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Alopecia androgenetic

Erkin Pekmezci, Cihat Dundar, Murat Turkoglu
Background: Currently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features...
April 2018: Medical Archives
Angela Wipf, Nicholas Boysen, Maria K Hordinsky, Emily E Dando, Neil Sadick, Ronda S Farah
INTRODUCTION: Fractional lasers and microneedling devices are increasingly used with topical drugs to treat various conditions, including alopecia, as they grant access to dermal structures such as hair follicles and cutaneous vasculature. OBJECTIVE: To perform a comprehensive review on transcutaneous drug delivery for the management of alopecia. METHODS: PubMed, Embase, and Ovid Medline databases were searched using terms including: alopecia, microneedling, lasers, androgenetic alopecia (AGA), alopecia areata (AA), drug delivery...
October 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Bruno L Rodrigues, Silmara Al Montalvão, Rebeca Bb Cancela, Francesca Ar Silva, Aline Urban, Stephany C Huber, José Luiz Rc Júnior, José Fábio Sd Lana, Joyce M Annichinno-Bizzacchi
BACKGROUND: Promising results were described with platelet-rich plasma (PRP) in androgenetic alopecia that could be associated to platelet number and growth factor levels. OBJECTIVE: Analyze the platelet number and growth factor levels in PRP and its correlation with hair growth parameters evaluated by TrichoScan. METHODS: Twenty-six patients randomized to receive four subcutaneous injections of PRP or saline. Hair growth, hair density, and percentage of anagen hairs were evaluated before, after and three months after the last injection using TrichoScan method...
October 1, 2018: Journal of the American Academy of Dermatology
Tyler Werbel, Philip R Cohen
Taxane chemotherapy and adjuvant endocrine therapy are commonly used in breast cancer patients following surgery. We describe a 59-year-old woman with a triple-positive invasive right breast cancer that was treated with surgery, radiation, chemotherapy, and adjuvant hormonal therapy. She subsequently developed scalp alopecia, with histopathological features of both androgenetic alopecia and alopecia areata; the hair loss did not resolve after completion of her chemotherapy. Significant clinical improvement was observed with topical minoxidil therapy...
July 27, 2018: Curēus
Silvia Diviccaro, Silvia Giatti, Francesca Borgo, Matteo Barcella, Elisa Borghi, José Luis Trejo, Luis Miguel Garcia-Segura, Roberto Cosimo Melcangi
Persistent alteration of plasma neuroactive steroid levels associated with major depression has been recently reported in men after the suspension of the treatment for androgenetic alopecia with finasteride, an inhibitor of the enzyme 5alpha-reductase. Observations in male rats confirmed persistent alterations in neuroactive steroid levels also in the brain. In the present study, we have ascertained possible effects on depressive-like behavior, neurogenesis, gliosis, neuroinflammation and gut microbiota in male rats after subchronic treatment for 20 days with finasteride and after one month of its withdrawal...
September 18, 2018: Psychoneuroendocrinology
Burhan Ahmed, Sami Gritli
Growth retardation, Alopecia, Pseudoanodontia and Optic atrophy (GAPO) syndrome is a rare autosomal recessive condition whose cardinal features include a recognizable craniofacial dysmorphosis, growth retardation, alopecia, pseudoanodontia, and premature aging. We report on a 2-year-old Pakistani man affected with GAPO syndrome who additionally shows an androgenetic-like alopecia with normal testosterone levels and telogen hair loss. These are novel findings in GAPO syndrome.
September 25, 2018: Australasian Journal of Dermatology
Goren Andy, McCoy John, Situm Mirna, Dhurat Rachita, Krychman Michael, Kovacevic Maja, Sharma Aseem, Bolanca Zeljana
Male androgenetic alopecia (AGA) affects up to 60% of men by the age of 50. Currently, there are only two approved drugs for the treatment of male AGA: topical minoxidil and oral finasteride. Topical minoxidil is readily available over the counter and has a well-established safety record. However, following 24 weeks of treatment, less than 40% of men respond to the drug. Additionally, due to the topical route of administration, compliance with minoxidil remains low. In contrast, oral finasteride, a 5-alpha reductase inhibitor, demonstrated efficacy in arresting hair loss in more than 80% of patients following 12 months of treatment...
