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Steroid bone density

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https://www.readbyqxmd.com/read/27918081/st1926-attenuates-steroid-induced-osteoporosis-in-rats-by-inhibiting-inflammation-response
#1
Hong-Xing Zhao, Yuan-Xia Huang, Jin-Gang Tao
Steroid, also known as glucocorticoid, induced osteonecrosis of the femoral head in young adults, which has been a challenging disorder for the frequent incidence of collapse of femoral head, leading to dysfunction of hip joint and impairing life quality of human. Bioavailable and less toxic synthetic retinoids, such as the atypical adamantyl retinoid ST1926, have been developed and investigated in clinical trials for many diseases. Serum lipid-related indicators were assessed to elucidate the role of ST1926 in regulating lipid metabolism...
December 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27912889/hormone-replacement-therapy-in-young-women-with-primary-ovarian-insufficiency-and-early-menopause
#2
REVIEW
Shannon D Sullivan, Philip M Sarrel, Lawrence M Nelson
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone deficiency and infertility in women. In addition to causing infertility, POI is associated with multiple health risks, including bothersome menopausal symptoms, decreased bone density and increased risk of fractures, early progression of cardiovascular disease, psychologic impact that may include depression, anxiety, and decreased perceived psychosocial support, potential early decline in cognition, and dry eye syndrome. Appropriate hormone replacement therapy (HRT) to replace premenopausal levels of ovarian sex steroids is paramount to increasing quality of life for women with POI and ameliorating associated health risks...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27909782/associations-between-serum-vitamin-e-concentration-and-bone-mineral-density-in-the-us-elderly-population
#3
J Zhang, X Hu, J Zhang
: Mixed findings regarding effects of vitamin E on bone metabolism existed. We were the first to find a negative association between serum α-tocopherol concentration and bone mineral density in the US elderly population. Using vitamin E supplement as α-tocopherol to promote bone health was not warranted at this time. INTRODUCTION: The aim of the study is to examine the associations between serum vitamin E (α-tocopherol and γ-tocopherol) status and bone mineral density (BMD) among the US elderly population...
December 1, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27821253/bone-mineral-density-in-children-with-idiopathic-nephrotic-syndrome
#4
Ghada Mohamed El-Mashad, Mahmoud Ahmed El-Hawy, Sally Mohamed El-Hefnawy, Sanaa Mansour Mohamed
OBJECTIVES: To assess bone mineral density (BMD) in children with idiopathic nephrotic syndrome (NS) and normal glomerular filtration rate (GFR). METHODS: Cross-sectional case-control study carried out on 50 children: 25 cases of NS (16 steroid-sensitive [SSNS] and nine steroid-resistant [SRNS] under follow up in the pediatric nephrology unit of Menoufia University Hospital, which is tertiary care center, were compared to 25 healthy controls with matched age and sex...
November 5, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27805313/the-effect-of-inhaled-corticosteroids-on-bone-mineral-density-measured-by-quantitative-ultrasonography-in-an-older-population
#5
Ghulam Sarwar, Alessandra Bisquera, Roseanne Peel, Stephen Hancock, Christopher Grainge, John Attia
INTRODUCTION: Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk of minimal trauma fractures with their associated morbidity and mortality in elderly populations. However, the effect of inhaled corticosteroids on bone mineral density has been debated in the medical literature. OBJECTIVES: We aimed to determine the effect of inhaled corticosteroids on bone mineral density measured using calcaneal quantitative ultrasonography in a cohort of older Australians...
November 2, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27733909/prediction-of-low-bone-mineral-density-in-patients-with-inflammatory-bowel-diseases
#6
Solvey Schüle, Jean-Benoît Rossel, Diana Frey, Luc Biedermann, Michael Scharl, Jonas Zeitz, Natália Freitas-Queiroz, Valérie Pittet, Stephan R Vavricka, Gerhard Rogler, Benjamin Misselwitz
BACKGROUND: Low bone mineral density (BMD) remains a frequent problem in patients with inflammatory bowel diseases (IBD). There is no general agreement regarding osteoporosis screening in IBD patients. METHODS: Cases of low BMD and disease characteristics were retrieved from 3172 patients of the Swiss IBD cohort study. Multivariate logistic regression analysis was conducted for predictive modeling. In a subgroup of 877 patients, 253 dual-energy X-ray absorptiometry (DXA) scans were available for validation...
October 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27728929/effects-of-glucocorticoids-on-bone-what-we-can-learn-from-pediatric-endogenous-cushing-s-syndrome
#7
L J W Tack, C Tatsi, C A Stratakis, M B Lodish
Chronic exposure to supraphysiologic levels of glucocorticoids (GCs) is associated with impaired bone mineral density, an increase in fracture rates, and, in growing children, compromised linear growth. GCs inhibit bone formation in part by decreasing the number of osteoblasts and by increasing bone resorption by stimulating osteoclasts. While GCs are used to treat many chronic diseases, it is difficult to isolate the effects of the steroids on the bone from the effects of the underlying disease itself. Investigation into the effects of GC exposure on the bone in endogenous Cushing syndrome have contributed to our understanding of bone microarchitecture, growth, healing, and regeneration...
