Read by QxMD icon Read


Suk-Yu Yau, Thomas Ho-Yin Lee, Ang Li, Aimin Xu, Kwok-Fai So
Streptozotocin (STZ)-induced diabetes impairs learning and memory performance and reduces adult hippocampal neurogenesis. Physical exercise brings beneficial effects. We have previously shown that adiponectin, an adipocyte-secreted hormone critically involved in the pathology of diabetes, is a key mediator for exercise-enhanced adult hippocampal neurogenesis. Here, we tested whether adiponectin is required for exercise to restore adult hippocampal neurogenesis in an animal model of diabetes. The findings showed that a single injection of 195 mg/kg STZ-induced diabetes significantly increased serum levels of corticosterone and reduced hippocampal adiponectin levels in adult mice...
2018: Frontiers in Neuroscience
Daniel Moreira-Silva, Daniel C Carrettiero, Adriele S A Oliveira, Samanta Rodrigues, Joyce Dos Santos-Lopes, Paula M Canas, Rodrigo A Cunha, Maria C Almeida, Tatiana L Ferreira
Alzheimer's disease (AD) is characterized by multiple cognitive deficits including memory and sensorimotor gating impairments as a result of neuronal and synaptic loss. The endocannabinoid system plays an important role in these deficits but little is known about its influence on the molecular mechanism regarding phosphorylated tau (p-tau) protein accumulation - one of the hallmarks of AD -, and on the density of synaptic proteins. Thus, the aim of this study was to investigate the preventive effects of anandamide ( N -arachidonoylethanolamine, AEA) on multiple cognitive deficits and on the levels of synaptic proteins (syntaxin 1, synaptophysin and synaptosomal-associated protein, SNAP-25), cannabinoid receptor type 1 (CB1 ) and molecules related to p-tau degradation machinery (heat shock protein 70, HSP70), and Bcl2-associated athanogene (BAG2) in an AD-like sporadic dementia model in rats using intracerebroventricular (icv) injection of streptozotocin (STZ)...
2018: Frontiers in Neuroscience
Ítalo Medeiros Azevedo, Irami Araújo-Filho, Marianny Maiara Antas Teixeira, Marília Daniela Ferreira de Carvalho Moreira, Aldo Cunha Medeiros
PURPOSE: To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats. METHODS: Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.o. Group 2 received moringa extract (100mg/kg v.o) for 3 weeks. Groups 3 and 4: Streptozotocin (STZ) induced diabetes. Group 3 received NS; Group 4 received aqueous ME (100mg/kg) v.o.The wounds of groups 1 and 3 rats were topically treated with NS; wounds of groups 2 and 4 treated with 200µL of 10% ME...
September 2018: Acta Cirúrgica Brasileira
Rajappa Rashmi, Salai Bojan Magesh, Kunka Mohanram Ramkumar, Sarvajayakesavulu Suryanarayanan, Madhunapantula Venkata SubbaRao
Background: Naringenin is a bioactive flavonoid found in grapes and citrus fruits including tangelo, blood orange, lemons, and tangerines. The aims of this study were to investigate the ability of naringenin to scavenge free radicals and determine its ability to protect animals from streptozotocin (STZ) -induced liver damage. Methods: The free radical-scavenging activity of naringenin was evaluated by in vitro cell-free assay systems. In animals, the antioxidant potential of orally administered 50 and 100 mg/kg body weight naringenin for 45 days was assessed by measuring TBARS, lipid hydroperoxides, SOD, catalase, GST, GPx, and glutathione levels in liver homogenates prepared from animals injected intraperitoneally with multiple low dose streptozotocin at 50 mg/kg for five consecutive days...
October 2018: Reports of Biochemistry & Molecular Biology
Chen Lei, Han Xueming, Duan Ruihang
Diabetes mellitus is known as a main cause to induce osteoporosis. However, the pathogenesis of osteoporosis induced by diabetes has not been fully understood. MLN64 is highly homologous to the steroidogenic acute regulatory (STAR) protein, sharing the highly conserved START domain and exhibiting various biological activities. In the study, we attempted to explore the role of MLN64 in osteoporosis progression through the in vitro and in vivo studies. At first, the in vitro study suggested that MLN64 was over-expressed during the osteoclast differentiation induced by receptor activator of NF-kB ligand (RANKL)...
October 12, 2018: Biochemical and Biophysical Research Communications
Parisa Hasanein, Abbasali Emamjomeh, Nasibeh Chenarani, Mussa Bohlooli
OBJECTIVES: Cognitive impairment and hyperalgesia are among the common manifestations of diabetes. Hyperglycemia may contribute to their developments but the exact pathophysiology underlying these complications is not fully understood. Flavonoids from plants original have beneficial effects on diabetes by improving glycemic control. Rutin (RUT) is a bioflavonoid found in many plants and foods with many biological activities including neuroprotective and antidiabetic effects. In this study, we hypothesized that administration of RUT (10, 25 and 50 mg/kg, i...
