postoperative recovery, and reducing incisional pain. Similar surgical and oncological principles should be observed in both minimally invasive and open procedures so as to ensure radical resection and accurate staging of the tumor...
June 2018: Journal of Thoracic Disease
Martina Imbimbo, Milena Vitali, Alessandra Fabbri, Margaret Ottaviano, Giulia Pasello, Iacopo Petrini, Giovannella Palmieri, Rossana Berardi, Paolo Zucali, Monica Ganzinelli, Mirko Marabese, Massimo Broggini, Mirella Marino, Annalisa Trama, Eliana Rulli, Lital Hollander, Giancarlo Pruneri, Valter Torri, Marina Chiara Garassino
Thymic epithelial tumors are rare malignancies. Thymic carcinoma represents about 20% of all thymic epithelial tumors and has aggressive behavior, with a greater tendency to metastatic spread. Thymic carcinoma is often diagnosed in advanced stages for which systemic treatment is the main therapeutic option. The association of chemotherapy and antiangiogenic agents in the first-line setting has never been investigated in this very rare cancer. However, preclinical and clinical evidence has suggested that inhibition of angiogenesis could be beneficial...
July 3, 2018: Clinical Lung Cancer
Kohei Aoki, Masatoshi Yamaguchi, Ato Sugiyama, Yoshiaki Inoue, Hiroki Fukuda, Masatoshi Gika, Mami Yamazaki, Ryutarou Kawano, Shuji Momose, Mitsuo Nakayama
We report the first known case of a metastatic thymic tumor arising from spermatic cord leiomyosarcoma, occurring in a 35-year-old man. He had undergone an orchiectomy 24 months previously and a surgical excision of a subcutaneous metastasis 4 months prior to his current presentation. Computed tomography revealed a 1.5-cm, round-shaped anterior mediastinal mass. A thymectomy was performed and the diagnosis of metastatic leiomyosarcoma was made.
July 21, 2018: General Thoracic and Cardiovascular Surgery
Tamer B Shabaneh, Aleksey Molodtsov, Shannon M Steinberg, Peisheng Zhang, Gretel M Torres, Gadisti A Mohamed, Andrea Boni, Tyler J Curiel, Christina V Angeles, Mary Jo Turk
Regulatory T cells (Tregs) are critical mediators of immune suppression in established tumors, although little is known about their role in restraining immune surveillance during tumorigenesis. Here we employ an inducible autochthonous model of melanoma to investigate the earliest Treg and CD8 effector T cell responses during oncogene-driven tumorigenesis. Induction of oncogenic BRAFV600E and loss of Pten in melanocytes led to localized accumulation of FoxP3+ Tregs, but not CD8 T cells, within 1 week of detectable increases in melanocyte differentiation antigen expression...
July 19, 2018: Cancer Research
Na-Ra Han, Phil-Dong Moon, Min-Sun Yoo, Ka-Jung Ryu, Hyung-Min Kim, Hyun-Ja Jeong
The aim of this study is to determine whether AST2017-01 which consists of Rumex crispus and Cordyceps militaris would improve atopic dermatitis (AD). We analyzed anti-AD effects of AST2017-01 and chrysophanol, a bioactive compound of AST2017-01, using a 2,4-dinitrofluorobenzene-induced AD murine model. AST2017-01 and chrysophanol relieved clinical severity in AD-like skin lesions and significantly decreased scratching behavior. The thickness of epidermis and infiltration of inflammatory cells in AD-like skin lesions were reduced by AST2017-01 or chrysophanol...
September 2018: International Immunopharmacology
Olga Sizova, Denis Kuriatnikov, Ying Liu, Dong-Ming Su
Tumor metastatic relapse is the primary cause for cancer-associated mortality. Metastatic relapse is believed to arise from quantities of tumor cells that are below detectable thresholds, which are able to resist radio/chemotherapy by obtaining a dormant state and hiding in certain organs, i.e. tumor reservoirs. The thymus, a central T cell immune organ, has been suggested to be a pre-metastatic tumor reservoir for B-lymphoma cells. However, it remains unknown whether the thymus is able to harbor non-lymphoid solid tumor cells, and whether chemotherapy can thoroughly eliminate cancer cells in the thymus...
