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T3 T4 breast cancer surgery

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https://www.readbyqxmd.com/read/29800703/perioperative-inhibition-of-%C3%AE-adrenergic-and-cox2-signaling-in-a-clinical-trial-in-breast-cancer-patients-improves-tumor-ki-67-expression-serum-cytokine-levels-and-pbmcs-transcriptome
#1
Rita Haldar, Lee Shaashua, Hagar Lavon, Yasmin A Lyons, Oded Zmora, Eran Sharon, Yehudit Birnbaum, Tanir Allweis, Anil K Sood, Iris Barshack, Steve Cole, Shamgar Ben-Eliyahu
Catecholamines and prostaglandins are secreted abundantly during the perioperative period in response to stress and surgery, and were shown by translational studies to promote tumor metastasis. Here, in a phase-II biomarker clinical trial in breast cancer patients (n = 38), we tested the combined perioperative use of the β-blocker, propranolol, and the COX2-inhibitor, etodolac, scheduled for 11 consecutive perioperative days, starting 5 days before surgery. Blood samples were taken before treatment (T1), on the mornings before and after surgery (T2&T3), and after treatment cessation (T4)...
May 22, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29422254/the-assisi-think-tank-meeting-and-survey-of-post-mastectomy-radiation-therapy-after-breast-reconstruction-the-attm-smart-report
#2
Cynthia Aristei, Orit Kaidar-Person, Luca Tagliaferri, Meritxell Arenas, Charlotte E Coles, Birgitte V Offersen, Giovanni Frezza, Maria Cristina Leonardi, Vincenzo Valentini, Céline Bourgier, Philip M P Poortmans
PURPOSE: To describe the current European practise on post-mastectomy radiation therapy (PMRT) in relation to breast reconstruction. METHODS: A 21-item questionnaire was distributed online via Survey Monkey. Items referred to 1. general topics (country, centre, years of experience in breast cancer); 2. clinical decision making; 3. RT techniques and dosimetry; 4. dose fractionation. RESULTS: 283 responses were received from 19 countries. Most responders worked in public health services and in academic institutions and had 5-20 years experience...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28989150/-parecoxib-suppresses-the-increase-of-neutrophil-to-lymphocyte-ratio-after-the-modified-radical-mastectomy
#3
Yunli Li, Lei Zhou, Xiaoxiao Li, Gong Chen, Kaiming Duan, Boni Ding, Wen Ouyang
To observe the effect of parecoxib on neutrophil-to-lymphocyte ratio (NLR)after the modified radical mastectomy, and to explore its potential mechanisms for inhibition of perioperative inflammation.
 Methods: A total of 40 breast cancer patients undergone the modified radical mastectomy were randomly divided into a parecoxib group (n=20) and a control group (n=20). The parecoxib group received intravenous parecoxib (40 mg, 5 mL) during general anesthesia induction, post-operative day 1 and day 2; the control group received intravenous normal saline (5 mL) at the corresponding time points...
September 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28360434/locally-advanced-breast-cancer-in-elderly-patients
#4
COMPARATIVE STUDY
Jana Hornova, Zbynek Bortlicek, Petra Majkova, Jitka Abrahamova, Drahomira Kordikova, Zuzana Donatova, Martin Kupec, Ludmila Boublikova, Josef Dvorak, Radek Zapletal, Tomas Buchler
BACKGROUND: Although locally advanced breast cancer (LABC) is more common in the elderly population, there is little data on the clinical characteristics and survival of these patients. The aim of the present study was to compare different factors affecting survival in elderly patients with LABC. METHODS: Retrospective analysis was carried out on a cohort of 80 patients aged 70 to 96 years, diagnosed with LABC defined as T3 N1, T4 N0, any N2 or N3, and M0. The prognostic impact of selected clinical parameters including age, comorbidities, tumour grade, HER2 status, tumour stage, local therapies, and systemic treatments was studied...
June 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28355358/breast-conserving-surgery-in-locally-advanced-breast-cancer-submitted-to-neoadjuvant-chemotherapy-safety-and-effectiveness-based-on-ipsilateral-breast-tumor-recurrence-and-long-term-follow-up
#5
Guilherme Freire Angotti Carrara, Cristovam Scapulatempo-Neto, Lucas Faria Abrahão-Machado, Maria Mitzi Brentani, João Soares Nunes, Maria Aparecida Azevedo Koike Folgueira, René Aloisio da Costa Vieira
OBJECTIVE: To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced breast cancer. METHODS: A retrospective observational cohort study was performed in patients with locally advanced breast cancer submitted to breast-conserving surgery after neoadjuvant chemotherapy based on an adriamycin-cyclophosphamide-paclitaxel regimen. We evaluated the clinical, pathologic, immunohistochemistry, and surgical factors that contribute to ipsilateral breast tumor recurrence and locoregional recurrence...
