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https://www.readbyqxmd.com/read/28527522/precision-medicine-genomic-profiles-to-individualize-therapy
#1
REVIEW
Oscar E Streeter, Phillip J Beron, Prashant Natarajan Iyer
Precision medicine is the application of genotypic and Omics biomarkers to determine the most appropriate, outcome-driven therapy for individual patients. To determine the best choice of therapy, institutions use significant information technology-enabled data from imaging, electronic medical records, sensors in the clinic/hospitals, and wearable sensors to determine treatment response. With genomic profiling, targets to affect a disease course are continuing to be developed. As clonal mutational prevalence continues to be understood, information can be communicated to patients to inform them that resistance is common, requiring collection of more genetic mutations from patients with further biopsies or blood collection...
May 17, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28523760/bioinspired-composite-microfibers-for-skin-adhesion-and-signal-amplification-of-wearable-sensors
#2
Dirk-M Drotlef, Morteza Amjadi, Muhammad Yunusa, Metin Sitti
A facile approach is proposed for superior conformation and adhesion of wearable sensors to dry and wet skin. Bioinspired skin-adhesive films are composed of elastomeric microfibers decorated with conformal and mushroom-shaped vinylsiloxane tips. Strong skin adhesion is achieved by crosslinking the viscous vinylsiloxane tips directly on the skin surface. Furthermore, composite microfibrillar adhesive films possess a high adhesion strength of 18 kPa due to the excellent shape adaptation of the vinylsiloxane tips to the multiscale roughness of the skin...
May 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28520781/physical-activity-and-sedentary-behaviour-in-daily-life-a-comparative-analysis-of-the-global-physical-activity-questionnaire-gpaq-and-the-sensewear-armband
#3
Michelle Laeremans, Evi Dons, Ione Avila-Palencia, Glòria Carrasco-Turigas, Juan Pablo Orjuela, Esther Anaya, Christian Brand, Tom Cole-Hunter, Audrey de Nazelle, Thomas Götschi, Sonja Kahlmeier, Mark Nieuwenhuijsen, Arnout Standaert, Patrick De Boever, Luc Int Panis
Reduction of sedentary time and an increase in physical activity offer potential to improve public health. However, quantifying physical activity behaviour under real world conditions is a major challenge and no standard of good practice is available. Our aim was to compare the results of physical activity and sedentary behaviour obtained with a self-reported instrument (Global Physical Activity Questionnaire (GPAQ)) and a wearable sensor (SenseWear) in a repeated measures study design. Healthy adults (41 in Antwerp, 41 in Barcelona and 40 in London) wore the SenseWear armband for seven consecutive days and completed the GPAQ on the final day...
2017: PloS One
https://www.readbyqxmd.com/read/28518079/a-method-for-quantifying-upper-limb-performance-in-daily-life-using-accelerometers
#4
Catherine E Lang, Kimberly J Waddell, Joseph W Klaesner, Marghuretta D Bland
A key reason for referral to rehabilitation services after stroke and other neurological conditions is to improve one's ability to function in daily life. It has become important to measure a person's activities in daily life, and not just measure their capacity for activity in the structured environment of a clinic or laboratory. A wearable sensor that is now enabling measurement of daily movement is the accelerometer. Accelerometers are commercially-available devices resembling large wrist watches that can be worn throughout the day...
April 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28513545/a-study-on-immersion-and-presence-of-a-portable-hand-haptic-system-for-immersive-virtual-reality
#5
Mingyu Kim, Changyu Jeon, Jinmo Kim
This paper proposes a portable hand haptic system using Leap Motion as a haptic interface that can be used in various virtual reality (VR) applications. The proposed hand haptic system was designed as an Arduino-based sensor architecture to enable a variety of tactile senses at low cost, and is also equipped with a portable wristband. As a haptic system designed for tactile feedback, the proposed system first identifies the left and right hands and then sends tactile senses (vibration and heat) to each fingertip (thumb and index finger)...
