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https://www.readbyqxmd.com/read/29442407/prediction-and-prevention-of-pre-eclampsia-in-asian-subpopulation
#1
REVIEW
Tuangsit Wataganara, Jarunee Leetheeragul, Suchittra Pongprasobchai, Anuwat Sutantawibul, Chayawat Phatihattakorn, Surasak Angsuwathana
The benefit of the early administration of aspirin to reduce preterm pre-eclampsia among screened positive European women from multivariate algorithmic approach (ASPRE trial) has opened an intense debate on the feasibility of universal screening. This review aims to assess the new perspectives in the combined screening of pre-eclampsia in the first trimester of pregnancy and the chances for prevention using low-dose aspirin with special emphasis on the particularities of the Asian population. PubMed, CENTRAL and Embase databases were searched from inception until 15 November 2017 using combinations of the search terms: preeclampsia, Asian, prenatal screening, early prediction, ultrasonography, pregnancy, biomarker, mean arterial pressure, soluble fms-like tyrosine kinase-1, placental growth factor, pregnancy-associated plasma protein-A and pulsatility index...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29438905/induction-of-systemic-inflammation-by-hyaluronan-and-hsp70-in-women-with-pre-eclampsia
#2
Mariana Romão-Veiga, Mariana Leticia Matias, Vanessa Rocha Ribeiro, Priscila Rezeck Nunes, Vera Therezinha M Borges, José Carlos Peraçoli, Maria Terezinha S Peraçoli
Pre-eclampsia (PE) is a human pregnancy syndrome with abnormal activation of the innate immune response. The study evaluated the involvement of molecular structures called damage-associated molecular patterns (DAMPs), such as hyaluronan (HA) and heat shock proteins (Hsp) on NLRP1 and NLRP3 inflammasomes activation in peripheral blood monocytes. Twenty pre-eclamptic women, 20 normotensive pregnant women (NT) and 20 non-pregnant women (NP) were studied. Enzyme immunoassay was employed for the determination of HA, Hsp70 and High mobility group Box 1 (HMGB1) in plasma, as well as for the detection of Interleukin-1β (IL-1β), IL-18 and tumor necrosis factor alpha (TNF-α) in the supernatant of monocytes cultured with or without HA and Hsp70...
February 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29438637/population-attributable-fractions-of-perinatal-outcomes-for-nulliparous-women-associated-with-overweight-and-obesity-1990-2014
#3
Kate Cheney, Rachel Farber, Alexandra L Barratt, Kevin McGeechan, Bradley de Vries, Robert Ogle, Kirsten I Black
OBJECTIVE: To examine the prevalence across 25 years of overweight and obesity among nulliparous Australian women during early pregnancy; to estimate the proportions of adverse perinatal outcomes attributable to overweight and obesity in this population. DESIGN: Cohort study; retrospective analysis of electronic maternity data. Setting, participants: 42 582 nulliparous women with singleton pregnancies giving birth at the Royal Prince Alfred Hospital, an urban teaching hospital in Sydney, January 1990 - December 2014...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29437882/decidual-regulation-of-trophoblast-is-altered-in-pregnancies-at-risk-of-pre-eclampsia
#4
Laura B James-Allan, Guy StJ Whitley, Karin Leslie, Alison E Wallace, Judith E Cartwright
Successful implantation and placentation are dependent on the interaction between decidual stromal cells (DSC) and extravillous trophoblast (EVT) cells. The extent of trophoblast invasion relies on communication between the placenta and maternal decidua. The cyclical process of decidualisation induces a transformation of endometrial fibroblasts to secretory DSC; these secreted products have many functions including the control of trophoblast invasion. Inadequate trophoblast invasion and remodelling of the uterine vessels (the spiral arteries) are associated with pregnancy disorders such as pre-eclampsia...
