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Steroid bone density

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https://www.readbyqxmd.com/read/29340241/risk-factors-for-osteoporosis-in-male-patients-with-chronic-obstructive-pulmonary-disease-in-taiwan
#1
Chu-Hsu Lin, Kai-Hua Chen, Chien-Min Chen, Chia-Hao Chang, Tung-Jung Huang, Chia-Hung Lin
Objective: To investigate the risk factors for osteoporosis in male Taiwanese patients with chronic obstructive pulmonary disease (COPD). Methods: This cross-sectional study evaluated male COPD outpatients and age-matched male subjects at a regional teaching hospital. The following data were obtained and analyzed: bone mineral density of the lumbar spine and hip on dual-energy X-ray absorptiometry, demographic characteristics, questionnaire interview results, pulmonary function test results, chest posterior-anterior radiographic findings, and biochemical and high-sensitivity C-reactive protein (hs-CRP) levels...
2018: PeerJ
https://www.readbyqxmd.com/read/29328885/radiographic-emphysema-circulating-bone-biomarkers-and-progressive-bone-mineral-density-loss-in-smokers
#2
Jessica Bon, Yingze Zhang, Joseph K Leader, Carl Fuhrman, Subashan Perera, Divay Chandra, Marnie Bertolet, Brenda Diergaarde, Susan L Greenspan, Frank C Sciurba
RATIONALE: Osteoporosis is common in individuals with chronic obstructive pulmonary disease. Lung-specific factors, including radiographic emphysema, independently associate with low bone mineral density (BMD) in cross-sectional smoking cohorts. However, factors associated with progressive bone loss in smokers are under-studied and largely unknown. OBJECTIVES: To determine the relationship between radiographic emphysema, circulating bone metabolism markers, and pulmonary function and accelerated BMD loss in smokers...
January 12, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29304843/effect-of-cox-2-inhibition-on-tendon-to-bone-healing-and-pge2-concentration-after-anterior-cruciate-ligament-reconstruction
#3
Martin Sauerschnig, Josef Stolberg-Stolberg, Carmen Schmidt, Valerie Wienerroither, Michael Plecko, Karin Schlichting, Carsten Perka, Christian Dynybil
BACKGROUND: Non-steroidal anti-inflammatory drugs are commonly used to reduce pain and inflammation in orthopaedic patients. Selective cyclooxygenase-2 (COX-2) inhibitors have been developed to minimize drug-specific side effects. However, they are suspected to impair both bone and tendon healing. The objective of this study is to evaluate the effect of COX-2 inhibitor administration on tendon-to-bone healing and prostaglandin E (PGE2) concentration. METHODS: Thirty-two New Zealand white rabbits underwent reconstructions of the anterior cruciate ligaments and were randomized into four groups: Two groups postoperatively received a selective COX-2 inhibitor (Celecoxib) on a daily basis for 3 weeks, the two other groups received no postoperative COX-2 inhibitors at all and were examined after three or 6 weeks...
January 5, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29304236/the-effect-of-epidural-steroid-injections-on-bone-mineral-density-and-vertebral-fracture-risk-a-systematic-review-and-critical-appraisal-of-current-literature
#4
Panagiotis Kerezoudis, Lorenzo Rinaldo, Mohammed Ali Alvi, Christine L Hunt, Wenchun Qu, Timothy P Maus, Mohamad Bydon
Objective: The aim of this paper is to review the available literature investigating the effect of epidural steroid injections (ESIs) on bone mineral density (BMD) and vertebral fracture risk. Study design: Systematic review of current literature. Methods: The sources of the data were PubMed, Embase, Cochrane, and Scopus. Papers included in the review were original research articles in peer-reviewed journals. Results: A total of 7,233 patients (eight studies) with a mean age ranging between 49 and 74 years and an average follow-up between six and 60 months were studied...