May 17, 2017: Sensors
https://www.readbyqxmd.com/read/28512341/a-new-paradigm-in-sweat-based-wearable-diagnostics-biosensors-using-room-temperature-ionic-liquids-rtils
#6
Rujuta D Munje, Sriram Muthukumar, Badrinath Jagannath, Shalini Prasad
Successful commercialization of wearable diagnostic sensors necessitates stability in detection of analytes over prolonged and continuous exposure to sweat. Challenges are primarily in ensuring target disease specific small analytes (i.e. metabolites, proteins, etc.) stability in complex sweat buffer with varying pH levels and composition over time. We present a facile approach to address these challenges using RTILs with antibody functionalized sensors on nanoporous, flexible polymer membranes. Temporal studies were performed using both infrared spectroscopic, dynamic light scattering, and impedimetric spectroscopy to demonstrate stability in detection of analytes, Interleukin-6 (IL-6) and Cortisol, from human sweat in RTILs...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28504674/printable-elastic-conductors-by-in-situ-formation-of-silver-nanoparticles-from-silver-flakes
#7
Naoji Matsuhisa, Daishi Inoue, Peter Zalar, Hanbit Jin, Yorishige Matsuba, Akira Itoh, Tomoyuki Yokota, Daisuke Hashizume, Takao Someya
Printable elastic conductors promise large-area stretchable sensor/actuator networks for healthcare, wearables and robotics. Elastomers with metal nanoparticles are one of the best approaches to achieve high performance, but large-area utilization is limited by difficulties in their processability. Here we report a printable elastic conductor containing Ag nanoparticles that are formed in situ, solely by mixing micrometre-sized Ag flakes, fluorine rubbers, and surfactant. Our printable elastic composites exhibit conductivity higher than 4,000 S cm(-1) (highest value: 6,168 S cm(-1)) at 0% strain, and 935 S cm(-1) when stretched up to 400%...
May 15, 2017: Nature Materials
https://www.readbyqxmd.com/read/28503062/contraction-sensing-with-smart-braid-mckibben-muscles
#8
Wyatt Felt, Khai Yi Chin, C David Remy
The inherent compliance of soft fluidic actuators makes them attractive for use in wearable devices and soft robotics. Their flexible nature permits them to be used without traditional rotational or prismatic joints. Without these joints, however, measuring the motion of the actuators is challenging. Actuator-level sensors could improve the performance of continuum robots and robots with compliant or multi-degree-of-freedom joints. We make the reinforcing braid of a pneumatic artificial muscle (PAM or McKibben muscle) "smart" by weaving it from conductive, insulated wires...
June 2016: IEEE/ASME Transactions on Mechatronics
https://www.readbyqxmd.com/read/28498233/wearable-sensor-technology-efficacy-in-peripheral-vascular-disease-wstep-a-randomized-controlled-trial
#9
Pasha Normahani, Richard Kwasnicki, Colin Bicknell, Louise Allen, Mike P Jenkins, Richard Gibbs, Nicholas Cheshire, Ara Darzi, Celia Riga
OBJECTIVE: To evaluate the effect of using wearable activity monitors (WAMs) in patients with intermittent claudication (IC) within a single-center randomized controlled trial. BACKGROUND: WAMs allow users to set daily activity targets and monitor their progress. They may offer an alternative treatment to supervised exercise programs (SEPs) for patients with IC. METHODS: Thirty-seven patients with IC were recruited and randomized into intervention or control group...
