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Spinal AND Cord AND Injury

Eyrún Arna Kristinsdóttir, Sigrún Knútsdóttir, Kristinn Sigvaldason, Halldór Jónsson, Páll E Ingvarsson
Study design: A retrospective epidemiological study. Setting: Landspítali University Hospital, Iceland. Objectives: Assessment of epidemiological data and risk factors for traumatic spinal fractures (SFs) and associated spinal cord injury (SCI). Methods: A retrospective review of hospital admissions due to traumatic SFs during a 5-year period, with analysis of epidemiological parameters and occurrence of concomitant SCI...
2018: Spinal Cord Series and Cases
Phani Krishna Karthik Yelamarthy, Tarush Rustagi, Rajat Mahajan, Vishwajeet Singh, Kalidutta Das, Murari Lal Bansal, Bibhudendu Mohapatra, Harvinder Singh Chhabra
Background: Charcot spinal arthropathy (CSA), a destructive spinal pathology, is seen in patients with impaired sensation. Superimposed infection in the affected spinal segments can lead to a challenge in the diagnosis and management. Spinal cord injury (SCI) is the leading cause of CSA as persons with SCI have significantly impaired sensation. Though infection of the CSA is rare, SCI persons are prone to superimposed infection of the Charcot spine. We report atypical presentations of three cases of CSA with superimposed infection...
2018: Spinal Cord Series and Cases
Pasang Doma Sherpa, Luppana Kitrungrote, Wipa Sae-Sia
Study design: Descriptive cross-sectional study. Objective: This study aims to determine the factors predicting quality of life among Nepalese family caregivers of people with spinal cord injury (SCI) having low back pain. Setting: Eight districts of the Bagmati Zone of Nepal. Methods: Sixty-five family caregivers of people with SCI having chronic low back pain were recruited from January to March 2017. The factors examined as independent variables included monthly household income, daily caregiving hours, functional independence of people with SCI, low back pain intensity, and functional disability of family caregivers...
2018: Spinal Cord Series and Cases
Fin Biering-Sørensen, Stacey Cohen, Gianna Maria Rodriguez, Kelly Tausk, Josh Martin
Study design: Presentation of implementation of International Spinal Cord Injury (SCI) Data Sets, International Standards for Neurological Classification of SCI (ISNCSCI), and other structured SCI tools in to the Electronic Medical Record (EMR) Epic. Objectives: To describe the implementation of SCI tools in Epic at Rigshospitalet, University of Hospital, Capital Region of Denmark, and the ambitions for the future development of SCI related structured data and their reporting in the Epic EMR to be able to standardize data collection to facilitate research within institutions and collaboratively with other institutions locally and globally...
2018: Spinal Cord Series and Cases
Richard Acland
Cannabis use in medicine continues to confound practitioners. There is confusing interpretation of the efficacy and adverse event data, highlighting the complexity of this unique plant. Cannabis may have a neuroprotective role in SCI.
2018: Spinal Cord Series and Cases
Daniel E Graves
Cannabis is an effective treatment for pain following spinal cord injury that should be available to patients and researchers. The major argument against the rescheduling of cannabis is that the published research is not convincing. This argument is disingenuous at best, given that the evidence has been presented and rejected at many points during the political dialog. Moreover, the original decision to criminalize cannabis did not utilize scientific or medical data. There is tension between the needs of a society to protect the vulnerable by restricting the rights of others to live well and with less pain...
2018: Spinal Cord Series and Cases
Amanda L Botticello, David Tulsky, Allen Heinemann, Susan Charlifue, Claire Kalpakjian, Mary Slavin, Rachel Byrne, Tanya Rohrbach
STUDY DESIGN: Secondary analysis of cross-sectional data from a multisite cohort study. OBJECTIVES: To analyze the association between the built environment and physical functioning reported by adults living with chronic spinal cord injury (SCI). SETTING: Four US Spinal Cord Injury Model Systems centers in New Jersey, Colorado, Illinois, and Michigan. METHODS: Participants were from the Spinal Cord Injury-Functional Index/Capacity (SCI-FI/C) development study...
