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pre eclampsia

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https://www.readbyqxmd.com/read/27904751/association-of-serum-concentrations-of-persistent-organic-pollutants-pops-and-risk-of-pre-eclampsia-a-case-control-study
#1
Bita Eslami, Hossein Malekafzali, Noushin Rastkari, Batool Hossein Rashidi, Abolghasem Djazayeri, Kazem Naddafi
BACKGROUND: There is increasing evidence that persistent organic pollutants (POPs) may contribute to pre-eclampsia. The objective of this study was to evaluate the association between Polychlorinated Biphenyls (PCBs) and Polybrominated Diphenyl Ethers (PBDEs) as POPs with pre-eclampsia. METHODS: This case-control study was performed in the three general university hospitals of Tehran University of Medical Sciences. Serum samples were collected from cases (n = 45) who had diagnosed with preeclampsia and from control samples (n = 70) with normal pregnancy and attended the same hospital for a routine prenatal visit at the third trimester of pregnancy...
2016: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/27901638/atlantic-dip-insulin-therapy-for-women-with-iadpsg-diagnosed-gestational-diabetes-mellitus-does-it-work
#2
D Bogdanet, A M Egan, C Reddin, O Kgosidialwa, B Kirwan, L Carmody, F P Dunne
INTRODUCTION: Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using IADPSG criteria require insulin therapy. OBJECTIVE: To assess if the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT). MATERIALS AND METHODS: This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and foetal outcomes were examined...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27898523/role-of-corin-in-the-regulation-of-blood-pressure
#3
Hui Li, Yue Zhang, Qingyu Wu
PURPOSE OF REVIEW: Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases. RECENT FINDINGS: Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia...
November 24, 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27892433/efficacy-of-prophylactic-b-lynch-suture-during-lower-segment-caesarian-section-in-high-risk-patients-for-atonic-postpartum-haemorrhage
#4
M Vijayasree
Background Postpartum Haemorrhage causes significant maternal mortality and morbidity all over the world. Active management of the third stage of labour with oxytocics is come into practice. If postpartum haemorrhage is anticipated conservative surgical procedures like B-lynch suture is being applied. Objective To evaluate the effect of elective B-Lynch suture in preventing atonic postpartum haemorrhage during emergency caesarian section with high risk factors for atonicity. Method Forty antenatal women undergoing emergency caesarean section with risk factors for atony of the uterus were selected in our study...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27891797/the-aetiology-of-pre-eclampsia-1945-1953
#5
Xue Qing Wu, Yao Yao Cai, Wei Ting Xia, M J Quinn
No abstract text is available yet for this article.
December 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27891368/is-the-mean-platelet-volume-a-predictive-marker-of-a-low-apgar-score-and-insulin-resistance-in-gestational-diabetes-mellitus-a-retrospective-case-control-study
#6
Levent Kebapcilar, Ayse Gul Kebapcilar, Tolgay Tuyan Ilhan, Suleyman Hilmi Ipekci, Suleyman Baldane, Aybike Pekin, Mustafa Kulaksizoglu, Cetin Celik
INTRODUCTION: Gestational diabetes is defined as various degrees of glucose intolerance diagnosed or detected for the first time during pregnancy and is the most common metabolic complication of pregnancy. Early diagnosis and adequate treatment are important to prevent complications. Pre-eclampsia, polyhydramnios, fetalmacrosomia, and operative delivery are some of the complications seen in pregnant women diagnosed with Gestational Diabetes Mellitus (GDM). AIM: The present study was designed to determine whether there was an association between Mean Platelet Volume (MPV) in predicting poor fetal outcome, insulin resistance, neonatal Apgar scores and gestational age for women with GDM...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891361/serum-frap-levels-and-pre-eclampsia-among-pregnant-women-in-a-rural-community-of-northern-india
#7
Anant Gupta, Shashi Kant, Sanjeev Kumar Gupta, Shyam Prakash, Mani Kalaivani, Chandrakant S Pandav, Sanjay Kumar Rai, Puneet Misra
INTRODUCTION: There is a balance between the oxidative and the anti-oxidative forces in human body. Some studies document decreased level of anti-oxidant in pre-eclampsia while other studies showed normal level of anti-oxidant in pre-eclampsia and the evidence is equivocal. AIM: The aim of the present study was to assess enzymatic anti-oxidant activities in pre-eclamptic women and compare it with normotensive pregnant women with period of gestation between 28 to 36 weeks...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27887594/first-trimester-serum-placental-growth-factor-and-hyperglycosylated-human-chorionic-gonadotropin-are-associated-with-pre-eclampsia-a-case-control-study
#8
Elina Keikkala, Sini Koskinen, Piia Vuorela, Hannele Laivuori, Jarkko Romppanen, Seppo Heinonen, Ulf-Håkan Stenman
BACKGROUND: To study whether maternal serum hyperglycosylated human chorionic gonadotropin (hCG-h) improves first trimester prediction of pre-eclampsia when combined with placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A) and maternal risk factors. METHODS: Gestational-age-adjusted concentrations of hCG, hCG-h, PlGF and PAPP-A were analysed in serum samples by time-resolved immunofluorometric assays at 8-13 weeks of gestation. The case-control study included 98 women who developed pre-eclampsia, 25 who developed gestational hypertension, 41 normotensive women with small-for-gestational-age (SGA) infants and 177 controls...