February 7, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29436641/mir%C3%A2-203-contributes-to-pre%C3%A2-eclampsia-via-inhibition-of-vegfa-expression
#5
Fulin Liu, Kejia Wu, Wanrong Wu, Yurou Chen, Hanshu Wu, Hui Wang, Wei Zhang
Pre-eclampsia (PE) is a common but complex condition that can occur in pregnancy. It is estimated to affect 3-8% of pregnancies worldwide. PE development is thought to be multifactorial and to involve the dysregulation of microRNA (miR) expression. However, the precise mechanisms of PE development remain unclear. The present study aimed to illustrate the association between miR‑203 expression and PE development in samples of human placenta collected from mothers with (n=18) and without (n=20) PE. It was demonstrated that miR‑203 expression was significantly increased in the PE placenta compared with the normal placenta samples, while the expression of vascular endothelial growth factor A (VEGFA) was decreased...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436313/pre-eclampsia-and-the-risk-of-autism-spectrum-disorder-in-offspring-meta-analysis
#6
Berihun Assefa Dachew, Abdullah Mamun, Joemer Calderon Maravilla, Rosa Alati
BACKGROUND: Evidence about the effect of intrauterine exposure to pre-eclampsia on offspring autism-spectrum disorder (ASD) is not well established. Aims To examine the association between pre-eclampsia and ASD. METHOD: PubMed, Embase and PsycINFO databases were searched. Pooled relative risks (RR) with 95% confidence intervals were calculated. Subgroup and sensitivity analyses were performed. Heterogeneity was assessed using Cochran's Q- and the I 2-test. The presence of publication bias was evaluated by Egger's test and visual inspection of the symmetry in funnel plots...
January 24, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432379/dexmedetomidine-as-a-part-of-general-anaesthesia-for-caesarean-delivery-in-patients-with-pre-eclampsia-efficacy-and-foetal-outcome-a-randomised-double-blinded-trial
#7
Ashraf M Eskandr, Ahmed A Metwally, Abd-Elrahman A Ahmed, Elham M Elfeky, Islam M Eldesoky, Manar A Obada, Osama A Abd-Elmegid
BACKGROUND: During general anaesthesia, endotracheal intubation of patients with pre-eclampsia causes stimulation of the sympathetic nervous system and catecholamine release, which may lead to maternal and neonatal complications. OBJECTIVE: To attenuate both the stress response and the haemodynamic response to tracheal intubation in patients with pre-eclampsia. DESIGN: A randomised, double-blind, controlled study. SETTING: Single University Hospital...
February 9, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29430974/maternal-serum-irisin-levels-in-early-and-late-onset-pre-eclamptic-and-healthy-pregnancies
#8
Aysegul Ozel, Ebru Alici Davutoglu, Asuman Firat, Hakan Erenel, Mehmet Fatih Karslı, Sevim Özge Korkmaz, Riza Madazli
The aim of the study was to investigate whether plasma irisin concentrations differ between uncomplicated, early-onset and late-onset pre-eclamptic pregnancies. This cross-sectional study was conducted on 27 women with early-onset, 27 women with late-onset pre-eclampsia (PE) and 26 healthy pregnant women. Maternal levels of serum irisin were measured with the use of an enzyme-linked immunosorbent assay kit. The mean maternal serum irisin level of early-onset PE was significantly lower than late-onset PE (1...
February 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29427369/pre-eclampsia-affects-procalcitonin-production-in-placental-tissue
#9
Chiara Agostinis, Damiano Rami, Paola Zacchi, Fleur Bossi, Tamara Stampalija, Alessandro Mangogna, Leonardo Amadio, Romana Vidergar, Liza Vecchi Brumatti, Giuseppe Ricci, Claudio Celeghini, Oriano Radillo, Ian Sargent, Roberta Bulla
PROBLEM: Procalcitonin (PCT) is the prohormone of calcitonin which is usually released from neuroendocrine cells of the thyroid gland (parafollicular) and the lungs (K cells). PCT is synthesized by almost all cell types and tissues, including monocytes and parenchymal tissue, upon LPS stimulation. To date, there is no evidence for PCT expression in the placenta both in physiological and pathological conditions. METHOD: Circulating and placental PCT levels were analysed in pre-eclamptic (PE) and control patients...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29422154/audit-for-quality-of-care-and-fate-of-maternal-critical-cases-at-women-s-health-hospital
#10
Howieda Fouly, Fayza Ahmed Abdou, Ahmed M Abbas, Ayat Masoud Omar
Maternal deaths remain high, numbers at the facility level are relatively low. AIM: To evaluate effect of management guidelines on occurrence of maternal near miss in Women's Health Hospital. DESIGN: A cross-sectional study. SETTING: ICU of Women's Health Hospital's at Assiut Main University Hospital and Al-fayoum University Hospital. SUBJECTS: Convenient sample of 93 maternal near-miss cases including (Pregnancy or postpartum complications)...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29421928/a-case-of-partial-hydatidiform-molar-pregnancy-with-a-placental-diploid-triploid-mosaicism-associated-with-a-euploid-viable-foetus-complicated-with-severe-pre-eclampsia
#11
Sam Booth, Osama Eskandar
No abstract text is available yet for this article.
