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Bijan Ghorbanpour Oskouei, Soheil Abbaspour-Ravasjani, Seyed Jamal Musavinejad, Seyed Ahmad Salehzadeh, Alireza Abdolhosseinzadeh, Hamed Hamishehkar, Kazem Ghahremanzadeh, Behrooz Shokouhi
AIM: The evaluation of the positive and protective effects thymol as a natural compound on the STZ -induced diabetic rats. MATERIALS AND METHODS: In this study, seven groups of the streptozotocin induced diabetic and normal rats (overall 42 males) were tested through various biochemical and histopathological factors such as: serum glucose, insulin, creatinine, lipids, lipoproteins, liver function-related enzymes, and antioxidant status in liver and kidney. RESULTS: The obtained results in this work indicated that thymol had a significant anti-hypoglycemic, anti-hypolipidemic activities on the STZ-induced diabetic rats...
August 13, 2018: Drug Research
Amit Kumar, Nirmal Singh
AIM: The present study was designed to investigate the outcome of combination of Calcineurin (CaN) inhibitor (Tacrolimus) and Protein Kinase A (PKA) activator (Forskolin), in mouse models of experimental dementia. METHODS: Streptozotocin [STZ, 3mg/kg, injected intracerebroventricular (i.c.v.)] was used to induce memory deficits in NIH mice, while aged mice separately taken served as a natural model of dementia. Morris water maze (MWM) test was employed to evaluate learning and memory of the animals...
August 13, 2018: Current Neurovascular Research
Kathiroli Sujithra, Subramani Srinivasan, Dhananjayan Indumathi, Veerasamy Vinothkumar
Therapeutic approaches based on dietary compounds obtained from food products to handle diabetes involving oxidative stress and inflammation. Garlic is a common spice and has a long history as a folk remedy. Allyl methyl sulfide (AMS) is a potential garlic-derived organosulfur compound displaying a substantial range of optimistic actions in various diseases. Herein, we investigated the potential role of AMS in ameliorating the effects of oxidative stress and inflammation in the liver of streptozotocin (STZ)-induced experimental rats...
August 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ming Wu, Weixia Han, Shan Song, Yunxia Du, Chao Liu, Nan Chen, Haijiang Wu, Yonghong Shi, Huijun Duan
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been reported in diabetic kidney, yet the potential role of NLRP3 inflammasome in DN is not well known. In this study, we explored the role of NLRP3 inflammasome on inflammation and fibrosis in diabetic kidney using NLRP3 knockout mice. Renal expression of NLRP3, caspase-1 p10, interleukin-18 (IL-18) and cleaved IL-1β was increased in diabetic wild-type (WT) mice at 24 weeks...
August 8, 2018: Molecular and Cellular Endocrinology
Fatemeh Delkhosh-Kasmaie, Amir Abbas Farshid, Esmaeal Tamaddonfard, Mehdi Imani
Safranal is one of saffron constituents and has antioxidant and neuroprotective properties. Metformin is used as an anti-diabetic drug. This study was planned to investigate the separate and combined treatment effects of safranal and metformin on diabetes-induced learning and memory impairments by behavioral and hippocampal histopathological and biochemical evaluations. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ), treatments with safranal (0.025, 0.1 and 0.4 mg/kg), metformin (50 and 200 mg/kg), and a combination of low doses of this chemicals were initiated after confirmation of diabetes and continued for 37 days...
August 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mariana G de Oliveira, Daniel M Nascimento, Eduardo C Alexandre, Sandra M Bonilla-Becerra, Adriana Zapparoli, Fabiola Z Mónica, Edson Antunes
AIMS: Overactive bladder (OAB) is one of the most common complications of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). In healthy conditions, menthol infused intravesically reduces the threshold for initiating micturition reflex, but no study evaluated its effects in diabetic conditions. Therefore, we have used mouse models of T1DM and T2DM to evaluate the effects of menthol on cystometric alterations and increased bladder contractility in vitro. METHODS: For T1DM induction, male C57BL6 mice were injected with streptozotocin (STZ) and evaluated after 4 weeks...
August 8, 2018: Neurourology and Urodynamics
Jing-Xue Gu, Xiao-Jing Cheng, Xuan Luo, Xia Yang, Yi-Peng Pang, Xiao-Fei Zhang, Yu-Yun Zhang, Yi Liu
Luteolin, a flavonoid isolated from Cirsium japonicum, has antioxidant, anti-inflammatory and neuroprotective activities. Our previous studies brought a prospect that luteolin benefited diabetic rats with cognitive impairments. In this study, we examined whether luteolin could suppress the inflammatory cytokines, thus increasing synapse-associated proteins in streptozotocin (STZ)-induced diabetes in rat models. The model rats underwent luteolin treatment for 8 consecutive weeks, followed by assessment of cognitive performances with MWM test...
