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Involuntary weight loss

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https://www.readbyqxmd.com/read/28764647/relationship-between-oral-health-and-fried-s-frailty-criteria-in-community-dwelling-older-persons
#1
Benedikta Kamdem, Laurence Seematter-Bagnoud, Fabiana Botrugno, Brigitte Santos-Eggimann
BACKGROUND: Oral health and frailty might be linked through several pathways, but previous studies are scarce. This study examined the association between oral health and components of Fried's frailty phenotype. METHODS: This cross-sectional analysis was based on a sample of 992 community-dwelling persons aged 73 to 77 years observed in the 2011 follow-up of the Lausanne 65+ cohort (Lc65+) study. Data were collected through annual mailed questionnaires, interview and physical examination...
August 1, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28760658/frailty-body-composition-and-nutritional-status-in-non-institutionalised-elderly
#2
Leonel São Romão Preto, Maria do Carmo Dias Conceição, Telma Martins Figueiredo, Maria Augusta Pereira Mata, Pedro Miguel Barreira Preto, Ester Mateo Aguilar
OBJECTIVE: Frailty is a clinical syndrome characterized, among other signs, by involuntary weight loss and decreased muscle strength. The aim of this study was to analyse associations between frailty, body composition and nutritional status in non-institutionalised elderly people in the municipality of Alfândega (Braganza-Portugal). METHOD: Observational, prevalence and association study involving 220 elderly (mean 75.8±6.8 years of age; 68.8% women). Frailty was assessedt according to Fried criteria, body composition by bioelectrical impedance analysis and nutritional status using the Mini Nutritional Assessment Short-Form...
July 28, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28759113/feasibility-and-preliminary-effects-of-resistance-training-and-nutritional-supplements-during-versus-after-radiotherapy-in-patients-with-head-and-neck-cancer-a-pilot-randomized-trial
#3
Jon Arne Sandmael, Asta Bye, Tora Skeidsvoll Solheim, Guro Birgitte Stene, Lene Thorsen, Stein Kaasa, Jo-Åsmund Lund, Line Merethe Oldervoll
BACKGROUND: Patients with head and neck cancer (HNC) experience involuntary weight loss that has a negative impact on physical function, morbidity, and survival. The objective of the current study was to evaluate the feasibility of an exercise and nutrition intervention during radiotherapy (RT) compared with after RT, and to examine preliminary effects on skeletal muscle mass. METHODS: Patients with HNC were randomized to an exercise and nutrition intervention during RT (EN-DUR) or after RT (EN-AF)...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28758698/patients-with-established-cancer-cachexia-lack-the-motivation-and-self-efficacy-to-undertake-regular-structured-exercise
#4
David Wasley, Nichola Gale, Sioned Roberts, Karianne Backx, Annmarie Nelson, Robert van Deursen, Anthony Byrne
OBJECTIVES: Patients with advanced cancer frequently suffer a decline in activities associated with involuntary loss of weight and muscle mass (cachexia). This can profoundly affect function and quality of life. Although exercise participation can maintain physical and psychological function in patients with cancer, uptake is low in cachectic patients who are underrepresented in exercise studies. To understand how such patients' experiences are associated with exercise participation we investigated exercise history, self-confidence and exercise motivations in patients with established cancer cachexia, and relationships between relevant variables...
July 31, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28717810/association-between-adiposity-and-disability-in-the-lc65-cohort
#5
N Danon-Hersch, S Fustinoni, P Bovet, J Spagnoli, B Santos-Eggimann
OBJECTIVES: To examine the longitudinal association between body mass index (BMI) and waist circumference (WC) with mortality and incident disability in Lc65+ cohort. DESIGN: Population-based cohort of non-institutionalized adults with up to 8.9 years of follow-up. SETTING: City of Lausanne, Switzerland. PARTICIPANTS: 1,293 individuals aged 65 to 70 at baseline (58% women). MEASUREMENTS: BMI, WC and covariates were measured at baseline in 2004-2005...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28674366/m-protein-negative-myeloma-mimicking-lumbar-disc-herniation
#6
Yusuke Hirota, Shingo Suzuki, Yota Katsuyama, Tohru Iseki, Masatomi Ikusaka
A 60-year-old man was referred to us with high levels of aspartate aminotransferase and lactate dehydrogenase (LDH). He did not complain of any symptoms; however, he had been diagnosed with lumbar disc herniation, even though his back pain improved only to half of its previous level with pregabalin. Thus, we asked about the red flag of back pain and confirmed that he had involuntary body weight loss, which led us to diagnose truly non-secretory multiple myeloma, a variant of multiple myeloma that is associated with M-protein negativity and a normal serum free light chain level...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28629899/high-adherence-to-a-mediterranean-diet-and-lower-risk-of-frailty-among-french-older-adults-community-dwellers-results-from-the-three-city-bordeaux-study
#7
Berna Rahi, Soufiane Ajana, Maturin Tabue-Teguo, Jean-François Dartigues, Karine Peres, Catherine Feart
BACKGROUND & AIMS: Mediterranean diet (MeDi) is considered as a key component for healthy aging, including prevention of age-related disability, while its association with frailty, independent of disability has never been assessed. Our objective was to investigate the relation between MeDi adherence and frailty incidence among persons aged ≥75 years participating at the prospective population-based French Three-City Study. METHODS: The study sample consisted of 560 initially non-frail participants of the Three-City-Bordeaux center, seen at the 2009-2010 follow-up, and re-examined two years later...
