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Fever of unknown origin

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https://www.readbyqxmd.com/read/29780139/methotrexate-associated-intravascular-large-b-cell-lymphoma-in-a-patient-with-rheumatoid-arthritis-a-very-rare-case
#1
Masao Hagihara, Toru Mese, Shin Ohara, Jian Hua, Shiro Ide, Morihiro Inoue
we herein report a rare case of methotrexate (MTX)-associated intravascular large B-cell lymphoma (IVLBCL) in a man with rheumatoid arthritis. Two episodes of a fever of unknown origin accompanied by elevated levels of serum lactate dehydrogenase and the soluble interleukin-2 receptor occurred within a year, so the patient was suspected of having an MTX-associated lymphoproliferative disorder. His clinical symptoms resolved after the cessation of MTX. However, after treatment with iguratimod, another disease-modified anti-rheumatic drug, markedly similar symptoms recurred, and random skin biopsies resulted in a diagnosis of IVLBCL...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29776655/diagnosis-of-vasculitis-with-18-f-fdg-pet-ct-study-in-patient-with-fever-of-unknown-origin
#2
Juan Jose Martin-Marcuartu, Jose Antonio Lojo-Ramirez, Victor Manuel Pachón-Garrudo, José Manuel Jimenez-Hoyuela
No abstract text is available yet for this article.
May 15, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29774477/cefepime-vs-cefoperazone-sulbactam-in-combination-with-amikacin-as-empirical-antibiotic-therapy-in-febrile-neutropenia
#3
M Ponraj, Biswajit Dubashi, B H Harish, S Kayal, S L Cyriac, Jogamaya Pattnaik, K Ranjith, Unni S Pillai, Naresh Jadhav, Kiran K Matta, Jagdeep Singh, Esha Jaffa, Bhanu Prakash
PURPOSE: Beta lactams are standard empirical therapy for febrile neutropenia (FN). The aim of this study was to evaluate the efficacy and safety of cefepime monotherapy compared with cefoperazone/sulbactam plus amikacin (CS + A) for empirical treatment of high risk FN. METHODS: One hundred seventy-five patients with 336 FN episodes were randomized to receive either cefepime (2 g q8h for adults and 50 mg/kg q8h for children) or CS (2 g q8h for adults and 50 mg/kg q8h for children) plus amikacin (15 mg/kg once a day)...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29774460/multi-layer-cube-sampling-for-liver-boundary-detection-in-pet-ct-images
#4
Xinxin Liu, Jian Yang, Shuang Song, Hong Song, Danni Ai, Jianjun Zhu, Yurong Jiang, Yongtian Wang
Liver metabolic information is considered as a crucial diagnostic marker for the diagnosis of fever of unknown origin, and liver recognition is the basis of automatic diagnosis of metabolic information extraction. However, the poor quality of PET and CT images is a challenge for information extraction and target recognition in PET-CT images. The existing detection method cannot meet the requirement of liver recognition in PET-CT images, which is the key problem in the big data analysis of PET-CT images. A novel texture feature descriptor called multi-layer cube sampling (MLCS) is developed for liver boundary detection in low-dose CT and PET images...
May 17, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29773090/vsita-an-improved-approach-of-target-amplification-in-the-identification-of-viral-pathogens
#5
Yi Zhang, Chen Zhang, Bo Li, Yang Li, Xiao Zhou He, Acher Li, Wei Wu, Su Xia Duan, Fang Zhou Qiu, Ji Wang, Xin Xin Shen, Meng Jie Yang, De Xin Li, Xue Jun Ma
OBJECTIVE: Unbiased next generation sequencing (NGS) is susceptible to interference from host or environmental sequences. Consequently, background depletion and virome enrichment techniques are usually needed for clinical samples where viral load is much lower than background sequences. METHODS: A viral Sequence Independent Targeted Amplification (VSITA) approach using a set of non-ribosomal and virus-enriched octamers (V8) was developed and compared with traditionally used random hexamers (N6)...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29771320/immunoglobulin-profiling-identifies-unique-signatures-in-patients-with-kawasaki-disease-during-intravenous-immunoglobulin-treatment
#6
Tai-Ming Ko, Kazuma Kiyotani, Jeng-Sheng Chang, Jae-Hyun Park, Poh Yin Yew, Yuan-Tsong Chen, Jer-Yuarn Wu, Yusuke Nakamura
Identifying the causes of high fever syndromes such as Kawasaki disease (KD) remains challenging. To investigate pathogen exposure signatures in suspected pathogen-mediated diseases like KD, we performed immunoglobulin (Ig) profiling using a next-generation sequencing method. After intravenous Ig (IVIG) treatment, we observed disappearance of clonally expanded IgM clonotypes, which were dominantly observed in acute-phase patients. The complementary-determining region 3 (CDR3) sequences of dominant IgM clonotypes in acute-phase patients were commonly observed in other Ig isotypes...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29742054/overview-of-fever-of-unknown-origin-in-adult-and-paediatric-patients
#7
REVIEW
Luciano Attard, Marina Tadolini, Domenico Umberto De Rose, Marco Cattalini