March 2017: Clinics
https://www.readbyqxmd.com/read/27872528/evaluation-of-surgical-outcomes-of-oncoplasty-breast-surgery-in-locally-advanced-breast-cancer-and-comparison-with-conventional-breast-conservation-surgery
#6
Ashutosh Chauhan, Mala Mathur Sharma, Kishore Kumar
The purpose of this study was to compare early oncologic outcomes of oncoplastic breast surgery and conventional breast conservation surgery in patients of locally advanced breast cancer. A single-center, prospective, non-randomized study enrolled select cases of locally advanced breast cancer (TNM T3/T4, N0/1/2) who after neoadjuvant chemotherapy, were considered for breast conservation surgery with oncoplasty techniques. The specimen volume resected, the mean margins and mean closest margin obtained were noted...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27688732/male-breast-cancer-a-clinicopathological-study-of-an-egyptian-population-alexandria-experience
#7
Maher Soliman, Marcin Hetnał
AIM OF THE STUDY: The purpose of this retrospective study is to evaluate the clinicopathological features and treatment results of male breast cancer presented to our tertiary referral center. MATERIAL AND METHODS: Between January 1998 and December 2005, a total of 39 men with breast cancer treated at Alexandria Main University Hospital and their medical records were reviewed. RESULTS: The median age of patients was 59 years. Only 3 (7.7%) patients had positive family history...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27635622/evaluating-candidacy-for-hypofractionated-radiation-therapy-accelerated-partial-breast-irradiation-and-endocrine-therapy-after-breast-conserving-surgery-a-surveillance-epidemiology-and-end-results-seer-analysis
#8
Bindu V Manyam, Rahul Tendulkar, Sheen Cherian, Frank Vicini, Shahed N Badiyan, Chirag Shah
PURPOSE/OBJECTIVE(S): After breast conserving surgery, adjuvant radiation therapy represents the standard of care for most patients. However, multiple options exist beyond standard fractionated whole breast irradiation including hypofractionated whole breast irradiation (HFRT), accelerated partial breast irradiation (APBI), and endocrine therapy (ET) alone, which can limit treatment duration, and potentially reduce morbidity and cost. Limited data are available on the percentage of patients eligible for these alternatives; therefore, a Surveillance Epidemiology and End Results (SEER) analysis was performed to assess candidacy for these alternative options in women with early stage breast cancer...
June 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27522187/-radiotherapy-of-breast-cancer
#9
C Hennequin, I Barillot, D Azria, Y Belkacémi, M Bollet, B Chauvet, D Cowen, B Cutuli, A Fourquet, J M Hannoun-Lévi, M Leblanc, M A Mahé
In breast cancer, radiotherapy is an essential component of the treatment. After conservative surgery for an infiltrating carcinoma, radiotherapy must be systematically performed, regardless of the characteristics of the disease, because it decreases the rate of local recurrence and by this way, specific mortality. Partial breast irradiation could not be proposed routinely but only in very selected and informed patients. For ductal carcinoma in situ, adjuvant radiotherapy must be also systematically performed after lumpectomy...
September 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27453779/attaining-pathological-complete-regression-for-breast-conservation%C3%A2-%C3%A2-a-pilot-experience-in-a-developing-country
#10
E A Sule, M A Nzegwu
CONTEXT: Local recurrence is a formidable risk consideration in employing breast conservation for breast cancer. However pathological complete regression (PCR) from chemotherapy has been associated with improved rates of recurrence. Lower PCR rates have been reported from earlier studies and our approach seeks to obtain higher PCR rates utilizing a two pronged approach of surgery and chemotherapy. OBJECTIVE: To determine success rates in attaining pathologically complete regression for breast conservation in non-metastatic breast cancer cases in a developing country and their clinical outcome...