May 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28496101/stretchable-twisted-conductive-microtubules-for-wearable-computing-robotics-electronics-and-healthcare
#10
Thanh Nho Do, Yon Visell
Stretchable and flexible multifunctional electronic components, including sensors and actuators, have received increasing attention in robotics, electronics, wearable, and healthcare applications. Despite advances, it has remained challenging to design analogs of many electronic components to be highly stretchable, to be efficient to fabricate, and to provide control over electronic performance. Here, we describe highly elastic sensors and interconnects formed from thin, twisted conductive microtubules. These devices consist of twisted assemblies of thin, highly stretchable (>400%) elastomer tubules filled with liquid conductor (eutectic gallium indium, EGaIn), and fabricated using a simple roller coating process...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494321/objective-assessment-of-movement-competence-in-children-using-wearable-sensors-an-instrumented-version-of-the-tgmd-2-locomotor-subtest
#11
Maria Cristina Bisi, G Pacini Panebianco, R Polman, R Stagni
Movement competence (MC) is defined as the development of sufficient skill to assure successful performance in different physical activities. Monitoring children MC during maturation is fundamental to detect early minor delays and define effective intervention. To this purpose, several MC assessment batteries are available. When evaluating movement strategies, with the aim of identifying specific skill components that may need improving, widespread MC assessment is limited by high time consumption for scoring and the need for trained operators to ensure reliability...
April 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28485567/stretchable-transparent-and-stretch-unresponsive-capacitive-touch-sensor-array-with-selectively-patterned-silver-nanowires-reduced-graphene-oxide-electrodes
#12
Taeyoung Choi, Byeong-Ung Hwang, Bo-Yeong Kim, Tran Quang Trung, Yun Hyoung Nam, Do-Nyun Kim, Kilho Eom, Nae-Eung Lee
Stretchable and transparent touch sensors are essential input devices for future stretchable transparent electronics. Capacitive touch sensors with a simple structure of only two electrodes and one dielectric are an established technology in current rigid electronics. However, the development of stretchable and transparent capacitive touch sensors has been limited due to changes in capacitance resulting from dimensional changes in elastomeric dielectrics and difficulty in obtaining stretchable transparent electrodes that are stable under large strains...
May 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28485457/a-wearable-strain-sensor-based-on-a-carbonized-nano-sponge-silicone-composite-for-human-motion-detection
#13
Xiao-Guang Yu, Yuan-Qing Li, Wei-Bin Zhu, Pei Huang, Tong-Tong Wang, Ning Hu, Shao-Yun Fu
Melamine sponge, also known as nano-sponge, is widely used as an abrasive cleaner in our daily life. In this work, the fabrication of a wearable strain sensor for human motion detection is first demonstrated with a commercially available nano-sponge as a starting material. The key resistance sensitive material in the wearable strain sensor is obtained by the encapsulation of a carbonized nano-sponge (CNS) with silicone resin. The as-fabricated CNS/silicone sensor is highly sensitive to strain with a maximum gauge factor of 18...
May 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28485447/flexible-and-transparent-strain-sensors-based-on-super-aligned-carbon-nanotube-films
#14
Yang Yu, Yufeng Luo, Alexander Guo, Lingjia Yan, Yang Wu, Kaili Jiang, Qunqing Li, Shoushan Fan, Jiaping Wang
Highly flexible and transparent strain sensors are fabricated by directly coating super-aligned carbon nanotube (SACNT) films on polydimethylsiloxane (PDMS) substrates. The fabrication process is simple, low cost, and favorable for industrial scalability. The SACNT/PDMS strain sensors present a high sensing range of 400%, a fast response of less than 98 ms, and a low creep of 4% at 400% strain. The SACNT/PDMS strain sensors can withstand 5000 stretching-releasing cycles at 400% strain. Moreover, the SACNT/PDMS strain sensors are transparent with 80% transmittance at 550 nm...
May 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28482892/a-preliminary-investigation-into-the-design-of-pressure-cushions-and-their-potential-applications-for-forearm-robotic-orthoses
#15
N Alavi, S Zampierin, M Komeili, S Cocuzza, S Debei, C Menon
BACKGROUND: Load cells are often used in rehabilitation robotics to monitor human-robot interaction. While load cells are accurate and suitable for the stationary end-point robots used in rehabilitation hospitals, their cost and inability to conform to the shape of the body hinder their application in developing affordable and wearable robotic orthoses for assisting individuals in the activities of daily living. This exploratory work investigates the possibility of using an alternative technology, namely compliant polymeric air cushions, to measure interaction forces between the user and a wearable rigid structure...