November 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27718508/psoriasis-fracture-risk-and-bone-mineral-density-the-hunt-study-norway
#8
E H Modalsli, B O Åsvold, P R Romundstad, A Langhammer, M Hoff, S Forsmo, L Naldi, M Saunes
BACKGROUND: An association between psoriasis and osteoporosis has been reported. OBJECTIVE: In a large prospective population-based Norwegian study, we investigated whether psoriasis was associated with increased risk of forearm or hip fracture. We also investigated the cross-sectional association between psoriasis and bone mineral density (BMD) T-score in a sub-population. METHODS: Hospital-derived fracture data from Nord-Trøndelag County 1995-2013 was linked to psoriasis-information, BMD measurements and lifestyle factors from the third survey of the Nord-Trøndelag Health Study 2006-08 (HUNT3), socioeconomic data from the National Education Database and use of medication from the Norwegian Prescription Database...
October 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27706804/bisphosphonates-for-steroid-induced-osteoporosis
#9
REVIEW
Claire S Allen, James Hs Yeung, Ben Vandermeer, Joanne Homik
BACKGROUND: This is an update of a Cochrane Review first published in 1999. Corticosteroids are widely used in inflammatory conditions as an immunosuppressive agent. Bone loss is a serious side effect of this therapy. Several studies have examined the use of bisphosphonates in the prevention and treatment of glucocorticosteroid-induced osteoporosis (GIOP) and have reported varying magnitudes of effect. OBJECTIVES: To assess the benefits and harms of bisphosphonates for the prevention and treatment of GIOP in adults...
October 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27701004/cervical-fracture-from-chronic-steroid-usage-presenting-as-a-stroke-a-case-report
#10
Christian Fisahn, Marc D Moisi, Shiveindra Jeyamohan, Mary Wingerson, R Shane Tubbs, Charles Cobbs, Rod J Oskouian, Jens R Chapman
INTRODUCTION: Misdiagnosis of Brown-Séquard-like presentations can delay treatment; potentially endangering the positive outcomes a patient might otherwise have had. Stroke mimics can be perceived as signaling the end of urgent investigation and care once stroke is ruled out; however, stroke mimics themselves can require prompt care. Herein, we discuss an extremely rare case where stroke was ruled out, resulting in a lapse in care that lead to an exacerbated hemiparesis over the following week...
September 29, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27693042/a-summary-of-the-influence-of-exogenous-estrogen-administration-across-the-lifespan-on-the-gh-igf-1-axis-and-implications-for-bone-health
#11
Emily A Southmayd, Mary Jane De Souza
Bone growth, development, and remodeling are modulated by numerous circulating hormones. Throughout the lifespan, the extent to which each of the hormones impacts bone differs. Understanding the independent and combined impact of these hormones on controlling bone remodeling allows for the development of more informed decision making regarding pharmacology, specifically the use of hormonal medication, at all ages. Endocrine control of bone health in women is largely dictated by the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis and the hypothalamic-pituitary-ovarian (HPO) axis...
September 13, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27692101/application-of-calcium-phosphates-and-fibronectin-as-complementary-treatment-for-osteoporotic-bone-fractures
#12
Javier Quintana Plaza, Lorena Benito Garzón, Beatriz Bravo Gimenez, Belén Fernández-Montes Moraleda, Francisco Collía, Luis M Rodríguez-Lorenzo
INTRODUCTION: The gradual aging of the population results in increased incidence of osteoporotic bone fractures. In a good quality bone, the fixation with the usual methods is adequate, but not in osteoporotic bone, in which consolidation delays and other complications are common, with failure rates for screws up to 25%. OBJECTIVE: To test fibronectin loaded hydroxyapatite as a complementary treatment for osteoporotic fractures. MATERIAL AND METHODS: This study was performed in a vivo model; 42 female osteoporotic adult rabbits 4-5kg (White New Zealand) were used...
September 2016: Injury
https://www.readbyqxmd.com/read/27678103/long-term-outcomes-of-children-treated-for-cushing-s-disease-a-single-center-experience
#13
Galina Yordanova, Lee Martin, Farhad Afshar, Ian Sabin, Ghassan Alusi, Nicholas P Plowman, Fiona Riddoch, Jane Evanson, Matthew Matson, Ashley B Grossman, Scott A Akker, John P Monson, William M Drake, Martin O Savage, Helen L Storr
PURPOSE: Pediatric Cushing's disease (CD) is rare and there are limited data on the long-term outcomes. We assessed CD recurrence, body composition, pituitary function and psychiatric comorbidity in a cohort of pediatric CD patients. METHODS: Retrospective review of 21 CD patients, mean age at diagnosis 12.1 years (5.7-17.8), managed in our center between 1986 and 2010. Mean follow-up from definitive treatment was 10.6 years (2.9-27.2). RESULTS: Fifteen patients were in remission following transsphenoidal surgery (TSS) and 5 were in remission following TSS + external pituitary radiotherapy (RT)...
