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Hemoglobin variability

Lu Yuan, Fengfei Li, Ting Jing, Bo Ding, Yong Luo, Rui Sun, Xiuping Wang, Hefeng Diao, Xiaofei Su, Lei Ye, Jianhua Ma
INTRODUCTION: Patients with type 2 diabetes (T2D) receiving premixed insulin often fail to achieve optimal glycemic control. The insulin injection technique (IT) itself may be one of the factors affecting glycemic variability (GV). The aim of this study was to assess the relationship between GV and IT in patients with T2D using premixed insulin. METHODS: This was a single center, cross-sectional, and self-controlled trial. Patients with T2D using premixed insulin were enrolled as inpatients...
October 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Masatake Kobayashi, Patrick Rossignol, João Pedro Ferreira, Irene Aragão, Yuki Paku, Yoichi Iwasaki, Masataka Watanabe, Marat Fudim, Kevin Duarte, Faiez Zannad, Nicolas Girerd
AIMS: Estimated plasma volume status (ePVS) predicts prognosis in patients with heart failure (HF). It remains unclear whether admission, discharge or change ePVS best predicts post-discharge outcome in patients with acute decompensated heart failure (ADHF). METHODS: We retrospectively analyzed three cohort studies: 383 patients admitted at the Tokyo Medical University hospital, 165 patients admitted at the Centro Hospitalar do Porto and 164 patients admitted at the Université de Lorraine (ICALOR study)...
October 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Isabel de Roever, Gemma Bale, Subhabrata Mitra, Judith Meek, Nicola J Robertson, Ilias Tachtsidis
It has been 20 years since functional near-infrared spectroscopy (fNIRS) was first used to investigate the evoked hemodynamic response to a stimulus in newborns. The hemodynamic response to functional activation is well-established in adults, with an observed increase in concentration change of oxygenated hemoglobin (Δ[HbO2 ]) and decrease in deoxygenated hemoglobin (Δ[HHb]). However, functional studies in newborns have revealed a mixed response, particularly with Δ[HHb] where an inconsistent change in direction is observed...
2018: Frontiers in Human Neuroscience
Ohad Yossef Hay, Meir Cohen, Itamar Nitzan, Yair Kasirer, Sarit Shahroor-Karni, Yitzhak Yitzhaky, Shlomo Engelberg, Meir Nitzan
Oxygen saturation in arterial blood (SaO₂) provides information about the performance of the respiratory system. Non-invasive measurement of SaO₂ by commercial pulse oximeters (SpO₂) make use of photoplethysmographic pulses in the red and infrared regions and utilizes the different spectra of light absorption by oxygenated and de-oxygenated hemoglobin. Because light scattering and optical path-lengths differ between the two wavelengths, commercial pulse oximeters require empirical calibration which is based on SaO₂ measurement in extracted arterial blood...
October 15, 2018: Sensors
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are known as predictors of CVD in these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. Recently, elevated NGAL levels have been reported in patients with CVD. This study aimed to evaluate the association between plasma NGAL levels and LVH/LVDD in patients with CKD...
2018: PloS One
Kaitlin Graham, Evan Unger
Hypoxia exists to some degree in most solid tumors due to inadequate oxygen delivery of the abnormal vasculature which cannot meet the demands of the rapidly proliferating cancer cells. The levels of oxygenation within the same tumor are highly variable from one area to another and can change over time. Tumor hypoxia is an important impediment to effective cancer therapy. In radiotherapy, the primary mechanism is the creation of reactive oxygen species; hypoxic tumors are therefore radiation resistant. A number of chemotherapeutic drugs have been shown to be less effective when exposed to a hypoxic environment which can lead to further disease progression...
2018: International Journal of Nanomedicine
Zhong Ye, Chun Wang, Limin Guo, Juan P Palazzo, Zhixing Han, Yinzhi Lai, Jing Jiang, James A Posey, Atrayee Basu Mallick, Bingshan Li, Li Jiang, Hushan Yang
Background: Use of chemotherapy in stage II colorectal cancer (CRC) is controversial because it improves survival only in some patients. We aimed to develop a statistical model using routine and readily available blood tests to predict the prognosis of patients with stage II CRC and to identify which patients are likely to benefit from chemotherapy. Methods: We divided 422 patients with stage II CRC into a training and a testing set. The association of routine laboratory variables and disease-free survival (DFS) was analyzed...
