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"Chitosan Nanoparticle"

Jing Zhang, Yang Chen, Jing Xu, Jingjing Wang, Chengzhang Li, Liyan Wang
The purposes of this study were to construct a novel tissue engineered bone composed of 3D-printed bioactive glass block/chitosan nanoparticles (BD/CSn) composites loaded with Nel-like Type I molecular-1 DNA (pDNA-NELL1) and/or bone marrow mesenchymal stem cells (BMSCs), and study their osteogenic activities by repairing bone defects in rhesus monkeys. CSn with NELL1 gene plasmid and rhesus monkey BMSCs were composited with a BD scaffold to prepare the tissue-engineered bone. Four adult female rhesus monkeys with 10- to 12-years old and 5-7 kg in weight were used in animal experiments...
August 2018: Regenerative Biomaterials
Francisco J Caro-León, Waldo Argüelles-Monal, Elizabeth Carvajal-Millán, Yolanda L López-Franco, Francisco M Goycoolea-Valencia, Julio San Román Del Barrio, Jaime Lizardi-Mendoza
The materials produced by the supercritical CO2 drying have outstanding properties that allow the incorporation of molecules in their porous structure. In this context, dried chitosan nanoparticles including β-lactoglobulin were obtained. First, the nanoparticles in water suspension were produced by ionotropic gelation incorporating the protein with high loading efficiency. Later, solvent exchange and CO2 supercritical drying procedures were performed. The physicochemical characteristics and structural properties were determined, demonstrating a stable porous structure in the dried materials and corroborating the presence of the protein after the drying...
October 15, 2018: Carbohydrate Polymers
Jianmei Zhang, Yijun Wang, Yunyao Jiang, Tingwu Liu, Yanyan Luo, Enjie Diao, Yufeng Cao, Liang Chen, Liang Zhang, Qian Gu, Jinyi Zhou, Fengting Sun, Wancai Zheng, Jianxun Liu, Xueqin Li, Weicheng Hu
Ginsenoside compound K (CK) has been shown to exhibit anticancer properties. In this study, chitosan nanoparticles loaded with ginsenoside compound K (CK-NPs) were prepared as a delivery system using a self-assembly technique with amphipathic deoxycholic acid-O carboxymethyl chitosan as the carrier, which improved the water solubility of CK. By evaluating drug loading, entrapment efficiency, and in vitro release behavior, the feasibility of CK-NPs as a drug carrier nanoparticle for the treatment of human hepatic carcinoma cells (HepG2) was investigated...
October 15, 2018: Carbohydrate Polymers
Peixiao Tang, Qiaomei Sun, Ludan Zhao, Hongyu Pu, Hongqin Yang, Shuangshuang Zhang, Ruixue Gan, Na Gan, Hui Li
This study aimed to develop a novel sustained release system for mesalazine (MSZ) by preparing hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex loaded chitosan (CS) nanoparticles (NPs). The HP-β-CD/MSZ complex was prepared at 1:1 stoichiometry and characterized by using various analysis techniques. The HP-β-CD/MSZ/CS NPs prepared under the optimum condition had a spherical shape (90±17 nm diameter), a narrow size distribution, and a high loading efficiency. Compared with free MSZ, the HP-β-CD/MSZ/CS NPs exhibited an obvious sustained release of MSZ...
October 15, 2018: Carbohydrate Polymers
Carla Pereira Gomes, Victoria Leiro, Cátia Daniela Ferreira Lopes, Ana Patrícia Spencer, Ana Paula Pêgo
Poly(ethylene glycol) (PEG) has been extensively used to coat the surface of nanocarriers to improve their physicochemical properties and allow the grafting of targeting moieties. Still, to date there is no common agreement on the ideal PEG coverage-density or length to be used for optimum vector performance. In this study, we aimed to investigate the impact of both PEG density and length on the vectoring capacity of neuron-targeted gene-carrying trimethyl chitosan nanoparticles. The non-toxic fragment from the tetanus toxin (HC) was coupled to a 5 kDa heterobifunctional PEG (HC-PEG5k ) reactive for the thiol groups inserted into the polymer backbone and grafted at different densities onto the nanoparticles...
August 6, 2018: Acta Biomaterialia
Kandasamy Saravanakumar, Elango Jeevithan, Ramachandran Chelliah, Kandasamy Kathiresan, Wu Wen-Hui, Deog-Hwan Oh, Myeong-Hyeon Wang
Chitosan (CS), a novel biomaterial is widely used as a drug nano-carrier for cancer treatment. Towards this aim, anticancer and antibacterial activities of CS-nanoparticles-linked zinc (Zn-CSNPs) were evaluated. Particle size of CSNPs lowered (113.09 nm) compared to Zn-CSNPs (160.7 nm). Both nanoparticles (CSNPs and Zn-CSNPs) were spherical in shape, polydispersive, homogenous, amorphous and uniform size. Fourier transforms infrared spectrophotometer (FTIR) and energy dispersive X-ray spectroscopy (EDX) analysis confirmed the different molecular arrangement of NPs and presence of Zn in Zn-CSNPs and CS in both NPs, respectively...
