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Hemoglobin variability

Jesse A Goodrich, Benjamin J Ryan, William C Byrnes
Hemoglobin mass (tHb) is a key determinant of maximal oxygen uptake (VO 2 max). We examined whether oxyhemoglobin desaturation (ΔS a O 2 ) at VO 2 max modifies the relationship between tHb and VO 2 max at moderate altitude (1,625 m). Seventeen female and 16 male competitive, endurance-trained moderate-altitude residents performed two tHb assessments and two graded exercise tests on a cycle ergometer to determine VO 2 max and ΔS a O 2 . In males and females respectively, VO 2 max (ml·kg -1 ·min -1 ) ranged from 62...
July 2018: Sports Med Int Open
Simone Pratesi, Simona Montano, Stefano Ghirardello, Fabio Mosca, Luca Boni, Lorenzo Tofani, Carlo Dani
Background: Preterm newborns receiving briefly delayed cord clamping or cord milking at birth have better neonatal outcomes. However, the time frame in which both these procedures are performed (< 60 s of life) is too short to explore the possible beneficial effects on early infant postnatal adaptation and outcomes of a prolonged transfusion strategy associated with neonatal respiration. Methods and Design: We have designed a randomized, multicenter, controlled two-phase study: phase 1 to assess the feasibility of carrying out the protocol in a large randomized trial, and phase 2 to assess the efficacy of bedside assistance with intact placental circulation for 3 min in comparison to cord milking to improve outcome in the neonatal period; we present here the feasibility and safety phase of the study...
2018: Frontiers in Pediatrics
Lisiane Stefani Dias, Otto Henrique Nienov, Fernanda Dapper Machado, Camila Perlin Ramos, Daiane Rodrigues, Rodrigo Koprovsky Menguer, Helena Schmid
BACKGROUND: Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated conditions are not well characterized. The aim of this study was to evaluate the prevalence of PNP in severely obese (SO) women without DM or common nutritional deficiencies in order to determine factors associated with the presence of PNP...
December 7, 2018: Obesity Surgery
Klaus Abraham, Jan Hielscher, Tobias Kaufholz, Hans Mielke, Alfonso Lampen, Bernhard Monien
Fatty acid esters of glycidol (glycidyl esters) are heat-induced food contaminants predominantly formed during industrial deodorization of vegetable oils and fats. After consumption, the esters are digested in the gastrointestinal tract, leading to a systemic exposure to the reactive epoxide glycidol. The compound is carcinogenic, genotoxic and teratogenic in rodents, and rated as probably carcinogenic to humans (IARC group 2A). Assessment of exposure from occurrence and consumption data is difficult, as lots of different foods containing refined oils and fats may contribute to human exposure...
December 10, 2018: Archives of Toxicology
Ching-Chung Hsiao, Kun-Hua Tu, Chun-Yih Hsieh, Cheng-Chia Lee, Chih-Hsiang Chang, Pei-Chun Fan, Ya-Chung Tian, Ji-Tseng Fang
Purpose: The diagnosis of minimal change disease in adults relies mainly on renal biopsy, but this procedure is not without complications. Despite the advancements in technique of percutaneous renal biopsy, biopsy-related complications still occur. Bleeding is one of the major complications, which may lead to hemodynamic instability and, sometimes, even death. Thus, we developed a model to predict MCD for high-risk patients unsuitable for renal biopsy. Methods: We enrolled 142 patients with nephrotic syndrome who received renal biopsy between October 2007 and April 2011 at one tertiary medical center in this study...
2018: BioMed Research International
Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno
Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy. Subjects and methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate...
2018: Clinical Ophthalmology
Derrick M Chu, Joshua Aagaard, Ryan Levitt, Megan Whitham, Joan Mastrobattista, Martha Rac, Catherine Eppes, Manisha Gandhi, Michael A Belfort, Kjersti M Aagaard
OBJECTIVE: To assess whether recent anti-immigration rhetoric is significantly associated with inadequate prenatal care. METHODS: This was a population-based cohort study (2011-2017). In their native language, patients were consented and queried regarding country of origin and time in the United States. Additional variables were collected or abstracted from the medical record, including documentation and timing of prenatal visits. Based on relevance and prevalence during the study period, publicly available Google search trends were mined for the terms "Make America Great Again," "Mexico Wall," and "Deportation" by geographic region...
