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Catherine H Bozio, Jeni Vuong, E Kainne Dokubo, Mosoka P Fallah, Lucy A McNamara, Caelin C Potts, John Doedeh, Miatta Gbanya, Adam C Retchless, Jaymin C Patel, Thomas A Clark, Henry Kohar, Thomas Nagbe, Peter Clement, Victoria Katawera, Nuha Mahmoud, Harouna M Djingarey, Anne Perrocheau, Dhamari Naidoo, Mardia Stone, Roseline N George, Desmond Williams, Alex Gasasira, Tolbert Nyenswah, Xin Wang, LeAnne M Fox
BACKGROUND: On April 25, 2017, a cluster of unexplained illnesses and deaths associated with a funeral was reported in Sinoe County, Liberia. Molecular testing identified Neisseria meningitidis serogroup C (NmC) in specimens from patients. We describe the epidemiological investigation of this cluster and metagenomic characterisation of the outbreak strain. METHODS: We collected epidemiological data from the field investigation and medical records review. Confirmed, probable, and suspected cases were defined on the basis of molecular testing and signs or symptoms of meningococcal disease...
October 15, 2018: Lancet Infectious Diseases
Yaqin Wang, Xinxin Xu, Luyao Liu, Jin Chen, Guimei Shi
Zn-air batteries, promising energy storage equipment with high energy density, light weight and a compact structure, are a perfect power source for electric vehicles. For a Zn-air battery, the activity of the air cathode electrocatalyst plays an important role in its performance. Here, employing a coordination polymer as a precursor, a composite material built from Co3O4 and Co-N active centres with nitrogen-doped mesoporous carbon as a matrix has been synthesized successfully. This composite material possesses outstanding activity and stability in the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) processes...
October 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Georg Griesinger, Christophe Blockeel, Gennady T Sukhikh, Ameet Patki, Bharati Dhorepatil, Dong-Zi Yang, Zi-Jiang Chen, Elke Kahler, Claire Pexman-Fieth, Herman Tournaye
STUDY QUESTION: Is oral dydrogesterone 30 mg daily non-inferior to 8% micronized vaginal progesterone (MVP) gel 90 mg daily for luteal phase support in IVF? SUMMARY ANSWER: Oral dydrogesterone demonstrated non-inferiority to MVP gel for the presence of fetal heartbeats at 12 weeks of gestation (non-inferiority margin 10%). WHAT IS KNOWN ALREADY: The standard of care for luteal phase support in IVF is the use of MVP; however, it is associated with vaginal irritation, discharge and poor patient compliance...
October 10, 2018: Human Reproduction
Sachiko Kanaji, Jennifer N Orje, Taisuke Kanaji, Yuichi Kamikubo, Yosuke Morodomi, Yunfeng Chen, Alessandro Zarpellon, Jerome Eberhardt, Stefano Forli, Scot A Fahs, Rashmi Sood, Sandra L Haberichter, Robert R Montgomery, Zaverio M Ruggeri
The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacologic inhibitors have been hindered by the lack of animal models because of the species specificity of the interaction. To address this problem, we generated a knockin mouse with Vwf exon 28-encoding domains A1 and A2 replaced by the human homolog (VWFh28 )...
October 9, 2018: Blood Advances
Jacqueline Leigh, Debbie Roberts
Following its consultation with key stakeholder groups the Nursing and Midwifery Council (NMC) has launched Future nurse: standards of proficiency for registered nurses ( NMC, 2018a ). These compulsory new standards will be available for use in curricula by approved education institutions (AEIs) from the end of January 2019. In this article, the authors provide their personal perspectives on the potential impact of the new standards, particularly focusing on those relating to supporting and assessing students from within the practice environment...
October 4, 2018: British Journal of Nursing: BJN
Liang Yin, Gerard S Mattei, Zhou Li, Jianming Zheng, Wengao Zhao, Fredrick Omenya, Chengcheng Fang, Wangda Li, Jianyu Li, Qiang Xie, Ji-Guang Zhang, M Stanley Whittingham, Ying Shirley Meng, Arumugam Manthiram, Peter G Khalifah
Although the determination of site occupancies is often a major goal in Rietveld refinement studies, the accurate refinement of site occupancies is exceptionally challenging due to many correlations and systematic errors that have a hidden impact on the final refined occupancy parameters. Through the comparison of results independently obtained from neutron and synchrotron powder diffraction, improved approaches capable of detecting occupancy defects with an exceptional sensitivity of 0.1% (absolute) in the class of layered NMC (Li[Nix Mny Coz ]O2 ) Li-ion battery cathode materials have been developed...