November 25, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27885772/clinical-practice-patterns-on-the-use-of-magnesium-sulphate-for-treatment-of-pre-eclampsia-and-eclampsia-a-multi-country-survey
#9
Q Long, O T Oladapo, S Leathersich, J P Vogel, G Carroli, P Lumbiganon, Z Qureshi, A M Gülmezoglu
OBJECTIVE: To characterise the current clinical practice patterns regarding the use of magnesium sulphate (MgSO4 ) for eclampsia prevention and treatment in a multi-country network of health facilities and compare with international recommendations. DESIGN: Cross-sectional survey. SETTING: A total of 147 health facilities in 15 countries across Africa, Latin America and Asia. POPULATION: Heads of obstetric departments or maternity units...
November 24, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27883242/sflt-1-plgf-for-early-onset-pre-eclampsia-prediction-steps-study-of-early-pre-eclampsia-in-spain
#10
A Perales, J L Delgado, M De La Calle, J A García-Hernández, A I Escudero, J M Campillos, M D Sarabia, B Laíz, M Duque, M Navarro, P Calmarza, M Hund, F V Álvarez
OBJECTIVES: A high ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) has been linked with pre-eclampsia (PE). We evaluated the sFlt-1/PlGF ratio as a predictive marker for early-onset PE in women at risk of PE. METHODS: This prospective, Spanish, multicenter study included pregnant women with PE risk factors (including: history of intrauterine growth restriction; PE; eclampsia; hemolysis, elevated liver enzymes and low platelet count syndrome; pre-gestational diabetes; and abnormal uterine artery Doppler ultrasound)...
November 24, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27882748/-application-of-the-concetrations-ratio-of-soluble-receptor-tyrosine-kinase-type-1-and-placental-growth-factor-for-short-term-prediction-and-diagnosis-of-preeclampsia
#11
Š Bubeníková, A Cíchová, L Roubalová, V Durdová, R Vlk
OBJECTIVE: Bring a comprehensive overview of the available information about applications of the concetration ratio of soluble receptor tyrosine kinase type 1 (sFlt-1), and placental growth factor for short-term prediction and diagnosis of preeclampsia. DESIGN: Overview study. SETTINGS: Department of Midwifery, Faculty of Health Sciences, Olomouc; Department of Clinical Biochemistry, University Hospital Olomouc; Department of Obstetrics and Gynecology, University Hospital Olomouc; Department of Obstetrics and Gynecology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27880069/role-of-first-trimester-hba1c-as-a-predictor-of-adverse-obstetric-outcomes-in-a-multi-ethnic-cohort
#12
Laura Mañé, Juana Antonia Flores-Le Roux, David Benaiges, Marta Rodríguez, Irene Marcelo, Juan José Chillarón, Juan Pedro-Botet, Gemma Llauradó, Lucía Gortazar, Ramón Carreras, Antonio Payà
CONTEXT: Risk of obstetric complications increases linearly with rising maternal glycaemia. Testing HbA1c is an effective option to detect hyperglycemia but its association with adverse pregnancy outcomes remains unclear. Emerging data sustains that an early HbA1c≥5.9% could act as a pregnancy risk marker. OBJECTIVE: To determine, in a multi-ethnic cohort, whether an early ≥5.9% HbA1c could be useful to identify women without diabetes mellitus at increased pregnancy risk...
November 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27871468/increased-levels-of-soluble-corin-in-pre-eclampsia-and-fetal-growth-restriction
#13
Jun Miyazaki, Haruki Nishizawa, Asuka Kambayashi, Mayuko Ito, Yoshiteru Noda, Sumire Terasawa, Takema Kato, Hironori Miyamura, Kazuya Shiogama, Takao Sekiya, Hiroki Kurahashi, Takuma Fujii
Atrial natriuretic peptide is biologically activated by the atrial natriuretic peptide-converting enzyme, corin, and has an important role in regulating blood pressure. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction (FGR) without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. CORIN mRNA levels were not elevated in placentas from pre-eclampsia or unexplained FGR cases...
