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Steroid bone density

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https://www.readbyqxmd.com/read/28715798/bone-mineral-density-in-women-living-with-complete-androgen-insensitivity-syndrome-and-intact-testes-or-removed-gonads
#1
Silvano Bertelloni, Maria C Meriggiola, Elenora Dati, Antonio Balsamo, Giampiero I Baroncelli
Complete androgen insensitivity syndrome (CAIS) is due to complete androgen resistance in androgen-dependent tissues. Since androgens are involved in growth, development, and mass maintenance of the skeleton, bone health may be a relevant clinical issue for improving quality of life of women living with CAIS. Bone mineral density (BMD) in women with CAIS and intact gonads has been reported in a normal range, although exceptions are known showing a low BMD mainly at the lumbar level. In women with CAIS and removed gonads, BMD is usually reduced at both the lumbar spine and femoral neck...
July 18, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28666972/non-destructive-nir-spectral-imaging-assessment-of-bone-water-comparison-to-mri-measurements
#2
Chamith S Rajapakse, Mugdha V Padalkar, Hee Jin Yang, Mikayel Ispiryan, Nancy Pleshko
Bone fracture risk increases with age, disease states, and with use of certain therapeutics, such as acid-suppressive drugs, steroids and high-dose bisphosphonates. Historically, investigations into factors that underlie bone fracture risk have focused on evaluation of bone mineral density (BMD). However, numerous studies have pointed to factors other than BMD that contribute to fragility, including changes in bone collagen and water. The goal of this study is to investigate the feasibility of using near infrared spectral imaging (NIRSI) to determine the spatial distribution and relative amount of water and organic components in whole cross-sections of bone, and to compare those results to those obtained using magnetic resonance imaging (MRI) methods...
June 28, 2017: Bone
https://www.readbyqxmd.com/read/28658131/polymyalgia-rheumatica-and-giant-cell-arteritis-three-challenges-consequences-of-the-vasculitis-process-osteoporosis-and-malignancy-a-prospective-cohort-study-protocol
#3
Amir Emamifar, Søren Hess, Oke Gerke, Anne Pernille Hermann, Helle Laustrup, Per Syrak Hansen, Peter Thye-Rønn, Niels Marcussen, Frank Svendstrup, Rannveig Gildberg-Mortensen, Jacob Christian Bang, Ziba Ahangarani Farahani, Stavros Chrysidis, Pia Toftegaard, Rikke Asmussen Andreasen, Sebastian le Greves, Hanne Randi Andersen, Rudolf Nezlo Olsen, Inger Marie Jensen Hansen
INTRODUCTION: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to assess global disease activity in inflammatory diseases. 18F-FDG PET/CT may lead to the diagnosis at an earlier stage than conventional imaging and may also assess response to therapy...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28649096/-aging-and-homeostasis-aging-of-bone
#4
Seijiro Mori
Quantitative as well as qualitative bone loss occurs with aging in both men and women, leading to alterations in skeletal microarchitecture and increased fracture incidence. Sex steroids, primarily estrogen and testosterone, have been shown to play a central role in the aging process of bone. The relationship between diminishing estrogen levels in women caused by ovarian failure and the development of postmenopausal osteoporosis is widely recognized. Unexpectedly, bone mineral density at various skeletal sites in men is also better correlated with circulating levels of bioavailable estrogen than with testosterone...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28643272/prevalence-and-risk-factors-for-low-bone-mineral-density-in-ulcerative-colitis
#5
Ram Pratap Singh Bundela, Prachis Ashdhir, Kumar Shwetanshu Narayan, Mukesh Jain, Rupesh Kumar Pokharna, Sandeep Nijhawan
BACKGROUND: Inflammatory bowel disease (IBD) has been associated with increased risk of osteopenia and osteoporosis. Several risk factors contribute to this; however, studies evaluating their association have conflicting results. METHODS: We conducted a cross-sectional study with prospective enrollment of adult ulcerative colitis patients attending the Gastroenterology Department of Sawai Man Singh Hospital, Jaipur Rajasthan between June 2015 and December 2015. Demographic data including age, gender, body mass index (BMI), disease duration, type of disease, prior steroid use and vitamin D levels were recorded and compared with bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA)...
