keyword
https://read.qxmd.com/read/38527228/ultrasensitive-aptasensing-platform-for-the-detection-of-%C3%AE-amyloid-42-peptide-based-on-mof-containing-bimetallic-porphyrin-graphene-oxide-and-gold-nanoparticles
#1
JOURNAL ARTICLE
Fahimeh Sadat Vajedi, Reza Rasoolzadeh, Lúcio Angnes, Evelyn C S Santos, Ludmila de Paula Cabral Silva
The prompt detection of diseases hinges on the accessibility and the capability to identify relevant biomarkers. The integration of aptamers and the incorporation of nanomaterials into signal transducers have not only expedited but also enhanced the development of nanoaptasensors, enabling heightened sensitivity and selectivity. Here, the bimetallic nickel-cobalt-porphyrin metal-organic framework ((Ni + Cu)TPyP MOF) is regarded as an electron mediator, immobilization platform for an Alzheimer aptamer and to increase the electrochemical signal for the detection of the main biomarker of Alzheimer's disease (AD), amyloid β (Aβ-42)...
March 25, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38511254/exploring-the-role-of-ligand-connectivity-in-mofs-mechanical-stability-the-case-of-mil-100-cr
#2
JOURNAL ARTICLE
Anna Celeste, Pierre Fertey, Jean-Paul Itié, Gabriela Blanita, Claudia Zlotea, Francesco Capitani
The key parameters governing the mechanical stability of highly porous materials such as metal-organic frameworks (MOFs) are yet to be clearly understood. This study focuses on the role of the linker connectivity by investigating the mechanical stability of MIL-100(Cr), a mesoporous MOF with a hierarchical structure and a tritopic linker, and comparing it to MIL-101(Cr) having instead a ditopic linker. Using synchrotron X-ray diffraction and infrared spectroscopy, we investigate the high-pressure behavior of MIL-100(Cr) with both solid and fluid pressure transmitting media (PTM)...
March 21, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38500627/enhancement-of-pb-ii-adsorptive-removal-by-incorporation-of-uio-66-cooh-into-the-magnetic-graphitic-carbon-nitride-nanosheets
#3
JOURNAL ARTICLE
Sayeh Alvandi, Mojtaba Hosseinifard, Mohsen Bababmoradi
Efficient elimination of Lead (Pb(ii)) from aqueous solutions has become a crucial area of focus in the wastewater treatment industry. In this study, novel mesoporous magnetic g-C3 N4 /Fe3 O4 /UiO-66-COOH was synthesized by combining the acid-functionalized metal-organic framework (MOF) of UiO-66-COOH via a facile novel solvothermal method with magnetic graphitic carbon nitride (g-C3 N4 /Fe3 O4 ) sheets to enhance Pb(ii) adsorption in water. The study investigated various influential adsorption parameters, including pH, dosage, contact time, ion concentration, and temperature...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38500377/one-step-purification-and-immobilization-of-glycosyltransferase-with-zn-ni-mof-for-the-synthesis-of-rare-ginsenoside-rh2
#4
JOURNAL ARTICLE
Zhiyan Li, Xiaochen Liu, Zhansheng Wu, Xinjian Huang, Hongyang Long, Junsong Yue, Shanshan Cao, Daidi Fan
Uridine diphosphate (UDP)-glucosyltransferases (UGTs) have received increasing attention in the field of ginsenoside Rh2 conversion. By harnessing the metal chelation between transition metal ions and imidazole groups present on His-tagged enzymes, a specific immobilization of the enzyme within metal-organic frameworks (MOFs) is achieved. This innovative approach not only enhances the stability and reusability of the enzyme but also enables one-step purification and immobilization. Consequently, the need for purifying crude enzyme solutions is effectively circumvented, resulting in significant cost savings during experimentation...
March 18, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38488126/a-linker-selective-retention-strategy-to-construct-hierarchical-porous-metal-organic-frameworks-with-high-catalytic-activity-for-oxidative-desulfurization
#5
JOURNAL ARTICLE
Xiaowen Sun, Yun-Feng Gu, Xiao-Min Zhang, Yan Shen, Dan-Hong Wang, Shu-Ming Zhang, Mei-Hui Yu, Ze Chang
In order to improve the oxidative desulfurization (ODS) performance of MOF materials, an effective way is to convert a microporous MOF into a hierarchical porous MOF (HP-MOF) by utilizing the linker selective retention strategy. Herein, UiO-66 with the introduction of an unstable linker ligand (dihydro-1,2,4,5-tetrazine-3,6-dicarboxylate, dhtz) can selectively remove dhtz ligands to form HP-MOF (HP-UiO-66-dhtz) through heat treatment at high temperature. While maintaining the original structure of UiO-66, HP-UiO-66-dhtz features mesopores and abundant Lewis acid sites, showing excellent ODS performance for diphenylthiophene (DBT)...