January 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29290311/prevalence-and-risk-factors-for-osteoporosis-and-fractures-in-axial-spondyloarthritis-a-systematic-review-and-meta-analysis
#5
Julio Ramírez, Juan Carlos Nieto-González, Rafael Curbelo Rodríguez, Santos Castañeda, Loreto Carmona
OBJECTIVES: To describe the prevalence of osteoporosis, the prevalence and incidence of fractures, and the frequency of risk factors for low bone mineral density (BMD) in axial spondyloarthritis (Ax-SpA). METHODS: A systematic review and meta-analysis of observational studies was conducted. Medline, Embase, and Cochrane Library databases were searched with a sensitive strategy. Large cross-sectional and longitudinal studies published in the last 10 years (January 2006-2016) with representative samples of patients with Ax-SpA estimating the frequency of osteoporosis, risk factors or fractures were selected...
December 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29289377/treatment-of-paraphilic-disorders-in-sexual-offenders-or-men-with-a-risk-of-sexual-offending-with-luteinizing-hormone-releasing-hormone-agonists-an-updated-systematic-review
#6
REVIEW
Daniel Turner, Peer Briken
BACKGROUND: Different pharmacologic agents are used in the treatment of paraphilic disorders in sexual offenders or men with a risk of sexual offending, with luteinizing hormone-releasing hormone (LHRH) agonists being the agents introduced more recently to treatment regimens. AIM: To summarize the relevant literature concerning LHRH agonist treatment of paraphilic disorders in sexual offenders and update the previously published systematic review by Briken et al (J Clin Psychiatry 2003;64:890-897)...
January 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29287007/bone-mineral-density-of-very-long-term-survivors-after-childhood-liver-transplantation
#7
Looi C Ee, Charlton Noble, Jonathan Fawcett, Geoffrey J Cleghorn
OBJECTIVES: Liver transplant patients are at risk of osteopenia and fractures but limited information is available in long-term survivors after childhood transplantation. This study aimed to assess bone mineral density (BMD) of very long-term, >5 years, survivors after liver transplantation in childhood. METHODS: Patients aged <18 years at transplant, having survived >5 years after transplant were potentially eligible but only those with ongoing review in our state were included...
December 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29229111/toxicity-risk-from-glucocorticoids-in-sarcoidosis-patients
#8
Nauman A Khan, Christopher V Donatelli, Adriano R Tonelli, Jonathan Wiesen, Manuel L Ribeiro Neto, Debasis Sahoo, Daniel A Culver
BACKGROUND: Glucocorticoids (GC) are considered first-line therapy for treating sarcoidosis, but there are few data about the adverse consequences of GC. Although there are several steroid-sparing medications available for treatment, a large proportion of patients are treated with prolonged courses of GC. The toxicities of GC in sarcoidosis populations have not been carefully evaluated. METHODS: We performed a retrospective cohort study of all newly diagnosed sarcoidosis patients who had the entirety of their medical care in a single health system...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#9
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29207799/change-in-bone-mineral-density-and-role-of-vitamin-d-and-calcium-supplementation-during-treatment-of-first-episode-nephrotic-syndrome
#10
Virendra Kumar Yadav, Shobha Sharma, Pradeep Kumar Debata, Seema Patel, Bhaskar C Kabi, Kailash Chandra Aggrawal
Introduction: Nephrotic Syndrome (NS) is one of the common illnesses in childhood. Oral glucocorticoids are mainstay of treatment, which are known to cause various short term and long term adverse effects including osteoporosis. Children with first episode and infrequent relapsing NS are not prescribed Calcium (Ca) and Vitamin D (VitD) supplements routinely. Aim: To observe change in Bone Mineral Density (BMD) in children during first episode of NS and role of VitD and Ca supplementation during the treatment of first episode of NS...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29201897/combined-treatment-with-an-anticoagulant-and-a-vasodilator-prevents-steroid-associated-osteonecrosis-of-rabbit-femoral-heads-by-improving-hypercoagulability