Fever of unknown origin (FUO) can be caused by a wide group of diseases, and can include both benign and serious conditions. Since the first definition of FUO in the early 1960's, several updates to the definition, diagnostic and therapeutic approaches have been proposed. This review outlines a case report of an elderly Italian male patient with high fever and migrating arthralgia who underwent many procedures and treatments before a final diagnosis of Adult-onset Still's disease was achieved. This case report highlights the difficulties in diagnosing certain causes of FUO that requires a very high index of suspicion...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29742053/updated-overview-of-molecular-pathways-involved-in-the-most-common-monogenic-autoinflammatory-diseases
#8
REVIEW
Orso Maria Lucherini, Donato Rigante, Jurgen Sota, Claudia Fabiani, Laura Obici, Marco Cattalini, Marco Gattorno, Luca Cantarini
An apparently unprovoked recurrent inflammation is the quintessential hallmark of autoinflammatory diseases (AIDs), a large and heterogeneous group of disorders in which there is poor regulation of the innate immune system with no clearly demonstrated autoimmune machinery involvement. Innate immunity pathways are diverse and our understanding of their molecular composition and function is continuously expanding. The impaired immune responses we observe in monogenic AIDs, mostly in the hereditary periodic fever syndromes, is officiated by target molecules of microbial origin (pathogen-associated molecular patterns) and also host molecules (danger-associated molecular patterns)...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29737035/systemic-lupus-erythematosus-in-a-patient-with-noonan-syndrome-like-disorder-with-loose-anagen-hair-1-more-than-a-chance-association
#9
Tomoko Uehara, Naoki Hosogaya, Nobutake Matsuo, Kenjiro Kosaki
Systemic lupus erythematosus (SLE) has been reported among patients with RASopathy. Five patients have been reported: three with SHOC2 variants, one with a PTPN11 variant, and one with a KRAS variant. SHOC2 variant might represent a relatively common predisposing factor for SLE among the RASopathy genes. However, the clinical details were only reported for two patients, while information on the remaining patient appeared only in a tabular format with minimal clinical description. Here, we report a patient with a SHOC2 variant and SLE...
May 7, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29735828/histoplasmosis-in-non-endemic-north-western-part-of-india
#10
Atul K Patel, Ketan K Patel, Harsh Toshniwal, Swati Gohel, Arunaloke Chakrabarti
Purpose of Study: The western and North-Western parts of India are usually considered non-endemic for histoplasmosis. On the contrary, we observe histoplasmosis cases with relatively higher frequency from this region although the awareness and laboratory facility to diagnose the disease are not adequate. Hence, we planned the present retrospective study to compile the cases and to analyse different clinical parameters. Materials and Methods: Medical records of the patients diagnosed with histoplasmosis during January 2012-August 2017 at two infectious disease clinics of Ahmedabad were included in this study...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29733534/adult-onset-still-s-disease-initially-thought-to-be-an-odontogenic-infection-a-case-report
#11
Shunsuke Hino, Satoshi Nakamura, Takahiro Kaneko, Norio Horie, Tetsuo Shimoyama
OBJECTIVE: To present a case of Adult-onset Still's disease (AOSD) initially suspected to be odontogenic inflammation. BACKGROUND: Adult-onset Still's disease is a rare, complex autoinflammatory disease and a known cause of fever of unknown origin. MATERIALS AND METHODS: The patient had both a fever and dental pain. Following meticulous examination, the patient was diagnosed with AOSD. CONCLUSION: Clinicians should keep in mind that a patient such as AOSD may visit their clinics...
June 2018: Gerodontology
https://www.readbyqxmd.com/read/29724618/missed-opportunities-in-the-diagnosis-of-human-immunodeficiency-virus-infection-in-the-region-of-aragon-late-diagnosis-importance
#12
César Gargallo-Bernad, Francisco Javier Sangrós-González, Piedad Arazo-Garcés, Rosa Martínez-Álvarez, Carmen Malo-Aznar, Alicia Gargallo-Bernad, Alba Ballester-Luna, Luis Eduardo Cabrero-Pascual, Pablo Gil-Orna, Víctor José Abadía-Gallego, Isabel Torres-Peña, Héctor Ordiz-Suárez
INTRODUCTION: Late Diagnosis (LD) of Human Immunodeficiency Virus (HIV) infection (CD4 lymphocytes <350/μl at diagnosis of the disease), deteriorates the condition of those affected and increases the probability of transmission. The objective of the present study was to analyse the prevalence of LD, to identify missed diagnostic opportunities (MDO) and to find out which level of the health care delivery system they took place. METHODS: Retrospective, observational and descriptive study of the population diagnosed with infection of HIV/AIDS in the period 2011-2015 in Aragon...