September 25, 2018: Dermatologic Therapy
Sophie Wang, Divya Seth, Harib Ezaldein, Raghav Tripathi, Miesha Merati, Fuad Muakkassa, Jeffrey Scott
No abstract text is available yet for this article.
September 25, 2018: Journal of Dermatological Treatment
Jessica Lin, Inga Saknite, Manuel Valdebran, Mihaela Balu, Griffin Lentsch, Joshua N Williams, Karsten Koenig, Bruce J Tromberg, Natasha Atanaskova Mesinkovska
OBJECTIVES: Non-invasive visualization of hair follicles is important for proper diagnosis and management of alopecia; however, histological assessment remains the gold standard. Laser imaging technologies have made possible noninvasive in vivo evaluation of skin and hair follicle. The aim of this study was to evaluate the ability of multiphoton microscopy (MPM) to non-invasively identify morphological features that can distinguish scarring from non-scarring alopecia. METHODS: MPM images were obtained from areas on the scalp affected by alopecia...
September 24, 2018: Lasers in Surgery and Medicine
Nicholas B Abt, Olivia Quatela, Alyssa Heiser, Nate Jowett, Oren Tessler, Linda N Lee
Importance: Androgenetic alopecia is a highly prevalent condition across both sexes and can be surgically corrected through hair transplant. Health utility scores, which represent quantitative estimates of individual preferences for a given state of health, are a measure of health-related quality of life. The health utility scores for sex-specific alopecia and the posttransplant state have not previously been quantified. Objective: To obtain health utility measurements for the objective assessment of sex-specific alopecia and hair transplant surgery and to analyze layperson perception of alopecia compared with other chronic health conditions...
September 13, 2018: JAMA Facial Plastic Surgery
A Goren, A Sharma, R Dhurat, J Shapiro, R Sinclair, M Situm, M Kovacevic, L V Skudar, M Goldust, T Lotti, J McCoy
Topical minoxidil is the only US FDA approved OTC drug for the treatment of androgenetic alopecia (AGA). Minoxidil is a pro-drug converted into its active form, minoxidil sulfate, by the sulfotransferase enzymes in the outer root sheath of hair follicles. Previously, we demonstrated that sulfotransferase activity in hair follicles predicts response to topical minoxidil in the treatment of AGA. In the human liver, sulfotransferase activity is significantly inhibited by salicylic acid. Low dose OTC aspirin (75mg-81mg), a derivative of salicylic acid, is used by millions of people daily for the prevention of coronary heart disease and cancer...
September 18, 2018: Dermatologic Therapy
Ming-Chou Ku, Lean-San Teh, Po-Ming Chen, Ting-I Yang, Ji-Ching Lai
Androgenetic alopecia (AGA) is a common hair loss disorder, especially in men and the elderly. In this study, we analyzed the therapeutic effects of platelet-rich plasma (PRP) injections and embedded sutures in patients with AGA. In each participant, we administered different treatments in one area of hair loss that was divided into four sections. Each section received one of the following treatments: No treatment, PRP injection, suture embedding, and combined PRP injection/suture-embedded areas. The thickness of the scalp, and scalp perfusion were measured using an ultrasound imaging system and Moor FLPI full-field laser perfusion imaging system, respectively...
September 2018: Clinics in Dermatology
Karam W Badran, Jordan P Sand
Given substantial advances in hair regrowth research and platelet-rich plasma (PRP) science, a review of currently used systems and results is informative for physicians using a biologics approach to hair restoration. Overall positive clinical response to the use of PRP in androgenetic and alopecia areata patients is observed. The effects on hair density, count, and thickness were demonstrated through multiple clinical trials. Use as an adjunct to hair transplantation and with other technologies is also described...