December 4, 2018: Obstetrics and Gynecology
Chung-Huei Huang, Yu-Yao Huang, Brend Ray-Sea Hsu
BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2is, gliflozins) are associated with lower all-cause mortality than other anti-diabetic agents in patients with type 2 diabetes. In patients who may benefit from SGLT2is, but cannot add them to a dipeptidyl peptidase-4 inhibitor (DPP4i, gliptin) treatment for various reasons, replacement of the DPP4i with a SGLT2i may be considered. OBJECTIVES: Evaluate changes in metabolic parameters in patients with diabetes after replacing a DPP4i with the SGLT2i empagliflozin...
November 2018: Annals of Saudi Medicine
Seyed Amineh Hojati, Elham Maserat, Mohammad Ghorbani, Alireza Safarpour, Mohammad Reza Fattehi
Introduction: Patients with drug addiction have high risk for hepatitis C virus (HCV). Effective treatment response is essential to optimize treatment for drug abusers infected by hepatitis C virus. Aim: The aim of this present study was to show that hepatitis C treatment in patients with drug addiction is effective like patients without drug addiction. Material and Methods: Total amount of 57 patients with hepatitis C (25 drug abuser and 32 non-drug abuser) that referred to Shahid Motahari clinic of Shiraz were selected...
November 2018: Medical Archives
Domenico Penna, Terra L Lasho, Christy M Finke, Rangit R Vallapureddy, Curtis A Hanson, Rhett P Ketterling, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
In the last decade, several prognostic models for primary myelofibrosis (PMF) have been introduced and shown to be effective in predicting overall survival. The main objective for this study was to identify clinical and genetic markers of very long (20+ years) survival in PMF. A total of 1282 patients with PMF were considered (median age 65 years, range 19-92; 63% males); 26 (2%) patients (median age 51 years, range 28-71; 38% males) survived their disease for at least 20 years (long-lived patients) and 626 (49%) patients (median age 68 years, range 27-92; 66% males) died within 5 years of their diagnosis (short-lived patients)...
December 5, 2018: American Journal of Hematology
Won Young Yong Jin, Jin Hee Jeong, Dong Hoon Kim, Tae Yun Kim, Changwoo Kang, Soo Hoon Lee, Sang Bong Lee, Seong Chun Kim, Yong Joo Park, Daesung Lim
BACKGROUND: The aim of this study was to identify factors predicting early mortality in trauma patients. METHODS: This was a study of 6288 trauma patients admitted to the hospital between July 2011 and June 2016. Among the variables recorded for a prospective trauma registry, the following were selected for analysis: sex; age; a combination of the Glasgow Coma Scale score, age, and systolic blood pressure (SBP) (GAP); a combination of the mechanism of injury, the Glasgow Coma Scale score, age, and SBP (MGAP); SBP; respiratory rate; peripheral oxygen saturation (SpO2 value); the Glasgow Coma Scale score; laboratory variables; and presentation time...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Amos K Laar, Margaret Y Lartey, Augustine Ankomah, Michael P K Okyerefo, Ernest A Ampah, Demi P Letsa, Priscillia A Nortey, Awewura Kwara
BACKGROUND: Optimal nutrition is a determinant of health in all persons. In persons living with HIV (PLHIV), nutrition is particularly important. Various factors, including dietary practices, play a role in guaranteeing nutritional health. OBJECTIVES: We investigated multiple non-prescription drugs use among HIV-positive persons receiving antiretroviral therapy (ART) from four treatment centers in southern Ghana. This paper, however, focuses on nutrient supplement use, food elimination, and food substitution practices by the PLHIV...
December 4, 2018: Journal of Health, Population, and Nutrition
James R Jauchem, Jennie M Burns, William B Voorhees, Michael B Jirjis
In laboratory studies of the pig Sus scrofa, hematocrit has consistently increased after conducted-electrical-weapon (CEW) exposures, possibly due to contraction of the spleen. Splenectomized animals and intact sham control animals were exposed, each for 30 sec, to a benchtop-produced electrical waveform of net charge levels similar to those of some CEWs. Changes in the blood were compared statistically. Hematocrit increased significantly in both splenectomized and sham animals. There were no significant main-effect differences between values of hematocrit from the two groups...
