Read by QxMD icon Read

diabetes model

Bao Sun, Fazhong He, Lei Sun, Jiecan Zhou, Jiayi Shen, Jing Xu, Bin Wu, Rong Liu, Xingyu Wang, Heng Xu, Xiaoping Chen, Honghao Zhou, Zhaoqian Liu, Wei Zhang
PURPOSE: Glycated hemoglobin A1c (HbA1c ) and fasting plasma glucose (FPG) was identified to account for the risk of cardiovascular diseases in type 2 diabetic patients, but no study evaluated the risk based on both HbA1c and FPG levels. We described the risk of major adverse cardiovascular events (MACE) and hypoglycemic in type 2 diabetic patients according to both HbA1c and FPG levels. METHODS: With the usage of databases of Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE), 1815 patients from 61 centers in China was identified and grouped according to the criterion value of HbA1c and FPG: Good glycemic control (HbA1c  < 6...
August 18, 2018: Endocrine
Alessandra Feraco, Andrea Armani, Riccardo Urbanet, Aurelie Nguyen Dinh Cat, Vincenzo Marzolla, Frederic Jaisser, Massimiliano Caprio
Obesity is a major risk factor that contribute to the development of cardiovascular disease and type 2 diabetes. Mineralocorticoid receptor (MR) expression is increased in the adipose tissue of obese patients and several studies provide evidence that MR pharmacological antagonism improves glucose metabolism in genetic and diet-induced mouse models of obesity. In order to investigate whether the lack of adipocyte MR is sufficient to explain these beneficial metabolic effects, we generated a mouse model with inducible adipocyte-specific deletion of Nr3c2 gene encoding MR (adipo-MRKO)...
August 18, 2018: Journal of Endocrinology
Jan Borggrefe, Berit Glück, Volker Maus, Oezgur Onur, Nuran Abdullayev, Utako Barnikol, Christoph Kabbasch, Gereon Rudolf Fink, Anastasios Mpotsaris
BACKGROUND: Among patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT), diabetic patients (DP) show a poorer outcome compared to non-diabetic patients (NDP). This study aims to provide a comprehensive analysis of factors associated with unfavorable outcome in DP receiving MT for stroke of the anterior circulation. METHODS: This study includes 317 out of 498 consecutive patients who received interventional treatment for AIS in the terminal internal carotid artery and/or middle cerebral artery, including 46 DP...
August 16, 2018: World Neurosurgery
Steven J McAnany, John M Rhee, Evan O Baird, Weilong Shi, Jeffrey Konopka, Thomas M Neustein, Rafael Arceo
BACKGROUND: Traditionally, cervical radiculopathy is thought to present with symptoms and signs in a standard, textbook, reproducible pattern as seen in a "Netter diagram." To date, no study has directly examined cervical radicular patterns attributable to single level pathology in patients undergoing ACDF. PURPOSE: The purpose of this study is to examine cervical radiculopathy patterns in a surgical population and determine how often patients present with the standard textbook (i...
August 16, 2018: Spine Journal: Official Journal of the North American Spine Society
Ondrej Cinek, Lenka Kramna, Karla Mazankova, Rasha Odeh, Abeer Alassaf, MaryAnn Ugochi Ibekwe, Gunduz Ahmadov, Bashir Mukhtar Elwasila Elmahi, Hanan Mekki, Jan Lebl, Mohammed Ahmed Abdullah
OBJECTIVES: Gut bacteriome profiling studies in type 1 diabetes (T1D) to date are mostly limited to populations of Europe, with two studies from China and one study each from Mexico and the USA. We therefore sought to characterize the stool bacteriome in children after onset of T1D along with age- and place-matched control subjects from four geographically distant African and Asian countries. METHODS: Samples were collected from 73 children and adolescents shortly after T1D onset (Azerbaijan 19, Jordan 20, Nigeria 14, Sudan 20) and 104 matched control subjects of similar age and locale...
August 16, 2018: Diabetes Research and Clinical Practice
Mee Kyoung Kim, Jee Sun Jeong, Jae-Seung Yun, Hyuk-Sang Kwon, Ki Hyun Baek, Ki-Ho Song, Yu-Bae Ahn, Seung-Hyun Ko
BACKGROUND AND AIMS: Previous studies have suggested that the hemoglobin glycation index (HGI) can be used as a predictor of diabetes-related complications. We examined the prognostic significance of a high HGI for cardiovascular disease (CVD) in an ongoing hospital-based cohort. METHODS: From March 2003 to December 2004, 1302 consecutive patients with type 2 diabetes and without a prior history of CVD were enrolled. CVD was defined as the occurrence of coronary artery disease or ischemic stroke...
