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Fever of unknown origin

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https://www.readbyqxmd.com/read/28185603/outbreak-investigation-of-fever-mimicking-dengue-in-havelock-island-an-important-tourist-destination-in-the-andaman-nicobar-archipelago-2014
#1
C Kartick, G S J Bharathi, P Surya, M Anwesh, S Arun, N Muruganandam, R Avijit, P Vijayachari
An upsurge of fever cases of unknown origin, but resembling dengue and leptospirosis was reported in Havelock, Andaman & Nicobar Islands, an important tourism spot, during May 2014. Investigations were carried out to determine the aetiology, and to describe the epidemiology of the outbreak. The data on fever cases attending Primary Health Centre (PHC), Havelock showed that the average number of cases reporting per week over the last 2 years was 46·1 (95% confidence interval 19·4-72·9). A total of 27 (43·5%) patients out of the 62 suspected cases were diagnosed as having DENV infection based on a positive enzyme immunoassay or reverse transcriptase-polymerase chain reaction...
February 10, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28174656/fever-of-unknown-origin-due-to-intrahepatic-wooden-toothpick
#2
Giuseppe Currò, Salvatore Lazzara, Andrea Cogliandolo, Saverio Latteri, Giuseppe Navarra
Ingestion of foreign bodies is a common clinical problem, but intrahepatic migration is an exceptional occurrence. Clinical history is not helpful. Abdominal ultrasonography and CT are fundamental to exclude surgical causes of fever of unknown origin. Laparoscopic segmental liver resection is recommendable to avoid generalized peritonitis.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28151863/miliary-tuberculosis-epidemiologicaland-clinical-analysis-of-large-case-series-from-moderate-to-low-tuberculosis-endemic-country
#3
Ali Mert, Ferhat Arslan, Tülin Kuyucu, Emine Nur Koç, Mesut Ylmaz, Demet Turan, Sedat Altn, Filiz Pehlivanoglu, Gonul Sengoz, Dilek Yldz, Ilyas Dokmetas, Suheyla Komur, Behice Kurtaran, Tuna Demirdal, Hüseyin A Erdem, Oguz Resat Sipahi, Ayse Batirel, Emine Parlak, Recep Tekin, Özlem Güzel Tunçcan, Ilker Inanc Balkan, Osman Hayran, Bahadr Ceylan
The aim of this study was to determine the clinical features, and outcome of the patients with miliary tuberculosis (TB).We retrospectively evaluated 263 patients (142 male, 121 female, mean age: 44 years, range: 16-89 years) with miliary TB. Criteria for the diagnosis of miliary TB were at least one of the followings in the presence of clinical presentation suggestive of miliary TB such as prolonged fever, night sweats, anorexia, weight loss: radiologic criterion and pathological criterion and/or microbiological criterion; pathological criterion and/or microbiological criterion...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28148588/lesson-of-the-month-1-subacute-thyroiditis-a-rare-cause-of-fever-of-unknown-origin
#4
Fatima Amar Bahowairath, Nicholas Woodhouse, Samir Hussain, Mujahid Al Busaidi
Fever of unknown origin (FUO) is sometimes a diagnostic dilemma for clinicians. Endocrine causes reported in the literature include subacute thyroiditis, thyrotoxicosis, adrenal insufficiency and pheochromocytoma. Among these, subacute thyroiditis is often overlooked as it can occasionally lack typical symptoms. This case illustrates the fact that subacute thyroiditis should be considered as a possible cause of fever even if signs and symptoms of hyperthyroidism and thyroid tenderness are absent.