July 13, 2018: Molecular Cancer Research: MCR
Virgilijus Beiša, Neringa Pranskevičiūtė, Gabija Makūnaitė, Kęstutis Strupas
Primary hyperparathyroidism is overproduction of parathyroid hormone, causing hypercalcemia. Parathyroid adenomas have been found to be the etiology for 80% of cases of primary hyperparathyroidism, while almost a quarter of them are ectopic. We present a case of ectopic thymic parathyroid adenoma, treated by the thoracoscopic approach. Preoperative computed tomogram and technetium-99-sestamibi imaging showed an adenoma, located in the front mid-mediastinum, approximately 8 × 10 mm in size. Resection of the tumor was indicated according to the persistent hypercalcemia after unsuccessful surgical treatment performed 3 years ago...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Claudia Lozano C, Marcela Molina P
INTRODUCTION: Among the causes of peripheral precocious puberty in men are the beta-human cho rionic gonadotropin (Β-HCG)-secreting tumors, such as hepatoblastomas, dysgerminomas, chorio carcinomas, and immature teratomas. In pediatrics, the mediastinal teratomas are rare, representing the 7-10% of extragonadal teratomas. OBJECTIVE: To describe the case of a patient with peripheral precocious puberty due to a Β-HCG -secreting thymic teratoma. CLINICAL CASE: A seven-years-old schoolboy presents a three-months history of voice changes, gynecomastia, pubic hair appearance, and increased genital volume...
June 2018: Revista Chilena de Pediatría
Hanyue Li, Jiantao Li, Jia Huang, Yunhai Yang, Qingquan Luo
Background: To report the first and largest series of robotic-assisted mediastinal surgeries performed in a single center by the same surgical team in mainland China. Methods: From May 2009 to June 2017, 167 patients (100 males, 67 females), with a mean age of 50.2 years (range, 12-78 years), underwent robotic surgery for the treatment of a mediastinal mass. Data regarding the operation time, docking time, blood loss, conversion rate, morbidity, mortality and survival follow-up were collected and analyzed...
May 2018: Journal of Thoracic Disease
David Suster, German Pihan, Alexander C Mackinnon, Saul Suster
Thymic carcinoma represents a rare and poorly understood type of thymic epithelial neoplasm that has been the subject of much controversy. Poorly differentiated nonkeratinizing squamous cell carcinoma, also known as lymphoepithelioma-like thymic carcinoma, is a rare variant of thymic carcinoma that has not been adequately characterized in the literature. The clinicopathologic, immunohistochemical, ultrastructural, and molecular features of 25 cases are reported. The patients were 19 men and 6 women, ranging in age from 20 to 85 years (mean: 60 y)...
July 3, 2018: American Journal of Surgical Pathology
David Suster, German Pihan, Alexander C Mackinnon, Saul Suster
Poorly differentiated non-keratinizing squamous cell carcinoma of the thymus, also known as lymphoepithelioma-like carcinoma, is a rare primary malignant neoplasm of thymic origin. The mainstay of treatment for these tumors is surgical and they tend to respond poorly to chemotherapy. The checkpoint programmed cell death ligand-1 protein (PD-L1) bound to its receptor (PD-1) has been demonstrated to be an important therapeutic target for many different tumors. Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus may indicate that these tumors are potential targets for inhibitor therapy...
July 4, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Seung Shin Park, Sung Hye Kong, Ye Seul Yang, Chang Ho Ahn, Jung Hee Kim
No abstract text is available yet for this article.
June 29, 2018: Polish Archives of Internal Medicine
Hee-Yun Kim, Na-Ra Han, Hyung-Min Kim, Hyun-Ja Jeong
Our previous study showed that an iron chelator and anticancer agent Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) has an antiinflammatory effect in human mast cells. However, antiinflammatory effect of Dp44mT remains unclear in animal models. In this study, we assessed whether administration of Dp44mT could relieve clinical symptoms of ovalbumin (OVA)-induced allergic rhinitis (AR) mice. After administration of Dp44mT, number of rubs was significantly decreased, and levels of histamine and IgE were suppressed in serum of AR mice...
July 2, 2018: Inflammation
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