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Alopecia androgenetic

Jung-Won Shin, Euy-Hyun Chung, Moon-Bum Kim, Tae-Ook Kim, Woo-Il Kim, Chang-Hun Huh
Finasteride 1 mg is considered to be the standard treatment method for male androgenetic alopecia (AGA). However, there have only been a few studies investigating its long-term efficacy. Moreover, its effect on various types of AGA remains unknown. In this study, the authors investigated the 5-year efficacy of finasteride 1 mg in Korean men with AGA and analyzed the changes in hair growth according to the distribution of hair loss. The medical records of male AGA patients who were treated with oral finasteride for a period of at least 5 years at two university hospitals were retrospectively reviewed...
December 7, 2018: Journal of Dermatology
María Librada Porriño-Bustamante, Miguel Ángel López-Nevot, José Aneiros-Fernández, Elena García-Lora, María Antonia Fernández-Pugnaire, Salvador Arias-Santiago
BACKGROUND/OBJECTIVES: Frontal fibrosing alopecia (FFA) is a scarring alopecia whose prevalence is increasing. The pathogenesis of this disease is not well known. Genetic, environmental, hormonal and autoimmunity related factors have been considered; however, only a few cases of familial frontal fibrosing alopecia have been reported. MATERIAL AND METHODS: A cross-sectional study was performed at University Hospital in Granada (Spain). Twenty patients with frontal fibrosing alopecia belonging to nine different families were included, and clinical and dermoscopic features were analysed...
November 15, 2018: Australasian Journal of Dermatology
Pedro Colli Rocha Dias, Hélio Amante Miot, Ralph Michel Trüeb, Paulo Müller Ramos
No abstract text is available yet for this article.
October 2018: Skin Appendage Disorders
Lizeth Martinez-Jacobo, Claudia I Ancer-Arellano, Rocio Ortiz-Lopez, Mauricio Salinas-Santander, Cesar Daniel Villarreal-Villarreal, Jesus Ancer-Rodriguez, Bianka Camacho-Zamora, Viviana Zomosa-Signoret, Carlos E Medina-De la Garza, Jorge Ocampo-Candiani, Augusto Rojas-Martinez
Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage...
October 2018: Skin Appendage Disorders
Rupak Bishwokarma Ghimire
INTRODUCTION: Androgenetic alopecia, also known as as male pattern baldness, affects up to 50% of men and 10% females worldwide. Patients with baldness seem to have a great impact on quality of life including their self-esteem, confidence, relationship as well as work. METHODS: This is a cross-sectional descriptive study on dermatology quality of life index in patients with androgenetic alopecia who came for hair transplantation surgery at Aavaran Skin Clinic Pvt Ltd, Battisputali, Kathmandu between 15th July 2017 to 15th February 2018...
July 2018: JNMA; Journal of the Nepal Medical Association
Kathrin Neuhaus, Clemens Schiestl, Rosmarie Adelsberger, Lisa Weibel, Martin Meuli, Sophie Böttcher-Haberzeth
BACKGROUND: The scalp is the only hidden donor site for split thickness skin grafts. Nevertheless, it is underappreciated due to fear of iatrogenic scarring alopecia. Long-term data showing whether androgenetic hair loss can reveal previously hidden scarring alopecia is unavailable. We aimed to evaluate results and patient satisfaction up to 30years after skin harvest from the scalp. METHODS: Burn patients, hospitalized between 1977 and 1987 at the University Children's Hospital Zurich with scalp skin harvest and currently over 30years old, were studied...
October 15, 2018: Burns: Journal of the International Society for Burn Injuries
Gordon H Sasaki
Plastic surgeons are frequently asked to manage male- and female-pattern hair loss in their practice. This article discusses the epidemiology, pathophysiology, and current management of androgenetic alopecia and emphasizes more recent knowledge of stem cell niches in hair follicles that drive hair cycling, alopecia, and its treatment. The many treatment programs available for hair loss include newer strategies that involve the usage of growth factors, platelet-rich plasma, and fat to stimulate follicle growth...
