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Steroid bone density

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https://www.readbyqxmd.com/read/29776756/sex-hormone-binding-globulin-is-a-biomarker-associated-with-nonvertebral-fracture-in-men-on-dialysis-therapy
#1
Jasna Aleksova, Phillip Wong, Robert McLachlan, Kay Weng Choy, Peter R Ebeling, Frances Milat, Grahame J Elder
Gonadal hormones impact bone health and higher values of sex hormone-binding globulin (SHBG) have been independently associated with fracture risk in men without chronic kidney disease. People with chronic kidney disease have a greatly increased fracture risk, and gonadal dysfunction is common in men receiving dialysis treatment. Nevertheless, in these men the effect of gonadal steroids and SHBG on bone mineral density (BMD) and fracture risk is unknown. Here we investigate relationships between gonadal steroids, SHBG, BMD and fracture in men on long-term dialysis therapy, awaiting kidney or simultaneous pancreas kidney transplantation...
May 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29768627/tsh-receptor-antibodies-may-prevent-bone-loss-in-pre-and-postmenopausal-women-with-graves-disease-and-graves-orbitopathy
#2
Mira Siderova, Kiril Hristozov, Aleksandra Tsukeva
OBJECTIVE: Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). SUBJECTS AND METHODS: Forty seven women with Graves' disease, mean age 55...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29749699/histological-findings-in-protocol-biopsies-following-pediatric-liver-transplant-low-incidence-of-abnormalities-at-5-years
#3
Amin Sheikh, Kai Y Chau, Helen M Evans
Histological abnormalities, including chronic hepatitis, fibrosis, and steatosis, are increasingly reported in liver biopsies of children after LT. These changes may be progressive and represent a form of rejection. Liver biochemistry is often initially normal. Our LT program began in 2002, utilizing tacrolimus and low-dose steroids for the first year post-LT. Patients undergo a protocol biopsy at 1 year post-LT prior to stopping steroids, then at 5 years and every 5 years thereafter. Target tacrolimus levels are 5-8 μg/L and 3-5 μg/L after 3 and 12 months, respectively...
May 11, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29649002/jak1-2-inhibition-with-baricitinib-in-the-treatment-of-autoinflammatory-interferonopathies
#4
Gina A Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason A Dare, Diane Brown, Deborah L Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A de Jesus, Dawn C Chapelle, Hanna Kim, Samantha Dill, Robert Colbert, Laura Failla, Bahar Kost, Michelle O'Brien, James C Reynolds, Les R Folio, Katherine R Calvo, Scott M Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angélique Biancotto, Edward W Cowen, John G Digiovanna, Massimo Gadina, Andrew J Lipton, Colleen Hadigan, Steven M Holland, Joseph Fontana, Ahmad S Alawad, Rebecca J Brown, Kristina I Rother, Theo Heller, Kristina M Brooks, Parag Kumar, Stephen R Brooks, Meryl Waldman, Harsharan K Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan M Janes, Seza Ozen, Paul G Wakim, Paul A Brogan, William L Macias, Raphaela Goldbach-Mansky
BACKGROUND: Monogenic Interferon (IFN)-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN-response-gene-signature (IRS), inflammatory organ damage and high mortality. We used the janus kinase (JAK) inhibitor baricitinib with IFN-blocking activity in vitro, to ameliorate disease. METHODS: Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 with SAVI (Stimulator of IFN genes (STING)-associated vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an Expanded Access Program...
