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Cholesterol treatment

Murat Albayrak, Abdulkerim Yıldız, Neşe Ateş, Çiğdem Pala
INTRODUCTION: Different modalities of low-density lipoprotein (LDL) apheresis are used to treat patients with familial hypercholesterolemia (FH). The aim of this study was to describe the efficacy of the Double Filtration Plasmapheresis (DFPP) method for FH cases in our hands and to compare with other LDL apheresis techniques. MATERIALS AND METHODS: This retrospective study was conducted between January 2016 and January 2018 in the University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Adult Hematology Clinic and Therapeutic Apheresis Unit...
December 5, 2018: Transfusion and Apheresis Science
Tara Nicole Downs
Alzheimer's disease is becoming more predominant in our aging population. Statin medications have been reported to contribute to cognitive impairment. Updated cholesterol treatment guidelines significantly increase the proportion of people eligible for treatment with statins. Therefore, uncommon adverse effects related to this medication class have the potential to impact health care by increasing cognitive impairment and/or contributing to statin treatment avoidance. CASE : An 83-year-old Caucasian male was seen in a cognitive evaluation clinic for noticeable memory decline...
December 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Nausheen Nazir, Muhammad Zahoor, Mohammad Nisar, Imran Khan, Nasiara Karim, Heba Abdel-Halim, Akhtar Ali
BACKGROUND: The fruit of Elaeagnus umbellata has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antioxidant, enzyme inhibitory and antidiabetic potential of Elaeagnus umbellata. METHODS: The antioxidant potential of the crude extract and subfractions of E. umbellata fruit were determined using DPPH (2, 20-diphenyl-1-picrylhydrazyl) and ABTS (2, 2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) assays. The enzyme inhibitory potentials of extracts against α-amylase and α-glucosidase enzymes were also determined...
December 13, 2018: BMC Complementary and Alternative Medicine
Raquel T Lima, Diana Sousa, Ana Sara Gomes, Nuno Mendes, Rune Matthiesen, Madalena Pedro, Franklim Marques, Madalena M Pinto, Emília Sousa, M Helena Vasconcelos
The search for novel anticancer small molecules and strategies remains a challenge. Our previous studies have identified TXA1 (1-{[2-(diethylamino)ethyl]amino}-4-propoxy-9H- thioxanthen-9-one) as a hit compound, with in vitro antitumor potential by modulating autophagy and apoptosis in human tumor cell lines. In the present study, the mechanism of action and antitumor potential of the soluble salt of this molecule (TXA1.HCl) was further investigated using in vitro and mouse xenograft tumor models of NSCLC. Our results showed that TXA1...
December 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhenxian Qin, Wei Wang, Dengqun Liao, Xiaoying Wu, Xian'en Li
Diabetes is a worldwide severe health issue which causes various complications. This study aimed to evaluate the hypoglycemic effects of Rehmannia glutinosa (RG), Coptis chinensis (CC) alone and their combination on high-fat-diet-induced diabetes in mice via biochemical assays and UPLC-Q/TOF-MS-based serum metabolomic analysis. Diabetic KK-Ay mice were induced by high-fat diet and treated for eight weeks, separately with RG, CC and their combination and the positive control drug metformin. Administration of RG and CC alone, and their combination could decrease the fasting blood glucose level, ameliorate the tolerance of glucose, and recover the levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in sera of diabetic mice...
December 11, 2018: International Journal of Molecular Sciences
Xue-Wen Li, Hui-Ping Chen, Ying-Yan He, Wei-Li Chen, Jian-Wen Chen, Lu Gao, Hai-Yan Hu, Jun Wang
Dendrobium is a traditional Chinese herb with anti-diabetic effects and has diverse bibenzyls as well as phenanthrenes. Little is known about Dendrobium polyphenols anti-diabetic activities, so, a rich-polyphenols extract of D. loddigesii (DJP) was used for treatment of diabetic db/db mice; the serum biochemical index and tissue appearance were evaluated. In order to gain an insight into the anti-diabetic mechanism, the oxidative stress index, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and gut microbiota modulation were determined by ELISA, immunohistochemistry or high throughput sequencing 16S rRNA gene...