October 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Charlene C Quinn, Krystal K Swasey, Jamila M Torain, Michelle D Shardell, Michael L Terrin, Erik A Barr, Ann L Gruber-Baldini
BACKGROUND: Type 2 diabetes (T2D) is a major chronic condition requiring management through lifestyle changes and recommended health service visits. Mobile health (mHealth) is a promising tool to encourage self-management, but few studies have investigated the impact of mHealth on health care utilization. OBJECTIVE: The objective of this analysis was to determine the change in 2-year health service utilization and whether utilization explained a 1.9% absolute decrease in glycated hemoglobin (HbA1c ) over 1-year in the Mobile Diabetes Intervention Study (MDIS)...
October 15, 2018: JMIR MHealth and UHealth
Stuart Chalew, Ricardo Gomez, Alfonso Vargas, Jodi Kamps, Brittney Jurgen, Richard Scribner, James Hempe
INTRODUCTION: Black youth with type 1 diabetes (T1D) have higher HbA1c than whites. To understand HbA1c differences, we examined the relationship of psycho-social factors and glucose testing with HbA1c. METHODS: Glucose tests per day (BGs/d) and mean blood glucose (MBG) were calculated from meter data of youth self-identified as black (n = 33) or white (n = 53) with T1D. HbA1c, family income, insurance status, concentrated disadvantage (CDI), psychological depression (DSC), mother educational attainment (MEA), and insulin delivery method (IDM) data was were analyzed...
August 10, 2018: Journal of Diabetes and its Complications
Katarzyna Szczeklik, Tomasz Mach, Dorota Cibor, Danuta Owczarek, Jacek Sapa, Monika Papież, Jolanta Pytko-Polończyk, Wirginia Krzyściak
Diagnostics of Crohn's disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shu-Shang Chen, Mei-Jiao Lin, Ming-Fang Weng, Ling-Feng Zhu, Zhen Deng, Cheng-Yao Wu, Jin-Quan Cai, Wei-Zhen Wu, Jian-Ming Tan
To explore the influence of prostate size on the outcome of Plasmakinetic enucleation of the prostate (PkEP) for the treatment of benign prostate hyperplasia (BPH), The data of 892 patients with symptomatic BPH who underwent PkEP were retrospectively reviewed. Among them, 199 (22.31%) had the prostate size smaller than 40 g (Group 1), 409 (45.85%) between 40 and 79 g (Group 2), 197 (22.09%) between 80 and 120 g (Group 3), and 87 (9.75%) larger than 120 g (Group 4). Perioperative variables, perioperative and postoperative complications were recorded...
October 2018: Kaohsiung Journal of Medical Sciences
Sanni Yaya, Michael Ekholuenetale, Ghose Bishwajit
BACKGROUND: Even with the widespread recognition of non- communicable diseases (NCDs) in sub-Saharan Africa region, yet, sufficient evidence-based surveillance systems to confirm the prevalence and correlates of these diseases is lacking. In an attempt to understand the problem of NCDs in resource-constrained settings, this study was conducted to establish the pattern of the risk factors of NCDs in sub-Sahara Africa region. METHODS: The current Demographic and Health Survey (DHS) data sets from 33 countries in sub-Sahara Africa region were used in this study...
October 11, 2018: BMC Public Health
Melaku Tadege Engidaw, Molla Mesele Wassie, Alemayehu Shimeka Teferra
BACKGROUND: Adolescent girls have a higher risk of anemia due to an increased requirement, low intake of hematopoietic nutrients and low intake of a nutrient that enhance absorption of these hematopoietic nutrients. Adolescent girls living in refugee camps are more vulnerable to anemia. The study aimed to determine the prevalence of anemia and associated factors among adolescent girls aged 10-19 years in Aw-Barre refugee camp, Somalia regional state, Southeast Ethiopia. METHODS: A cross-sectional study design was employed...
2018: PloS One
Abigail Y Wang, Michelle S Wong, Casey Jo Humbyrd
BACKGROUND: Cost-containment strategies may discourage hospitals from performing surgery for patients with preexisting risk factors such as those with high body mass index (BMI), those with high hemoglobin A1c (HbA1c), or those who smoke cigarettes. Because these risk factors may not appear in equal proportions across the population, using these risk factors as inflexible eligibility criteria for lower extremity joint arthroplasty may exacerbate existing racial-ethnic, gender, and socioeconomic disparities pertaining to access to an operation that can improve health and quality of life...