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28143446/kikuchi-fujimoto-disease-histiocytic-necrotizing-lymphadenitis-with-atypical-encephalitis-and-painful-testitis-a-case-report
#5
Hidenori Kido, Osamu Kano, Asami Hamai, Hiroyuki Masuda, Yutaka Fuchinoue, Masaaki Nemoto, Chiaki Arai, Teppei Takeda, Fumihito Yamabe, Toshihiro Tai, Mizuki Kasahara, Kenichi Suzuki, Nobuyuki Shiraga, Sota Sadamoto, Megumi Wakayama, Yukitoshi Takahashi, Yasuo Iwasaki, Kazutoshi Shibuya, Yoshihisa Urita
BACKGROUND: Kikuchi-Fujimoto disease is a self-limited clinicopathologic entity that is increasingly recognized worldwide. Kikuchi-Fujimoto disease is characterized by cervical lymphadenopathy occurring in young adults. Neurologic involvement is rare, and testitis directly caused by Kikuchi-Fujimoto disease has not yet been reported. CASE PRESENTATION: A 19-year-old man was brought to our clinic with complaints of fever, headache, fatigue, and left lower quadrant pain that had persisted for 3 weeks...
February 1, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28120605/hemophagocytic-lymphohistiocytosis-mimics-many-common-conditions-case-series-and-review-of-literature
#6
A T Akenroye, N Madan, F Mohammadi, J Leider
Introduction. Hemophagocytic lymphohistiocytosis (HLH), a rare but potentially fatal disease, is characterized by excessive immune activation and cytokine release which stimulates bone marrow macrophages to engulf hematopoietic cells. HLH could be secondary to infections: viral, fungal, and bacterial; malignancies and autoimmune diseases. The diagnosis of HLH is usually delayed due to the presence of non-specific symptoms at presentation. This delay contributes to increased mortality. Cases and review. We present the case of 4 patients who presented with subjective fevers and extreme fatigue...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28105348/thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-a-case-report
#7
Taro Horino, Osamu Ichii, Kazu Hamada-Ode, Tatsuki Matsumoto, Yoshiko Shimamura, Kosuke Inoue, Yoshio Terada
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical, morphological and immunohistochemical characteristics. The patient was a 25-year-old Japanese woman complaining of a 2-year history of fever of unknown origin. There were no remarkable physical findings and the laboratory tests, including C-reactive protein levels, were normal...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28103059/re-worsening-psychosis-after-fever-of-unknown-origin-in-an-adolescent-boy-with-autism-by-huynh-et-al-j-child-adolesc-psychopharmacol-2013-23-224-227
#8
Keith Fluegge
No abstract text is available yet for this article.
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28099198/osteomyelitis-of-the-navicular-bone-a-case-report
#9
Nobuyuki Kumahashi, Suguru Kuwata, Shinji Imade, Yuji Uchio
A 16-year-old boy developed left foot pain of unknown cause that was unresponsive to conservative treatment, associated with fever and difficulty walking. He was admitted to our hospital with osteomyelitis of the accessory and body of the navicular bone. Surgery could not be performed because the patient had been diagnosed with Wiskott-Aldrich syndrome. After antibiotic therapy, laboratory abnormalities and pain had resolved. One year after treatment, the patient had returned to his original level of sports activity...
January 17, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28093613/recent-trends-in-the-distribution-of-causative-diseases-of-fever-of-unknown-origin
#10
Jin Shang, Libo Yan, Lingyao Du, Lingbo Liang, Qiaoling Zhou, Tao Liang, Lang Bai, Hong Tang
Fever of unknown origin is a challenging diagnostic problem and the aim of this research was to analyze trends in the distribution of its causative diseases. This retrospective study makes a comparison between two different clinical series of patients from two different periods: 227 from period 1 (1998-2002) and 602 from period 2 (2008-2012). There were fewer infections (31.72% vs.16.45%) and more miscellaneous causes (5.29% vs. 13.12%) in the period 2 series, whereas no significant differences in autoimmune diseases, malignancies and undiagnosed cases were found...
January 16, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28074266/fever-of-unknown-origin-giant-cell-arteritis-and-aortic-dissection
#11
K Hofheinz, S Bertz, J Wacker, G Schett, B Manger
Giant cell arteritis is one of the most frequent causes of pyrexia of unknown origin after infectious or malignant causes have been ruled out. In this case report we describe a 66-year old female patient, who after five weeks of remitting fever developed a life-threatening, painless severe aortic dissection. The timely use of modern imaging technologies such as magnetic resonance angiography or positron emission computed tomography could in the future be of help to recognize aortic involvement early and to avoid this devastating complication in patients with fever of unknown origin...
