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https://www.readbyqxmd.com/read/29908643/investigating-human-placentation-and-pregnancy-using-first-trimester-chorionic-villi
#1
Roberta L Hannibal, Margarida Cardoso-Moreira, Shilpa P Chetty, Joanne Lau, Zhongxia Qi, Eduardo Gonzalez-Maldonado, Athena M Cherry, Jingwei Yu, Mary E Norton, Julie C Baker
Chorionic villus sampling (CVS), routinely used for prenatal diagnosis of cytogenetic disorders, also possesses great potential for the study of placentation. To better understand villus biology, human placentation, and how these relate to pregnancy outcomes, we examined the morphology and transcriptomes of villi obtained via CVS from 10 to 14 weeks of pregnancy and correlated these with pregnancy attributes and clinical outcomes. First, we established a morphological scoring system based on three main villus features: branching, budding and vascularization...
May 2018: Placenta
https://www.readbyqxmd.com/read/29907426/maternal-obesity-as-a-risk-factor-for-the-development-of-total-anomalous-pulmonary-venous-connection-in-their-offspring
#2
Evelyn G Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Klünder-Klünder, Begoña Segura-Stanford, Julio R Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T Granados Riverón, Leonardo J Mejía-Marín, Norma A Balderrabano-Saucedo, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Rocío Sánchez-Urbina
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. METHODS: 55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included...
June 12, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29907146/are-women-with-history-of-pre-eclampsia-starting-a-new-pregnancy-in-good-nutritional-status-in-south-africa-and-zimbabwe
#3
Gabriela Cormick, Ana Pilar Betrán, Janetta Harbron, Tina Dannemann Purnat, Catherine Parker, David Hall, Armando H Seuc, James M Roberts, José M Belizán, G Justus Hofmeyr
BACKGROUND: Maternal nutritional status before and during pregnancy is an important contributor to pregnancy outcomes and early child health. The aim of this study was to describe the preconceptional nutritional status and dietary intake during pregnancy in high-risk women from South Africa and Zimbabwe. METHODS: This is a prospective observational study, nested to the CAP trial. Anthropometric measurements before and during pregnancy and dietary intake using 24-h recall during pregnancy were assessed...
June 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29898693/peripartum-fetal-distress-in-diabetic-women-a-retrospective-case-cohort-study
#4
B Castelijn, Kwp Hollander, J F Hensbergen, R G IJzerman, A W Valkenburg-van den Berg, Jwr Twisk, Cjm De Groot, Mgaj Wouters
BACKGROUND: Major concerns of pregnancies complicated by diabetes mellitus are an increased risk of adverse perinatal outcome. The objective of this study was to analyse the rate of fetal distress during labor in women with type 1, type 2 and gestational diabetes compared to control women. METHODS: A retrospective case-cohort study was conducted at the VU University Medical Center, Amsterdam; a tertiary care hospital. 117 women with type 1 diabetes, 59 women with type 2 diabetes, 303 women with gestational diabetes and 15,260 control women were included, who delivered between March 2004 and February 2014...
June 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29898442/a-novel-early-pregnancy-risk-prediction-model-for-gestational-diabetes-mellitus
#5
Arianne N Sweeting, Jencia Wong, Heidi Appelblom, Glynis P Ross, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
INTRODUCTION: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated novel biomarker predictors to develop a first-trimester risk prediction model in a large multiethnic cohort. METHODS: Maternal clinical, aneuploidy and pre-eclampsia screening markers (PAPP-A, free hCGβ, mean arterial pressure, uterine artery pulsatility index) were measured prospectively at 11-13+6 weeks' gestation in 980 women (248 with GDM; 732 controls)...