August 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27400910/effect-of-a-multidiscipline-mentor-based-program-be-resilient-to-breast-cancer-brbc-on-female-breast-cancer-survivors-in-mainland-china-a-randomized-controlled-theoretically-derived-intervention-trial
#11
RANDOMIZED CONTROLLED TRIAL
Zeng Jie Ye, Mu Zi Liang, Hong Zhong Qiu, Mei Ling Liu, Guang Yun Hu, Yun Fei Zhu, Zhen Zeng, Jing Jing Zhao, Xiao Ming Quan
To reduce the risk of adjustment problems for breast cancer patients in mainland China, we examined the efficacy of a multidiscipline mentor-based program, Be Resilient to Breast Cancer (BRBC), delivered after breast surgery to (a) increase protective factors of social support, hope for the future, etc.; (b) decrease risk factors of Physical and Emotional Distress; and (c) increase outcomes of Resilience, Transcendence and Quality of Life (QOL). A multisite randomized controlled trial was conducted at 6 specialist cancer hospitals...
August 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26981506/molecular-classification-and-prognostication-of-300-node-negative-breast-cancer-cases-a-tertiary-care-experience
#12
K M Zuhara Shemin, N V Smitha, Annie Jojo, D K Vijaykumar
BACKGROUND: The proportion of node-negative breast cancer patients has been increasing with improvement of diagnostic modalities and early detection. However, there is a 20-30% recurrence in node-negative breast cancers. Determining who should receive adjuvant therapy is challenging, as the majority are cured by surgery alone. Hence, it requires further stratification using additional prognostic and predictive factors. SUBJECTS AND METHODS: Ours is a single institution retrospective study, on 300 node-negative breast cancer cases, who underwent primary surgery over a period of 7 years (2005-2011)...
October 2015: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/26691964/predictors-of-surgery-types-after-neoadjuvant-therapy-for-advanced-stage-breast-cancer-analysis-from-florida-population-based-cancer-registry-1996-2009
#13
Jamila Al-Azhri, Tulay Koru-Sengul, Feng Miao, Constantine Saclarides, Margaret M Byrne, Eli Avisar
PURPOSE: Despite the established guidelines for breast cancer treatment, there is still variability in surgical treatment after neoadjuvant therapy (NT) for women with large breast tumors. Our objective was to identify predictors of the type of surgical treatment: mastectomy versus breast-conserving surgery (BCS) in women with T3/T4 breast cancer who received NT. METHODS: Population-based Florida Cancer Data System Registry, Florida's Agency for Health Care Administration, and US census from 1996 to 2009 were linked for women diagnosed with T3/T4 breast cancer and received NT followed by either BCS or mastectomy...
2015: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/26683801/comparative-analysis-of-the-effects-of-radiotherapy-versus-radiotherapy-after-adjuvant-chemotherapy-on-the-composition-of-lymphocyte-subpopulations-in-breast-cancer-patients
#14
COMPARATIVE STUDY
Eva K Sage, Thomas E Schmid, Michael Sedelmayr, Mathias Gehrmann, Hans Geinitz, Marciana N Duma, Stephanie E Combs, Gabriele Multhoff
BACKGROUND: Breast cancer is the most common cancer in women worldwide and surgery, radiotherapy (RT) and chemotherapy (ChT) are frequently used to treat this cancer. Adjuvant RT has been shown to cause long-term changes in lymphocyte counts in the peripheral blood. Herein, the time course of changes in lymphocyte subpopulations upon RT was studied in patients with and without adjuvant ChT in order to explore its potential clinical impact. MATERIALS AND METHODS: Total lymphocyte counts and the composition of lymphocyte subpopulations before RT (t0), after 30 Gy (t1), at the end of RT (t2), and 6 weeks (t3), 6 months (t4), and 1 year (t5) after RT were studied by flow cytometry...
January 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26663035/breast-ultrasonography-for-detection-of-metachronous-ipsilateral-breast-tumor-recurrence
#15
Woon-Ju Park, Eun-Kyung Kim, Hee Jung Moon, Min Jung Kim, Seung Il Kim, Byeong-Woo Park
BACKGROUND: Early detection of recurrence improves the survival rate of patients treated with breast conservation therapy (BCT). Therefore, ultrasonography (US) may be useful for metachronous ipsilateral breast tumor recurrence (MIBTR) obscured on mammography by dense breast tissue and distortion. PURPOSE: To evaluate clinical, radiologic, and pathologic findings of MIBTR retrospectively, and to assess the role of surveillance US additional to mammography for MIBTR detection...