August 14, 2018: Spinal Cord
A B Spejo, G B Chiarotto, A D F Ferreira, D A Gomes, R S Ferreira, B Barraviera, A L R Oliveira
BACKGROUND: Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors to lesioned neurons. METHODS: Lewis adult female rats were submitted to a unilateral ventral funiculus cut at the spinal levels L4, L5, and L6. The animals were divided into the following groups: IA (intramedullary axotomy), IA + DMEM (Dulbecco's modified Eagle's medium), IA + FS (fibrin sealant), IA + MSC (106 cells), and IA + FS + MSC (106 cells)...
August 14, 2018: Journal of Neuroinflammation
Victoria Dreier Thøfner Hultén, Fin Biering-Sørensen, Niklas Rye Jørgensen, Poul Jørgen Jennum
STUDY OBJECTIVES: The aim of this study was to investigate circadian rhythm and sleep complaints in individuals with spinal cord injury (SCI) as determined by diurnal saliva melatonin and cortisol as well as activity measurements and subjective sleep quality. METHODS: Fourteen patients with cervical SCI (cSCI), six patients with thoracic SCI (tSCI) and eight able-bodied controls all underwent two consecutive weeks wearing a wrist actigraph in addition to filling out a sleep diary...
July 19, 2018: Sleep Medicine
Nicholas Annetta, Jeffrey Friend, Andrew Schimmoeller, Vimal S Buck, David Friedenberg, Chad E Bouton, Marcia A Bockbrader, Patrick Ganzer, Sam Colachis, Mingming Zhang, W Jerry Mysiw, Ali R Rezai, Gaurav Sharma
OBJECTIVE: Paralysis resulting from spinal cord injury (SCI) can have a devastating effect on multiple arm and hand motor functions. Rotary hand movements, such as supination and pronation, are commonly impaired by upper extremity paralysis, and are essential for many activities of daily living. In this proof-of-concept study, we utilize a neural bypass system (NBS) to decode motor intention from motor cortex to control combinatorial rotary hand movements elicited through stimulation of the arm muscles, effectively bypassing the SCI of the study participant...
August 7, 2018: IEEE Transactions on Bio-medical Engineering
Andrew J Sun, Craig V Comiter, Christopher S Elliott
METHODS: We estimated the prevalence of CIC use in the United States using a neurogenic population, consisting of persons with multiple sclerosis, spina bifida, and spinal cord injury. We measured catheter samples to obtain the amount of waste per catheter. RESULTS: At least 300 800 persons in the United States perform CIC for neurogenic bladder management. Assuming five catheterization events per day, the amount of waste generated by single-use CIC is between 26 500 to 235 400 pounds or 22 600 to 564 000 liters per day, depending on catheter model...
August 14, 2018: Neurourology and Urodynamics
Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
The unique hypoxic inflammatory microenvironment observed in the spinal cord following spinal cord injury (SCI) limits the survival and efficacy of transplanted bone mesenchymal stem cells (BMSCs). The aim of the present study was to determine whether hypoxic preconditioning (HP) increased the therapeutic effects of BMSC on SCI. BMSCs were pretreated with cobalt chloride (CoCl2) in vitro, and the proliferative apoptotic and migratory abilities of these hypoxic BMSCs (H‑BMSCs) were assessed. BMSCs and H‑BMSCs derived from green fluorescent protein (GFP) rats were transplanted into SCI rats in vivo...
August 7, 2018: International Journal of Molecular Medicine
Chuan-Wen Chiu, Wen-Hung Huang, Huai-Sheng Kuo, May-Jywan Tsai, Ching-Jung Chen, Meng-Jen Lee, Henrich Cheng
Alternatively activated macrophages (M2 macrophages) promote central nervous system regeneration. Our previous study demonstrated that treatment with peripheral nerve grafts and fibroblast growth factor-1 recruited more M2 macrophages and improved partial functional recovery in spinal cord transected rats. The migration of macrophages is matrix metalloproteinase (MMP) dependent. We used a general inhibitor of MMPs to influence macrophage migration, and we examined the migration of macrophage populations and changes in spinal function...
