Kim Phung, Laura McAdam, Jinhui Ma, Hugh J McMillan, Stefan Jackowski, Maya Scharke, Mary-Ann Matzinger, Nazih Shenouda, Khaldoun Koujok, Jacob L Jaremko, Nagwa Wilson, Scott Walker, Colleen Hartigan, Nasrin Khan, Marika Page, Marie-Eve Robinson, David S Saleh, Kevin Smit, Frank Rauch, Kerry Siminoski, Leanne M Ward
PURPOSE: Prevention of fractures is an unmet need in glucocorticoid (GC)-treated Duchenne muscular dystrophy. This study explored factors associated with incident vertebral fractures (VFs) to inform future fracture prevention efforts. METHODS: VFs were evaluated prospectively at study baseline and 12 months on lateral spine radiographs in participants aged 4 to 25 years with Duchenne muscular dystrophy. Clinical factors were analyzed for their association with the change in Spinal Deformity Index (sum of the Genant-defined VF grades from T4 to L4) between baseline and 12 months...
August 23, 2023: Journal of Clinical Endocrinology and Metabolism