August 7, 2018: Neurochemical Research
Ya-Feng Zhou, Xiao-Ming Ying, Xiao-Fen He, Sheng-Yun Shou, Jun-Jun Wei, Zhao-Xia Tai, Xiao-Mei Shao, Yi Liang, Fang Fang, Jian-Qiao Fang, Yong-Liang Jiang
Painful diabetic neuropathy (PDN) is a common and troublesome diabetes complication. Protein kinase C (PKC)-mediated dorsal root ganglia (DRG) P2X3 receptor upregulation is one important mechanism underlying PDN. Accumulating evidence demonstrated that electroacupuncture (EA) at low frequency could effectively attenuate neuropathic pain. Our previous study showed that 2-Hz EA could relieve pain well in PDN. The study aimed to investigate whether 2-Hz EA relieves pain in PDN through suppressing PKC-mediated DRG P2X3 receptor upregulation...
August 7, 2018: Purinergic Signalling
Xiaomin Yu, Xin An, Hui Lu, Xingting Wang, Yan Jiang
OBJECTIVE: To study hypoglycemic effects of different mulberry leaf extracts on diabetic mice. METHODS: STZ-induced diabetic mice were intragastricly administrated with different mulberry leaf extracts( water extracts: 800 mg/kg, ethanol extracts: 500 mg/kg, water extracts + ethanol extracts: low dose 150 mg/kg, high dose300 mg/kg) and positive control group( melbine: 227. 5 mg/kg). Four weeks later, serum glucose levels, insulin levels, antioxidase activities were tested...
May 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Ping Liu, Jiao Xue, Shisheng Tong, Wenxia Dong, Peipei Wu
In the present study, two polysaccharides (HIOP1-S and HIOP2-S) were isolated and purified from Inonotus obliquus using DEAE-52 cellulose and Sephadex G-100 column chromatography. The structural characterization and in vitro and in vivo hypoglycaemic activities of these molecules were investigated. HPLC analysis HIOP1-S was a heterpolysaccharide with glucose and galactose as the main compontent monosaccharides (50.247%, molar percentages). However, HIOP2-S was a heterpolysaccharide with glucose as the main monosaccharide (49...
August 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Bin Leng, Futian Tang, Meili Lu, Zhen Zhang, Hongxin Wang, Yingjie Zhang
AIMS: Astragaloside IV (As-IV) is the major active ingredient of Astragalus membranaceus and has diverse pharmacological activities, including anti-inflammatory and antioxidant effects. However, the beneficial effect of As-IV on protecting vascular endothelial dysfunction is not completely understood. The aim of this study was to investigate the protective effect and mechanism of As-IV on vascular endothelial dysfunction. MATERIALS AND METHODS: A diabetes model was established by intraperitoneal injection of streptozotocin (STZ)...
August 3, 2018: Life Sciences
Cheng-Di Chiu, You-Pen Chiu, Cheng-Li Lin, Hui-Ru Ji, Chiung-Chyi Shen, Hsu-Tung Lee, Chen Chang
Hyperglycemia is associated with the poor outcome after intracerebral hemorrhage (ICH). Acetazolamide (AZA), a kind of carbonic anhydrogenase (CA) inhibitor, its effectiveness in ICH had been reported. However, the connections between AZA and ICH especially in hyperglycemia condition had never been defined. In this study, adult Sprague Dawley rats were administered with vehicle or streptozotocin (STZ) to render them into normoglycemic (NG) or hyperglycemic (HG), respectively. Collagenase was then injected into the striatum...
August 6, 2018: Free Radical Research
Wang Chengji, Fan Xianjin
To explore the protective effect of exercise training on the injury of myocardium tissues induced by streptozotocin (STZ) in diabetic rats and the relationship with endoplasmic reticulum stress (ERS), the male sprague-dawley (SD) rats were fed with high-fat and high-sugar diet for 4 weeks, followed by intraperitoneal injection of STZ, 40 mg/kg, to establish a diabetes model, and then 10 rats were randomly selected as diabetes mellitus (DM) controls and 20 eligible diabetic rats were randomized into two groups: low-intensity exercise training (n = 10) and high-intensity exercise training (n = 10)...
August 4, 2018: Journal of Cellular Physiology
Missaoui Samira, Tlili Mounira, Kacem Kamel, Mohamed Tahar Yacoubi, Khemais Ben Rhouma, Mohsen Sakly, Olfa Tebourbi
This study aimed to examine the effects of vanadyl sulfate (VOSO4) on liver in nondiabetic and sterptozotocin (STZ)-induced diabetic rats. Rats were divided into six groups. Groups1, 2 and 3 are nondiabetic and are respectively, control and given (ip) 5 or 10 mg/kg of VOSO4 for 30 days. Groups 4, 5 and 6 are diabetic animals and are respectively, control and treated with 5 or 10 mg/kg of VOSO4. Results showed that VOSO4 reduced weight gain in nondiabetic rats, whereas it increased body weight in diabetic groups...