April 30, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29706135/de-novo-subgaleal-abscess-a-rare-presentation-of-melioidosis-a-case-report
#13
Chamara Dalugama, Asanka Tennegedara, Indika Bandara Gawarammana
BACKGROUND: Melioidosis is an emerging infection in the tropics caused by the bacterium Burkholderia pseudomallei. Poorly controlled diabetes is a known risk factor. Melioidosis has a broad spectrum of clinical manifestations ranging from a localized abscess to pneumonia to disseminated sepsis with multiorgan failure. Pyrexia of unknown origin is a common presentation. Abscesses in unusual anatomical locations are well known to be associated with melioidosis. CASE PRESENTATION: We report a case of a 64-year-old Sri Lankan Sinhalese man with prolonged fever and constitutional symptoms with a neglected swelling over the back of the scalp who was found to have an abscess in the subgaleal space of the scalp during surgical drainage...
April 30, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29705516/icones-plantarum-malabaricarum-early-18th-century-botanical-drawings-of-medicinal-plants-from-colonial-ceylon
#14
Tinde Van Andel, Ariane Scholman, Mieke Beumer
ETHNOPHARMACOLOGICAL RELEVANCE: From 1640-1796, the Dutch East India Company (VOC) occupied the island of Ceylon (now Sri Lanka). Several VOC officers had a keen interest in the medicinal application of the local flora. The Leiden University Library holds a two-piece codex entitled: Icones Plantarum Malabaricarum, adscriptis nominibus et viribus, Vol. I. & II. (Illustrations of Plants from the Malabar, assigned names and strength). This manuscript contains 262 watercolour drawings of medicinal plants from Sri Lanka, with handwritten descriptions of local names, habitus, medicinal properties and therapeutic applications...
April 27, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29703835/fever-of-unknown-origin-bilateral-sensorineural-hearing-loss-with-canal-paresis-and-uveitis-with-iridocyclitis-and-episcleritis-a-case-of-cogan-s-syndrome
#15
Takashi Watari, Yasuharu Tokuda
No abstract text is available yet for this article.
April 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29701398/trauma-an-unusual-cause-of-endocarditis
#16
Ana Braga, Marta Marques, Miguel Abecacis, José Pedro Neves
INTRODUCTION: Infective endocarditis (IE) remains a dangerous condition with considerable associated mortality. Usual risk factors for IE include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a recent history of invasive procedures. METHODS: The authors describe the case report of a patient with IE having trauma as an unusual risk factor. RESULTS: A 33-year old male patient was referred to our department due to infective endocarditis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29697928/recto-urethral-fistula-presenting-as-fever-of-unknown-origin-a-rare-complication-of-prostatic-abscess
#17
Sun Hwa Lee, Seong Jong Yun, Seokyong Ryu
No abstract text is available yet for this article.
March 18, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29697421/a-case-report-and-literature-review-of-scrub-typhus-with-acute-abdomen-and-septic-shock-in-a-child-the-role-of-leukocytoclastic-vasculitis-and-granulysin
#18
Po-Hsiung Chang, Yu-Pin Cheng, Po-Sheng Chang, Chiao-Wei Lo, Lung-Huang Lin, Chin-Fang Lu, Wen-Hung Chung
Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. It has various systemic manifestations, including GI symptoms. In some, the illness progresses to multiorgan dysfunction syndrome and death...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#19
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29683400/molecular-evidence-of-rickettsia-in-human-and-dog-blood-in-bangkok
#20
Nanthanida Mongkol, Yupin Suputtamongkol, Piyanan Taweethavonsawat, Suporn Foongladda
Rickettsia spp. has been detected in dog fleas in Bangkok, Thailand. With the intent of collecting evidence to confirm the presence of rickettsioses in dogs and to assess the level of associated potential for accidental human infection, human buffy coat from patients with fever of unknown origin (n = 168), whole blood samples from dogs (n = 353), and 19 flea groups from our dog sample population were studied during the 2012 to 2014 study period. The presence of Rickettsia was investigated by molecular detection of 23S rRNA gene of Rickettsia genus, citrate synthase (gltA) gene, and 17-kDa outer membrane gene...
April 23, 2018: Vector Borne and Zoonotic Diseases
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