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Giulio Serreli, Livia Ruffini, Ornella Ortenzia, Carla Cidda, Chiara Lazzara, Caterina Ghetti
OBJECTIVE: We describe our experience with a dose-tracking software (Radimetrics) that was used to optimize, from a dosimetric point of view, the single-photon emission computed tomography/computed tomography protocols used in myocardial perfusion imaging. PATIENTS AND METHODS: We extracted and assessed the major dosimetric indices as the administered activity, the computed tomography dose index, the dose length product and the size-specific dose estimates for a large sample of patients before and after an optimization process...
August 8, 2018: Nuclear Medicine Communications
Willem Verpoest, Catherine Staessen, Patrick M Bossuyt, Veerle Goossens, Gheona Altarescu, Maryse Bonduelle, Martha Devesa, Talia Eldar-Geva, Luca Gianaroli, Georg Griesinger, Georgia Kakourou, Georgia Kokkali, Jana Liebenthron, Maria-Cristina Magli, Monica Parriego, Andreas G Schmutzler, Monica Tobler, Katrin van der Ven, Joep Geraedts, Karen Sermon
STUDY QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome analysis? SUMMARY ANSWER: PGT-A by CCS in the first and second polar body to select euploid embryos for transfer does not substantially increase the live birth rate in women aged 36-40 years...
August 6, 2018: Human Reproduction
Karen Harrison-White, John Owens
In the United Kingdom student nurses spend approximately half of their education programme in a practical setting commonly referred to as the Clinical Learning Environment (CLE). The significant amount of time student nurses spend in CLEs, combined with reports of negative experiences, indicate that it is important to consider the challenges of learning within this environment. Nurse Link Lecturers spend up to 20% of their teaching time supporting student nurses in CLEs. Link lecturers' proximity to the CLE means that they are well-placed to articulate the challenges facing student nurses in this context...
July 24, 2018: Nurse Education in Practice
Taebum Lee, Sangjoon Choi, Joungho Han, Yoon-La Choi, Kyungjong Lee
Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and here we report two rare cases of thoracic NMC with cytohistologic correlation. In aspiration cytology, the tumor presented with mixed cohesive clusters and dispersed single cells with diffuse background necrosis and many neutrophils. Most of the tumor cells had scanty cytoplasm and medium-sized irregular nuclei, which had fine to granular nuclear chromatin...
July 27, 2018: Journal of Pathology and Translational Medicine
Roman Nölle, Andreas J Achazi, Payam Kaghazchi, Martin Winter, Tobias Placke
Due to its high specific and volumetric capacity and relatively low operation potential, silicon (Si) has attracted much attention to be utilized as a high-capacity anode material for lithium-ion batteries (LIBs) with increased energy density. However, the application of Si within commercial LIBs is still hindered by its poor cycling stability related to the huge volume changes of Si upon lithiation/delithiation, followed by continuous electrolyte decomposition and active lithium loss at the anode side. In this work, we present the application of pentafluorophenyl isocyanate (PFPI) as an effective electrolyte additive for lithium-ion full cells, containing a pure, magnetron-sputtered Si anode and a LiNi1/3 Mn1/3 Co1/3 O2 (NMC-111) cathode...
August 8, 2018: ACS Applied Materials & Interfaces
Markus O Scheinhardt, Tamara Lerman, Inke R König, Georg Griesinger
STUDY QUESTION: What is the performance of previously established regression models in predicting low and high ovarian response to 150 μg corifollitropin alfa/GnRH-antagonist ovarian stimulation in an independent dataset? SUMMARY ANSWER: The outcome of ovarian stimulation with 150 μg corifollitropin alfa in a fixed, multiple dose GnRH-antagonist protocol can be validly predicted using logistic regression models with AMH being of paramount importance. WHAT IS KNOWN ALREADY: Predictors of ovarian response have been identified in FSH/GnRH agonist protocols as well as ovarian stimulation with corifollitropin alfa/GnRH-antagonist...
July 10, 2018: Human Reproduction
Rachel Carter, Corey T Love
Li-ion battery safety is often threatened by undesirable lithium metal electrodeposition or dendrite growth, during charging. The unpredictable and complex onset of widely ranging lithium morphologies limits reproducibility, making prevention and detection strategies difficult to assess. This work blends the fundamentals of classical metallurgical dendrite growth with traditional Li-ion battery charging, to prove the ability to modulate lithium metal deposition through an applied interelectrode thermal gradient...