May 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28585024/job-displacement-and-first-birth-over-the-business-cycle
#8
Barbara Hofmann, Michaela Kreyenfeld, Arne Uhlendorff
In this article, we investigate the impact of job displacement on women's first-birth rates as well as the variation in this effect over the business cycle. We use mass layoffs to estimate the causal effects of involuntary job loss on fertility in the short and medium term, up to five years after displacement. Our analysis is based on rich administrative data from Germany, with an observation period spanning more than 20 years. We apply inverse probability weighting (IPW) to flexibly control for the observed differences between women who were and were not displaced...
June 2017: Demography
https://www.readbyqxmd.com/read/28570949/does-hypoxia-play-a-role-in-the-development-of-sarcopenia-in-humans-mechanistic-insights-from-the-caudwell-xtreme-everest-expedition
#9
Liesl Wandrag, Mario Siervo, Heather L Riley, Maryam Khosravi, Bernadette O Fernandez, Carl A Leckstrom, Daniel S Martin, Kay Mitchell, Denny Z H Levett, Hugh E Montgomery, Monty G Mythen, Michael A Stroud, Michael P W Grocott, Martin Feelisch
OBJECTIVES: Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and inflammatory mediators have been suggested. Sarcopenia also occurs upon exposure to the hypoxia of high altitude. Using data from the Caudwell Xtreme Everest expedition we therefore sought to analyze the extent of hypoxia-induced body composition changes and identify putative pathways associated with fat-free mass (FFM) and fat mass (FM) loss...
May 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/28528063/an-involuntary-and-unexpected-treatment-of-nutcracker-esophagus
#10
Diane Mege, Alban Benezech, Henri de Lesquen, Véronique Vitton, Pascal-Alexandre Thomas
A 76-year-old woman complained of painful dysphagia and loss of weight. Esophagoscopy results were negative, whereas computed tomography (CT) disclosed a 25-mm mediastinal tumor without a connection to the esophagus. A diagnosis of nutcracker esophagus was made on high-resolution esophageal manometry. Peroral endoscopic esophageal myotomy failed to improve the symptoms. Right video thoracoscopy allowed resection of the tumor, which looked like a neurogenic tumor of the posterior mediastinum that developed from the right vagus nerve...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28494385/l-leucine-dietary-supplementation-modulates-muscle-protein-degradation-and-increases-pro-inflammatory-cytokines-in-tumour-bearing-rats
#11
Bread Cruz, André Oliveira, Maria Cristina Cintra Gomes-Marcondes
Cancer cachexia is characterised by involuntary weight loss associated with systemic inflammation and metabolic changes. Studies aimed at maintaining lean body mass in cachectic tumour-bearing hosts have made important contributions reducing the number of deaths and improving the quality of life. In recent years, leucine has demonstrated effective action in maintaining lean body mass by decreasing muscle protein degradation. Currently, there is a growing need to understand how leucine stimulates protein synthesis and acts protectively in a cachectic organism...
May 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28427849/sarcopenia-cachexia-and-muscle-performance-in-heart-failure-review-update-2016
#12
REVIEW
Masakazu Saitoh, Junichi Ishida, Wolfram Doehner, Stephan von Haehling, Markus S Anker, Andrew J S Coats, Stefan D Anker, Jochen Springer
Cachexia in the context of heart failure (HF) has been termed cardiac cachexia, and represents a progressive involuntary weight loss. Cachexia is mainly the result of an imbalance in the homeostasis of muscle protein synthesis and degradation due to a lower activity of protein synthesis pathways and an over-activation of protein degradation. In addition, muscle wasting leads to of impaired functional capacity, even after adjusting for clinical relevant variables in patients with HF. However, there is no sufficient therapeutic strategy in muscle wasting in HF patients and very few studies in animal models...
April 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28417157/impact-of-cachexia-on-outcomes-in-aggressive-lymphomas
#13
Reem Karmali, Taha Alrifai, Ibtihaj A M Fughhi, Ronald Ng, Vineela Chukkapalli, Palmi Shah, Sanjib Basu, Sunita Nathan, Kelly Szymanski-Grant, Leo I Gordon, Parameswaran Venugopal, Frank J Penedo, Jeffrey A Borgia
Cancer cachexia is defined as a state of involuntary weight loss, attributed to altered body composition with muscle mass loss and/or loss of adiposity. Identifying the association between cancer cachexia and outcomes may pave the way for novel agents that target the cancer cachexia process. Clinical parameters for measurement of cancer cachexia are needed. We conducted a single-institution retrospective analysis that included 86 NHL patients with the aim of identifying an association between cancer cachexia and outcomes in aggressive lymphomas using the cachexia index (CXI) suggested by Jafri et al...