February 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29421927/twin-gestation-in-a-swyer-syndrome-patient-with-superimposed-pre-eclampsia
#12
Jaimin S Shah, Oscar A Viteri, Monica Longo, Mazen Abdallah, Baha Sibai
No abstract text is available yet for this article.
February 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29416695/association-between-hypertensive-disorders-of-pregnancy-and-risk-of-autism-in-offspring-a-systematic-review-and-meta-analysis-of-observational-studies
#13
Ruo-Ting Xu, Qing-Xian Chang, Qi-Qiong Wang, Jian Zhang, Lai-Xin Xia, Nanbert Zhong, Yan-Hong Yu, Mei Zhong, Qi-Tao Huang
Background: Autism spectrum disorder (ASD) is a common severe pervasive neurodevelopmental disorder of undetermined etiology. Environmental exposures, especially pregnancy complications, have been increasingly recognized as a potential risk factor for ASD. Our aim was to (1) systematically evaluate the association between hypertensive disorders of pregnancy (HDP) and the risk of ASD in offspring, (2) specifically draw a subgroup analysis of disease severity in patients with HDP to achieve more sufficient evidence on this issue...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29412430/neonatal-sepsis-mortality-in-a-municipality-in-southern-brazil-2000-to-2013
#14
Jakeline Barbara Alves, Flávia Lopes Gabani, Rosângela Aparecida Pimenta Ferrari, Mauren Teresa Grubisich Mendes Tacla, Arnildo Linck Júnior
OBJECTIVE: To describe the neonatal mortality coefficient attributed to sepsis and other causes, and to report the maternal, neonatal and death characteristics of newborn infants that died in the city of Londrina, Paraná, in Southern Brazil. METHODS: This is a cross-sectional study with a time series analysis. Neonatal deaths that contained neonatal sepsis records in any field of the death certificate between the years 2000 and 2013 were studied. The years were grouped into biennia, and cause specific neonatal mortality coefficient was calculated, according to the International Classification of Diseases, 10th revision...
January 15, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29405972/combination-of-first-trimester-serum-afamin-levels-and-three-dimensional-placental-bed-vascularization-as-a-possible-screening-method-to-detect-women-at-risk-for-adverse-pregnancy-complications-like-pre-eclampsia-and-gestational-diabetes-mellitus-in-low-risk
#15
Allessandra Tramontana, Eleonore Pablik, Gerhard Stangl, Beda Hartmann, Hans Dieplinger, Erich Hafner
OBJECTIVE: Aim of the study was to assess the correlation of first trimester serum afamin levels with three-dimensional placental bed vascularization in pregnant women and its prognostic value for predicting pre-eclampsia and future fetal and maternal complications during pregnancy. METHODS: In this nested case-control study all pregnant women registered for delivery during a period of 3 years were routinely screened in the first trimester. Serum afamin levels were assessed in 764 women and correlated to 5 pregnancy outcome groups: gestational hypertension (n = 76), pre-eclampsia (n = 33), intrauterine growth restriction (n = 91), pre-term birth (n = 39), gestational diabetes mellitus (n = 170); In addition, measurements of first trimester myometrial vascularization index were performed and, in combination with afamin tested as a possible screening method to detect women at-risk for the development of adverse complications in low-risk pregnancies at the time of the first trimester...