February 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28068282/serological-and-molecular-biological-studies-of-parvovirus-b19-coxsackie-b-viruses-and-adenoviruses-as-potential-cardiotropic-viruses-in-bulgaria
#12
Stefka Kr Ivanova, Svetla G Angelova, Asya P Stoyanova, Irina L Georgieva, Lubomira K Nikolaeva-Glomb, Zafira G Mihneva, Neli St Korsun
BACKGROUND: Inflammatory diseases of the heart (myocarditis, pericarditis) are commonly caused by viruses. Among the human cardiotropic viruses, parvovirus B19, Coxsackie B viruses, and adenoviruses play a leading role. AIM: The aim of the present study was to determine the presumptive causative role of parvovirus B19, Coxsackie B viruses, and adenoviruses in the development of myocarditis, pericarditis and dilated cardiomyopathy by demonstrating the presence of specific antiviral antibodies or viral DNA in patients' serum samples...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28062417/pulmonary-tuberculosis-presenting-as-post-operative-fever-of-unknown-origin
#13
Patrick Bogue, Mhairi Bolland, Peter How, Harrison Benziger
Post-operative fever is common following emergency surgery. Investigation and management of post-operative fever can be challenging when a clear source of sepsis is not evident or the underlying source of infection is not recognised. We herein report a case of secondary pulmonary tuberculosis presenting as post-operative fever following emergency laparotomy for a perforated duodenal ulcer. This case of tuberculosis was diagnosed on day 41 post-operatively and prior inconclusive results meant that we relied mainly on re-visiting history and examination in order to identify 3 targeted investigations: plain chest X-ray, sputum sample and blood test...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28052948/tb-or-not-to-be-kikuchi-fujimoto-disease-a-rare-but-important-differential-for-tb
#14
C McKenna, T Whitfield, N Patel, A Bonington
A 29-year-old British Pakistani woman presented with a 2-month history of drenching fevers, night sweats, lethargy and tender cervical and axillary lymphadenopathy. Initial investigations, bloods and imaging were unremarkable. Fever persisted during her admission, and treatment for tuberculosis (TB) lymphadenitis was started postbiopsy until histology confirmed a diagnosis of Kikuchi-Fujimoto's disease (KFD). KFD has a non-specific presentation of fever, night sweats and lymphadenopathy and commonly raises a clinical suspicion of a number of other serious conditions such as TB, lymphoma, HIV, systemic lupus erythematous, toxoplasmosis and infectious mononucleosis...
January 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28018446/familial-mediterranean-fever-presenting-as-fever-of-unknown-origin-in-korea
#15
Jun Hee Lee, Jong Hyun Kim, Jung Ok Shim, Kwang Chul Lee, Joo Won Lee, Jung Hwa Lee, Jae Jin Chae
Familial Mediterranean fever (FMF) is the most common Mendelian autoinflammatory disease, characterized by uncontrolled activation of the innate immune system that manifests as recurrent brief fever and polyserositis (e.g., peritonitis, pleuritic, and arthritis). FMF is caused by autosomal recessive mutations of the Mediterranean fever gene, MEFV which encodes the pyrin protein. Although FMF predominantly affects people from Mediterranean and Middle Eastern ethnic origins, 3 cases of FMF have been reported in Korea since 2012...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28009946/successful-surgical-treatment-of-a-huge-candida-albicans-aortic-fungus-ball-with-pseudoaneurysm
#16
Satoru Tobinaga, Yuichirou Hirata, Hiroyuki Saisho, Kumiko Wada, Kohsuke Saku, Satoshi Kikusaki, Tohru Takaseya, Hiroyuki Tanaka