July 24, 2018: ACS Applied Materials & Interfaces
Hui Hong, Xiaoyu Wang, Ting Lu, Diego A R Zorio, Yuan Wang, Jason Tait Sanchez
In the auditory system, tonotopy is the spatial arrangement of where sounds of different frequencies are processed. Defined by the organization of neurons and their inputs, tonotopy emphasizes distinctions in neuronal structure and function across topographic gradients and is a common feature shared among vertebrates. In this study we characterized action potential firing patterns and ion channel properties from neurons located in the extremely low-frequency region of the chicken nucleus magnocellularis (NM), an auditory brainstem structure...
2018: Frontiers in Cellular Neuroscience
Avner Thaler, Tal Gonen, Anat Mirelman, Rick C Helmich, Tanya Gurevich, Avi Orr-Urtreger, Bastiaan R Bloem, Nir Giladi, Talma Hendler
Disturbances in reward processing occur in Parkinson's disease (PD) however it is unclear whether these are solely drug-related. We applied an event-related fMRI gambling task to a group of non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene, in order to assess the reward network in an "at risk" population for future development of PD. Sixty-eight non-manifesting participants, 32 of which were non-manifesting non-carriers (NMNC), performed a gambling task which included defined intervals of anticipation and response to both reward and punishment in an fMRI setup...
July 3, 2018: Brain Imaging and Behavior
Kathleen Duffy, Alan Gillies
In the UK, mentors of pre-registration nurses must achieve the stage 2 outcomes of the Nursing and Midwifery Council (NMC) (2008) standards to support learning and assessment in practice. Approval for new standards for student supervision and assessment was granted at the NMC meeting in March 2018 ( NMC 2018a ). The introduction of the new standards will see the dissolution of mentorship and the emergence of new roles to support students in academic and practice environments. This article gives an overview of these standards and, drawing on the recommendations from a collaborative event hosted by NHS Education for Scotland and some of the findings from a rapid literature review undertaken for that event, provides nurse managers with information to help inform their discussions as they work in partnership with approved education institution colleagues to realise, support and sustain the roles outlined in the new standards...
June 27, 2018: Nursing Management (Harrow)
U Golla-Schindler, D Zeibig, L Prickler, S Behn, T Bernthaler, G Schneider
The application of detector strategies in scanning electron microscopy (SEM) correlated with computer tomography (CT) and light microscopy (LM) delivered unique new insights in degeneration effects of lithium-ion batteries. There we exemplary studied reference, cycled and storage cells. High-resolution SEM permit to visualize a coating on top of the cathode material of the treated cells for the first time, which also connects the conductive additives and battery active material. This confirms the assumption of a solid permeable interface on top of the cathode...
June 20, 2018: Micron: the International Research and Review Journal for Microscopy
James D Steiner, Linqin Mu, Julia Walsh, Muhammad Mominur Rahman, Benjamin Zydlewski, F Marc Michel, Huolin L Xin, Dennis Nordlund, Feng Lin
Nickel-rich layered cathode materials have the potential to enable cheaper and higher energy lithium ion batteries. However, these materials face major challenges (e.g., surface reconstruction, microcracking, potential oxygen evolution) that can hinder the safety and cycle life of lithium ion batteries. Many studies of nickel-rich materials have focused on ways to improve performance. Understanding the effects of temperature and cycling on the chemical and structural transformations is essential to assess the performance and suitability of these materials for practical battery applications...
July 18, 2018: ACS Applied Materials & Interfaces
Sam Foster
Sam Foster, Chief Nurse, Oxford University Hospitals, discusses concerns over the Nursing and Midwifery Council's response to patient complaints.
June 14, 2018: British Journal of Nursing: BJN
Cathryn Watters
Cathryn Watters of campaign group NMCWatch:registrant care argues that health problems and high attrition rates are down to the harsh treatment faced by nurses undergoing NMC investigation.
June 14, 2018: British Journal of Nursing: BJN
Sevil Ceyhan Doğan, Ahmet Karadağ, Kasım Durmuş, Özlem Şahin, Emine Elif Altuntaş
BACKROUND: The exact etiopathogenesis of fibromyalgia syndrome (FM) is still unclear but the pathogenesis of FM is associated with neurogenic inflammation. Allergic rhinitis (AR) is a common inflammatory and immunological disease of the nasal mucosa. As a result, it is known that neurogenic inflammation has a role in the pathophysiology of both FM and AR. OBJECTIVE: The aim of this study was to evaluate AR and nasal allergic inflammation using nasal mucociliary clearance time (NMC) in FM patients...