October 9, 2018: Clinical Orthopaedics and related Research
Yeoree Yang, Eun Young Lee, Jae Hyoung Cho, Yong Moon Park, Seung Hyun Ko, Kun Ho Yoon, Moo Il Kang, Bong Yun Cha, Seung Hwan Lee
BACKGROUND: This study aimed to investigate the association between the presence and severity of cardiovascular autonomic neuropathy (CAN) and development of long-term glucose fluctuation in subjects with type 2 diabetes mellitus. METHODS: In this retrospective cohort study, subjects with type 2 diabetes mellitus who received cardiovascular autonomic reflex tests (CARTs) at baseline and at least 4-year of follow-up with ≥6 measures of glycosylated hemoglobin (HbA1c) were included...
September 28, 2018: Diabetes & Metabolism Journal
Ki-Ho Song, Jee-Sun Jeong, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Seung-Hyun Ko, Yu-Bae Ahn
AIMS: We aimed to investigate whether there are differences in the risk factors or markers for the progression of diabetic retinopathy (DR) and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up...
October 9, 2018: Journal of Diabetes Investigation
Amer Sebaaly, Pomme Jouffroy, Pierre Emmanuel Moreau, Camille Rodaix, Guillaume Riouallon
OBJECTIVES: To evaluate the accuracy of reduction of the acetabular articular surface using an intraoperative CT scanner (O-Arm) and screw navigation compared to a classical open technique. DESIGN: Prospective matched Cohort study SETTING:: Tertiary referral center PATIENTS/PARTICIPANTS:: Adult patients with acute acetabular fractures. All patients were treated by two senior surgeons using intraoperative imaging and screw navigation. MAIN OUTCOME MEASUREMENTS: The primary outcome measure was articular reduction...
September 25, 2018: Journal of Orthopaedic Trauma
Abdelbari Baitar, Cindy Kenis, Lore Decoster, Jacques De Grève, Jean-Pierre Lobelle, Johan Flamaing, Koen Milisen, Hans Wildiers
BACKGROUND: The current study was performed to evaluate the prognostic value of laboratory parameters and geriatric assessment (GA) in addition to a baseline model with clinical information regarding overall survival (OS) in patients with cancer. METHODS: GA was systematically performed in patients aged ≥70 years. The baseline model consisted of age, tumor type, and stage of disease. The incremental prognostic values of the GA as a whole (10-item GA) and laboratory parameters were assessed separately and combined...
October 9, 2018: Cancer
Yoshinori Ozeki, Takayuki Masaki, Yuichi Yoshida, Mitsuhiro Okamoto, Manabu Anai, Koro Gotoh, Yuichi Endo, Masayuki Ohta, Masafumi Inomata, Hirotaka Shibata
We investigated the association between body composition and changes in glucose metabolism following laparoscopic sleeve gastrectomy (LSG) in obese Japanese patients. Thirty-two Class III obese patients were assessed before LSG and 3, 6, and 12 months postoperatively. Variables including fat mass (FM), % body fat (%FM), total and skeletal muscle mass (MM), the ratio of lower extremity MM to body weight (BW) (L/W), and the ratio of upper extremity MM to BW (U/W) were measured while using bioelectrical impedance analysis (BIA)...
October 8, 2018: Nutrients
Shi-Xiang Zhao, Zhi-Xiang Lu, Li-Qun Yu, Xin Guan, Hai-Ping He, Ke-Qian Shi, Ren-Bin Zhao, Tong-Hua Yang
OBJECTIVE: To better define the effect of JAK2V617F mutant allele burden on clinical presentation of patients with essential thrombo cythamia (ET), especially thrombosis. METHODS: Two ml of heparin anti-coagulated bone marrow was collected from 229 ET cases, who were diagnosed and treated in the First People's Hospital of Yunnan Province during 2013.10 to 2016.12. and then the mononuclear cells were separated by Red Blood Cell Lysis Buffer, genomic DNA was extracted from mononuclear cells by using a commercial DNA isolation kit and amplified by allele specific polymerase chain reaction (PCR)...
October 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
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