June 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28367435/effect-of-underlying-renal-disease-on-nutritional-and-metabolic-profile-of-older-adults-with-reduced-renal-function
#14
Silvia Lai, Maria Ida Amabile, Silvia Altieri, Daniela Mastroluca, Carlo Lai, Paola Aceto, Massimiliano Crudo, Anna Rita D'Angelo, Maurizio Muscaritoli, Alessio Molfino
BACKGROUND: Chronic kidney disease is a common condition in the general population, particularly among older adults. Renal impairment is in turn associated with metabolic and nutritional derangements and with increased risk of cardiovascular disease. AIM: To compare the metabolic, nutritional, and cardiovascular impact of reduced kidney function between patients with and without known renal disease. MATERIALS AND METHODS: We enrolled consecutive outpatients (age ≥65 years) with reduced renal function who were divided into two groups: Group A with history of renal disease and Group B with unknown renal disease...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28361740/association-between-adductor-pollicis-muscle-thickness-anthropometric-and-immunological-parameters-in-hiv-positive-patients
#15
Arthur Fernandes Cortez, Julio Cesar Tolentino, Rodrigo Moura Elarrat, Roberta Benitez Freitas Passos
BACKGROUNDS AND AIMS: Involuntary weight loss and muscle mass loss among HIV-positive patients are only detectable in late stages, leading poor life quality. The reduction of adductor pollicis muscle thickness (APMT) can be easily and earlier uncovered in those cases. The purpose was to estimate APMT and compare it with immunological and anthropometric parameters of HIV-infected people. METHODS: A crosssectional study was carried out in an University Hospital including 103 HIV-infected outpatients by subjective global assessment (SGA)...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28240621/weighted-mean-of-signal-intensity-for-unbiased-fiber-tracking-of-skeletal-muscles-development-of-a-new-method-and-comparison-with-other-correction-techniques
#16
Chiara Giraudo, Stanislav Motyka, Michael Weber, Christoph Resinger, Feiweier Thorsten, Hannes Traxler, Siegfried Trattnig, Wolfgang Bogner
OBJECTIVES: The aim of this study was to investigate the origin of random image artifacts in stimulated echo acquisition mode diffusion tensor imaging (STEAM-DTI), assess the role of averaging, develop an automated artifact postprocessing correction method using weighted mean of signal intensities (WMSIs), and compare it with other correction techniques. MATERIALS AND METHODS: Institutional review board approval and written informed consent were obtained. The right calf and thigh of 10 volunteers were scanned on a 3 T magnetic resonance imaging scanner using a STEAM-DTI sequence...
August 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28024997/androgen-receptor-ar-gene-cag-n-and-ggn-n-length-polymorphisms-and-symptoms-in-young-males-with-long-lasting-adverse-effects-after-finasteride-use-against-androgenic-alopecia
#17
Sabina Cauci, Giovanni Chiriacò, Erika Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
INTRODUCTION: Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). AIM: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. METHODS: AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). MAIN OUTCOME MEASURES: Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS)...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/27990420/prevalence-and-factors-associated-with-undernutrition-among-adults-with-major-depressive-disorder-in-northwest-ethiopia
#18
Edmialem Gezahegn, Melkie Edris, Berihun Assefa Dachew
Background. Undernutrition and major depressive disorder are frequently co-occurring. Patients with impaired mental health are strongly vulnerable to the risks of having involuntary weight loss or deficiency of essential nutrients. However, there is no study which assesses undernutrition among major depressive patients in Ethiopia. Method. A total of 422 clients were included in the study. Structured questionnaires and anthropometric measurements were used for collecting the data. Bivariate and multivariate logistic regression model was fitted to identify factors associated with undernutrition...
2016: Psychiatry Journal
https://www.readbyqxmd.com/read/27939358/the-new-espen-diagnostic-criteria-for-malnutrition-predict-overall-survival-in-hospitalised-patients
#19
A L M A Rondel, J A E Langius, M A E de van der Schueren, H M Kruizenga
BACKGROUND: In 2015 the European Society for Clinical Nutrition and Metabolism (ESPEN) presented new consensus criteria for the diagnosis of malnutrition. Whereas most previous definitions were based on involuntary weight loss and/or a low BMI, the ESPEN definition added Fat Free Mass Index (FFMI) to the set of criteria. AIM: To study the predictive value of the new ESPEN diagnostic criteria for malnutrition on survival, with specific focus on the additional value of FFMI...
November 24, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27870708/sarcopenia-in-advanced-serous-ovarian-cancer
#20
Holger Bronger, Philipp Hederich, Alexander Hapfelmeier, Stephan Metz, Peter B Noël, Marion Kiechle, Barbara Schmalfeldt
OBJECTIVE: Cancer cachexia is a paraneoplastic syndrome comprising involuntary weight loss and muscle depletion (sarcopenia). Although weight loss has been associated with poor clinical outcome, there is only limited information on the prevalence and prognostic impact of sarcopenia in ovarian cancer so far. METHODS: Total skeletal muscle mass was determined by computed tomography image analysis of the third lumbar skeletal muscle cross-sectional area in 128 patients with advanced serous ovarian cancer...
February 2017: International Journal of Gynecological Cancer
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