April 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29629607/predictors-of-fracture-risk-in-patients-with-systemic-lupus-erythematosus
#5
M Dey, M Bukhari
Objectives Bone loss in systemic lupus erythematosus is multifactorial. Recent studies demonstrate corticosteroids, previous fractures and increasing age decrease bone mineral density. The effect of body mass index and fat mass are less well characterized. We sought to determine fracture risk factors in patients undergoing dual-energy X-ray absorptiometry scanning at a district hospital in 2004-2015. Methods Standard dual-energy X-ray absorptiometry parameters were recorded, plus rheumatoid arthritis diagnosis, smoking status, alcohol consumption, family history of fractures, history of secondary operation and corticosteroid use...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29626053/insulin-like-growth-factors-actions-on-the-skeleton
#6
Shoshana Yakar, Haim Werner, Cliff Rosen
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins), insulin-like growth factor (IGF)-I and -II, has elicited an enormous interest primarily amongst endocrinologists who study growth and metabolism. The advancement of molecular endocrinology over the past four decades enables investigators to re-examine and refine the established somatomedin hypothesis. Specifically, gene deletions, transgene overexpression, or more recently, cell-specific gene-ablations, have enabled investigators to study the effects of the Igf-I and Igf-II genes in temporal and spatial manners...
April 6, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29624728/respective-role-of-membrane-and-nuclear-estrogen-receptor-er-%C3%AE-in-the-mandible-of-growing-mice-implications-for-er%C3%AE-modulation
#7
A Vinel, A E Coudert, M Buscato, M C Valera, Ostertag Agnès, J A Katzenellenbogen, B S Katzenellenbogen, A Berdal, S Babajko, J F Arnal, C Fontaine
Estrogens play an important role in bone growth and maturation as well as in the regulation of bone turnover in adults. Although the effects of 17β-estradiol (E2) are well documented in long bones and vertebrae, little is known regarding its action in the mandible. E2 actions could be mediated by estrogen receptor (ER) α or β. ERs act primarily as transcriptional factors through two activation functions (AF)-1 and 2, but they can also elicit membrane-initiated steroid signaling (MISS). The aim of the present study was to define ER pathways involved in E2 effects on mandibular bone...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29620678/quantitative-ultrasound-of-proximal-phalanxes-in-childhood-acute-lymphoblastic-leukemia-survivors
#8
Antonia De Matteo, Fara Petruzziello, Rosanna Parasole, Antonella Esposito, Argia Mangione, Giovanna Giagnuolo, Giuseppe Menna, Antonio Del Puente
Reduced bone mineral density (BMD) is a well-known complication in childhood acute lymphoblastic leukemia (ALL) survivors; the optimal method to assess BMD is still debated. We studied BMD by quantitative ultrasound (QUS) in 72 ALL survivors, and evaluated any correlation with cumulative doses of steroids and cytotoxic agents. Mean age at diagnosis was 61±45 months, while mean age at QUS was 318.3±129.6 months; mean period of follow-up was 41.2±37.8 months. Mean amplitude-dependent speed of sound z-score was -1...
April 3, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29609210/does-sle-care-provided-in-a-lupus-clinic-result-in-higher-quality-of-care-than-general-rheumatology-clinic
#9
Shilpa Arora, Ailda Nika, Laura Trupin, Hrudya Abraham, Joel Block, Winston Sequeira, Jinoos Yazdany, Meenakshi Jolly
PURPOSE: We compared the quality of care received by SLE patients in two settings within the same academic institution (Lupus Clinic, LC and General Rheumatology Clinic, GRC) using validated SLE quality measures (QM). METHODS: 150 consenting, consecutive SLE patients receiving longitudinal care at Rush University GRC (73) and subspecialty LC (77) were recruited. An updated QM survey and retrospective medical chart review was used for evaluation of each QM. The overall and individual (20) QM performance was calculated and compared between two groups...
April 2, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29589087/imbalanced-bone-turnover-markers-and-low-bone-mineral-density-in-patients-with-osteonecrosis-of-the-femoral-head
#10
Lulu Tian, Seung-Hoon Baek, JinAn Jang, Shin-Yoon Kim
PURPOSE: There have been few studies investigating the cumulative effect of individual factors related to bone metabolism on the systemic balance between bone formation and resorption in patients with osteonecrosis of the femoral head (ONFH). We investigated bone mineral density (BMD) of lumbar spine and bone turnover markers that reflect systemic bone metabolism. METHODS: Two-hundred twenty patients with ONFH were matched to 220 healthy subjects according to age, gender, and body mass index...