August 6, 2018: International Journal of Biological Macromolecules
Laurane Léost, Jérôme Roques, Anne Van Der Meeren, Luc Vincent, Nicolas Sbirrazzuoli, Christoph Hennig, André Rossberg, Jean Aupiais, Sophie Pagnotta, Christophe Den Auwer, Christophe Di Giorgio
Since the 1940s, great amounts of Plutonium (Pu) have been produced for both military and civil purposes. Until now, the standard therapy for decorporation following inhalation has been the intravenous injection of diethylenetriaminepentaacetic acid ligand (Ca-DTPA form). This method offers a strong complexing constant for Pu(iv) but has poor chemical specificity, therefore its efficacy is limited to actinides present in the blood. Consequently, there is no decorporation treatment currently available which efficiently removes the intracellular Pu(iv) trapped in the pulmonary macrophages...
August 9, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Sayan Roy Chowdhury, Subrata Mondal, Balakrishnan Muthuraj, S N Balaji, Vishal Trivedi, Parameswar Krishnan Iyer
Amyloid oligomers have emerged as a key neurotoxin in Alzheimer's dementia. Amyloid aggregation inhibitors and modulators have therefore offered potential applications in therapeutics and diagnosis. However, crossing the blood-brain barrier (BBB) and finding the toxic aggregates among aggregates of different sizes and shapes remain a challenge. The ability of identifying early aggregates can provide a new approach to find inhibitors of the initial nucleation events correlating presenile dementia. In this study, we have prepared polyfluorene nanoparticles using chitosan as an additive, which enables it to cross BBB efficiently and employed as a highly efficient amyloid oligomer modulator...
July 31, 2018: ACS Omega
Enrica Chiesa, Rossella Dorati, Bice Conti, Tiziana Modena, Emanuela Cova, Federica Meloni, Ida Genta
Bronchiolitis obliterans syndrome (BOS), caused by lung allograft-derived mesenchymal cells' abnormal proliferation and extracellular matrix deposition, is the main cause of lung allograft rejection. In this study, a mild one-step ionotropic gelation method was set up to nanoencapsulate the everolimus, a key molecule in allograft organ rejection prevention, into hyaluronic acid-decorated chitosan-based nanoparticles. Rationale was the selective delivery of everolimus into lung allograft-derived mesenchymal cells; these cells are characterized by the CD44-overexpressing feature, and hyaluronic acid has proven to be a natural selective CD44-targeting moiety...
August 7, 2018: International Journal of Molecular Sciences
Gita Kiaee, Pooria Mostafalu, Mohamadmahdi Samandari, Sameer Sonkusale
Topical administration of drugs in a timely manner according to the physiological need at the wound site can enhance the healing rate of chronic wounds. Herein, an electronic wound dressing that enables active topical drug delivery in response to electrically induced pH change is demonstrated for potential treatment of chronic wounds. In this platform, the pH of the dressing is controlled using an electrical field. This allows precise electrical control over the temporal profile of pH-mediated drug release...
August 2, 2018: Advanced Healthcare Materials
Reza Jafari, Naime Majidi Zolbanin, Jafar Majidi, Fatemeh Atyabi, Mehdi Yousefi, Farhad Jadidi-Niaragh, Leili Aghebati-Maleki, Dariush Shanehbandi, Mohammad-Sadegh Soltani Zangbar, Houshang Rafatpanah
Background: Targeted co-delivery of siRNA and a chemotherapeutic drug is an attractive approach to cancer drug design and treatment. This study was carried out to design an anti-Mucin 1 aptamer (Apt)-conjugated chitosan nanoparticle (NP) for targeted co-delivery of insulin-like growth factor receptor 1 (IGF-1R) siRNA and docetaxel (DTX) to SKBR3 cells. Methods: Characterization of nano-drugs, cellular uptake of NPs, cell viability, and gene expression studies were evaluated based on metastatic breast cancer cells...
July 25, 2018: Iranian Biomedical Journal
Mohammad Hasan Karimi, Gholam Reza Mahdavinia, Bakhshali Massoumi
The main objective of this work was to develop κ-carrageenan-crosslinked magnetic chitosan with different molecular weights as pH-responsive carriers for controlled release of anticancer drug sunitinib. The characterization of magnetic carriers revealed that the size of magnetic nanoparticles is affected by the molecular weight of chitosan. Drug encapsulation efficiency and release performance influenced by the size of magnetic nanoparticles. Encapsulation efficiencies of sunitinib by low, medium and high molecular weights of magnetic chitosan carriers were found to be 62...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Maycon Carvalho Ribeiro, Viviane Lopes Rocha Corrêa, Francenya Kelley Lopes da Silva, Jerônimo Raimundo de Oliveira Neto, Ariádine Amorim Casas, Liliana Borges de Menezes, André Corrêa Amaral
No abstract text is available yet for this article.