October 15, 2018: Nutritional Neuroscience
José Manuel Valdivielso, Conxita Jacobs-Cachá, María José Soler
PURPOSE OF REVIEW: The majority of end-stage renal disease including dialysis and kidney transplant patients are men. In contrast, the incidence of chronic kidney disease (CKD) is higher in women compared with men. In this review, we dissect the sex hormone levels and its effects on experimental models and patients with CKD. RECENT FINDINGS: Sex hormones are clearly involved in CKD progression to end-stage renal disease (ESRD). A significant reduction in lipid peroxidation as a mechanism of renoprotection has been observed in kidneys of streptozotocin (STZ)-diabetic ovariectomized rats after estradiol administration...
October 12, 2018: Current Opinion in Nephrology and Hypertension
Xiaofei An, Maoxiang Zhang, Sisi Zhou, Tian Lu, Yongjun Chen, Lin Yao
Hyperglycemia induces glomerular hyper-filtration, which contributes to the development of diabetic nephropathy (DN), a condition that remains a challenge for treatment. The present study investigated the effect of Xiao-Shen-Formula (XSF) used for treatment of renal injury in type 1 DN mice model induced by streptozotocin (STZ) and its underlying mechanism in cultured human glomerular endothelial cell (hGECs). Studies were performed using control, diabetic DN, DN treated with XSF groups (1 g/kg/d, LXSF or 3 g/kg/d, HXSF) for 6 weeks and hGECs were post-treated with mice serum containing HXSF (MS-HXSF) and arginase inhibitor (ABH, 100 μM) in high glucose medium...
2018: Frontiers in Physiology
Kathiroli Sujithra, Srinivasan Subramani, Indumathi Dhananjayan, Veerasamy Vinothkumar
Diabetes is a major non-communicable life threatening chronic and pervasive condition that is consuming the world health in a petrifying rate. The circulatory system is one of the major sources of hyperglycemia induced ROS generation. Historically, garlic has been revered as part of a healthful diet. Organosulfur compounds have been attributed to the medicinal properties and health benefits of garlic. The present study focuses on the ameliorative role of Allyl methyl sulfide (AMS) in combating diabetic complications in diabetic rats...
October 15, 2018: Toxicology Mechanisms and Methods
Xiaohui Ma, Sitong Liu, Dongxue Liu, Qian Wang, Hongwei Li, Zhen Zhao
This study was to examine the role of exercise intervention in modulating neuropathic pain induced by diabetes. Diabetes was induced by streptozotocin (STZ, i.p.) in rats and mechanical hyperalgesia was observed three weeks after STZ. Mechanical withdrawal thresholds were increased after four to five weeks of exercise in STZ rats. We also examined the role of signal of mammalian target of rapamycin (mTOR) in regulating neuropathic pain. Inhibition of neuropathic pain by exercise in STZ rats was accompanied with decreases of p-mTOR, p-S6K1, and p-4E-BP1 in sensory nerves...
October 13, 2018: Archives of Physiology and Biochemistry
B Tutun, H Elbe, N Vardi, H Parlakpinar, A Polat, M Gunaltili, M M Guclu, E N Yasar
Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress contributes to the development of diabetic complications. Dexpanthenol (Dxp) is the biological active form of pantothenic acid. We investigated whether Dxp administration could decrease oxidative stress as a way to treat renal complications of diabetes mellitus (DM). Thirty-two male Wistar albino rats were divided into four groups: control, Dxp, DM and DM + Dxp. Experimental diabetes was induced by a single dose of streptozotocin (STZ)...
October 15, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
H F Miranda, P Poblete, F Sierralta, V Noriega, J C Prieto, R J Zepeda
Neuropathic pain is a complication of cancer and diabetes mellitus and the most commonly used drugs in the treatment of the diabetic neuropathic pain have only limited efficacy. The aim of this study was to evaluate the role of the biomarker interleukin-1beta (IL-1ß) in the pharmacological interaction of gabapentin with tramadol in a model of diabetic neuropathic pain. CF-1 male mice, pretreated with 200 mg/kg i.p. of streptozocin (STZ), were used and at day 3 and 7 were evaluated by the hot plate test and the spinal cord level of IL-1ß was determined...
October 13, 2018: Inflammopharmacology
Hossein Azizian, Mohammad Khaksari, Gholamreza Asadikaram, Gholamreza Sepehri, Hamid Najafipour
In postmenopausal women, the risk of diabetic cardiovascular disease drastically increases compared with that of premenopausal women. In the present study we surveyed the effects of Tamoxifen (TAM) and 17-β-estradiol (E2) on diabetic cardiovascular dysfunction. Female wistar rats were divided into six groups: sham-control, Diabetes, Ovariectomized (OVX) + Diabetes, OVX + Diabetes + Vehicle, OVX + Diabetes + E2, OVX + Diabetes + TAM. Type 2 diabetes was induced by High Fat Diet and low doses of STZ...