November 2018: Facial Plastic Surgery Clinics of North America
Samer A Dhaher, Abdulla A Yacoub, Ausama Ayob Jacob
Background: Although female androgenetic alopecia (FAGA) occurs in genetically susceptible women, some trace elements may play an important role. Aim of the Study: This study aimed to evaluate serum and hair zinc and iron levels in patients with FAGA and to compare the findings with normal controls. Patients and Methods: A case-control study that was conducted at Dermatology Clinic in Basra General Hospital, Basra, Iraq. The participants were divided into two groups: The first group consisted of 27 women with FAGA and the second was age-matched 28 healthy women control group...
September 2018: Indian Journal of Dermatology
Yu Seob Shin, Keshab Kumar Karna, Bo Ram Choi, Jong Kwan Park
Finasteride is primarily used to treat benign prostatic hyperplasia (BPH) and male androgenetic alopecia (MAA). Five-alpha reductase inhibitors (5α-RIs) could induce male sexual dysfunction due to their effects on testosterone and dihydrotestosterone. There is evidence suggesting that 5α-RIs may independently increase the risk of erectile dysfunction (ED). However, many investigators believe that side effects of 5α-RIs will disappear with continuous treatment. Considerable controversy exists regarding the severity and persistence of side effects of finasteride on ED...
August 10, 2018: World Journal of Men's Health
Alexandros C Katoulis, Aikaterini I Liakou, Antigoni Alevizou, Stefanos Bonovas, Evangelia Bozi, Dimitra Kontogiorgi, Dimitrios Rigopoulos
Introduction: Androgenetic alopecia (AGA) in females is a difficult to treat skin disorder. A novel topical botanical lotion has been approved for its treatment. It acts by increasing Bcl-2, perifollicular Langerhans and mast cells, and perifollicular collagen. The aim of this study was to evaluate the efficacy and safety of this lotion in females. Methods: Forty women with AGA were randomized to apply the active lotion or placebo, twice daily for 24 weeks. Subjects were evaluated at 0, 12, and 24 weeks by clinical examination, photographic documentation, quality of life evaluation (DLQI), and trichogram (anagen to telogen ratio)...
August 2018: Skin Appendage Disorders
Nicholas John Sadgrove
ETHNOPHARMACOLOGICAL RELEVANCE: Research in the past half a century has gradually sketched the biological mechanism leading to androgenetic alopecia (AGA). Until recently the aetiological paradigm has been too limited to enable intelligent commentary on the use of folk remedies to treat or reduce the expression of this condition. However, our understanding is now at a point where we can describe how some folk remedies work, predict how effective they will be or why they fail. RESULTS: The new paradigm of AGA is that inheritance and androgens (dihydrotestosterone) are the primary contributors and a secondary pathology, microinflammation, reinforces the process at more advanced stages of follicular miniaturisation...
December 5, 2018: Journal of Ethnopharmacology
Amelia K Hausauer, Derek H Jones
BACKGROUND: Studies suggest platelet-rich plasma (PRP) may mitigate androgenetic alopecia (AGA), but each varies in the frequency of and interval between treatments. OBJECTIVE: To compare the efficacy, satisfaction, tolerability, and safety of 2 initial PRP injection protocols over 6 months. METHODS: Prospective, randomized, single-blinded trial among 40 patients with moderate AGA. Participants received subdermal PRP injections according to 1 of 2 treatment protocols: 3 monthly sessions with booster 3 months later (Group 1) or 2 sessions every 3 months (Group 2)...
September 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Osama Aa Ahmed, Waleed Y Rizq
Introduction: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness...
2018: Drug Design, Development and Therapy
Jitlada Meephansan, Nawaporn Ungpraphakorn, Saranyoo Ponnikorn, Poonkiat Suchonwanit, Yong Poovorawan
BACKGROUND: A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth. OBJECTIVE: The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with AGA...
October 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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