December 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Vinay Narwal, Ritu Deswal, Bhawna Batra, Vijay Kalra, Ritu Hooda, Minakshi Sharma, J S Rana
Cholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. It is a necessary constituent of cell membranes, it acts as a precursor for the synthesis of steroid hormones, vitamin D, and bile acids. Cholesterol is transported in plasma primarily in the form of low-density lipoproteins (LDL), the principal route for its removal from tissues to the liver is in high-density lipoproteins (HDL), followed by excretion in the bile. Cholesterol level is less than 200 mg/dL in healthy persons...
December 10, 2018: Steroids
Chuntida Kamalashiran, Sombat Muengtaweepongsa, Junya Pattaraarchachai, Kusuma Sriyakul
BACKGROUND: Dementia is a common medical disorder in elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. We investigate neuroprotective effects of perilla seed oil as an additional treatment in patients with mild to moderate dementia. METHOD: A double-blind, randomized-control trial (perilla seed oil versus placebo) in patients with mild to moderate dementia was conducted...
December 12, 2018: Current Alzheimer Research
Daisuke Uehara, Yosuke Seki, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Ken Sato, Masanobu Yamada, Toshio Uraoka, Kazunori Kasama
BACKGROUND: Patients with morbid obesity are complicated with metabolic diseases and have a high incidence of non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH). METHODS: We report on a follow-up study of a cohort included 102 obese patients (55 males and 47 females, mean age 42.9 ± 10.6 years) undergoing bariatric surgery for the management of morbid obesity. Abdominal computed tomography was performed before and 1 year after surgery...
December 12, 2018: Obesity Surgery
Bin Huang, Shenju Yan, Chao Chen, Shandong Ye
BACKGROUND: Various studies have reported a lower Helicobacter pylori eradication rate and a more frequent reinfection rate in type 2 diabetes mellitus (T2DM). Vitamin D has anti-inflammatory and immunoregulatory activity and the role of the vitamin D receptor (VDR) in the antimicrobial activity against H. pylori has been reported. When it comes to the risk factors of H. pylori eradication, the function of vitamin D is not always taken into account. The aim of this study was to assess the role of 25-hydroxyvitamin D in H...
December 12, 2018: Wiener Klinische Wochenschrift
Marek M Nagiec, Jeremy R Duvall, Adam P Skepner, Eleanor A Howe, Jessica Bastien, Eamon Comer, Jean-Charles Marie, Stephen E Johnston, Joseph Negri, Michelle Eichhorn, Julien Vantourout, Clary Clish, Kiran Musunuru, Michael Foley, Jose R Perez, Michelle A J Palmer
Increased expression of the Tribbles pseudokinase 1 gene ( TRIB1 ) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We identified a class of tricyclic glycal core-based compounds that upregulate TRIB1 expression in human HepG2 cells and phenocopy the effects of genetic TRIB1 overexpression as they inhibit expression of triglyceride synthesis genes and ApoB secretion in cells...
November 1, 2018: MedChemComm
Wei He, Qingguang Wang, Lujun Gu, Lingling Zhong, Dinghua Liu
Single-nucleotide polymorphisms (SNPs) play an important role in our susceptibility to disease, the severity of illness and the way our body responds to treatment. This study evaluated the impact of three polymorphisms on the susceptibility and functional outcome of ischemic stroke (IS). Three hundred and eight patients and 300 healthy volunteers were enrolled. Polymorphisms of NOX4 rs11018628, MTHFR rs1801133 and NEIL3 rs12645561 were detected in both groups. Smoking (P<0.001), drinking (P<0.001), hypertension (P<0...
December 2018: Experimental and Therapeutic Medicine
Xiao-Nan Li, Lu-Yi Ma, Hong Ji, Yuan-Hua Qin, Shan-Shan Jin, Li-Xin Xu
The aim of the present study was to investigate the potential mechanism underlying the anti-obesity-asthmatic effects of resveratrol (RSV) in a rat model of obese-asthma. Rat models of obesity and asthma were established using a high-fat diet and the administration of ovalbumin, respectively. Rats were divided into 7 different groups: A normal control, a normal obese, a normal asthma, a normal obese + asthma, a RSV obese, a RSV asthma and a RSV obese + asthma group. Body weight, Lee index, body fat and lung histopathological changes were evaluated...