July 20, 2018: International Journal of Biological Macromolecules
Abdolreza Ardeshirylajimi, Sayyed Mohammad-Hossein Ghaderian, Mir Davood Omrani, Sadegh Lotfalah Moradi
Since the functional recovery of the reconstructed bladder is related to the bladder wall contraction and existing therapies do not respond to this, tissue engineering could be worth considered promising candidates for developing of conventional treatments in these kinds of ailments. Due to the low mechanical properties of natural scaffolds, biocompatible synthetic scaffolds can play a key role in the stem cells proliferation and differentiation and apply for many tissue-engineering applications. On the other hand, considering the low shelf life of TGFβ, encapsulating this growth factor can help maintain its functionality throughout the study period...
July 17, 2018: Gene
Sultan F Alsharari, Ahmed A Tayel, Shaaban H Moussa
The bioremediation of water and soil, from heavy metal (HM) contamination, is a continuing worldwide demand. Chitosan, as a promising bioactive polymer, was produced from grown fungal (Cunninghamella elegans) mycelia and had a molecular weight of 112 kDa and a deacetylation degree of 87%. Sodium tripolyphosphate was applied for the synthesis of chitosan nanoparticles (NCt) from fungal chitosan (Cts); the particle size of produced NCt was in range of 5-45 nm. The produced biopolymers were used for HM absorption, Pb2+ and Cu2+ at concentration range of 100-300 ppm, from aqueous solution and soil matrix...
July 17, 2018: International Journal of Biological Macromolecules
László Janovák, Árpád Turcsányi, Éva Bozó, Ágota Deák, László Mérai, Dániel Sebők, Ádám Juhász, Edit Csapó, Mohamed M Abdelghafour, Eszter Farkas, Imre Dékány, Ferenc Bari
The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d = 5.2 ± 1.1 nm) was presented in the case of poorly water soluble Ca2+ channel blocker nimodipine (NIMO) drug molecules. The adequate pH-sensitivity, i.e. the suitable drug carrier properties of the initial hydrophilic Chit were achieved by reductive amination of Chit with hexanal (C6 -) and dodecanal (C12 -) aldehydes. The successful modifications of the macromolecule were evidenced via FTIR measurements: the band appearing at 1412 cm-1 (CN stretching in aliphatic amines) in the cases of the hydrophobically modified Chit samples shows that the CN bond successfully formed between the Chit and the aldehydes...
July 17, 2018: European Journal of Pharmaceutical Sciences
Yuangang Liu, Weiji Weng, Shibin Wang, Ruimin Long, Hanwen Li, Huihui Li, Tengteng Li, Mengyi Wu
Diabetes mellitus is the most common endocrine disease worldwide; hyperglycemia is a hallmark of this disease. To alleviate the pain caused by diabetes, developing and utilizing effective diabetic drugs to maintain or recover the function of the residual β-cells is an attractive therapeutic approach. γ-aminobutyric acid (GABA) has been shown to have such effects, but it is easy to have reduced GABA activity under physiological conditions. In the present study, GABA-chitosan nanoparticles (GABA-CS NPs) were prepared, and glucose homeostasis, pancreatic β-cell protection, and anti-inflammatory effects of GABA-CS NPs were investigated in vivo...
March 31, 2018: ACS Omega
Juan Li, Shuangyan Tian, Qi Tao, Yawen Zhao, Ruyi Gui, Fan Yang, Lingquan Zang, Yanzhong Chen, Qineng Ping, Dongzhi Hou
Background: To date, the rapid clearance from ocular surface has been a huge obstacle for using eye drops to treat glaucoma, since it has led to the short preocular residence time and low bioavailability. Methods: The novel nanoparticles (NPs) were designed for topical ophthalmic controlled drug delivery system through intercalating the BH into the interlayer gallery of Na-montmorillonite (Na+Mt) and then further enchasing chitosan nanoparticles. The resulting nanoparticles had a positive charge (+29±0...
2018: International Journal of Nanomedicine
Mohamed I Elshinawy, Lamiaa A Al-Madboly, Walaa M Ghoneim, Nehal M El-Deeb
This study was conducted to investigate the antimicrobial-biofilm activity of chitosan (Ch-NPs), silver nanoparticles (Ag-NPs), ozonated olive oil (O3 -oil) either separately or combined together against endodontic pathogens. While testing the antimicrobial activity, Ch-NPs showed the least minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values exerting eightfold higher bactericidal activity than O3 -oil against both Enterococcus faecalis and Streptococcus mutans as well as fourfold higher fungicidal activity against Candida albicans ...
2018: Frontiers in Microbiology
Brenna Louise Cavalcanti Gondim, Lúcio Roberto Cançado Castellano, Ricardo Dias de Castro, Giovanna Machado, Hugo Lemes Carlo, Ana Maria Gondim Valença, Fabíola Galbiatti de Carvalho
OBJECTIVES: Chitosan nanoparticles (ChNPs) have antifungal effects, however there is a lack of information about the effects of ChNPs against Candida biofilm on denture base surface. This study investigated the ChNPs effect against C. albicans biofilm adhesion and formation, and against Candida spp. biofilm on heat-cured acrylic resin. DESIGN: The ChNPs were synthetized (3800 μg/mL) and characterized by infra-red spectrophotometry and transmission electron microscopy...
July 9, 2018: Archives of Oral Biology
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