June 23, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28642854/measurement-uncertainty-in-spine-bone-mineral-density-by-dual-energy-x-ray-absorptiometry
#6
Ae-Ja Park, Jun-Il Yoo, Jee-Hye Choi, Kyun Shik Chae, Chang Geun Kim, Dal Sik Kim
BACKGROUND: The purpose of this study was to calculate the measurement uncertainty of the process of bone mineral density (BMD) analysis using dual energy X-ray absorptiometry with traceability. METHODS: Between March 2015 and October 2016, among healthy participants in their 20s and 30s, the study included those who had not taken calcium, vitamin D supplements and steroids and were without a history of osteoporosis, osteopenia and diseases related to osteoporosis...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28609392/the-role-of-hormone-therapy-in-the-management-of-severe-postpartum-depression-in-patients-with-turner-syndrome
#7
Alison K Shea, Wendy Wolfman
OBJECTIVE: Premature ovarian failure associated with Turner syndrome presents clinicians with a vast range of health concerns, including infertility, cardiovascular disease, and decreased bone mineral density, in addition to psychological sequelae. Hormone therapy is paramount in managing these complications, but the additional needs in the postpartum period for those who are able to carry out a successful pregnancy have not been described. METHODS: We present a case of severe postpartum depression (PPD) with psychotic features in a patient with Turner syndrome, which presented at 4 weeks after the birth of her first child via egg donation RESULTS:: We describe the case of a previously well 32-year-old patient with an 46 X, i(Xq) karyotype, who went through a 4-week intensive inpatient treatment course for PPD, requiring electroconvulsant therapy for persistent infanticidal and suicidal ideation...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28562531/widely-differing-screening-and-treatment-practice-for-osteoporosis-in-patients-with-inflammatory-bowel-diseases-in-the-swiss-ibd-cohort-study
#8
MULTICENTER STUDY
Solvey Schüle, Jean-Benoît Rossel, Diana Frey, Luc Biedermann, Michael Scharl, Jonas Zeitz, Natália Freitas-Queiroz, Thomas Kuntzen, Thomas Greuter, Stephan R Vavricka, Gerhard Rogler, Benjamin Misselwitz
Low bone mineral density (BMD) and osteoporosis remain frequent problems in patients with inflammatory bowel diseases (IBDs). Several guidelines with nonidentical recommendations exist and there is no general agreement regarding the optimal approach for osteoporosis screening in IBD patients. Clinical practice of osteoporosis screening and treatment remains insufficiently investigated.In the year 2014, a chart review of 877 patients included in the Swiss IBD Cohort study was performed to assess details of osteoporosis diagnostics and treatment...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28527160/study-of-bone-mineral-density-bmd-in-patients-with-rheumatoid-arthritis-and-its-co-relation-with-severity-of-the-disease
#9
Liyakat Ali Gauri, Qadir Fatima, Sharanbasu Diggi, Asim Khan, Ambreen Liyakat, B R Ajay
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis.1-3 People with rheumatoid arthritis are at increased risk of osteoporosis. Hence this article intends to highlight the importance of BMD measurement in patients with RA as a tool for assessment of disease activity and severity. OBJECTIVE: To evaluate Bone Mineral Density in patients of Rheumatoid Arthritis and Co-relate it with severity of disease...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28492740/selective-cox-2-inhibitor-meloxicam-and-tooth-supporting-bone-quality-a-histomorphometric-study-in-rats
#10
Bruno César de Vasconcelos Gurgel, Krysna Torres de Almeida, Raniel Fernandes Peixoto, Kenio Costa Lima, Kamila Rosamilia Kantovitz, Francisco Humberto, Sergio de Toledo
The effects of the non-steroidal anti-inflammatory drugs (NSAIDs) on bone quantity and quality were investigated for years. However, there is lack of information on the impact of NSAIDs on the quality of tooth-supporting alveolar bone in absence of periodontal inflammation. Thus, the aim of this study was to evaluate histometrically the influence of a selective COX-2 NSAID (Meloxicam) on the inter-radicular bone mineral density in rats. Forty-nine adult male Wistar rats were randomly divided into four experimental groups: Subcutaneous injection of 0...