#11
Fang Cao, Ge Liu, Wei Wang, Benjie Wang, Xiaowei Wei, Faqiang Lu, Fan Yang, Kai Kang, Yongxuan Wang, Jiahui Yang, Kairong Qin, Dewei Zhao
Steroid-associated osteonecrosis of the femoral head remains a challenging problem in orthopedics worldwide. One pathomechanism is ischemia of the femoral head, as a result of thrombus formation and vasoconstriction. The present study investigates the effects of combination prevention with enoxaparin and EGb 761 on steroid-associated ONFH in rabbits. Rabbits were randomly divided into 5 groups (control group, model group, enoxaparin group, ginkgo group, and combination group). With the exception of the control group, the groups of rabbits were modeled with lipopolysaccharide and methylprednisolone acetate...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29102474/lumbar-spine-trabecular-bone-score-tbs-reflects-diminished-bone-quality-in-patients-with-diabetes-mellitus-and-oral-glucocorticoid-therapy
#12
Yunfeng Xue, Andrea L Baker, Shahla Nader, Philip Orlander, Anthony J Sanchez, James Kellam, Nahid J Rianon, Catherine G Ambrose
Trabecular bone score (TBS) is a texture parameter that measures the grayscale variation within dual-energy X-ray absorptiometry (DXA) images, and has been shown to significantly correlate with the 3-dimensional bone microarchitecture. The objective of this study was to determine whether TBS is a better clinical tool than traditionally used bone mineral density (BMD) to detect the skeletal deterioration seen in patients with diabetes (DM), patients undergoing oral glucocorticoid (GC) therapy, and patients who are both diabetic and taking steroids (GC + DM)...
November 1, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29066903/fat-embolism-after-fractures-in-duchenne-muscular-dystrophy-an-underdiagnosed-complication-a-systematic-review
#13
REVIEW
David Feder, Miriam Eva Koch, Beniamino Palmieri, Fernando Luiz Affonso Fonseca, Alzira Alves de Siqueira Carvalho
Duchenne muscular dystrophy is the most frequent lethal genetic disease. Several clinical trials have established both the beneficial effect of steroids in Duchenne muscular dystrophy and the well-known risk of side effects associated with their daily use. For many years it has been known that steroids associated with ambulation loss lead to obesity and also damage the bone structure resulting in the bone density reduction and increased incidence of bone fractures and fat embolism syndrome, an underdiagnosed complication after fractures...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29039554/microrna-23a-3p-inhibitor-decreases-osteonecrosis-incidence-in-a-rat-model
#14
Yulei Dong, Tao Li, Yulong Li, Shaoda Ren, Junfen Fan, Xisheng Weng
The mechanism of steroid-associated femoral head necrosis remains unclear. The present study investigated the role of microRNA-23a-3p (miR-23a-3p) in the incidence of osteonecrosis in a rat model. An miR-23a-3p mimic, an inhibitor and a negative control were transfected into bone mesenchymal stem cells using a lentiviral vector, and then injected into the steroid-induced femoral head necrosis model. Osteonecrosis incidence was assessed by micro computed tomography and histopathology. Low-density lipoprotein receptor-related protein 5 (LRP-5) expression was assessed by immunohistochemistry...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29022558/klinefelter-syndrome-in-childhood-variability-in-clinical-and-molecular-findings
#15
Neşe Akcan, Şükran Poyrazoğlu, Firdevs Baş, Rüveyde Bundak, Feyza Darendeliler
OBJECTIVE: Klinefelter syndrome (KS) is the most common (1/500-1/1000) chromosomal disorder in males, but only 10% of cases are identified in childhood. This study aimed to review the data of the children with KS to assess the age and reason for diagnosis, clinical and laboratory findings, as well as the presence of comorbidities. METHODS: Twenty-three KS patients were analyzed retrospectively. Age at admission, presenting symptoms, comorbid problems, height, weight, pubertal status, biochemical findings, hormone profiles, bone mineral density, and karyotype were evaluated...