August 2018: Neural Regeneration Research
Jairam R Eswara, Miguel Castellan, Ricardo González, Nicolas Mendieta, Marc Cendron
BACKGROUND: The urologic management of children with spinal cord injury (SCI) differs from that of the adult insofar as the care involves a developing organ system and will be ongoing for years. Preservation of renal function as well as prevention of urinary tract infection in concert with both bladder and bowel continence are the essential guiding principles. METHODS: This is a non-systematic review of the literature and represents expert opinion where data are non-existent...
August 13, 2018: World Journal of Urology
Katherine Figel, Kelly Pritchett, Robert Pritchett, Elizabeth Broad
Low energy availability (LEA) and nutrient intake have been well studied in able-bodied athletes, but there is a lack of research examining these issues amongst athletes with spinal cord injury (SCI). To date, there have been no studies that have examined energy availability (EA) amongst this population. Furthermore, athletes with SCI may experience unique challenges around nutrition that may increase their risk of LEA. This review will evaluate the literature and assess whether this population is at risk for LEA...
August 13, 2018: Nutrients
Mushfiquddin Khan, Tajinder S Dhammu, Inderjit Singh, Avtar K Singh
BACKGROUND: Spinal cord injury (SCI) is one of the leading causes of disability and chronic pain. In SCI-induced pathology, homeostasis of the nitric oxide (NO) metabolome is lost. Major NO metabolites such as S-nitrosoglutathione (GSNO) and peroxynitrite are reported to play pivotal roles in regulating the activities of key cysteine proteases, calpains. While peroxynitrite (a metabolite of NO and superoxide) up regulates the activities of calpains leading to neurodegeneration, GSNO (a metabolite of NO and glutathione) down regulates the activities of calpains leading to neuroprotection...
August 13, 2018: BMC Neuroscience
Cameron M Gee, Melissa A Lacroix, Christopher R West
Boosting is the induction of autonomic dysreflexia (AD) to reflexively activate otherwise dormant thoracolumbar sympathetic circuitry to 'boost' the capacity of the cardiovascular system and enhance exercise performance. AD is a life-threatening condition unique to individuals with spinal cord injury (SCI) characterized by a sudden increase in sympathetic activity below the level of the SCI. Here we report on the temporal heart rate response to an episode of unintentional boosting during a validated field-based exercise performance test in an athlete with tetraplegia...
August 10, 2018: Medicine and Science in Sports and Exercise
Suliang Chen, Mathew J Gallagher, Florence Hogg, Marios C Papadopoulos, Samira Saadoun
To guide management of patients with acute spinal cord injuries, we developed intraspinal pressure monitoring from the injury site. Here, we examine the complex fluctuations in the intraspinal pressure signal using network theory. We analyzed 7,097 hours of intraspinal pressure data from 58 patients with severe cord injuries. Intraspinal pressure signals were split into hourly windows. Each window was mapped into a visibility graph as follows: Vertical bars were drawn at 0.1 Hz representing signal amplitudes...
August 13, 2018: Journal of Neurotrauma
Xi Lu, T Hiran Perera, Alexander B Aria, Laura A Smith Callahan
Polyethylene glycol (PEG) is a synthetic biocompatible polymer with many useful properties for developing therapeutics to treat spinal cord injury. Direct application of PEG as a fusogen to the injury site can repair cell membranes, mitigate oxidative stress, and promote axonal regeneration to restore motor function. PEG can be covalently or noncovalently conjugated to proteins, peptides, and nanoparticles to limit their clearance by the reticuloendothelial system, reduce their immunogenicity, and facilitate crossing the blood-brain barrier...
2018: Journal of Experimental Pharmacology
Dawei Xu, Wei Zhao, Chengniu Wang, Hao Zhu, Mingqing He, Xinhui Zhu, Wei Liu, Fei Wang, Jianbo Fan, Chu Chen, Daoran Cui, Zhiming Cui
TNF receptor-associated factor 7 (TRAF7), is an E3 ubiquitin ligase for several proteins involved in the activation of TLR-dependent NF-kappaB signaling. TRAF7 links TNF receptor family proteins to signaling pathways, thus participates in regulating cell death and survival mediated by TNF family ligands. To date, the biological function of TRAF7 after spinal cord injury (SCI) is still with limited acquaintance. In this study, we have performed an acute SCI model in adult rats and investigated the dynamic changes of TRAF7 expression in the spinal cord...
August 8, 2018: Neuropeptides
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