June 13, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29896812/screening-for-pre-eclampsia-by-maternal-factors-and-biomarkers-at-11-13-weeks-gestation
#6
Min Yi Tan, Argyro Syngelaki, Liona C Poon, Daniel L Rolnik, Neil O'Gorman, Juan Luis Delgado, Ranjit Akolekar, Liountmila Konstantinidou, Maria Tsavdaridou, Slavyana Galeva, Ursula Ajdacka, Francisca S Molina, Nicola Persico, Jacques C Jani, Walter Plasencia, Elena Greco, George Papaioannou, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for early-, preterm- and term-preeclampsia (PE) at 11-13 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum pregnancy associated plasma protein-A (PAPP-A). METHODS: The data for this study were derived from three previously reported prospective non-intervention screening studies at 11+0 - 13+6 weeks' gestation in a combined total of 61,174 singleton pregnancies, including 1,770 (2...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29896778/screening-for-pre-eclampsia-at-35-37-weeks-gestation
#7
Anca Panaitescu, Anca Ciobanu, Argyro Syngelaki, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for preeclampsia (PE) at 35-37 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum soluble fms-like tyrosine kinase-1 (sFLT). METHODS: This was a prospective observational study in women with singleton pregnancies attending for an ultrasound scan at 35+0 - 36+6 weeks as part of routine pregnancy care...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29895936/int6-eif3e-silencing-promotes-placenta-angiogenesis-in-a-rat-model-of-pre-eclampsia
#8
Qin Li, Baolin Yao, Alexander Endler, Li Chen, Futoshi Shibasaki, Haidong Cheng
We investigated whether stable eukaryotic translation initiation factor 3e/inter 6 (eIF-3e/Int6) RNA-silencing (siRNA-Int6) can ameliorate pre-eclampsia (PE) by promoting angiogenesis in an N-nitro-L-arginine methyl ester (L-NAME)-induced rat pre-eclampsia (PE) model. Twenty-four pregnant female Sprague-Dawley rats were allocated into 4 groups, including controls (Con) without any treatment, and 18 from gestational day (GD) 7 to GD17 L-NAME-treated rats, which were divided into stable siRNA-Int6 transfected (siRNA-Int6), negative vector control siRNA (NC-siRNA) and PE control (PE-Con) groups...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29893994/predictive-factors-for-successful-cervical-ripening-using-a-double-balloon-catheter-after-previous-cesarean-delivery
#9
Mathilde Vital, Joséphine Grange, Aurélie Le Thuaut, Jérôme Dimet, Guillaume Ducarme
OBJECTIVE: To identify predictors of successful cervical ripening using double-balloon catheter (DBC) for labor induction among women with previous cesarean delivery (PCD) and unfavorable cervix at term. METHODS: The present prospective observational study was conducted among women who underwent cervical ripening with DBC at a French tertiary care hospital between January 1, 2014, and December 31, 2017. Inclusion criteria were PCD; singleton term fetus; cephalic presentation; and unfavorable cervix (Bishop score <6)...
June 12, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29892993/pre-pregnancy-weight-loss-in-women-with-obesity-requesting-removal-of-their-intra-uterine-contraceptive-device-in-order-to-conceive-a-pilot-study-of-full-meal-replacement
#10
L Brackenridge, N Finer, R L Batterham, K Pedram, T Ding, J Stephenson, J Barry, P Hardiman
Obesity during pregnancy is associated with increased risks of thromboembolism, gestational diabetes, pre-eclampsia, miscarriage, congenital anomaly, macrosomia and stillbirth. The current practice, directed at reducing gestational weight gain, is largely ineffective. The present pilot study was designed to assess the acceptability of a 24-week intensive weight management programme (IWMP; full meal replacement followed by partial meal replacement and weight stabilization) to achieve weight loss for women with obesity requesting removal of their intra-uterine contraceptive device in order to conceive...
June 11, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29890966/maternal-near-miss-collection-at-an-australian-tertiary-maternity-hospital
#11
Skandarupan Jayaratnam, Sonia Kua, Caroline deCosta, Richard Franklin
BACKGROUND: Australia has a maternal mortality ratio of 6.8/100000 live births, a rate akin to other developed countries and consistent with the high level care provided within the Australian health care system. With maternal mortality at very low levels assessment of severe maternal morbidity is increasingly being used as an indicator of quality of care and to identify areas for improvement in maternity services. The WHO maternal 'near miss' criteria is a standardised tool has been increasingly used worldwide to assess maternal morbidity and standards of maternity care...
June 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29889471/-perinatal-stroke-from-symptoms-to-follow-up
#12
Eszter Vojcek, Márta Csécsei, Edina Flach, Gábor Rudas, Rózsa Gráf, Erzsébet Princzkel
Background and purpose: We aimed to analyze patient characteristics of term neonates with the diagnosis of stroke between 2006 and 2017 at the 3rd level Neonatal Intensive Care Unit of the Szent János Hospital. Methods: We conducted a retrospective and prospective analysis including 18 newborns with stroke. Presentation, imaging methods, etiology and clinical context were discussed. All patients had a follow-up at 2 years of age or later. Subject of the study - In the past 10 years 17 term born and one premature neonate born at 36 weeks of age were diagnosed with stroke in our unit...