August 10, 2018: Journal of Diabetes and its Complications
Berenice Fernández-Rojas, Gloria Gutiérrez-Venegas
Flavonoids are plant-derived polyphenolic compounds claimed to help alleviate a variety of conditions, including diabetes, infectious endocarditis, and cancer. They have attracted substantial research interest as nutraceuticals owing to their diverse bioactivities. Periodontitis is a high-incidence inflammatory disease affecting the dentition-supporting periodontium. Although the etiology of periodontitis is diverse, microbial species in dental plaque are considered its main pathogenic agents. Here, we provide a review of flavonoid study findings relevant for periodontitis treatment and prevention...
August 16, 2018: Life Sciences
Luca Gianotti, Marta Sandini, Roberto Biffi, Daniele Marrelli, Andrea Vignali, Sebastian K S Begg, Davide P Bernasconi
BACKGROUND & AIMS: In retrospective studies an indisputable causal relationship between hyperglycemia and postoperative infections cannot be entirely disclaimed. We aimed investigate whether the time trends of blood glucose levels in the perioperative period could be a determinant of surgery-related infections. METHODS: Adult patients without diabetes who were candidates for elective major abdominal operation were prospectively enrolled in a longitudinal, observational multicenter study...
August 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Sneha S Pillai, S Mini
ETHNOPHARMACOLOGICAL RELEVANCE: Hibiscus rosa sinensis petals possess wide range of pharmacological properties, with remarkable nutritional values. Diabetes is one of the most devastating diseases affecting the world today. A few side effects associated with the use of insulin and oral hypoglycemic agents prompted us to search new bioactive principles from antidiabetic plants used in traditional medicine. AIM OF THE STUDY: The anti-diabetic therapeutic potential of the flavonoids rich ethyl acetate fraction of Hibiscus rosa sinensis petals (EHRS) was evaluated...
August 15, 2018: Journal of Ethnopharmacology
Arthur Sillah, Nathaniel F Watson, Stephen M Schwartz, David Gozal, Amanda I Phipps
PURPOSE: In vitro and animal models suggest that the physiological effects of sleep apnea could contribute to cancer risk, yet epidemiologic studies have been inconsistent. METHODS: We identified a cohort of adults diagnosed with sleep apnea between 2005 and 2014 using regional administrative databases. Linking this cohort to a population-based cancer registry, we identified first incident cancers diagnosed after sleep apnea diagnosis through 2015. We calculated age-sex standardized cancer incidence ratios (SIRs) to compare the observed number of cancers among those with sleep apnea with expected population estimates over a comparable period...
August 17, 2018: Cancer Causes & Control: CCC
Erika A Waters, Caitlin Biddle, Kimberly A Kaphingst, Elizabeth Schofield, Marc T Kiviniemi, Heather Orom, Yuelin Li, Jennifer L Hay
BACKGROUND: Health literacy and numeracy influence many health-related behaviors and outcomes. Health literacy and numeracy have been assessed objectively and subjectively, but interrelationships among the measures and the consistency of their association with health knowledge have not been examined. OBJECTIVE: To increase understanding of the structure and interrelations among objective and subjective health literacy and numeracy and how these constructs relate to knowledge of risk factors of two major diseases...
August 17, 2018: Journal of General Internal Medicine
Estelle Lowry, Nina Rautio, Ville Karhunen, Jouko Miettunen, Leena Ala-Mursula, Juha Auvinen, Sirkka Keinänen-Kiukaanniemi, Katri Puukka, Inga Prokopenko, Karl-Heinz Herzig, Alexandra Lewin, Sylvain Sebert, Marjo-Riitta Järvelin
BACKGROUND: The prevention of the risk of type 2 diabetes (T2D) is complicated by multidimensional interplays between biological and psychosocial factors acting at the individual level. To address the challenge we took a systematic approach, to explore the bio-psychosocial predictors of blood glucose in mid-age. METHODS: Based on the 31-year and 46-year follow-ups (5,078 participants, 43% male) of Northern Finland Birth Cohort 1966, we used a systematic strategy to select bio-psychosocial variables at 31 years to enable a data-driven approach...
August 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Erikka Loftfield, Weiyin Zhou, Barry I Graubard, Meredith Yeager, Stephen J Chanock, Neal D Freedman, Mitchell J Machiela
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural somatic event. Previous studies have indicated age and cigarette smoking increase the risk of mLOY, but the relationship of other exposures with mLOY and mLOY with disease has not been adequately investigated. We characterized mLOY in a large cohort of 223,338 men from the UK Biobank by scanning for deviations in genotyping array median log2 intensity ratios (mLRR) of the Y chromosome using a standard algorithm. A total of 3,789 (1...