October 15, 2018: Aesthetic Plastic Surgery
Erkin Pekmezci, Cihat Dundar, Murat Turkoglu
Background: Currently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features...
April 2018: Medical Archives
Angela Wipf, Nicholas Boysen, Maria K Hordinsky, Emily E Dando, Neil Sadick, Ronda S Farah
INTRODUCTION: Fractional lasers and microneedling devices are increasingly used with topical drugs to treat various conditions, including alopecia, as they grant access to dermal structures such as hair follicles and cutaneous vasculature. OBJECTIVE: To perform a comprehensive review on transcutaneous drug delivery for the management of alopecia. METHODS: PubMed, Embase, and Ovid Medline databases were searched using terms including: alopecia, microneedling, lasers, androgenetic alopecia (AGA), alopecia areata (AA), drug delivery...
October 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Bruno L Rodrigues, Silmara Al Montalvão, Rebeca Bb Cancela, Francesca Ar Silva, Aline Urban, Stephany C Huber, José Luiz Rc Júnior, José Fábio Sd Lana, Joyce M Annichinno-Bizzacchi
BACKGROUND: Promising results were described with platelet-rich plasma (PRP) in androgenetic alopecia that could be associated to platelet number and growth factor levels. OBJECTIVE: Analyze the platelet number and growth factor levels in PRP and its correlation with hair growth parameters evaluated by TrichoScan. METHODS: Twenty-six patients randomized to receive four subcutaneous injections of PRP or saline. Hair growth, hair density, and percentage of anagen hairs were evaluated before, after and three months after the last injection using TrichoScan method...
October 1, 2018: Journal of the American Academy of Dermatology
Tyler Werbel, Philip R Cohen
Taxane chemotherapy and adjuvant endocrine therapy are commonly used in breast cancer patients following surgery. We describe a 59-year-old woman with a triple-positive invasive right breast cancer that was treated with surgery, radiation, chemotherapy, and adjuvant hormonal therapy. She subsequently developed scalp alopecia, with histopathological features of both androgenetic alopecia and alopecia areata; the hair loss did not resolve after completion of her chemotherapy. Significant clinical improvement was observed with topical minoxidil therapy...
July 27, 2018: Curēus
Silvia Diviccaro, Silvia Giatti, Francesca Borgo, Matteo Barcella, Elisa Borghi, José Luis Trejo, Luis Miguel Garcia-Segura, Roberto Cosimo Melcangi
Persistent alteration of plasma neuroactive steroid levels associated with major depression has been recently reported in men after the suspension of the treatment for androgenetic alopecia with finasteride, an inhibitor of the enzyme 5alpha-reductase. Observations in male rats confirmed persistent alterations in neuroactive steroid levels also in the brain. In the present study, we have ascertained possible effects on depressive-like behavior, neurogenesis, gliosis, neuroinflammation and gut microbiota in male rats after subchronic treatment for 20 days with finasteride and after one month of its withdrawal...
September 18, 2018: Psychoneuroendocrinology
Burhan Ahmed, Sami Gritli
Growth retardation, Alopecia, Pseudoanodontia and Optic atrophy (GAPO) syndrome is a rare autosomal recessive condition whose cardinal features include a recognizable craniofacial dysmorphosis, growth retardation, alopecia, pseudoanodontia, and premature aging. We report on a 2-year-old Pakistani man affected with GAPO syndrome who additionally shows an androgenetic-like alopecia with normal testosterone levels and telogen hair loss. These are novel findings in GAPO syndrome.
September 25, 2018: Australasian Journal of Dermatology
Goren Andy, McCoy John, Situm Mirna, Dhurat Rachita, Krychman Michael, Kovacevic Maja, Sharma Aseem, Bolanca Zeljana
Male androgenetic alopecia (AGA) affects up to 60% of men by the age of 50. Currently, there are only two approved drugs for the treatment of male AGA: topical minoxidil and oral finasteride. Topical minoxidil is readily available over the counter and has a well-established safety record. However, following 24 weeks of treatment, less than 40% of men respond to the drug. Additionally, due to the topical route of administration, compliance with minoxidil remains low. In contrast, oral finasteride, a 5-alpha reductase inhibitor, demonstrated efficacy in arresting hair loss in more than 80% of patients following 12 months of treatment...
