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Alopecia androgenetic

Jitlada Meephansan, Nawaporn Ungpraphakorn, Saranyoo Ponnikorn, Poonkiat Suchonwanit, Yong Poovorawan
BACKGROUND: A new treatment for androgenetic alopecia (AGA) is 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth. OBJECTIVE: The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with AGA...
August 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Deepika Yadav, Sujay Khandpur, M Ramam, Manoj K Singh, Vinod K Sharma
BACKGROUND: Androgenetic alopecia (AGA) and alopecia areata (AA) are common causes of alopecia which can sometimes be difficult to differentiate clinically. Horizontal sections of scalp biopsies are used to study non-cicatricial alopecias due to the ability to perform both quantitative and morphometric analysis of hair follicles on them. METHODS: It was a prospective, cross-sectional study conducted to assess the utility of horizontal sections to differentiate between the alopecias...
August 9, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Yau-Li Huang, Mei-Ching Lee, Shyue-Luen Chang, Sindy Hu, Chun-Shin Chang, Ying-Fang Lin, Chun-Yu Cheng
BACKGROUND: The follicular unit transplantation strip harvesting surgery is one of the gold standard methods of hair transplantation; the counting follicular unit ratio and hair density is a major step in donor site evaluation. AIMS: We conducted the study for analyzing the preoperative donor site evaluation and comparison of the actual harvested and estimated follicular units in hair transplantation. PATIENTS/METHODS: In this retrospective study, we enrolled 65 male patients with androgenetic alopecia who underwent follicular unit transplantation...
August 6, 2018: Journal of Cosmetic Dermatology
Xia Wang, Chunping Xiong, Li Zhang, Bin Yang, Rongfang Wei, Liqian Cui, Xiangbin Xing
Although the association of the psychological problems and androgenetic alopecia (AGA) gained the increasing attention, the psychosocial state in college students with AGA remains unknown. We recruited a total number of 355 college students with AGA from 18 universities in Southern China for interview. The Symptom Checklist-90-R (SCL-90-R) survey was used to assess the psychological state of these students. There were significant differences in somatization, obsessive-compulsive, interpersonal sensitivity, depression, phobic anxiety, psychoticism, and global severity index (GSI) between college students with AGA and the controls...
August 2018: Medicine (Baltimore)
Bo-Kyung Kim, Solam Lee, Myeongsoo Jun, Hee-Chul Chung, Sung-Soo Oh, Won-Soo Lee
Background: Androgenetic alopecia (AGA) has a negative impact on self-image and decrease in quality of life. However, relatively few men have sought treatment for AGA. Improvement in treatment willingness is important for maintaining long-term management in patients with AGA. Objectives: We aimed to identify the prevalence of patients' perception of hair loss and evaluate various factors that affect the treatment willingness in patients with AGA. Methods: We conducted a population-based cross-sectional survey of 503 patients with AGA (329 men, 174 women)...
August 2018: Annals of Dermatology
Erkin Pekmezci, Murat Türkoğlu
Although more than three decades have passed since the first use of minoxidil in androgenetic alopecia (AGA), its mechanisms of action have still not been comprehensively understood. 5α-reductase (5α-R) has an active role as the predominant enzyme in both AGA and female pattern hair loss (FPHL), which are also the main therapeutic indications of topical minoxidil. But there is insufficient literature data regarding the interaction of minoxidil and the enzyme 5α-R. Herein, we studied the in vitro expression levels of 5α-R type 2 (5α-R2) in a minoxidil-treated human keratinocyte cell line (HaCaT) in order to elucidate the relation of these two parameters...
December 2017: Acta Dermatovenerologica Croatica: ADC
Rupak Bishwokarma Ghimire
INTRODUCTION: Hair transplant surgery is a minimally invasive surgery, where hair follicle is transplanted from donor area of patient's own body to the desired area. METHODS: Patient with hair transplant surgery from a clinic were followed up for one year. The patients were asked for their complications within 2 days, 7 days, one month, 2 to 6 months and one year for assessment of results, side effects. At the end of one-year, subjective evaluation was done with patient's satisfaction to growth as- poor growth, satisfactory and good growth...