September 2018: Review of Scientific Instruments
Andrew Clifton, Jo Higman, John Stephenson, Alfonso R Navarro, Nikki Welyczko
The UK nursing workforce is facing a crisis. More nurses are leaving than entering the profession, and there are tens of thousands of unfilled vacancies. Political factors are having a significant impact on numbers, in particular the decision to withdraw bursaries for nursing undergraduates, and a steep decline in EU nurses registering to work in the UK post-Brexit. Against this backdrop, there is a stark gender imbalance in the workforce, with only around 11% of registered nurses being male. We surveyed UK higher education institutions to try to identify whether the gendered nature of nursing was considered a concern and whether steps were being taken to address it...
September 19, 2018: Nurse Education Today
Hamid R Sohrabi, Michael Weinborn, Christoph Laske, Kristyn A Bates, Daniel Christensen, Kevin Taddei, Stephanie R Rainey-Smith, Belinda M Brown, Samantha L Gardener, Simon M Laws, Georgia Martins, Samantha C Burnham, Romola S Bucks, Barry Reisberg, Nicola T Lautenschlager, Jonathan Foster, Ralph N Martins
ABSTRACTBackground:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions. METHODS: A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints...
October 2, 2018: International Psychogeriatrics
Mirco Ruttert, Florian Holtstiege, Jessica Hüsker, Markus Börner, Martin Winter, Tobias Placke
In this work, silicon/carbon composites are synthesized by forming an amorphous carbon matrix around silicon nanoparticles (Si-NPs) in a hydrothermal process. The intention of this material design is to combine the beneficial properties of carbon and Si, i.e., an improved specific/volumetric capacity and capacity retention compared to the single materials when applied as a negative electrode in lithium-ion batteries (LIBs). This work focuses on the influence of the Si content (up to 20 wt %) on the electrochemical performance, on the morphology and structure of the composite materials, as well as the resilience of the hydrothermal carbon against the volumetric changes of Si, in order to examine the opportunities and limitations of the applied matrix approach...
2018: Beilstein Journal of Nanotechnology
Brenda A Kwambana-Adams, Rahab C Amaza, Catherine Okoi, Murtala Rabiu, Archibald Worwui, Ebenezer Foster-Nyarko, Bernard Ebruke, Abdul K Sesay, Madikay Senghore, Abdullahi S Umar, Rabi Usman, Adamu Atiku, Garba Abdullahi, Yahaya Buhari, Rabiu Sani, Husaini U Bako, Bashir Abdullahi, Alliyu I Yarima, Badaru Sikiru, Aderinola Olaolu Moses, Michael O Popoola, Eme Ekeng, Adebola Olayinka, Nwando Mba, Adamu Kankia, Ibrahim N Mamadu, Ifeanyi Okudo, Mary Stephen, Olivier Ronveaux, Jason Busuttil, Jason M Mwenda, Mohammed Abdulaziz, Sulaiman A Gummi, Adebayo Adedeji, Andre Bita, Linda Omar, Mamoudou Harouna Djingarey, Wondimagegnehu Alemu, Umberto D'Alessandro, Chikwe Ihekweazu, Martin Antonio
After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5-14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5-9 years was 10%, double that reported among adults ≥ 30 years (5%)...
September 21, 2018: Scientific Reports
Jonathan J Stone, Nikhil K Prasad, Pierre Laumonerie, B Matthew Howe, Kimberly K Amrami, Jodi M Carter, Mark E Jentoft, Robert J Spinner
OBJECTIVE Desmoid-type fibromatosis (DTF) presents a therapeutic dilemma. While lacking metastatic potential, it is a locally aggressive tumor with a strong propensity for occurrence near nerve(s) and recurrence following resection. In this study, the authors introduce the association of an occult neuromuscular choristoma (NMC) identified in patients with DTF. METHODS After experiencing a case of DTF found to have an occult NMC, the authors performed a retrospective database review of all other cases of biopsy-proven DTF involving the extremities or limb girdles in patients with available MRI data...
August 31, 2018: Journal of Neurosurgery
Sida Liao, Ophélia Maertens, Karen Cichowski, Stephen J Elledge
Bromodomain and extraterminal (BET) domain inhibitors (BETis) show efficacy on NUT midline carcinoma (NMC). However, not all NMC patients respond, and responders eventually develop resistance and relapse. Using CRISPR and ORF expression screens, we systematically examined the ability of cancer drivers to mediate resistance of NMC to BETis and uncovered six general classes/pathways mediating resistance. Among these, we showed that RRAS2 attenuated the effect of JQ1 in part by sustaining ERK pathway function during BRD4 inhibition...
September 1, 2018: Genes & Development
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Arief Arrowaili, David L Morris
BACKGROUND: It is believed that the oncologic behavior of mucinous colorectal adenocarcinoma (MC) is different from non-mucinous adenocarcinoma (NMC). The aim of the study is to compare long-term survivals between patients with MC and those with NMC following cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC). METHODS: This was a retrospective study of prospectively collected data of patients with peritoneal metastases of colorectal origin following CRS and IPC...