October 2016: Acta Radiologica
https://www.readbyqxmd.com/read/26456897/association-with-pregnancy-increases-the-risk-of-local-recurrence-but-does-not-impact-overall-survival-in-breast-cancer-a-case-control-study-of-87-cases
#16
A S Genin, Y De Rycke, D Stevens, A Donnadieu, A Langer, R Rouzier, F Lerebours
Pregnancy-associated breast cancer (PABC) constitutes 7% of all BCs in young women. The prognosis of PABC remains controversial. In this study, we evaluated the impact of the association of pregnancy with BC on the rates of overall survival (OS), disease free survival (DFS), and distant and local recurrence-free survival. We conducted a retrospective unicenter case-control study. We enrolled PABC patients treated at our institution between 1992 and 2009. For each case, 2 BC controls were matched for age and year of diagnosis...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/26370420/the-position-and-current-status-of-radiation-therapy-after-primary-systemic-therapy-in-breast-cancer-a-national-survey-based-expert-consensus-statement
#17
M Arenas, Á Montero, M D de Las Peñas, M Algara
BACKGROUND: Primary systemic therapy (PST) is changing the role of radiation therapy (RT) in breast cancer. Without randomized studies, the optimal indications for RT after PST and surgery are not clear. The present study provides consensus-based recommendations to clarify the role of RT. METHODS: Radiation oncologists (n = 82; 77 % response rate) in Spain were surveyed to determine their recommendations for locoregional RT following PST and surgery. RESULTS: Most (98 %) specialists support whole breast irradiation after breast-conserving surgery (BCS), regardless of pathologic response to PST...
June 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/26324160/a-comparative-validation-of-primary-surgical-versus-post-neo-adjuvant-chemotherapy-sentinel-lymph-node-biopsy-for-stage-iii-breast-cancers
#18
COMPARATIVE STUDY
Gaurav Agarwal, Sendhil Rajan, Sanjay Gambhir, Punita Lal, Narendra Krishnani, Subhash Kheruka
INTRODUCTION: Sentinel lymph node biopsy (SLNB) is the standard of care for staging N0 primary early breast cancers (EBC). Patients in developing countries mostly present with large (LOBC) or locally advanced cancers (LABC) and are treated with neo-adjuvant chemotherapy (NACT). Accuracy of SLNB in staging stage III N0 and post-NACT N0 patients is uncertain. This prospective validation study on LOBC/LABC patients compared the accuracy of SLNB between primary versus post-NACT surgery. MATERIALS AND METHODS: Fifty T3/T4, N0 patients undergoing primary surgery (Group I) and 70 LOBC/LABC (index stage) treated with NACT and N0 at the time of surgery (Group II) were inducted...
July 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/25949218/breast-cancer-in-young-women-in-southern-tunisia-anatomical-study-and-clinical-prognostic-factors-about-a-series-of-83-patients
#19
REVIEW
Mouna Kallel, Fatma Elloumi, Abdelmajid Khabir, Lilia Ghorbal, Souhir Chaabouni, Habib Amouri, Mounir Frikha, Jamel Daoud
PURPOSE: To define epidemiological, clinical, therapeutic and prognostic factors influencing survival of breast cancer in young women younger than 35 in southern Tunisia. MATERIAL AND METHODS: This is a retrospective study of 83 patients younger than 35 years and treated within tumors mammary committee of Sfax. RESULTS: The mean age was 31.7 years. T2 stage, high grade with positive node tumors were frequent. Breast surgery was performed for 73 patients...
May 2015: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/25578377/tumour-size-is-the-only-predictive-factor-of-distant-recurrence-after-pathological-complete-response-to-neoadjuvant-chemotherapy-in-patients-with-large-operable-or-locally-advanced-breast-cancers-a-sub-study-of-eortc-10994-big-1-00-phase-iii-trial
#20
RANDOMIZED CONTROLLED TRIAL
F Fei, C Messina, L Slaets, C Chakiba, D Cameron, J Bogaerts, H Bonnefoi
PURPOSE: Although achieving a pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) in breast cancer predicts a better outcome, some patients still relapse. The objectives of this study were to describe the types of events in this group of patients and to identify predictive factors for relapse. METHODS: Patients with large operable or locally advanced breast cancers (T4d tumours were excluded) were randomised to receive either six cycles of anthracycline-based chemotherapy or three cycles of docetaxel followed by three cycles of eprirubicin/docetaxel...
February 2015: European Journal of Cancer
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