May 25, 2018: Journal of Back and Musculoskeletal Rehabilitation
Shailaja Chandra, Kishor Patwardhan
This paper looks at the treatment seeking behaviour of rural households and presents factors that discourage them from using public health facilities. It also brings out how Allopathic medical graduates as well as institutionally qualified AYUSH doctors predominantly offer services in cities and townships which results in lakhs of village households having to depend on unqualified medical practitioners as the first line of medical treatment; also how this situation will continue unless the approach to providing medical treatment is modified...
April 2018: Journal of Ayurveda and Integrative Medicine
Avner Thaler, Efrat Kliper, Inbal Maidan, Talia Herman, Keren Rosenberg-Katz, Noa Bregman, Tanya Gurevich, Tamara Shiner, Jeffrey M Hausdorff, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
Cerebral atrophy has been detected in patients with Parkinson's disease (PD) both with and without dementia, however differentiation based on genetic status has thus far not yielded robust findings. We assessed cortical thickness and subcortical volumes in a cohort of PD patients and healthy controls carriers of the G2019S mutation in the LRRK2 gene and the common GBA mutations, in an attempt to determine whether genetic status influences structural indexes. Cortical thickness and subcortical volumes were computed and compared between six groups of participants; idiopathic PD, GBA-PD, LRRK2-PD, non-manifesting non-carriers (NMNC), GBA-non-manifesting carriers (NMC) and LRRK2-NMC utilizing the FreeSurfer software program...
May 30, 2018: Brain Topography
Gaoxin Lin, Ruguang Ma, Yao Zhou, Chun Hu, Minghui Yang, Qian Liu, Stefan Kaskel, Jiacheng Wang
In this paper, a series of nitrogen-doped mesoporous carbons (NMCs) with three-dimensional (3D) interconnected mesopores have been prepared using flour as carbon source, dicyanamide as nitrogen source and colloidal silica as hard template. The optimized material (NMC-4) prepared with the colloidal silica/flour mass ratio of 4 has a high nitrogen doping level of 5.69 at.% and large specific surface area of 995 m2  g-1 as well as 3D interconnected mesopores (12.9 nm). As the oxygen reduction reaction (ORR) electrocatalyst among various NMCs, NMC-4 exhibits the superior performance and much better stability and methanol crossover with a four-electron dominant reaction pathway compared to commercial 20 wt% Pt/C...
October 1, 2018: Journal of Colloid and Interface Science
Jonathan J Stone, Kimberly K Amrami, Jodi M Carter, Robert J Spinner
Neuromuscular choristoma (NMC) is a rare congenital nerve lesion that is classified by the presence of heterotopic muscle fibers intercalated within nerve fascicles.1 The presence of NMC typically causes progressive neuropathy and bony/soft tissue undergrowth, often leading to a shortened atrophic limb.2,3 The typical appearance of NMC on magnetic resonance imaging is an enlarged fusiform nerve that exhibits minimal gadolinium enhancement.4 While there is increasing documentation of pathognomonic clinical and radiographic features for various diffuse fusiform peripheral nerve lesions, nerve biopsy is still occasionally required for some patients given the rarity of these diseases and progressive neuropathic features...
May 24, 2018: Operative Neurosurgery (Hagerstown, Md.)
Markus W Löffler, Daniel J Kowalewski, Linus Backert, Jörg Bernhardt, Patrick Adam, Heiko Schuster, Florian Dengler, Daniel Backes, Hans-Georg Kopp, Stefan Beckert, Silvia Wagner, Ingmar Königsrainer, Oliver Kohlbacher, Lothar Kanz, Alfred Königsrainer, Hans-Georg Rammensee, Stefan Stevanovic, Sebastian P Haen
Immune cell infiltrates have proven highly relevant for colorectal carcinoma (CRC) prognosis, making CRC a promising candidate for immunotherapy. Since tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for understanding this relationship. Here we comprehensively describe the naturally presented HLA-ligandome of CRC and corresponding non-malignant colon (NMC) tissue. Mass spectrometry identified 35,367 and 28,132 HLA-class I ligands on CRC and NMC, attributable to 7,684 and 6,312 distinct source proteins, respectively...
May 22, 2018: Cancer Research
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