December 3, 2018: Journal of Forensic Sciences
Jaehyun Bae, Gyuri Kim, Yong-Ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
INTRODUCTION: Comparisons of the glycemic durability between thiazolidinediones (TZDs) and dipeptidyl peptidase-4 (DPP-4) inhibitors remain insufficient. This study aimed to find clues for the differences in glycemic durability between TZDs and DPP-4 inhibitors by comparing the insulin resistance and β-cell function among patients using these agents. METHODS: A total of 241 patients with type 2 diabetes mellitus (T2DM) treated with either pioglitazone (a TZD) or DPP-4 inhibitors as combination therapy with metformin for at least 1 year were analyzed...
December 1, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Rozita Naseri, Hamid Reza Mozaffari, Mazaher Ramezani, Masoud Sadeghi
Background: Saliva is a fluid with the complex compound which can be used as diagnostic markers for type 2 diabetes (T2D). This meta-analysis evaluated salivary glucose, immunoglobulin A (IgA), total protein, and amylase levels in adult T2D compared with the controls as well as the correlation of salivary glucose levels with serum glucose and hemoglobin A1C (HbA1c) levels in both groups. Materials and Methods: Web of Science, Scopus, PubMed, and Cochrane Library databases were searched up to July 2017...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Staffan Larsson, Bo Åkerström, Magnus Gram, L Stefan Lohmander, André Struglics
Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1 -microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. We studied matched knee synovial fluid (sf) and serum (s) samples from 122 subjects (mean age 40 years, 31% females): 10 were knee healthy references, 13 had acute inflammatory arthritis (AIA), 79 knee injury 0-10 years prior to sampling, and 20 knee OA...
2018: Frontiers in Physiology
Bharat Bhushan, Vijay Sardana, Dilip Maheshwari, Piyush Ojha, Sankalp Mohan, Parag Moon, Sumit Kamble, Nishtha Jain, Sunil K Sharma
Introduction: Our aim was to study dengue-related immune-mediated neurological complications (IMNC) during the recent epidemic. Materials and Methods: This was a cross-sectional observational study of 79 IMNC cases from 1627 laboratory confirmed dengue cases from January 2015 to January 2016 and their follow-up for 3 months. According to the World Health Organization, cases were categorized into those having dengue fever (DF), and those having a severe syndrome that includes dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
November 2018: Neurology India
Andrew J King, Douglas R Higgs
The α-thalassemia trait, associated with deletions removing both α-globin genes from 1 chromosome (genotype ζ αα/ζ--), is common throughout Southeast Asia. Consequently, many pregnancies in couples of Southeast Asian origin carry a 1 in 4 risk of producing a fetus inheriting no functional α-globin genes (ζ--/ζ--), leading to hemoglobin (Hb) Bart's hydrops fetalis syndrome (BHFS). Expression of the embryonic α-globin genes (ζ-globin) is normally limited to the early stages of primitive erythropoiesis, and so when the ζ-globin genes are silenced, at ∼6 weeks of gestation, there should be no α-like globin chains to pair with the fetal γ-globin chains of Hb, which consequently form nonfunctional tetramers (γ4 ) known as Hb Bart's...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
Léon Tshilolo, George Tomlinson, Thomas N Williams, Brígida Santos, Peter Olupot-Olupot, Adam Lane, Banu Aygun, Susan E Stuber, Teresa S Latham, Patrick T McGann, Russell E Ware
BACKGROUND: Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may affect the feasibility, safety, and benefits of hydroxyurea in low-resource settings. METHODS: We enrolled children 1 to 10 years of age with sickle cell anemia in four sub-Saharan countries. Children received hydroxyurea at a dose of 15 to 20 mg per kilogram of body weight per day for 6 months, followed by dose escalation...
December 1, 2018: New England Journal of Medicine
Dilan J Albarawi, Amer A Balatay, Nasir Al-Allawi
PURPOSE: Hemoglobin (Hb) F% is increased in up to half of beta-thalassemia (β-thal) carriers. Several polymorphisms have been linked to such variability in different populations, including HBG2 - 158(C>T) ( Xmn I polymorphism) on chromosome 11. To determine the role of this polymorphism in such variability among Iraqi Kurds, the current study was initiated. MATERIALS AND METHODS: A total of 102 consecutive patients diagnosed as β-thal minor were enrolled. The enrollees had their diagnosis based on peripheral blood counts and high-performance liquid chromatography to determine HbA2 and HbF...
October 2018: Journal of Laboratory Physicians
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