March 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29581748/osteoporosis-as-an-initial-manifestation-in-a-patient-with-crohn-s-disease-a-case-report
#11
Hongyun Wei, Chunhui Ouyang, Dehong Peng, Fanggen Lu, Jie Zhang
The present case report details a rare case of osteoporosis as the initial manifestation of Crohn's disease (CD). A 43-year-old male was referred to the Second Xiangya Hospital of Central South University (Changsha, China) for further examination of low back pain (LBP) without digestive symptoms. Bone mineral density (BMD) analysis indicated osteoporosis, particularly in the lumbar spine. Endoscopy revealed an inflamed and strictured ileocecal valve with less inflammation in the ascending, transverse colon, sigmoid colon and rectum, compatible with CD, which was in accordance with the appearance of an abdominal computed tomography scan...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29578195/assessment-of-osteoporotic-fracture-risk-in-urban-indian-population-using-quantitative-ultrasonography-frax-tool
#12
Raju Vaishya, Vipul Vijay, Amit K Agarwal, Prashant Maheshwari
Background & objectives: There have been studies around the world on the prevalence of osteoporosis and its related risk factors, but there have been limited studies on risk factors and osteoporosis in the Indian population. In this study, the incidence of osteoporosis and the associated clinical risk factors (CRFs) were studied in the urban Indian population. Methods: Bone mineral density of 445 individuals >38 yr of age using qualitative ultrasound (QUS) was assessed...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29576253/nutritional-management-of-cow-s-milk-allergy-in-children-an-update
#13
C Dupont, J-P Chouraqui, A Linglart, A Bocquet, D Darmaun, F Feillet, M-L Frelut, J-P Girardet, R Hankard, J-C Rozé, U Simeoni, A Briend
Cow's milk is one of the most common foods responsible for allergic reactions in children. Cow's milk allergy (CMA) involves immunoglobulin E (IgE)- and non-IgE-mediated reactions, the latter being both variable and nonspecific. Guidelines thus emphasize the need for physicians to recognize the specific syndromes of CMA and to respect strict diagnostic modalities. Whatever the clinical pattern of CMA, the mainstay of treatment is the elimination from the diet of cow's milk proteins. The challenge is that both the disease and the elimination diet may result in insufficient height and weight gain and bone mineralization...
March 22, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29535939/a-prospective-observational-study-of-osteoporosis-in-men
#14
Narendra Kotwal, Vimal Upreti, Amit Nachankar, K V S Hari Kumar
Context: The number of men afflicted with osteoporosis is unknown. Aims: This study aims to determine the prevalence of osteoporosis in men. Settings and Design: This was a prospective, observational study. Subjects and Methods: A total of 200 male attendants of patients attending endocrine outpatient department and who were >55 years were recruited for the study. All the patients with osteopenia and osteoporosis were advised lifestyle interventions, supplementation with calcium carbonate (1000-1500 mg/day) and 25-hydroxyl-Vitamin D (400-600 IU/day) and bisphosphonates if indicated...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29520605/opportunistic-screening-for-bone-disease-using-abdominal-ct-scans-obtained-for-other-reasons-in-newly-diagnosed-ibd-patients
#15
D Rebello, D Anjelly, D J Grand, J T Machan, M D Beland, M S Furman, J Shapiro, N LeLeiko, B E Sands, M Mallette, R Bright, H Moniz, M Merrick, S A Shah
Bone disease is prevalent among patients with inflammatory bowel disease (IBD), though bone density screening remains underutilized. We used CT scans performed for other indications in IBD patients to identify and monitor osteopenia using CT attenuation values at the lumbar spine. Significant rates of bone disease were detected which would have otherwise gone undiagnosed. INTRODUCTION: Osteoporosis affects about 14-42% of patients with IBD. Though screening is recommended in IBD patients with risk factors, it remains underutilized...