December 2016: Pituitary
https://www.readbyqxmd.com/read/27677691/bone-status-assessed-by-quantitative-ultrasound-in-children-with-inflammatory-bowel-disease-a-comparison-with-dxa
#14
Katarzyna Bąk-Drabik, Piotr Adamczyk, Agata Chobot, Jarosław Kwiecień, Wojciech Pluskiewicz
BACKGROUND: To determine the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement at hand phalanges and compare the obtained results with dual-energy X-ray absorptiometry (DXA). METHODS: Fifty-one children with IBD underwent DXA and QUS measurements at hand phalanges in the year 2013. The control group for the QUS consisted of 460 children. Reference data for DXA comes from Hologic Explorer. RESULTS: QUS measurements did not differ significantly between IBD patients and healthy controls...
October 11, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27639340/exploratory-analysis-of-the-potential-relationship-between-urinary-molybdenum-and-bone-mineral-density-among-adult-men-and-women-from-nhanes-2007-2010
#15
Ryan C Lewis, Lauren E Johns, John D Meeker
Human exposure to molybdenum (Mo) may play a role in reducing bone mineral density (BMD) by interfering with steroid sex hormone levels. To begin to address gaps in the literature on this topic, the potential relationship between urinary Mo (U-Mo) and BMD at the femoral neck (FN-BMD) and lumbar spine (LS-BMD) was explored in a sample of 1496 adults participating in the 2007-2010 cycles of the National Health and Nutrition Examination Survey. Associations were assessed using multiple linear regression models stratified on sex and age...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27569961/osteoporosis-in-lung-transplantation-candidates-association-with-6-minute-walking-test-and-body-mass-index
#16
M K Balci, E Ari, M Vayvada, C Salturk, E Asicioglu, A Yeginsu, C A Kutlu
BACKGROUND: Osteoporosis is a well-recognized complication in lung transplantation because of steroid use and immobilization. The aim of the study was to assess the prevalence of osteoporosis and risk factors associated with osteoporosis in lung transplantation candidates. METHODS: The bone mineral density of 174 patients with various end-stage lung diseases was assessed at the pretransplantation period. Osteoporosis risk factors were analyzed with the consideration to principal diagnosis, demographic, and clinical parameters of lung disease, lung function tests and mobility test (6-minute walking test)...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27516660/complementary-and-alternative-medicine-for-osteoporosis
#17
Zahra Alsadat Hejazi, Forough Namjooyan, Marjan Khanifar
BACKGROUND: A systemic skeletal disease is characterized by low bone mass and micro-architectural deterioration with a consequent increase in bone fragility and susceptibility to fracture. Asia has the highest increment in the elderly population; therefore, osteoporotic fracture should be a noticeable health issue. The incidence rate of hip fractures in Asia could rise to 45% by the year 2050. Complementary and alternative medicine (CAM) is a group of various medical and health care systems, practices, and products that are not presently considered as part of formal medicine...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27479687/low-bone-mineral-density-in-adolescents-with-leukemia-after-hematopoietic-stem-cell-transplantation-prolonged-steroid-therapy-for-gvhd-and-endocrinopathy-after-hematopoietic-stem-cell-transplantation-might-be-major-concerns
#18
W K Cho, M B Ahn, J-W Lee, N-G Chung, M H Jung, B Cho, B-K Suh
No abstract text is available yet for this article.
August 1, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27454269/effect-of-epidural-steroid-injection-on-bone-mineral-density-in-postmenopausal-women-according-to-antiosteoporotic-medication-use
#19
Young Uk Kim, Myung Hwan Karm, Yuseon Cheong, Jonghyuk Lee, Yu Gyeong Kong, Se Hun Kim, Jeong Hun Suh
BACKGROUND: No studies to date have compared bone mineral density (BMD) changes after epidural steroid injection (ESI) between postmenopausal patients taking antiosteoporotic medication and those who are not. OBJECTIVE: The aim of the present study was to analyze the relationship between ESI and BMD changes in postmenopausal patients according to antiosteoporotic medication use. STUDY DESIGN: Retrospective analysis. SETTING: Department of Anesthesiology and Pain Medicine at Asan Medical Center, Korea...
July 2016: Pain Physician
https://www.readbyqxmd.com/read/27400591/-osteoporosis-a-clinical-perspective
#20
REVIEW
Niina Matikainen
Osteoporosis is defined by decreased bone density and microarchitectural deterioration that predispose to fragility fractures. The WHO diagnostic criteria of osteoporosis require bone densitometry but treatment is possible on the basis of high clinical fracture risk and can be assessed by the FRAX risk algorithm. All those subject to fracture risk should be advised about proper basic treatment of osteoporosis, including exercise, prevention of falls, smoking cessation, avoidance of alcohol intake, and dietary or supplemental abundance of calcium and vitamin D...
2016: Duodecim; Lääketieteellinen Aikakauskirja
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