December 2018: Experimental and Therapeutic Medicine
Hanfang Mei, Jianhua Xu, Yinru He, Xia Yang, Wenbin Liu, Wei Tian, Y U Zeng, Jiayong Zhu
The study was designed to explore the beneficial effect of Musca domestica larvae extract (MDLE) on a metabolic disorder using a diabetic rat model. Streptozotocin-induced diabetic rats were treated with or without MDLE. Blood glucose, insulin levels, lipid profiles, and oxidative stress markers were measured. The morphological changes in the pancreas and liver were determined, as well as insulin expression. The expression of glucose transporter 4 (GLUT4), phospho-adenosine monophosphate-activated protein kinase (p-AMPK)/total AMPK, superoxide dismutase 1 (SOD1), catalase (CAT), and peroxisome proliferator-activated receptor gamma (PPARγ) were detected...
December 2018: Journal of Biosciences
Gabrielle Pastenkos, Jonathan L Miller, Suzanne M Pritchard, Anthony V Nicola
Bovine herpesvirus 1 (BoHV-1) is an alphaherpesvirus that causes disease in cattle populations worldwide. Sphingomyelin (SM) is the most abundant sphingolipid in the mammalian cell membrane, where it preferentially associates with cholesterol to form lipid raft domains. SM is a substrate for the lysosome-resident enzyme acid sphingomyelinase, which plays a role in cell membrane repair following injury. Treatment of cells with noncytotoxic concentrations of Staphylococcus aureus -derived sphingomyelinase successfully reduced cell surface-exposed sphingomyelin, but did not significantly inhibit BoHV-1 entry and infection as measured by beta-galactosidase reporter assay...
December 12, 2018: Journal of Virology
Ning Meng, Yan Gong, Jiefeng Zhang, Xin Mu, Zhimei Song, Runliang Feng, Hua Zhang
Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E-/- mice. Our results demonstrated that the Cur-NPs significantly decreased atherosclerotic lesion areas and were more effective in stabilizing vulnerable plaques compared with free curcumin...
December 12, 2018: Journal of Biomaterials Applications
Wild Alexander, Holasová Juliana, Králiková Eva
BACKGROUND: Although chylothorax is rare in patients with malignant lymphoma, it has been reported in cases with mediastinal lymphadenopathy, a bulky retroperitoneal mass, or thoracic ducts blocked by lymphocytes in chronic lymphocytic leukemia (CLL). The clinical picture is not specific. Patients become more immunocompromised and malnourished after repeated evacuations. Chylothorax is usually diagnosed when the triglyceride level is > 1.24 mmol/l and the cholesterol level is < 5...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang
Disorders of lipid metabolism and inflammation play an important role in atherosclerosis. LongShengZhi capsule (LSZ), a Chinese herbal medicine, has been used for treatment of patients with vascular diseases for many years. Herein, we determined the effect of LSZ on the progression of established atherosclerotic lesions in apoE deficient (apoE) mice. ApoE mice were pre-fed high-fat diet (HFD) for 8 weeks to induce atherosclerosis, then started with LSZ treatment contained in HFD for 10 weeks. Although LSZ had little effect on HFD-induced hypercholesterolemia, it substantially reduced en face and sinus aortic lesions...
December 10, 2018: Journal of Cardiovascular Pharmacology
Arman Qamar, Robert P Giugliano, Anthony C Keech, Julia F Kuder, Sabina A Murphy, Christopher E Kurtz, Scott M Wasserman, Peter S Sever, Terje R Pedersen, Marc S Sabatine
Importance: Little is known about the heterogeneity in low-density lipoprotein cholesterol levels (LDL-C) lowering with proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor medications. Objective: To evaluate the interindividual variability in LDL-C reduction with the PCSK9 inhibitor drug evolocumab. Design, Setting, and Participants: We examined the percentage change in LDL-C levels from baseline in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, a placebo-controlled randomized clinical trial of the PCSK9 inhibitor evolocumab in patients with stable atherosclerotic cardiovascular disease who were taking statin medications...
December 12, 2018: JAMA Cardiology
Morad Hebi, Lhoussaine Hajji, Mohamed Eddouks
OBJECTIVE: The present study was carried out in order to evaluate the antidiabetic and antihyperlipidemic potential of flavonoid-rich extract of Tamarix articulata (FRETA) in both normal and streptozotocin (STZ)-induced diabetic rats. MATERIAL AND METHODS: Normal and diabetic rats were treated with the FRETA for 7 days. At the end of treatment, a range of parameters were tested including blood lipid profile, histopathological changes in both liver and pancreas and oral glucose tolerance test (OGTT)...
December 11, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
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