December 2016: Placenta
https://www.readbyqxmd.com/read/27868334/consensus-on-the-standardization-of-terminology-in-thrombotic-thrombocytopenic-purpura-and-related-thrombotic-microangiopathies
#14
M Scully, S Cataland, P Coppo, J de la Rubia, K D Friedman, J Kremer Hovinga, B Lämmle, M Matsumoto, K Pavenski, E Sadler, R Sarode, H Wu
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are two important acute conditions to diagnose. Thrombotic Microangiopathy is a broad pathophysiological process that leads to microangiopathic hemolytic anemia, thrombocytopenia and involves capillary and small vessel platelet aggregates. The most common cause being disseminated intravascular coagulation (DIC), which may be differentiated by abnormal coagulation. Clinically, a number of conditions present with microangiopathic hemolytic anemia and thrombocytopenia (MAHAT), including cancer, infection, transplantation, drugs, autoimmune disease and pre-eclampsia and HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome in pregnancy...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27866432/maternal-cardiac-haemodynamics-in-severe-pre-eclampsia-complicated-by-acute-pulmonary-oedema-a-review
#15
I Bhorat, D P Naidoo, J Moodley
AIM: To establish alterations in maternal cardiac haemodynamics and function using electrocardiography and echocardiography in severe pre-eclampsia complicated by acute pulmonary oedema. METHODS: An extensive literature search including any research articles, randomised control trials, observational study, case report or expert or consensus statement pertaining to severe pre-eclampsia, eclampsia, hypertensive crises of pregnancy, pulmonary oedema, maternal cardiac haemodynamics, Holter monitoring and maternal echocardiography was done...
November 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27864359/endothelin-1-down-regulates-matrix-metalloproteinase-14-and-15-expression-in-human-first-trimester-trophoblasts-via-endothelin-receptor-type-b
#16
Alejandro Majali-Martinez, Philipp Velicky, Jürgen Pollheimer, Martin Knöfler, Hong Wa Yung, Graham J Burton, Nassim Ghaffari Tabrizi-Wizsy, Uwe Lang, Ursula Hiden, Gernot Desoye, Martina Dieber-Rotheneder
STUDY QUESTION: Does endothelin-1 (ET-1) regulate matrix metalloproteinase (MMP) 14 and 15 production and invasion of human first trimester trophoblasts? SUMMARY ANSWER: ET-1 in pathophysiological concentrations down-regulates MMP14 and MMP15 expression via endothelin receptor (ETR) type B and decreases trophoblast migration and invasion. WHAT IS KNOWN ALREADY: MMP14 and MMP15 are involved in trophoblast invasion. Impairment of invasion has been linked to pregnancy complications such as pre-eclampsia (PE)...
November 17, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27864302/interpregnancy-interval-following-miscarriage-and-adverse-pregnancy-outcomes-systematic-review-and-meta-analysis
#17
REVIEW
Chrishny Kangatharan, Saffi Labram, Sohinee Bhattacharya
BACKGROUND: A short interpregnancy interval (IPI) following a delivery is believed to be associated with adverse outcomes in the next pregnancy. The optimum IPI following miscarriage is controversial. Based on a single large-scale study in Latin and South America, the World Health Organization recommends delaying pregnancy for 6 months after a miscarriage to achieve optimal outcomes in the next pregnancy. OBJECTIVE AND RATIONALE: Our aim was to determine if a short IPI (<6 months) following miscarriage is associated with adverse outcomes in the next pregnancy...
November 17, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27862673/vitamin-d-restores-angiogenic-balance-and-decreases-tumor-necrosis-factor-%C3%AE-in-a-rat-model-of-pre-eclampsia
#18
Jing Song, Yue Li, Ruifang An
AIM: Deficiency of vitamin D is correlated with pre-eclampsia (PE), a hypertensive disorder of pregnancy, and is characterized by angiogenic imbalance and inflammation. The aim of this study was to investigate whether vitamin D supplementation can restore the angiogenic balance and ameliorate inflammation in a rat model of PE. METHODS: PE was induced using l-nitroarginine methylester. Normal pregnant and PE-induced rats were supplemented with vitamin D on gestation days 14-19...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27862669/association-between-nephrinuria-podocyturia-and-proteinuria-in-women-with-pre-eclampsia
#19
Itsuko Furuta, Tianyue Zhai, Satoshi Ishikawa, Takeshi Umazume, Kinuko Nakagawa, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami
AIM: Podocyte depletion in the kidney is associated with end-stage kidney disease (ESKD). Pre-eclampsia (PE) increases the risk of ESKD in later life. This study was performed to determine whether nephrinuria (soluble nephrin in the urine) is correlated with proteinuria and/or podocyturia (podocytes in the urine) in PE women. METHODS: Eighty-three urine samples, consisting of 45 and 38 samples from 27 normotensive and nine PE women, respectively, underwent simultaneous determination of nephrin, protein, and creatinine concentrations in the urine supernatant and quantitative analysis of podocyte-specific protein mRNA expression...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27860117/development-of-a-core-outcome-set-for-epilepsy-in-pregnancy-e-core-a-national-multi-stakeholder-modified-delphi-consensus-study
#20
B H Al Wattar, K Tamilselvan, R Khan, A Kelso, A Sinha, A M Pirie, D McCorry, K S Khan, S Thangaratinam
OBJECTIVE: To develop a set of core outcomes for studies on pregnant women with epilepsy. DESIGN: Delphi consensus study. POPULATION: Healthcare professionals, and patient representatives with lived experience of epilepsy in the UK. METHODS: We used a modified Delphi method and a consultation meeting to achieve consensus. Potential outcomes were identified by systematic review, and were scored using a Likert scale anchored between 1 (least important) and 5 (most important)...
November 16, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
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