September 25, 2018: Dermatologic Therapy
Sophie Wang, Divya Seth, Harib Ezaldein, Raghav Tripathi, Miesha Merati, Fuad Muakkassa, Jeffrey Scott
No abstract text is available yet for this article.
September 25, 2018: Journal of Dermatological Treatment
Jessica Lin, Inga Saknite, Manuel Valdebran, Mihaela Balu, Griffin Lentsch, Joshua N Williams, Karsten Koenig, Bruce J Tromberg, Natasha Atanaskova Mesinkovska
OBJECTIVES: Non-invasive visualization of hair follicles is important for proper diagnosis and management of alopecia; however, histological assessment remains the gold standard. Laser imaging technologies have made possible noninvasive in vivo evaluation of skin and hair follicle. The aim of this study was to evaluate the ability of multiphoton microscopy (MPM) to non-invasively identify morphological features that can distinguish scarring from non-scarring alopecia. METHODS: MPM images were obtained from areas on the scalp affected by alopecia...
September 24, 2018: Lasers in Surgery and Medicine
Nicholas B Abt, Olivia Quatela, Alyssa Heiser, Nate Jowett, Oren Tessler, Linda N Lee
Importance: Androgenetic alopecia is a highly prevalent condition across both sexes and can be surgically corrected through hair transplant. Health utility scores, which represent quantitative estimates of individual preferences for a given state of health, are a measure of health-related quality of life. The health utility scores for sex-specific alopecia and the posttransplant state have not previously been quantified. Objective: To obtain health utility measurements for the objective assessment of sex-specific alopecia and hair transplant surgery and to analyze layperson perception of alopecia compared with other chronic health conditions...
September 13, 2018: JAMA Facial Plastic Surgery
A Goren, A Sharma, R Dhurat, J Shapiro, R Sinclair, M Situm, M Kovacevic, V Lukinovic Skudar, M Goldust, T Lotti, J McCoy
Topical minoxidil is the only US FDA approved OTC drug for the treatment of androgenetic alopecia (AGA). Minoxidil is a pro-drug converted into its active form, minoxidil sulfate, by the sulfotransferase enzymes in the outer root sheath of hair follicles. Previously, we demonstrated that sulfotransferase activity in hair follicles predicts response to topical minoxidil in the treatment of AGA. In the human liver, sulfotransferase activity is significantly inhibited by salicylic acid. Low-dose OTC aspirin (75-81 mg), a derivative of salicylic acid, is used by millions of people daily for the prevention of coronary heart disease and cancer...
September 18, 2018: Dermatologic Therapy
Ming-Chou Ku, Lean-San Teh, Po-Ming Chen, Ting-I Yang, Ji-Ching Lai
Androgenetic alopecia (AGA) is a common hair loss disorder, especially in men and the elderly. In this study, we analyzed the therapeutic effects of platelet-rich plasma (PRP) injections and embedded sutures in patients with AGA. In each participant, we administered different treatments in one area of hair loss that was divided into four sections. Each section received one of the following treatments: No treatment, PRP injection, suture embedding, and combined PRP injection/suture-embedded areas. The thickness of the scalp, and scalp perfusion were measured using an ultrasound imaging system and Moor FLPI full-field laser perfusion imaging system, respectively...
September 2018: Clinics in Dermatology
Karam W Badran, Jordan P Sand
Given substantial advances in hair regrowth research and platelet-rich plasma (PRP) science, a review of currently used systems and results is informative for physicians using a biologics approach to hair restoration. Overall positive clinical response to the use of PRP in androgenetic and alopecia areata patients is observed. The effects on hair density, count, and thickness were demonstrated through multiple clinical trials. Use as an adjunct to hair transplantation and with other technologies is also described...
November 2018: Facial Plastic Surgery Clinics of North America
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