A 70-year-old woman with a history of aortic valve replacement and coronary artery bypass grafting (CABG) was transferred to the authors' hospital for further management of a three-month fever of unknown origin. Computed tomography showed a huge mass in the ascending aorta with pseudoaneurysm. Blood β-D-glucan levels were significantly high, and blood culture showed the growth of Candida albicans. The fungus ball was excised surgically, together with aortic root replacement and CABG, followed by six-month postoperative anti-fungal therapy...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28006774/the-prevalence-of-fabry-disease-in-patients-with-chronic-kidney-disease-in-turkey-the-turkfab-study
#17
Kultigin Turkmen, Aydın Guclu, Garip Sahin, Ismail Kocyigit, Levent Demirtas, Fatih Mehmet Erdur, Erkan Sengül, Oktay Ozkan, Habib Emre, Faruk Turgut, Hilmi Unal, Murat Karaman, Cengiz Acıkel, Hasan Esen, Ebru Balli, Gulfidan Bıtırgen, Halil Zeki Tonbul, Mahmut Ilker Yılmaz, Alberto Ortiz
BACKGROUND/AIMS: Fabry disease is a treatable cause of chronic kidney disease (CKD) characterized by a genetic deficiency of α-galactosidase A. European Renal Best Practice (ERBP) recommends screening for Fabry disease in CKD patients. However, this is based on expert opinion and there are no reports of the prevalence of Fabry disease in stage 1-5 CKD. Hence, we investigated the prevalence of Fabry disease in CKD patients not receiving renal replacement therapy. METHODS: This prospective study assessed α-galactosidase activity in dried blood spots in 313 stage 1-5 CKD patients, 167 males, between ages of 18-70 years whose etiology of CKD was unknown and were not receiving renal replacement therapy...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27999807/clinical-and-microbiological-characteristics-of-visceral-leishmaniasis-outbreak-in-a-northern-italian-nonendemic-area-a-retrospective-observational-study
#18
E Franceschini, C Puzzolante, M Menozzi, L Rossi, A Bedini, G Orlando, W Gennari, M Meacci, G Rugna, E Carra, M Codeluppi, C Mussini
Background. Visceral leishmaniasis (VL) caused by Leishmania infantum is endemic in the Mediterranean area. In the last decades a northward spread of the parasite has been observed in Italy. This paper describes a VL outbreak in Modena province (Emilia-Romagna, Northern Italy) between 2012 and 2015. Methods. Retrospective, observational study to evaluate epidemiological, microbiological characteristics, and clinical management of VL in patients referring to Policlinico Modena Hospital. Results. Sixteen cases of VL occurred in the study period...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27984785/comparison-of-n-and-o-linked-glycosylation-patterns-of-ebolavirus-glycoproteins
#19
Amanda L Collar, Elizabeth C Clarke, Eduardo Anaya, Denise Merrill, Sarah Yarborough, Scott M Anthony, Jens H Kuhn, Christine Merle, Manfred Theisen, Steven B Bradfute
Ebolaviruses are emerging pathogens that cause severe and often fatal viral hemorrhagic fevers. Four distinct ebolaviruses are known to cause Ebola virus disease in humans. The ebolavirus envelope glycoprotein (GP1,2) is heavily glycosylated, but the precise glycosylation patterns of ebolaviruses are largely unknown. Here we demonstrate that approximately 50 different N-glycan structures are present in GP1,2 derived from the four pathogenic ebolaviruses, including high mannose, hybrid, and bi-, tri-, and tetra-antennary complex glycans with and without fucose and sialic acid...
February 2017: Virology
https://www.readbyqxmd.com/read/27964789/rheumatologic-diseases-as-the-cause-of-fever-of-unknown-origin
#20
REVIEW
C M Mulders-Manders, A Simon, C P Bleeker-Rovers
In 30% of patients with fever or inflammation of unknown origin (FUO/IUO), the cause is eventually found to be a rheumatologic disease such as autoimmune or granulomatous disease or vasculitis. Most of these patients suffer from an uncommon presentation of a common disease, instead of an uncommon disease. We demonstrate the diagnostic challenge with several cases. The workup of FUO is based on the identification of potential diagnostic clues (PDCs). In the absence of PDCs, a standardized diagnostic protocol should be followed, including early FDG-PET/CT...
October 2016: Best Practice & Research. Clinical Rheumatology
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