August 21, 2018: International Journal of Hyperthermia
Han Gao, Qiang Wu, Yixin Hu, Jim P Zheng, Khalil Amine, Zonghai Chen
Increasing the loading of active materials by thickening the battery electrode coating can enhance the energy density of a Li-ion cell, but the trade-off is the much reduced Li+ transport kinetics. To reach the optimum energy and power density for thick electrodes, the effective chemical diffusion coefficient of Li+ ( DLi ) must be maximized. However, the diffusion of Li+ inside an electrode is a complex process involving both microscopic and macroscopic processes. Fundamental understandings are needed on the rate-limiting process that governs the diffusion kinetics of Li+ to minimize the negative impact of the large electrode thickness on their electrochemical performance...
September 6, 2018: Journal of Physical Chemistry Letters
Lana M Chahine, Liz Urbe, Chelsea Caspell-Garcia, Dag Aarsland, Roy Alcalay, Paolo Barone, David Burn, Alberto J Espay, Jamie L Hamilton, Keith A Hawkins, Shirley Lasch, James B Leverenz, Irene Litvan, Irene Richard, Andrew Siderowf, Christopher S Coffey, Tanya Simuni, Daniel Weintraub
INTRODUCTION: Several characteristics associated with increased risk for Parkinson's disease (PD) have been identified, including specific genotypes and various non-motor symptoms. Characterizing non-motor features, such as cognitive abilities, among individuals considered at-risk for PD is essential to improving prediction of future neurodegeneration. METHODS: Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations))...
2018: PloS One
Giulio Serreli, Livia Ruffini, Ornella Ortenzia, Carla Cidda, Chiara Lazzara, Caterina Ghetti
OBJECTIVE: We describe our experience with a dose-tracking software (Radimetrics) that was used to optimize, from a dosimetric point of view, the single-photon emission computed tomography/computed tomography protocols used in myocardial perfusion imaging. PATIENTS AND METHODS: We extracted and assessed the major dosimetric indices as the administered activity, the computed tomography dose index, the dose length product and the size-specific dose estimates for a large sample of patients before and after an optimization process...
October 2018: Nuclear Medicine Communications
Willem Verpoest, Catherine Staessen, Patrick M Bossuyt, Veerle Goossens, Gheona Altarescu, Maryse Bonduelle, Martha Devesa, Talia Eldar-Geva, Luca Gianaroli, Georg Griesinger, Georgia Kakourou, Georgia Kokkali, Jana Liebenthron, Maria-Cristina Magli, Monica Parriego, Andreas G Schmutzler, Monica Tobler, Katrin van der Ven, Joep Geraedts, Karen Sermon
STUDY QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome analysis? SUMMARY ANSWER: PGT-A by CCS in the first and second polar body to select euploid embryos for transfer does not substantially increase the live birth rate in women aged 36-40 years...
September 1, 2018: Human Reproduction
Karen Harrison-White, John Owens
In the United Kingdom student nurses spend approximately half of their education programme in a practical setting commonly referred to as the Clinical Learning Environment (CLE). The significant amount of time student nurses spend in CLEs, combined with reports of negative experiences, indicate that it is important to consider the challenges of learning within this environment. Nurse Link Lecturers spend up to 20% of their teaching time supporting student nurses in CLEs. Link lecturers' proximity to the CLE means that they are well-placed to articulate the challenges facing student nurses in this context...
July 24, 2018: Nurse Education in Practice
Taebum Lee, Sangjoon Choi, Joungho Han, Yoon-La Choi, Kyungjong Lee
Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and here we report two rare cases of thoracic NMC with cytohistologic correlation. In aspiration cytology, the tumor presented with mixed cohesive clusters and dispersed single cells, diffuse background necrosis and many neutrophils. Most of the tumor cells had scanty cytoplasm and medium-sized irregular nuclei, which had fine to granular nuclear chromatin...
September 2018: Journal of Pathology and Translational Medicine
Roman Nölle, Andreas J Achazi, Payam Kaghazchi, Martin Winter, Tobias Placke
Due to its high specific and volumetric capacity and relatively low operation potential, silicon (Si) has attracted much attention to be utilized as a high-capacity anode material for lithium-ion batteries (LIBs) with increased energy density. However, the application of Si within commercial LIBs is still hindered by its poor cycling stability related to the huge volume changes of Si upon lithiation/delithiation, followed by continuous electrolyte decomposition and active lithium loss at the anode side. In this work, we present the application of pentafluorophenyl isocyanate (PFPI) as an effective electrolyte additive for lithium-ion full cells, containing a pure, magnetron-sputtered Si anode and a LiNi1/3 Mn1/3 Co1/3 O2 (NMC-111) cathode...
August 22, 2018: ACS Applied Materials & Interfaces
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