March 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28492609/the-risk-of-osteoporosis-in-oral-steroid-treatment-for-nasal-polyposis-a-systematic-review
#11
L Winblad, C G Larsen, K Håkansson, B Abrahamsen, C von Buchwald
BACKGROUND: Systemic glucocorticoids are often used in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), and osteoporosis is a well-known complication to steroid treatment, associated with significant morbidity. Nevertheless, the burden of steroid induced osteoporosis is unknown in patients with CRSwNP. We aimed to assess the risk of acquiring osteoporosis caused by oral steroids in patients with CRSwNP, and provide recommendations on future research and guidelines. METHODOLOGY: Cochrane Review Database, EMBASE, Ovid Medline, and PubMed were searched for studies including adult patients with CRSwNP treated with oral steroids...
May 10, 2017: Rhinology
https://www.readbyqxmd.com/read/28469926/primary-hypertrophic-osteoarthropathy-due-to-a-novel-slco2a1-mutation-masquerading-as-acromegaly
#12
Ruth Mangupli, Adrian F Daly, Elvia Cuauro, Paul Camperos, Jaime Krivoy, Albert Beckers
SUMMARY: A 20-year-old man with an 8-year history of progressive enlargement of his hands and feet, coarsening facial features, painful joints and thickened, oily skin was referred for investigation of acromegaly. On examination, the subject was of normal height and weight. He had markedly increased skin thickness around the forehead, eyelids and scalp with redundant skin folds. Bilateral painful knee swelling was accompanied by enlargement of the extremities, and his fingers were markedly clubbed...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28466679/effect-of-two-prophylactic-bolus-vitamin-d-dosing-regimens-1000%C3%A2-iu-day-vs-400%C3%A2-iu-day-on-bone-mineral-content-in-new-onset-and-infrequently-relapsing-nephrotic-syndrome-a-randomised-clinical-trial
#13
Sravani Muske, Sriram Krishnamurthy, Sadish Kumar Kamalanathan, Medha Rajappa, K T Harichandrakumar, Palanisamy Sivamurukan
OBJECTIVES: To examine the efficacy of two vitamin D dosages (1000 vs. 400 IU/day) for osteoprotection in children with new-onset and infrequently-relapsing nephrotic syndrome (IFRNS) receiving corticosteroids. METHODS: This parallel-group, open label, randomised clinical trial enrolled 92 children with new-onset nephrotic syndrome (NS) (n = 28) or IFRNS (n = 64) to receive 1000 IU/day (Group A, n = 46) or 400 IU/day (Group B, n = 46) vitamin D (administered as a single bolus initial supplemental dose) by block randomisation in a 1:1 allocation ratio...
May 3, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28457365/understanding-bone-damage-after-kidney-transplantation-a%C3%A2-retrospective-monocentric-cross-sectional-analysis
#14
M Gregorini, G Sileno, E F Pattonieri, V Corradetti, M Abelli, E Ticozzelli, L Scudeller, M A Grignano, P Esposito, L Bogliolo, A Giacomoni, T Rampino
BACKGROUND: Kidney transplantation (KT) immunosuppression may induce bone tissue damage with bone mineral density (BMD) loss increasing bone fractures risk. Steroid therapy is considered the major player, but others factors are still under review. PATIENTS AND METHODS: We designed an observational retrospective cohort study to evaluate bone damage after KT. The prevalence of osteopenia, osteoporosis, bone fractures, and the associated risk factors were investigated...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28448615/emphysema-is-associated-with-thoracic-vertebral-bone-attenuation-on-chest-ct-scan-in-hiv-infected-individuals
#15
Alycia Petraglia, Joseph K Leader, Matthew Gingo, Meghan Fitzpatrick, John Ries, Cathy Kessinger, Lorrie Lucht, Danielle Camp, Alison Morris, Jessica Bon
BACKGROUND: Age-related chronic diseases are prevalent in HIV-infected persons in the antiretroviral therapy (ART) era. Bone mineral density (BMD) loss and emphysema have separately been shown to occur at a younger age and with lesser risk exposure in HIV-infected compared to HIV-uninfected individuals. In non-HIV infected smokers, emphysema has been shown to independently predict low BMD. We hypothesized that emphysema would independently associate with thoracic vertebral bone attenuation, a surrogate for bone mineral density, in HIV-infected individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28425086/the-clinical-benefits-of-denosumab-for-prophylaxis-of-steroid-induced-osteoporosis-in-patients-with-pulmonary-disease
#16