January 2018: JNMA; Journal of the Nepal Medical Association
Yohei Tanaka, Toru Aso, Jumpei Ono, Ryu Hosoi, Takuto Kaneko
Background: Androgenetic alopecia (AGA) is a common form of hair loss in Asian men. Although AGA is often regarded as a relatively minor dermatological condition, hair loss can impact self-image and is a main cause for anxiety and depression in some men. We have treated patients with AGA for seven years. Objective: The goal of this study was to evaluate the effectiveness of our combination therapy in Asian men with AGA. Participants: Between the years 2011 and 2017, 18,918 male patients were treated in our center...
July 2018: Journal of Clinical and Aesthetic Dermatology
Giovanni Schiavone, Andrea Paradisi, Francesco Ricci, Damiano Abeni
BACKGROUND: The role of enriched autologous plasmas in androgenetic alopecia (AGA) management is emerging in recent literature. OBJECTIVE: In this prospective study, the authors aimed to confirm that the induction of a minor local trauma immediately followed by injections of an enriched plasma made of a strongly concentrated platelet fraction, a robust white cell presence, concentrated fibrinogen, and other plasma proteins (injectable leukocyte platelet-rich fibrin [iL-PRF]) could be able to produce positive clinical results in patients with AGA...
July 17, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Soha S Tawfik, Osama A Sorour, Aly F Alariny, Eman H Elmorsy, Hoda Moneib
BACKGROUND: Androgenetic alopecia or female pattern hair loss is the condition that most commonly leads to hair loss in adult females. The trichoscope is used for the early diagnosis of the disease. The study aims at finding a possible association between trichoscopic signs and disease severity in dark-skinned females. METHODS: This was an observational study involving trichoscopic examination of 129 females with different hair disorders. RESULTS: Clinical and trichoscopic examination revealed 79 patients with androgenetic alopecia...
July 25, 2018: International Journal of Dermatology
Erkin Pekmezci, Murat Turkoğlu, Hilal Gökalp, Zekayi Kutlubay
Introduction: Minoxidil has been used topically to stimulate hair growth for male androgenetic alopecia (AGA) for more than 3 decades. It is currently being used for female AGA and alopecia areata (AA) as well. Although much time has passed since its first use, our understanding of its mechanism of action is highly limited. Therefore, we examined the inflammatory properties of AGA and AA, two entities in which minoxidil is being used as a therapeutic agent. We investigated the in vitro expression levels of cytokine interleukin-1 alpha (IL-1α), a potent inhibitor of hair growth, in minoxidil-treated human keratinocyte (HaCaT) cells to determine whether this molecule exerts anti-inflammatory effects...
May 2018: International Journal of Trichology
Gita Faghihi, Samaneh Mozafarpoor, Ali Asilian, Fatemeh Mokhtari, Alireza Asemi Esfahani, Behzad Bafandeh, Saeid Nouraei, Mohammad Ali Nilforoushzadeh, Seyed Mohsen Hosseini
Background: Androgenetic alopecia is the commonest type of alopecia affecting over half of men and women. Lowlevel light therapy is a new technique for stimulating hair growth in both genders. Aims: To overcome the shortcomings of previous epidemiological studies and a lack of controlled clinical trials on the subject, this study compared the effectiveness of adding lowlevel light therapy to minoxidil topical solution in the treatment of androgenetic alopecia in patients presenting to two skin clinics in Isfahan, Iran during 2014-2015...
July 16, 2018: Indian Journal of Dermatology, Venereology and Leprology
Lara M Hochfeld, Andreas Keller, Thomas Anhalt, Nadine Fricker, Markus M Nöthen, Stefanie Heilmann-Heimbach
No abstract text is available yet for this article.