March 15, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38483636/dispersive-hierarchically-porous-composites-based-on-defective-mofs-as-mixed-mode-stationary-phases-for-chromatographic-separation
#6
JOURNAL ARTICLE
Tiantian Si, Shuai Wang, Yong Guo, Xiaojing Liang, Rong Rong
Defective metal-organic frameworks-based composites with excellent separation properties were obtained. The mesoporous metal-organic frameworks were selected and deliberately designed to be deficient, and they were then combined with polyacrylamide to be modified on the surface of silica microspheres. The prepared composites were employed as mixed-mode stationary phase in chromatographic separation, and they were compared to both conventional microporous metal-organic framework-based columns and commercial columns...
March 14, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38452684/hybrid-plasmonic-aerogel-with-tunable-hierarchical-pores-for-size-selective-multiplexed-detection-of-vocs-with-ultrahigh-sensitivity
#7
JOURNAL ARTICLE
Xin Liu, Tiehu Li, Yuhui Liu, Yiting Sun, Yanying Han, Tung Chun Lee, Amir Zada, Zeqi Yuan, Fei Ye, Jiahe Chen, Alei Dang
Sensitive and rapid identification of volatile organic compounds (VOCs) at ppm level with complex composition is vital in various fields ranging from respiratory diagnosis to environmental safety. Herein, we demonstrate a SERS gas sensor with size-selective and multiplexed identification capabilities for VOCs by executing the pre-enrichment strategy. In particular, the macro-mesoporous structure of graphene aerogel and micropores of metal-organic frameworks (MOFs) significantly improved the enrichment capacity (1...
February 25, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38426438/a-biodegradable-nanosuspension-locally-used-for-inhibiting-postoperative-recurrence-and-brain-metastasis-of-breast-cancer
#8
JOURNAL ARTICLE
Min Qian, Guangwei Jiang, Wei Guo, Rongqin Huang
Addressing the urgent need to prevent breast cancer postoperative recurrence and brain metastasis, Fe-metal organic framework (MOF)-coated hollow mesoporous organosilica nanoparticles (HMON) with tumor microenvironment dual-responsive degradability were prepared to encapsulate doxorubicin (DOX), formulating a tissue-adhesive nanosuspension for perioperative topical medication. This nanosuspension can not only retain the sustainably released drug in the postoperative residual tumor sites but also enhance the intracellular oxidative stress of tumors for remarkable tumor ferroptosis...
March 1, 2024: Nano Letters
https://read.qxmd.com/read/38397928/advancing-cancer-treatment-enhanced-combination-therapy-through-functionalized-porous-nanoparticles
#9
REVIEW
Kibeom Kim, Myoung-Hwan Park
Cancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations associated with conventional methods. Combination therapy, integrating multiple treatment modalities such as chemotherapy, phototherapy, immunotherapy, and others, has emerged as an effective strategy to address the shortcomings of individual treatments...
January 31, 2024: Biomedicines
https://read.qxmd.com/read/38391559/advances-in-nanomaterials-and-composites-based-on-mesoporous-materials-as-antimicrobial-agents-relevant-applications-in-human-health
#10
REVIEW
Germán E Gomez, Mariana Hamer, Matías D Regiart, Gonzalo R Tortella, Amedea B Seabra, Galo J A A Soler Illia, Martín A Fernández-Baldo
Nanotechnology has emerged as a cornerstone in contemporary research, marked by the advent of advanced technologies aimed at nanoengineering materials with diverse applications, particularly to address challenges in human health. Among these challenges, antimicrobial resistance (AMR) has risen as a significant and pressing threat to public health, creating obstacles in preventing and treating persistent diseases. Despite efforts in recent decades to combat AMR, global trends indicate an ongoing and concerning increase in AMR...
February 9, 2024: Antibiotics
https://read.qxmd.com/read/38382787/fabrication-and-characterization-of-a-bi-2-o-3-modified-chitosan-zif-8-nanocomposite-for-enhanced-drug-loading-releasing-efficacy
#11
JOURNAL ARTICLE
Zahra Khalili, Negar Moatakef Kazemi, Zahra Jafari Azar, Zahra Mosavi, Mehdi Hasanzadeh
In this study, a simple novel hybrid mesoporous nanomaterial derived from a metal-organic framework (ZIF-8) and chitosan, which were coated on green bismuth oxide, has been successfully synthesized, characterized, and applied to investigate its dapsone loading-releasing capability in the aqueous media. This suggested nanocomposite showed promise for drug loading from water b using hydrogen bonds, pi-pi, and electrostatic interactions. Structural and morphological analyses were performed on the proposed green synthesized nanocomposite through scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, Brunauer-Emmett-Teller analysis, and thermogravimetric analysis...