March 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29886805/psychosocial-and-biological-paternal-role-in-pregnancy-outcomes
#13
Maryam Kashanian, Masoomeh Faghankhani, Hasti Hadizadeh, MMasoud Salehi, Masoomeh YousefzadehRoshan, Mohammad EhsaniPour, Ladan Sayyah, Narges Sheikhansari
BACKGROUND: Pregnancy outcomes are affected by many different factors. One of the influential factors on pregnancy outcomes is the male partner as an important person to mother's wellbeing. OBJECTIVE: The aim of the present study was to investigate the effects of male partner's role including socioeconomic support, emotional support, accompanying pregnant women during prenatal care visits (PNC) and labor, and the level of pregnant women's satisfaction from their partners' support and involvement during pregnancy on pregnancy outcomes...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29884955/focused-update-on-pharmacologic-management-of-hypertensive-emergencies
#14
REVIEW
Kristin Watson, Rachael Broscious, Sandeep Devabhakthuni, Zachary R Noel
PURPOSE OF REVIEW: Hypertensive emergency is defined as a systolic blood pressure > 180 mmHg or a diastolic blood pressure > 120 mmHg with evidence of new or progressive end-organ damage. The purpose of this paper is to review advances in the treatment of hypertensive emergencies within the last 5 years. RECENT FINDINGS: New literature and recommendations for managing hypertensive emergencies in the setting of pregnancy, stroke, and heart failure have been published...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29884919/preeclampsia-risks-in-kidney-donors-and-recipients
#15
REVIEW
Pratik B Shah, Manpreet Samra, Michelle A Josephson
PURPOSE OF REVIEW: To review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients. RECENT FINDINGS: There is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29884305/understanding-abnormal-uterine-artery-doppler-waveforms-a-novel-computational-model-to-explore-potential-causes-within-the-utero-placental-vasculature
#16
Alys R Clark, Joanna L James, Gordon N Stevenson, Sally L Collins
INTRODUCTION: Uterine artery (UtA) Doppler indices are one of the most commonly employed screening tests for pre-eclampsia worldwide. Abnormal indices appear to result from increased uterine vascular resistance, but anatomical complexity and lack of appropriate animal models mean that little is known about the relative contribution of each of the components of the uterine vasculature to the overall UtA Doppler waveform. Previous computational models suggested that trophoblast-mediated spiral artery remodeling has a dominant effect on the UtA Doppler waveform...
June 2018: Placenta
https://www.readbyqxmd.com/read/29883983/the-relationship-of-assisted-reproductive-technology-on-perinatal-outcomes-in-triplet-gestations
#17
Jaimin S Shah, Tania Roman, Oscar A Viteri, Ziad A Haidar, Alejandra Ontiveros, Baha M Sibai
OBJECTIVE:  To assess whether assisted reproductive technology (ART) is associated with increased risk of adverse perinatal outcomes in triplet gestations compared with spontaneous conception. STUDY DESIGN:  Secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. Triplets delivered at ≥ 24 weeks were studied. The primary outcome was the rate of composite neonatal morbidity (CNM) that included one or more of the following: bronchopulmonary dysplasia, respiratory distress syndrome, necrotizing enterocolitis, culture proven sepsis, pneumonia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, or perinatal death...
June 8, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29880699/associations-between-the-timing-and-dosing-of-aspirin-prophylaxis-and-term-and-preterm-pre-eclampsia
#18
REVIEW
Lisa Askie, Lelia Duley
No abstract text is available yet for this article.
June 7, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29880411/posterior-reversible-encephalopathy-syndrome-in-a-pregnant-patient-without-eclampsia-or-preeclampsia-a-case-report
#19
Hüseyin Acar, Kadriye Acar
Posterior Reversible Encephalopathy syndrome (PRES) is a rare neurologic disorder characterised by vasogenic edema in occipital and parietal lobes on MR. Patients usually complain about headache, visual disturbance, seizure and altered mental status. We repot a case of PRES seen in a pregnant patient. Although pre-eclampsia and eclampsia are among the common causes of this syndrome in this case patient was normotensive and no proteinuria was present. To our knowledge this is the first PRES case presented of a pregnant patient without eclampsia or pre-eclampsia...
May 30, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29880371/long-term-effects-of-pregnancy-on-renal-graft-function-in-women-after-kidney-transplantation-compared-with-matched-controls
#20
S Svetitsky, R Baruch, I F Schwartz, D Schwartz, R Nakache, Y Goykhman, P Katz, A Grupper
BACKGROUND: An important benefit associated with kidney transplantation in women of child-bearing age is increased fertility. We retrospectively evaluated the maternal and fetal complications and evolution of graft function associated with 22 pregnancies post-kidney and kidney-pancreas transplantation, compared with controls without pregnancy post-transplantation, who were matched for gender, year of transplantation, type of donor, age at transplantation, number of transplants, type of transplant (kidney vs kidney-pancreas), and cause of native kidney failure, as well as for renal parameters including serum creatinine and urine protein excretion 1 year before delivery...
June 2018: Transplantation Proceedings
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