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model of type 2 diabetes

Tonia de Las Heras Gala, Christian Herder, Femke Rutters, Maren Carstensen-Kirberg, Cornelia Huth, Coen D A Stehouwer, Giel Nijpels, Casper Schalkwijk, Allan Flyvbjerg, Paul W Franks, Jacqueline Dekker, Christa Meisinger, Wolfgang Koenig, Michael Roden, Wolfgang Rathmann, Annette Peters, Barbara Thorand
AIMS: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro- (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycemia, insulin resistance and secretion (HbA1c , HOMA-IR, HOMA-ß)...
August 16, 2018: Diabetes/metabolism Research and Reviews
Dahai Yu, Yamei Cai, Jonathan Graffy, Daniel Holman, Zhanzheng Zhao, David Simmons
AIMS: Cerebrovascular disease is one of more typical reasons for hospitalisation and re-hospitalisation in people with type 2 diabetes. We aimed to derive and externally validate two risk prediction algorithms for cerebrovascular hospitalisation and re-hospitalisation. METHODS: Two independent cohorts were used to derive and externally validate the two risk scores. The development cohort comprises 4,704 patients with type 2 diabetes registered in 18 general practices across Cambridgeshire...
August 13, 2018: Diabetes Research and Clinical Practice
Kirsten P J Smits, Grigory Sidorenkov, Nanne Kleefstra, Steven H Hendriks, Margriet Bouma, Marianne Meulepas, Gerjan Navis, Henk J G Bilo, Petra Denig
BACKGROUND: Guideline-adherent prescribing for treatment of multiple risk factors in type 2 diabetes (T2D) patients is expected to improve clinical outcomes. However, the relationship to Health-Related Quality of Life (HRQoL) is not straightforward since guideline-adherent prescribing can increase medication burden. OBJECTIVES: To test whether guideline-adherent prescribing and disease-specific medication burden are associated with HRQoL in patients with T2D. METHODS: Cross-sectional study including 1,044 T2D patients from the e-VitaDM/ZODIAC study in 2012 in the Netherlands...
2018: PloS One
Rubab Qureshi, Yuri Jadotte, Peijia Zha, Sallie Ann Porter, Cheryl Holly, Susan Salmond, Elizabeth Ann Watkins
OBJECTIVE: The objective of the review was to determine if prenatal exposure to environmental tobacco smoke (ETS) increases the risk of obesity and overweight in children. INTRODUCTION: Childhood obesity has reached epidemic proportions in many developed countries. This is of great concern as childhood obesity is associated with early onset of chronic diseases such as coronary artery disease, type II diabetes and hypertension in adulthood. Extensive research suggests a multifactorial etiology...
August 2018: JBI Database of Systematic Reviews and Implementation Reports
Muruganantham Koothappan, Roshana Devi Vellai, Iyyam Pillai Subramanian, Sorimuthu Pillai Subramanian
Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed-low dose streptozotocin induced T2DM in rats...
April 24, 2018: Diabetes & Metabolism Journal
Ji Hye Huh, Minyoung Lee, So Young Park, Jae Hyeon Kim, Byung Wan Lee
BACKGROUND: The aim of this study was to investigate which glycemic parameters better reflect urinary N-acetyl-β-D-glucosaminidase (uNAG) abnormality, a marker for renal tubulopathy, in subjects with type 2 diabetes mellitus (T2DM) subjects with normoalbuminuria and a normal estimated glomerular filtration rate (eGFR). METHODS: We classified 1,061 participants with T2DM into two groups according to uNAG level-normal vs. high (>5.8 U/g creatinine)-and measured their biochemical parameters...
May 2, 2018: Diabetes & Metabolism Journal
Arathi S Nandyala, Lyndsay A Nelson, Andrea E Lagotte, Chandra Y Osborn
Many people with type 2 diabetes do not take medications as prescribed, resulting in suboptimal glycemic control and a greater risk of diabetes complications. Taking medications regularly requires adequate health literacy and numeracy skills, but associations between health literacy and numeracy skills and medication taking are mixed. We used validated, reliable, and widely accepted measures to examine the relationship between health literacy, numeracy, and medication adherence among a sample of patients with T2D...