July 13, 2018: Journal of Investigative Dermatology
Ortensia Ilaria Parisi, Luca Scrivano, Fabio Amone, Rocco Malivindi, Mariarosa Ruffo, Anna Francesca Vattimo, Vincenzo Pezzi, Francesco Puoci
Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract...
July 12, 2018: Journal of Functional Biomaterials
Alireza Mohebipour, Serena Gianfaldoni, Torello Lotti, Marigdalia K Ramirez-Fort, Christopher S Lange, Homayoun Sadeghi-Bazargani, Uwe Wollina, Georgi Tchernev, Amir Feily
BACKGROUND: Hair transplantation has enhanced the realm of procedural dermatology. Before the advent of follicular transplantation, androgenetic alopecia was a difficult disease to manage, as there is a limited armamentarium of topical and systemic pharmaceuticals. However, as with other novel surgical procedures, there is a steep learning curve, that may result in poor transplantation or cosmesis. CASE REPORT: We present a case of androgenetic alopecia, where previously, poorly implanted hairs were recycled by follicular unit extraction to increase hair density at the vertex of the scalp, which resulted in improved cosmesis and patient satisfaction...
June 20, 2018: Open Access Macedonian Journal of Medical Sciences
P Suchonwanit, P Srisuwanwattana, N Chalermroj, S Khunkhet
BACKGROUND: The synergism of combined use between oral finasteride and topical minoxidil has been established in treating androgenetic alopecia among men. However, the concern regarding adverse effects of finasteride use has been rising. OBJECTIVE: To compare the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in men with androgenetic alopecia. METHODS: Forty men aged 18-60 years with androgenetic alopecia were randomized to 24 weeks of treatment with a finasteride/minoxidil or minoxidil solution twice daily...
July 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Sabrina Mai-Yi Fan, Yu-Pin Cheng, Ming-Yung Lee, Sung-Jan Lin, Hsien-Yi Chiu
BACKGROUND: Previous studies have reported the benefits of low-level/light laser therapy (LLLT) for the promotion of hair regrowth. However, the effectiveness of LLLT for the treatment of androgenetic alopecia (AGA) is still a topic of debate. OBJECTIVE: To investigate the efficacy and safety of LLLT on hair regrowth in patients with AGA. METHODS: This 24-week, randomized, double-blind, self-comparison, sham device-controlled trial enrolled 100 patients with AGA...
June 27, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Erkin Pekmezci, Cihat Dündar, Murat Türkoğlu
INTRODUCTION: Currently there are only a limited number of drugs available for treatment of androgenetic alopecia and telogen effluvium. However, certain plants and their standardized extracts may provide some clinical benefits against hair loss. We formulated a herbal shampoo and a solution to evaluate their efficacy, safety, and synergy in hair loss. METHODS: We conducted a randomized, placebo-controlled, single-blind, clinical and instrumental study for 6 months on 120 subjects with androgenetic alopecia and telogen effluvium, confirmed by pull test and phototricogram...
June 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
K C Dharam Kumar, Yadalla Hari Kishan Kumar, Vivekananda Neladimmanahally
Background: Androgenetic alopecia (AGA) is the most common cause of hair loss. Although it is a medically benign condition, it can have a significant psychosocial impact on patients. "Metabolic syndrome" (MetS) is a collection of clinical signs that focus on cardiovascular and diabetes-related parameters. Despite the high burden of AGA and MetS in India, specific data on the participants are relatively sparse. Aim of the Study: The aim of is to study the association of AGA with MetS and its parameters...
March 2018: Indian Journal of Endocrinology and Metabolism
Eduardo Anitua, Ander Pino, Pedro Jaén, Mª Rogelia Navarro
Platelet-rich plasma (PRP) and autologous protein-based treatments have recently emerged as a potential therapeutic approach for hair loss-related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs...
June 14, 2018: Journal of Cosmetic Dermatology
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