August 17, 2018: Scientific Reports
Zhouqing Kang, Jia-Ling Huo, Xiao-Jie Zhai
Background The optimal glycemic target during the perioperative period is still controversial. We aimed to explore the effects of tight glycemic control (TGC) on surgical mortality and morbidity. Methods PubMed, EMBASE, and CENTRAL were searched from January 1, 1946 to February 28, 2018. Appropriate trails comparing the postoperative outcomes (mortality, hypoglycemic events, acute kidney injury, etc.) between different levels of TGC and liberal glycemic control were identified. Quality assessments were performed with the Jadad Scale combined with the allocation concealment evaluation...
August 17, 2018: Endocrine Connections
Jing Li, Xiaoxu Huo, Yun-Feng Cao, Sai-Nan Li, Zuo Du, Ping Shao, Junhong Leng, Cuiping Zhang, Xiao-Yu Sun, Ronald C W Ma, Zhong-Ze Fang, XilinYang
BACKGROUND: Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM). METHODS: We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in China: 243 women with GDM were matched with 243 non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline were used to examine full-range associations of bile acid metabolites with GDM...
August 14, 2018: EBioMedicine
Shibo Sun, Huifen Zhai, Mei Zhu, Peili Wen, Xin He, Haoyan Wang
INTRODUCTION: Obstructive sleep apnea, a common disease, is usually complicated by insulin resistance and type 2 diabetes mellitus. Adipokine is considered to play an important role in the development of insulin resistance and type 2 diabetes mellitus in obstructive sleep apnea. OBJECTIVE: To assess whether secreted frizzled-related protein 5, a new adipokine, is involved in untreated obstructive sleep apnea patients. METHODS: Seventy-six subjects with obstructive sleep apnea and thirty-three control subjects without obstructive sleep apnea were recruited and matched in terms of body mass index and age...
August 4, 2018: Brazilian Journal of Otorhinolaryngology
Juan Salazar, Cristobal Espinoza, Andres Mindiola, Valmore Bermudez
Data mining consists of using large database analysis to detect patterns, relationships and models in order to describe (or even predict) the appearance of a future event; to accomplish this, it uses classification methods, rules of association, regression patterns, link and cluster analyses. Recently this approach has been used to propose a new diabetes mellitus classification, using information analysis techniques through which the selection bias minimally influences categorization, this new focus that includes data mining previously implemented to predict, identify biomarkers, complications, therapies, health policies, genetic and environmental effects of this disease; it could be generalized in the field of endocrinology, in the classification of other endocrine diseases...
August 14, 2018: Archives of Medical Research
Getu Teressa, Mengru Zhang, Philip Lavenburg, Gregg Cantor, Pamela Noack, Jie Yang, Michael Goyfman, Eric J Feldmann, Javed Butler, Michael Poon
Although the majority of acute chest pain patients are diagnosed with noncardiac chest pain after noninvasive testing, identifying these low-risk patients before testing is challenging. The objective of this study was to validate the coronary artery disease (CAD) consortium models for predicting obstructive CAD and 30-day major adverse cardiovascular events (MACE) in acute chest pain patients considered for coronary computed tomography angiogram, as well as to determine the pretest probability threshold that identifies low-risk patients with <1% MACE...
July 17, 2018: American Journal of Cardiology
Elizabeth J Mayer-Davis, David M Maahs, Michael Seid, Jamie Crandell, Franziska K Bishop, Kimberly A Driscoll, Christine M Hunter, Jessica C Kichler, Debra Standiford, Joan M Thomas
BACKGROUND: Adolescents with type 1 diabetes commonly have poor glycaemic control. We aimed to test the efficacy of a newly developed adaptive behavioral intervention (Flexible Lifestyles Empowering Change; FLEX) on metabolic and psychosocial outcomes in adolescents with type 1 diabetes. METHODS: Young people (13-16 years, type 1 diabetes duration >1 year, HbA1c of 64-119 mmol/mol [8·0-13·0%], and without other serious medical conditions or pregnancy) from two clinical sites (Colorado and Ohio, USA) were eligible for enrolment...
September 2018: Lancet Child & Adolescent Health
Jian Jia, Yayu Tang, Chong Shen, Ning Zhang, Haixia Ding, Yiyang Zhan
BACKGROUND: The goal of this study was to determine if vitamin D receptor (VDR) gene polymorphisms underlie susceptibility to dyslipidemia in a Chinese Han population. METHODS: Three tag single nucleotide polymorphisms (SNPs) (rs11574129, rs2228570, and rs739837) were genotyped using TaqMan assays to determine VDR SNP associations with dyslipidemia. We genotyped 877 cases of dyslipidemia from a normotensive, non-diabetes mellitus population and 1822 non-dyslipidemia subjects in a stage I study...
August 17, 2018: Lipids in Health and Disease
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"