October 10, 2018: International Immunopharmacology
Mengshan He, Pan Long, Weiming Yan, Tao Chen, Lunfeng Guo, Zouming Zhang, Siwang Wang
AIMS: Acetaldehyde dehydrogenase 2 (ALDH2) was reported for its protective properties on myocardial damage, stroke and neurodegeneration disease, but the effects and mechanisms of ALDH2 in the modulation of diabetic retinopathy remain unclear. The present study evaluated the protection effects of ALDH2 on streptozocin (STZ)-induced aged diabetic rats retinas damage. MAIN METHODS: 24 aged male diabetic Sprague-Dawley (SD) rats induced by a single intraperitoneal injection of STZ were randomly divided into Alda1-treated group and dimethylsulfoxide (DMSO) group...
October 10, 2018: Life Sciences
Celal Guven, Eylem Taskin, Handan Akcakaya, Rustem Nurten
BACKGROUND: The aim of the current study is to investigate the effect of leptin on cytoskeleton structures in both in vivo and in vitro model of diabetes. MATERIALS AND METHODS: For in vivo studies, leptin in different doses (240, and 480 mg/kg) was injected to the diabetic rats after one-week of Streptozotocin (STZ, 55 mg/kg) treatment. Leptin levels were analyzed in serum, liver, and pancreas samples. Hepatic and pancreatic F-and G- actin expressions were determined by Western blotting...
October 12, 2018: Folia Morphologica (Warsz)
JeanYu Hwang, Den-En Shieh, Yung-Shin Shyu, Cheng-Kuang Hsu, Chuan-Wang Lin
Mulberry lees are the sediment in the bottom of the barrel, which can be obtained from the processing of mulberry wine, and they are considered as low-value byproducts. In this study, mulberry lees were extracted with ethanol, and then fermented with Monascus pilosus to obtain fermented products (M × M). Male ICR mice were diabetes induced by STZ, and then oral administration of fermented products. The results showed that fermented products could reduce 31.9% to 47.9% plasma glucose, 25.8% to 48.2% total cholesterol, and 16...
October 12, 2018: Journal of Food Science
Tzu-Hsien Tsai, Cheng-Jei Lin, Sarah Chua, Sheng-Ying Chung, Shyh-Ming Chen, Chien-Ho Lee, Chi-Ling Hang
BACKGROUND: Diabetic cardiomyopathy (DCM) is characterized by cardiac fibrosis and stiffness, which often develops into heart failure. This study investigated the role of Ras protein-specific guanine nucleotide releasing factor 1 (RasGRF1) in the development of DCM. METHODS: Forty-eight mice were divided into four groups ( n = 12 per group): Group 1: Wild-type (WT) mice, Group 2: RasGRF1 deficiency (RasGRF1-/- ) mice. Group 3: Streptozotocin (STZ)-induced diabetic WT mice, Group 4: STZ-induced diabetic RasGRF1-/- mice...
October 10, 2018: International Journal of Molecular Sciences
Xing-Rong An, Xin Li, Wei Wei, Xiao-Xue Li, Ming Xu
BACKGROUND/AIMS: The phenotype switching of vascular smooth muscle cells (VSMCs) was associated with the onset or progression of the atherogenic process in type 2 diabetes mellitus (T2DM). Alprostadil (Prostaglandin E1, PGE1) as a bioactive drug had a protective effect on vascular function. However, it is unknown whether PGE1 inhibited the phenotype switching in VSMCs via autophagy, which played a protective role in the vascular complications of diabetes. METHODS: The phenotype switching was induced by high glucose (HG, 25mM) in VSMCs, the protein expression was measured by western blot analysis and immunofluorescent staining...
October 11, 2018: Cellular Physiology and Biochemistry
Weiqin Yin, Yongwei Jiang, Shiqing Xu, Zai Wang, Liang Peng, Qing Fang, Tingting Deng, Wanni Zhao, Wenjian Zhang, Jinning Lou
AIMS/INTRODUCTION: Blockade or reversal the progression of diabetic nephropathy is a clinical challenge. To study whether the recombinant human glucagon-like peptide-1 have an effect on alleviate urinary protein and urinary albumin levels in diabetic rats or not. MATERIALS AND METHODS: STZ induced Diabetes Rats were treated with rhGLP-1, Insulin, and Saline. Using Immunostaining, H&E, EM and PAS staining to study the pathology of DN, and we performed qRT-PCR, Western blot and IHC to identify the differentially expressed proteins...
October 11, 2018: Journal of Diabetes Investigation
Eunjin Oh, Miwon Ahn, Solomon Afelik, Thomas C Becker, Bart O Roep, Debbie C Thurmond
Syntaxin 4 (Stx4) enrichment in human and mouse islet grafts improves transplant success in reversing STZ-induced diabetes in mice, although the underlying molecular mechanisms remain elusive. Toward further understanding this, human islets and inducible transgenic mice over-expressing Stx4 selectively in the islet β-cells (βTG-Stx4) were challenged with pro-inflammatory stressors in vitro and in vivo. Remarkably, βTG-Stx4 mice resisted multiple-low dose streptozotocin (STZ)-induced loss of β-cell mass and glucose intolerance; under standard conditions glucose tolerance was enhanced, maintaining normal fasting glycemia and insulinemia...
October 10, 2018: Diabetes
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"