February 2018: Placenta
https://www.readbyqxmd.com/read/29394247/health-and-socio-demographic-profile-of-women-of-reproductive-age-in-rural-communities-of-southern-mozambique
#16
Charfudin Sacoor, Beth Payne, Orvalho Augusto, Faustino Vilanculo, Ariel Nhacolo, Marianne Vidler, Prestige Tatenda Makanga, Khátia Munguambe, Tang Lee, Eusébio Macete, Peter von Dadelszen, Esperança Sevene
Reliable statistics on maternal morbidity and mortality are scarce in low and middle-income countries, especially in rural areas. This is the case in Mozambique where many births happen at home. Furthermore, a sizeable number of facility births have inadequate registration. Such information is crucial for developing effective national and global health policies for maternal and child health. The aim of this study was to generate reliable baseline socio-demographic information on women of reproductive age as well as to establish a demographic surveillance platform to support the planning and implementation of the Community Level Intervention for Pre-eclampsia (CLIP) study, a cluster randomized controlled trial...
2018: PloS One
https://www.readbyqxmd.com/read/29393131/systemic-implications-of-hyperuricemia
#17
Juan A Tamayo Y Orozco
Systemic implications of hyperuricemia need to be reconsidered in the context of the energy and protein wasting being an early indicator of organ deterioration in patients affected by the cardiometabolic syndrome and other frequent pathology states like pre-eclampsia, hyperparathyroidism, and chronic renal failure. This chapter points out physiological alterations that are to be made related to hyperuricemia, new diagnostic strategies, and early therapeutic interventions in the context of the old enemy: asymptomatic hyperuricemia...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29390907/impact-of-late-pregnancy-haemoglobin-a1c-at-29-30-weeks-gestation-on-adverse-pregnancy-outcomes-among-women-with-pre-existing-diabetes-a-retrospective-analysis
#18
Soon Leong Yong, Beng Kwang Ng, Muhammad Abdul Jamil Mohd Yassin, Syed Zulkifli Syed Zakaria, Nor Azlin Mohamed Ismail
This study was to assess the relationship between late pregnancy haemoglobin A1C (HbA1C) at 29-30 weeks of gestation and adverse pregnancy outcomes (APOs) in 272 pregnant women with pre-existing diabetes. HbA1C ≥6.1% was associated with significantly increased risk of preterm delivery, Caesarean section, large for gestational age (LGA), neonatal respiratory distress, neonatal hypoglycaemia, and composite adverse neonatal outcome (p < .05). The risk of pre-eclampsia increased significantly at the lower HbA1C cut-off of > 5...
February 1, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29390102/extracellular-vesicles-in-human-reproduction-in-health-and-disease
#19
C Simon, D W Greening, D Bolumar, N Balaguer, L A Salamonsen, F Vilella
Extensive evidence suggests that the release of membrane enclosed compartments, more commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of cell-to-cell communication both in normal physiology and in pathological conditions. This article specifically reviews evidence about the formation and release of different EVs, their definitive markers and cargo content in reproductive physiological processes, and their capacity to convey information between cells through the transfer of functional protein and genetic information to alter phenotype and function of recipient cells associated with reproductive biology...
January 30, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29383061/training-in-emergency-obstetrics-a-needs-assessment-of-u-s-emergency-medicine-program-directors
#20
Daniel W Robinson, Michael Anana, Mary A Edens, Marc Kanter, Sorabh Khandelwal, Kaushal Shah, Todd Peterson
Introduction: Obstetrical emergencies are a high-risk yet infrequent occurrence in the emergency department. While U.S. emergency medicine (EM) residency graduates are required to perform 10 low-risk normal spontaneous vaginal deliveries, little is known about how residencies prepare residents to manage obstetrical emergencies. We sought to profile the current obstetrical training curricula through a survey of U.S. training programs. Methods: We sent a web-based survey covering the four most common obstetrical emergencies (pre-eclampsia/eclampsia, postpartum hemorrhage (PPH), shoulder dystocia, and breech presentation) through email invitations to all program directors (PD) of U...
January 2018: Western Journal of Emergency Medicine
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