Jing Ge, Ronghua Tan, Qian Gao, Rui Li, Pengxin Xu, Hang Song, Shenqi Wang, Ying Wan, Lei Zhou
Ketamine (KA), commonly used as an anesthetic, is now widely-used as an antidepressant for the treatment of clinical depression. However, due to its side effects, such as dependence, addiction, and cognitive impairment, the dosage and frequency of (S)-ketamine approved by the FDA for the treatment of refractory depression is very low, which limits its efficacy. Here, we developed a new multifunctional nanocarrier system (AC-RM@HA-MS) with specific targeting capabilities to improve the efficacy of KA treatment...
April 8, 2023: Advanced Healthcare Materials