February 19, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38364203/interior-and-exterior-surface-modification-of-zr-based-metal-organic-frameworks-for-trace-benzene-removal
#12
JOURNAL ARTICLE
Jia-Ao Lv, Zhen-Ling Tang, Yu-Hui Liu, Rui-Chao Zhao, Lin-Hua Xie, Xiao-Min Liu, Jian-Rong Li
The emission of volatile organic compounds (VOCs) significantly contributes to air pollution and poses a serious threat to human health. Benzene, one of the most toxic VOCs, is difficult for the human body to metabolize and is classified as a Group 1 carcinogen. The development of efficient adsorbents for removing trace amounts of benzene from ambient air is thus of great importance. In this work, we studied the benzene adsorption properties of four Zr-based metal-organic frameworks (Zr-MOFs) through static volumetric and dynamic breakthrough experiments...
February 16, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38356233/combination-of-click-chemistry-and-schiff-base-reaction-post-synthesis-of-covalent-organic-frameworks-as-an-immobilized-metal-ion-affinity-chromatography-platform-for-efficient-capture-of-global-phosphopeptides-in-serum-with-chronic-obstructive-pulmonary-disease
#13
JOURNAL ARTICLE
Qian Xu, Xiaoli Guo, Simeng Wang, Quanshou Feng, Shi Yan, Yinghua Yan
Reasonable design and construction of functionalized materials are of great importance for the enrichment of global phosphopeptides. In this work, Ti4+ functionalized hydrophilic covalent organic frameworks by introducing glutathione (GSH) and 2,3,4-trihydroxy benzaldehyde (THBA) via click chemistry and Schiff base reaction (COF-V@GSH-THBA-Ti4+ ) was constructed and applied for selective enrichment of phosphopeptides in serum. Benefit from the high surface area, excellent hydrophilicity as well as regular mesoporous structure, COF-V@GSH-THBA-Ti4+ displayed high selectivity (molar ratio of 2000:1), low limit of detection (0...
February 2024: Journal of Separation Science
https://read.qxmd.com/read/38353764/janus-quasi-solid-electrolyte-membranes-with-asymmetric-porous-structure-for-high-performance-lithium-metal-batteries
#14
JOURNAL ARTICLE
Zerui Chen, Wei Zhao, Qian Liu, Yifei Xu, Qinghe Wang, Jinmin Lin, Hao Bin Wu
Quasi-solid electrolytes (QSEs) based on nanoporous materials are promising candidates to construct high-performance Li-metal batteries (LMBs). However, simultaneously boosting the ionic conductivity (σ) and lithium-ion transference number (t+ ) of liquid electrolyte confined in porous matrix remains challenging. Herein, we report a novel Janus MOFLi/MSLi QSEs with asymmetric porous structure to inherit the benefits of both mesoporous and microporous hosts. This Janus QSE composed of mesoporous silica and microporous MOF exhibits a neat Li+ conductivity of 1...
February 14, 2024: Nano-Micro Letters
https://read.qxmd.com/read/38340327/facile-fabrication-of-hollow-nanoporous-carbon-architectures-by-controlling-mof-crystalline-inhomogeneity-for-ultra-stable-na-ion-storage
#15
JOURNAL ARTICLE
Ze-Lin Zheng, Ming-Min Wu, Xian Zeng, Xiao-Wei Zhu, Dong Luo, Xue-Ling Chen, Yan-Fei Chen, Guo-Zhan Yang, De-Shan Bin, Xiao-Ping Zhou, Dan Li
Hollow nanoporous carbon architectures (HNCs) present significant utilitarian value for a wide variety of applications. Facile and efficient preparation of HNCs has long been pursued but still remains challenging. Herein, we for the first time demonstrate that single-component metal-organic frameworks (MOFs) crystals, rather than the widely reported hybrid ones which necessitate tedious operations for preparation, could enable the facile and versatile syntheses of functional HNCs. By controlling the growth kinetics, the MOFs crystals (STU-1) are readily engineered into different shapes with designated styles of crystalline inhomogeneity...