January 2018: Health Literacy Research and Practice
Dongdong Jiang, Fang Wan
The anti-apoptotic effect of the incretin analog, exendin-4 (EX-4) on pancreatic β cells is mediated via the activation of protein kinase B (Akt) signaling, and its effect is partly produced through the inhibition of endoplasmic reticulum (ER) stress. However, the molecular mechanisms that underlie the effect of EX-4 on the suppression of ER stress and the upregulation of Akt signaling are poorly understood. Inositol-requiring enzyme 1 (IRE1), a member of the ER-localized transmembrane protein family, activates its downstream transcription factor X-box binding protein 1 (XBP1) to mediate a key part of the cellular unfolded protein response in order to cope with ER stress...
August 2018: Experimental and Therapeutic Medicine
Eugene Yu-Chuan Kang, Fu-Sung Lo, Jung-Pan Wang, Lung-Kun Yeh, An-Lun Wu, Yun-Ju Tseng, Chun-Ting Yeh, Laura Liu, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Nan-Kai Wang
The need for screening for retinopathy in patients with type 1 diabetes mellitus (T1DM) has been emphasised, but diagnostic delays were reported when screening was done at fixed intervals. To establish an individualised risk-prediction model to assist screening non-proliferative diabetic retinopathy (NPDR) in T1DM, we performed a retrospective cohort study enrolling participants in the Chang Gung Juvenile Diabetes Eye Study. There were 413 patients with 12 381 records analysed from 2005 to 2015. A time-dependent Cox proportional hazard analysis was used to evaluate the risks of NPDR development and a nomogram with risk-stratification indicators was established based on the results...
August 15, 2018: Scientific Reports
Hui-Ting Zheng, Ke-Ning Li, Chi Chen, Wei-Dong Lin, Shu-Mei Wang
Pancreas metabonomic profiles of the type 2 diabetic rats' induced by streptozotocin(STZ) and high-sugar, high fat diet on the treatment of Renshenjian decoction(RSJD) after 8 weeks were investigated.In this study, 48 Rats were randomly divided into four groups: normal control (NC), Pathological model (PM), Renshenjian decoction(RSJD 3.76 g·kg⁻¹) and glimepiride control (GC 0.04 mg·kg⁻¹). They are induced insulin resistance model of type 2 diabetes mellitus by streptozotocin(STZ) after 4 weeks' high-sugar, high fat diet except for NC...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Silvia Giatti, Silvia Diviccaro, Roberto Cosimo Melcangi
Diabetes mellitus is a metabolic disease where improper glycaemic control may induce severe complications in different organs. In this review, we will discuss alterations occurring in peripheral and central nervous system of patients with type 1 (i.e., insulin dependent diabetes mellitus,) or type 2 diabetes (i.e., non-insulin dependent diabetes mellitus), as well as related experimental models. A particular focus will be on the role exerted by neuroactive steroids (i.e., important regulators of nervous functions) in the nervous damage induced by diabetes...
August 14, 2018: Cellular and Molecular Neurobiology
Y Wan, N L Wang, J Hao, Z Dong, Y Zhang, K Cao
Objective: To assess the utilization of eye care services in the rural area of Handan, China under the New Rural Cooperative Medical Scheme, and to analyze the factors associated with the uptake of these services. Methods: In a cohort population-based study, subjects who joined both the baseline (2006-2007) and follow-up (2012-2013) were included. Information of demographic characteristics, participation in the New Rural Cooperative Medical Insurance and use of eye care services, comprehensive ophthalmic examinations, blood pressure and fasting was collected...
August 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
John Mark McLain, Wateen H Alami, Zachary T Glovak, Chris R Cooley, Susan J Burke, J Jason Collier, Helen A Baghdoyan, Michael D Karlstad, Ralph Lydic
Study Objective: This study tested the hypothesis that sleep fragmentation (SF) delays wound healing in obese B6.BKS(D)-Leprdb/J (db/db) mice with impaired leptin signaling and type 2 diabetes compared to wild-type C57BL/6J (B6) mice. Methods: Adult male mice (n=34) were anesthetized and bilateral full-thickness excisional wounds were created on the back of each mouse. Half of the db/db and B6 mice were housed in SF-cages equipped with a bar that moved across the cage floor every 2 min, 12 h/day for 23 days...
August 11, 2018: Sleep
S M Hosseini-Moghaddam, M Shokoohi, G Singh, S F Dufresne, A Boucher, A Jevnikar, G V R Prasad, A Shoker, D Kabbani, M Hebert, H Cardinal, I Houde, A Humar, D Kumar
Background: Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between post-transplant PCP and 3 variables: cytomegalovirus infection, allograft rejection and prophylaxis. Methods: Eight transplantation centers participated. For each case (SOT recipient with PCP), 3-5 controls (SOT recipients without PCP) were included. Controls were matched to the cases based on transplant center, type of allograft and date of transplantation (± 6 months)...