October 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29018933/from-osteoimmunology-to-osteomicrobiology-how-the-microbiota-and-the-immune-system-regulate-bone
#16
REVIEW
Emory Hsu, Roberto Pacifici
Osteomicrobiology refers to the role of microbiota in bone health and the mechanisms by which the microbiota regulates post-natal skeletal development, bone aging, and pathologic bone loss. Here, we review recent reports linking gut microbiota to changes in bone phenotype. A pro-inflammatory cytokine milieu drives bone resorption in conditions such as sex steroid hormone deficiency. The response of the immune system to activation by the microbiome results in increased circulating osteoclastogenic cytokines in a T cell-dependent mechanism...
October 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28901203/the-role-of-monocyte-percentage-in-osteoporosis-in-male-rheumatic-diseases
#17
Yu-Jih Su, Chao Tung Chen, Nai-Wen Tsai, Chih-Cheng Huang, Hung-Chen Wang, Chia-Te Kung, Wei-Che Lin, Ben-Chung Cheng, Chih-Min Su, Sheng-Yuan Hsiao, Cheng-Hsien Lu
Osteoporosis is easily overlooked in male patients, especially in the field of rheumatic diseases mostly prevalent with female patients, and its link to pathogenesis is still lacking. Attenuated monocyte apoptosis from a transcriptome-wide expression study illustrates the role of monocytes in osteoporosis. This study tested the hypothesis that the monocyte percentage among leukocytes could be a biomarker of osteoporosis in rheumatic diseases. Eighty-seven males with rheumatic diseases were evaluated in rheumatology outpatient clinics for bone mineral density (BMD) and surrogate markers, such as routine peripheral blood parameters and autoantibodies...
November 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28900675/bone-disease-in-connective-tissue%C3%A2-disease-systemic-lupus-erythematosus
#18
REVIEW
Irene E M Bultink
This article reviews recent advances in the research of the mechanisms of bone loss, as well as clinical features, economic impact and therapeutic implications of osteoporosis and fractures in patients with systemic lupus erythematosus (SLE) as an illustration of bone disease in a complex systemic autoimmune connective tissue disease. Recent studies demonstrated an increased incidence of osteoporosis and peripheral and vertebral fractures in patients with SLE. The aetiology of bone loss in SLE is multifactorial, including clinical osteoporosis risk factors, systemic inflammation, serological factors, metabolic factors, hormonal factors, possibly genetic factors and medication-induced adverse effects...
September 12, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28878383/avascular-necrosis-of-femoral-head-a-metabolomic-biophysical-biochemical-electron-microscopic-and-histopathological-characterization
#19
Aswath Narayanan, Prakash Khanchandani, Roshan M Borkar, Chandrashekar Reddy Ambati, Arun Roy, Xu Han, Ritesh N Bhoskar, Srinivas Ragampeta, Francis Gannon, Vijaya Mysorekar, Balasubramanyam Karanam, Sai Muthukumar V, Venketesh Sivaramakrishnan
Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the middle aged population. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse. Although Homocysteine (HC) has been implicated in AVNFH, levels of homocysteine and its associated pathway metabolites have not been characterized. We demonstrate elevated levels of homocysteine and concomitantly reduced levels of vitamins B6 and B12, in plasma of AVNFH patients...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877384/exosomes-secreted-from-mutant-hif-1%C3%AE-modified-bone-marrow-derived-mesenchymal-stem-cells-attenuate-early-steroid-induced-avascular-necrosis-of-femoral-head-in-rabbit
#20
Haile Li, Danping Liu, Chen Li, Shanjian Zhou, Dachuan Tian, Dawei Xiao, Huan Zhang, Feng Gao, Jianhua Huang
Mesenchymal stem cells (MSCs)-derived exosomes exhibit protective effects on damaged or diseased tissues. Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in bone development. However, HIF-1α is easily biodegradable under normoxic conditions. The bone-marrow-derived mesenchymal stem cells (BMSCs) were transfected with adenovirus carrying triple point-mutations (amino acids 402, 564, and 803) in the HIF-1α coding sequence (CDS). The mutant HIF-1α can efficiently express functional proteins under normoxic conditions...
September 6, 2017: Cell Biology International
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