Shigeo Ishiguro, Kentaro Ito, Shigenori Nakagawa, Osamu Hataji, Akihiro Sudo
Previous reports demonstrated that bone density decreased rapidly during the initial few months of steroid therapy and continued decreasing at a rate of 2 to 4% annually. Our data indicates that denosumab can also play a role in the treatment of osteoporosis in the steroid-taking population. INTRODUCTION: Respiratory physicians are often faced with the dilemma that long-term steroid use will deteriorate bone mineral density and quality. Previous reports demonstrated that bone density decreased 8 to 12% during the initial few months of steroid therapy then continued decreasing at a rate of 2 to 4% annually...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28419243/the-efficacy-and-safety-of-pubertal-induction-using-17beta-estradiol-in-transgirls
#17
Sabine E Hannema, Sebastian E E Schagen, Peggy T Cohen-Kettenis, Henriette A Delemarre-van de Waal
Introduction.: Puberty suppression using GnRH agonists, followed by induction of desired sex characteristics using sex steroids, is recommended by current guidelines as the treatment of choice for gender dysphoric adolescents although little evidence is available. Aim.: To evaluate the efficacy and safety of estrogen treatment for pubertal induction in transgirls (female-identifying adolescents assigned male at birth). Methods.: 28 Adolescents treated with oral estrogen for at least 1 year were included...
April 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28397714/effect-of-intravenous-pulse-dexamethasone-versus-daily-oral-prednisolone-on-bone-mineral-density-in-dermatology-patients-is-it-a-site-specific-response
#18
Sanjeev Handa, Gurjeet Singh, Amanjot Kaur Arora, Niranjan Khandelwal, Vivek Gupta
BACKGROUND: The use of glucocorticoids in various forms of administration is complicated by their systemic side effects. Although intravenous pulse therapy is considered to have lesser systemic side effects, there are few studies in literature comparing the effects of intravenous pulse glucocorticoids versus oral daily glucocorticoids on bone mineral density. AIM: To compare the effects of intravenous pulse glucocorticoids and oral daily glucocorticoids on bone mineral density with the aim of finding any site-specific osteopenic side effect...
April 10, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28370342/bone-mineral-density-increases-in-trans-persons-after-1-year-of-hormonal-treatment-a-multicenter-prospective-observational-study
#19
Chantal M Wiepjes, Mariska C Vlot, Maartje Klaver, Nienke M Nota, Christel Jm de Blok, Renate T de Jongh, Paul Lips, Annemieke C Heijboer, Alessandra D Fisher, Thomas Schreiner, Guy T'Sjoen, Martin den Heijer
Sex steroids are important determinants of bone acquisition and bone homeostasis. Cross-sex hormonal treatment (CHT) in transgender persons can affect bone mineral density (BMD). The aim of this study was to investigate in a prospective observational multicenter study the first-year effects of CHT on BMD in transgender persons. A total of 231 transwomen and 199 transmen were included who completed the first year of CHT. Transwomen were treated with cyproterone acetate and oral or transdermal estradiol; transmen received transdermal or intramuscular testosterone...
June 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28341762/a-prospective-observational-study-on-effect-of-short-term-periodic-steroid-premedication-on-bone-metabolism-in-gastrointestinal-cancer-espresso-01
#20
Michio Nakamura, Atsushi Ishiguro, Tetsuhito Muranaka, Hiraku Fukushima, Satoshi Yuki, Kota Ono, Taichi Murai, Chika Matsuda, Ayane Oba, Kazufumi Itaya, Takayuki Sone, Masataka Yagisawa, Yuta Koike, Ayana Endo, Yoko Tsukuda, Yuji Ono, Takahiko Kudo, Atsushi Nagasaka, Shuji Nishikawa, Yoshito Komatsu
BACKGROUND: A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short-term periodic steroid premedication on bone metabolism. PATIENTS AND METHODS: Seventy-four patients undergoing chemotherapy for gastrointestinal cancer were studied. The primary endpoints were changes in bone mineral densities (BMDs) and metabolic bone turnover 16 weeks after initiation of chemotherapy. BMDs, measured by dual-energy x-ray absorptiometry, and serum cross-linked N-telopeptides of type I collagen (sNTX), and bone alkaline phosphatase (sBAP) were assessed for evaluation of bone resorption and formation, respectively...
May 2017: Oncologist
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