February 10, 2024: Angewandte Chemie
https://read.qxmd.com/read/38325709/dressing-and-undressing-mof-nanophotosensitizers-to-manipulate-phototoxicity-for-precise-therapy-of-tumors
#16
JOURNAL ARTICLE
Cheng Tao, Nuo Yu, Qian Ren, Mei Wen, Pu Qiu, Shining Niu, Maoquan Li, Zhigang Chen
Photodynamic therapy (PDT) is a clinically approved treatment for tumors, and it relies on the phototoxicity of photosensitizers by producing reactive oxygen species (ROS) to destroy cancer cells under light irradiation. However, such phototoxicity is a double-edged sword, which is also harmful to normal tissues. To manipulate phototoxicity and improve the therapy effect, herein we have proposed a dressing-undressing strategy for de-activating and re-activating therapy functions of photosensitizer nanoparticles...
February 5, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38315971/a-gas-steamed-route-to-mesoporous-open-metal-organic-framework-cages-enhancing-flame-retardancy-and-smoke-suppression-of-polyurea
#17
JOURNAL ARTICLE
Kunpeng Song, Xue Bi, Chuang Yu, Ye-Tang Pan, Henri Vahabi, Vera Realinho, Jiyu He, Rongjie Yang
Up to now, metal-organic frameworks (MOFs) with open nanostructures have shown outstanding capabilities in trapping smoke particles compared to the original MOFs. However, only a few MOF-based strategies have been reported to synthesize hierarchical porous cages thus far, which are mainly restricted to environmentally unfriendly wet-chemical liquid methods. Herein, as a proof-of-concept, a gas-steamed metal-organic framework approach was designed to fabricate a series of cheeselike open cages with hierarchical porosity...
February 5, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38314739/surface-electroactive-sites-of-tungstated-zirconia-catalysts-for-vanadium-redox-flow-batteries
#18
JOURNAL ARTICLE
Aknachew Mebreku Demeku, Daniel Manaye Kabtamu, Guan-Cheng Chen, Yun-Ting Ou, Zih-Jhong Huang, Tai-Chin Chiang, Hsin-Chih Huang, Chen-Hao Wang
Surface electroactive sites for tungstate zirconia (WZ) were created by utilizing tungstate-immobilized UiO-66 as precursors via a double-solvent impregnation method under a mild calcination temperature. The WZ-22-650 catalyst, containing a moderate W content (22%), demonstrated a high density of surface electroactive sites. Proper heat treatment facilitated the binding of oligomeric tungsten clusters to stabilized tetragonal ZrO2 , resulting in improved catalytic performance toward the VO2+ /VO2 + redox couples compared to other tested samples...
February 5, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38280286/coupling-ultrafine-tio-2-within-pyridinic-n-enriched-porous-carbon-towards-high-rate-and-long-life-sodium-ion-capacitors
#19
JOURNAL ARTICLE
Cuiping Yu, Jianjian Sun, Chenhong Xia, Yan Wang, Jianfang Zhang, Rui Cai, Jiewu Cui, Hark Hoe Tan, Yong Zhang, Yucheng Wu
Coupling TiO2 within N-doped porous carbon (NPC) is essential for enhancing its Na+ storage performance. However, the role of different N configurations in NPC in improving the electrochemical performance of TiO2 is currently unknown. In this study, melamine is deliberately incorporated as a pore-forming agent in the self-assembly process of metal organic framework precursors (NH2 -MIL-125(Ti)). This intentional inclusion of melamine leads to the one-pot and in-situ formation of highly active edge-N, which is vital for the development of TiO2 /NPC with exceptional reactivity...
January 19, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38265230/mitochondrial-topoisomerase-1-targeted-anticancer-therapy-using-irinotecan-encapsulated-mesoporous-mil-101-fe-synthesized-via-a-vapour-assisted-method
#20
JOURNAL ARTICLE
Anirban Ghosh, Arijit Ghosh, Arpan Bhattacharyya, Riddhi Mitra, Benu Brata Das, Asim Bhaumik
Mitochondrial topisomerase 1 (Top1mt) is critical for mtDNA replication, transcription, and energy production. Here, we investigate the carrier-mediated targeted delivery of the anticancer drug irinotecan into the mitochondria to selectively trap Top1mt covalent complexes (Top1mtcc) and its role in anticancer therapeutics. We have designed a biocompatible mesoporous metal-organic framework (MOF) material, namely MIL-101(Fe), as the drug delivery carrier that selectively localizes inside mitochondria. In contrast to the traditional way of synthesising MOFs, here we have employed a vapour-assisted solvothermal method for the synthesis of MIL-101(Fe) using terephthalic acid as the organic linker and Fe(III) as the metal source...
January 24, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
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