May 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28481252/wearable-contactless-respiration-sensor-based-on-multi-material-fibers-integrated-into-textile
#16
Philippe Guay, Stepan Gorgutsa, Sophie LaRochelle, Younes Messaddeq
In this paper, we report on a novel sensor for the contactless monitoring of the respiration rate, made from multi-material fibers arranged in the form of spiral antenna (2.45 GHz central frequency). High flexibility of the used composite metal-glass-polymer fibers permits their integration into a cotton t-shirt without compromising comfort or restricting movement of the user. At the same time, change of the antenna geometry, due to the chest expansion and the displacement of the air volume in the lungs, is found to cause a significant shift of the antenna operational frequency, thus allowing respiration detection...
May 6, 2017: Sensors
https://www.readbyqxmd.com/read/28479561/a-hybrid-algorithm-for-fall-detection
#17
Serkan Turkeli, Fikri Elmas, Huseyin Tanzer Atay, Kenan Kaan Kurt, Remzi Yalın Sonmez
Falling is a major problem among the people globally, frequently due to some health problems including vision loss or balance disorder as a consequence of aging. As a result of the falling in elder people; injuries, complications, neurological problems and mortality are generally occurred. This situation also affects the patients' families psychologically. A large number of studies show that significant fractures, injuries and in some cases death are commonly encountered in elderly. Nonetheless, in the immediate intervention, the rate of damage is reduced and the life quality can be significantly restored...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28479557/architecture-and-user-context-models-of-cocare-a-context-aware-mobile-recommender-system-for-health-promotion
#18
Gineth Cerón-Rios, Diego M López, Bernd Blobel
Recommender systems (RS) are useful tools for filtering and sorting items and information for users. There is a wide diversity of approaches that help creating personalized recommendations. Context-aware recommender systems (CARS) are a kind of RS which provide adaptation capabilities to the user's environment, e.g., by sensing data through wearable devices or other biomedical sensors. In healthcare and wellbeing, CARS can support health promotion and health education, considering that each individual requires tailored intervention programs...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28475106/flexible-electronics-compatible-non-enzymatic-glucose-sensing-via-transparent-cuo-nanowire-networks-on-pet-films
#19
Caroline Bell, Abdullah Nammari, Pranay Uttamchandani, Amit Rai, Pujan Shah, Arden Moore
Diabetic individuals need simple, accurate, and cost effective means by which to independently assess their glucose levels in a non-invasive way. In this work, a sensor based on randomly oriented CuO nanowire networks supported by a polyethylene terephthalate thin film is evaluated as a flexible, transparent, non-enzymatic glucose sensing system analogous to those envisioned for future wearable diagnostic devices. The amperometric sensing characteristics of this type of device architecture are evaluated both before and after bending, with the system's glucose response, sensitivity, lower limit of detection, and effect of applied bias being experimentally determined...
May 5, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28474793/3d-printed-stretchable-tactile-sensors
#20
Shuang-Zhuang Guo, Kaiyan Qiu, Fanben Meng, Sung Hyun Park, Michael C McAlpine
The development of methods for the 3D printing of multifunctional devices could impact areas ranging from wearable electronics and energy harvesting devices to smart prosthetics and human-machine interfaces. Recently, the development of stretchable electronic devices has accelerated, concomitant with advances in functional materials and fabrication processes. In particular, novel strategies have been developed to enable the intimate biointegration of wearable electronic devices with human skin in ways that bypass the mechanical and thermal restrictions of traditional microfabrication technologies...
May 5, 2017: Advanced Materials
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