March 8, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29503677/an-ovariectomy-induced-rabbit-osteoporotic-model-a-new-perspective
#16
Nathan Robert Wanderman, Cindy Mallet, Hugo Giambini, Nirong Bao, Chunfeng Zhao, Kai-Nan An, Brett A Freedman, Ahmad Nassr
Study Design: Experimental Animal Model. Purpose: The aim of our study was to validate a pure bilateral ovariectomy (OVX) female New Zealand white rabbit model of postmenopausal osteoporosis utilizing animal-sparing in vivo techniques for evaluating bone mineral density (BMD). We also sought to demonstrate that bilateral OVX in female New Zealand white rabbits can produce diminished BMD in the spinal column and simulate osteoporosis, without the need for adjuvant chemotherapeutic agents (i...
February 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29418016/bone-mineral-density-in-young-adults-with-prader-willi-syndrome-a-randomized-placebo-controlled-crossover-gh-trial
#17
Stephany H Donze, Renske J Kuppens, Nienke E Bakker, Janiëlle A E M van Alfen-van der Velden, Anita C S Hokken-Koelega
CONTEXT: The prevalence of osteoporosis is increased in adults with Prader-Willi syndrome (PWS). In children with PWS, growth hormone (GH) treatment has beneficial effects on bone mineral density (BMD). BMD might deteriorate after cessation of GH at adult height (AH), while continuing GH might maintain BMD. OBJECTIVE: To investigate the effects of GH vs placebo, and furthermore the effects of sex steroid replacement therapy (SSRT), on BMD in GH-treated young adults with PWS who had attained AH...
February 8, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29379565/bone-mineral-density-and-bone-metabolism-in-patients-with-duchenne-muscular-dystrophy
#18
Mohammad Barzegar, Elnaz Niknam, Parinaz Habibi, Shadi Shiva, Sanaz Tahmasebi
Objective: Poor bone health with related morbidity is a major problem with Duchene Muscular Dystrophy (DMD). Decreased mobility and long-term corticosteroid therapy are involved in poor bone health in DMD. We investigated bone mineral density and bone metabolism in 30 steroid treated DMD patients and also compared mentioned factors between ambulated and non-ambulated patients. Materials & Methods: In this cross-sectional study, 30 boys (21 patients ambulate and 9 non-ambulate) with documented DMD, according to genetic analysis, were enrolled in 2015...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29368271/association-of-low-bone-mineral-density-with-anti-citrullinated-protein-antibody-positivity-and-disease-activity-in-established-rheumatoid-arthritis-findings-from-a-us-observational-cohort
#19
Harris A Ahmad, Evo Alemao, Zhenchao Guo, Christine K Iannaccone, Michelle L Frits, Michael Weinblatt, Nancy A Shadick
INTRODUCTION: To assess the relationship between low bone mineral density (BMD), anti-cyclic citrullinated peptide-2 (anti-CCP2) antibodies, and disease activity in patients with established rheumatoid arthritis (RA). METHODS: Patients enrolled in a single-center, observational cohort registry of patients with RA. Eligible patients had known BMD, as measured by digital X-ray radiogrammetry (DXR-BMD), and anti-CCP2 antibody measurements at the same time point or within 6 months...
January 25, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29353451/analysis-of-circulating-mediators-of-bone-remodeling-in-prader-willi-syndrome
#20
G Brunetti, G Grugni, L Piacente, M Delvecchio, A Ventura, P Giordano, M Grano, G D'Amato, D Laforgia, A Crinò, M F Faienza
We tested the hypothesis that the levels of bone remodeling mediators may be altered in Prader-Willi syndrome (PWS). We assessed RANKL, OPG, sclerostin, DKK-1 serum levels, and bone metabolism markers in 12 PWS children (7.8 ± 4.3 years), 14 PWS adults (29.5 ± 7.2 years), and 31 healthy controls matched for sex and age. Instrumental parameters of bone mineral density (BMD) were also evaluated. Lumbar spine BMD Z-scores were reduced in PWS children (P < 0.01), reaching osteopenic levels in PWS adults...
January 20, 2018: Calcified Tissue International
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