August 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Michael Asamoah-Boaheng, Eric Y Tenkorang, Osei Sarfo-Kantanka
Background: Type 2 diabetes affects an increasing number of Ghanaians. The timing of the onset of diabetes is linked to several other co-morbid conditions, yet no study has examined the timing of the onset of type 2 diabetes in Ghana. Methods: To fill this gap in the literature, this study applied logit models to data extracted from the medical records at the Diabetes Clinic of the Komfo Anokye Teaching Hospital in Kumasi, Ghana. Gender-specific models were also estimated...
August 11, 2018: International Health
Maxim D Seferovic, Christine A Beamish, Rockann E Mosser, Shannon E Townsend, Kirk Pappan, Vincent Poitout, Kjersti Aagaard, Maureen Gannon
Pancreatic β-cell expansion is a highly regulated metabolic adaptation to increased somatic demands, including obesity and pregnancy; adult β-cells otherwise rarely proliferate. We previously showed that high fat diet (HFD) feeding induces mouse β-cell proliferation in less than one week in the absence of insulin resistance. Here we metabolically profiled tissues from a short-term HFD β-cell expansion mouse model to identify pathways and metabolite changes associated with β-cell proliferation. Mice fed HFD vs CD showed a 14...
August 14, 2018: American Journal of Physiology. Endocrinology and Metabolism
Lu Lu, Yixiang Deng, Xuejin Li, He Li, George Em Karniadakis
Accumulation and aggregation of amyloid are associated with the pathogenesis of many human diseases, such as Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM). Therefore, a quantitative understanding of the molecular mechanisms causing different aggregated structures and biomechanical properties of amyloid fibrils could shed some light into the progression of these diseases. In this work, we develop coarse-grained molecular dynamics (CGMD) models to simulate the dynamic self-assembly of two types of amyloids (amylin and amyloid β (Aβ))...
August 14, 2018: Journal of Physical Chemistry. B
Yevgen Chornenkyy, Wang-Xia Wang, Angela Wei, Peter T Nelson
Alzheimer's disease (AD) and type-2 diabetes mellitus (T2DM) are highly prevalent aging-related diseases associated with significant morbidity and mortality. Some findings in human and animal models have linked T2DM to AD-type dementia. Despite epidemiological associations between the T2DM and cognitive impairment, the inter-relational mechanisms are unclear. The preponderance of evidence in longitudinal studies with autopsy confirmation have indicated that vascular mechanisms, rather than classic AD-type pathologies, underlie the cognitive decline often seen in self-reported T2DM...
August 14, 2018: Brain Pathology
Jannet Svensson, Anke Schwandt, Daniele Pacaud, Jacques Beltrand, Niels Birkebaek, Roque Cardona-Hernandez, Kristina Castell, Sofia Castro, Valentino Cherubini, Declan Cody, Naama Fisch, Dhruvi Hasnani, Olga Kordonouri, Ioanna Kosteria, Andrea Luczay, Auste Pundziute-Lyckå, Claudio Maffeis, Barbara Piccini, Poran Luxmi, Zdenek Sumnik, Carine de Beaufort
OBJECTIVE: To describe the association between height, demographics and treatment in youths with Type 1 Diabetes participating in an international network for pediatric diabetes centers (SWEET). METHODS: Data were collected from 55 centers with documented patients' height. All subjects below 20 years of age, diabetes duration >1 year, and without celiac disease were included. WHO growth charts were used to calculate height and BMI z-scores. Multiple hierarchic regression models adjusting for known confounders were applied...
August 13, 2018: Pediatric Diabetes
Zhaosheng Tang, Fuming Cao, Hao Zhang, Jing Tang, Huizhi Li, Yiyun Zhang, Bo Feng, Hua Wang
BACKGROUND: Insulin-like growth factor-1 (IGF-1) is a multidimensional neurotrophic factor. Nevertheless, it has been reported that IGF-1 may lead to hyperalgesia. This study aimed to investigate the effects of IGF-1 on the overall behaviour of diabetic mice and to explore the possible mechanisms of IGF-1-induced pain effects. METHODS: The mice were divided into five groups: db/m group, db/db group, db/db+vehicle group, IGF-1-treated db/db group and IGF-1-JB-1-treated db/db group...
August 13, 2018: Journal of Diabetes
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