August 3, 2018: Canadian Journal of Physiology and Pharmacology
Noha Abbas, Amal Salem
Many adipocytokines correlate with obesity and insulin resistance(IR). we examined the effects of metformin, sitagliptin, and liraglutide in diabetic rats. Group 1: control normal (CN) received oral saline daily. Group 2: The diabetic non treated (DNT) injected STZ to get diabetic then after 72 hours the rats received oral saline daily. Group 3: injected STZ then after 72 hours treated with metformin (200 mg/kg) orally. Group 4: injected STZ then after 72 hours received sitagliptin 6 mg/kg orally twice daily...
August 3, 2018: Canadian Journal of Physiology and Pharmacology
Enji Reda, Sherifa Hassaneen, Hanan S El-Abhar
Bromocriptine (BC), a sympatholytic dopaminergic D2 receptor agonist, has been comprehensively used in clinic to treat Parkinson's disease (PD) and prolactinomas. Besides, BC represents a novel therapeutic option in type 2 diabetes (T2DM); however, the precise mechanisms are not completely unveiled. Hence, the objective of the current work is to clarify the potential molecular pathways of the insulin sensitizing effect of BC in the skeletal muscle of diabetic rats and to evaluate its possible interaction with sitagliptin (SG) as an add-on therapy...
2018: Frontiers in Pharmacology
Lu Yang, Wenli Han, Ying Luo, Xiangnan Hu, Ying Xu, Huan Li, Congli Hu, Dan Huang, Jie Ma, Yang Yang, Qi Chen, Yuke Li, Jiahua Zhang, Hui Xia, Zhihao Chen, Hong Wang, Dongzhi Ran, Junqing Yang
Our previous studies indicated that adapentpronitrile, a new adamantane-based dipeptidyl peptidase-IV (DPP-IV) inhibitor, has a hypoglycemic effect and ameliorates rat pancreatic β cell dysfunction in type 2 diabetes mellitus through inhibiting DPP-IV activity. However, the effect of adapentpronitrile on the neurodegenerative diseases has not been studied. In the present study, we first found that adapentpronitrile significantly ameliorated neuronal injury and decreased amyloid precursor protein (APP) and amyloid beta (Aβ) expression in the hippocampus and cortex in the high fat diet/STZ rat model of diabetes...
2018: Frontiers in Cellular Neuroscience
Guangfeng Zuo, Xiaomin Ren, Xuesong Qian, Peng Ye, Jie Luo, Xiaofei Gao, Junjie Zhang, Shaoliang Chen
Inflammation plays a critical role in the development of diabetic cardiomyopathy (DCM), which has been identified as a major predisposing factor for heart failure in diabetic patients. Previous studies indicated that ivabradine (a specific agent for heart rate [HR] reduction) has anti-inflammatory properties, but its role in DCM remains unknown. This study investigated whether ivabradine exerts a therapeutic effect in DCM. C57BL/6J mice were injected intraperitoneally with streptozotocin (STZ) to induce diabetes; then administered with ivabradine or saline (control)...
August 1, 2018: Journal of Cellular Physiology
Mozafar Khazaei, Mona Pazhouhi
Natural plants have traditionally been used throughout the world for their anti-diabetic effects. The aim of the present study was to investigate the protective effect of hydroalcoholic extract of Trifolium pratens L . ( T. pratense ) on streptozotocin (STZ) cytotoxicity and insulin concentration from RIN-5F pancreatic β cell line. In this study, possible cytoprotective action of T. pratense extract (using pre-treatment, simultaneous, and post-treatment schedules) against STZ (30 mM) was evaluated using MTT assay...
August 2018: Research in Pharmaceutical Sciences
Liangcai Zhao, Minjian Dong, Dan Wang, Mengqian Ren, Yongquan Zheng, Hong Zheng, Chen Li, Hongchang Gao
Cognitive dysfunction is a central nervous system (CNS) complication of diabetes mellitus (DM) that is characterized by impaired memory and cognitive ability. An in-depth understanding of metabolic alterations in the brain associated with DM will facilitate our understanding of the pathogenesis of cognitive dysfunction. The present study used an in vitro culture of primary neurons in a high-glucose (HG) environment to investigate characteristic alterations in neuron metabolism using nuclear magnetic resonance (NMR)-based metabonomics...
2018: Frontiers in Cellular Neuroscience
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