Read by QxMD icon Read


Y Q Zhang, H Li, H H Wu, X N Zong
Objective: To analyze the current situation of gross motor development of infants in nine cities of China and their relationship with physical growth. Methods: Healthy full-term infants aged 1-24 months were investigated by cross-sectional survey, which was carried out in nine cities (Beijing, Harbin, Xi'an in northern, Shanghai, Nanjing, Wuhan in central, and Guangzhou, Fuzhou, Kunming in southern regions of China) from June to October in 2015. Subjects were grouped into 12 age groups (1 - <2, 2 - <3, 3 - <4, 4 - <5, 5 - <6, 6 - <8, 8 - <10, 10 - <12, 12 - <15, 15 - <18, 18 - <21, 21 - <24 months)...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
(no author information available yet)
Objective: To obtain baseline data of pediatricians' clinical use of antibacterial agents in children in China, and provide evidence for the follow-up of guidelines for the diagnosis and treatment of children's clinical medications and the development of rational drug management measures and norms. Methods: A multi-center cross-sectional study was designed to conduct a network electronic questionnaire survey of doctors with child prescription rights in hospitals of all provinces, municipalities and autonomous regions across the country through cluster sampling to understand the current status of antibacterial drugs use in 2016...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Marion Hubbard, F Michael Davis, Kate Malcolm, Scott J Mitchell
INTRODUCTION: Health and safety within the recreational diving industry are poorly described. We aimed to obtain the true prevalence of decompression illness (DCI) and other diving and non-diving injuries, including occupational injuries, in a large recreational diving charter operation. METHODS: A New Zealand recreational diving operator keeps detailed records of diving activity and event/incident reports. We extracted passenger and crew numbers, dive numbers and incident statistics from all boat trips and associated work-related injuries between 01 January 2008 and 31 December 2014...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Arif Asif, Mohamed M Bakr, Michael Levitt, Tushar Vachharajani
BACKGROUND: Conflicting data continue to surround the optimal dialysis access for the elderly. Many propose that catheters are the best option for this population; others emphasize the creation of an arteriovenous fistula. SUMMARY: While an arteriovenous access is the best available access, it has a high early failure rate, particularly in the elderly. However, significant differences exist in forearm (men ≥65 years ~70%; women ≥65 years ~80%) versus upper arm (men ≥65 years ~40%; women ≥65 years ~38%) fistula failure rates in the elderly, with upper arm having much lower failure rates...
December 5, 2018: Blood Purification
Irene González, Alejandro Molina-Ortega, Pilar Pérez-Romero, Juan E Echevarría, Lante He, David Tarragó
BACKGROUND: Despite childhood universal VZV immunization was introduced in 2015, there are no data on VZV clade distribution in Spain. OBJECTIVES: To characterize the varicella-zoster virus strains circulating in Spain between 1997 and 2016. STUDY DESIGN: In this retrospective study, we determined the VZV clades in 294 patients with different pathologies (mainly encephalitis, zoster and varicella) by sequencing three fragments within ORF 22, ORF 21 and ORF 50 and, subsequently analyzing 7 relevant SNPs...
November 28, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Michal Sobecki, Charbel Souaid, Jocelyne Boulay, Vincent Guerineau, Daan Noordermeer, Laure Crabbe
Mapping the binding sites of DNA- or chromatin-interacting proteins is essential to understanding biological processes. DNA adenine methyltransferase identification (DamID) has emerged as a comprehensive method to map genome-wide occupancy of proteins of interest. A caveat of DamID is the specificity of Dam methyltransferase for GATC motifs that are not homogenously distributed in the genome. Here, we developed an optimized method named MadID, using proximity labeling of DNA by the methyltransferase M.EcoGII...
December 4, 2018: Cell Reports
Yuki Hashimotodani, Fuyuki Karube, Yuchio Yanagawa, Fumino Fujiyama, Masanobu Kano
The supramammillary nucleus (SuM) of the hypothalamus projects to the dentate gyrus (DG) and the CA2 region of the hippocampus. Although the SuM-to-hippocampus circuits have been implicated in spatial and emotional memory formation, little is known about precise neural connections between the SuM and hippocampus. Here, we report that axons of SuM neurons make monosynaptic connections to granule cells (GCs) and GABAergic interneurons, but not to hilar mossy cells, in the DG and co-release glutamate and γ-aminobutyric acid (GABA) at these synapses...
December 4, 2018: Cell Reports
Keyvan Mahjoory, Elena Cesnaite, Friederike U Hohlefeld, Arno Villringer, Vadim V Nikulin
Resting state neuronal activity in EEG/MEG recordings is primarily characterized by the presence of alpha oscillations (approx. 8-12 Hz). However, their functional significance and link to cognitive task performance remains elusive. We investigated resting state neuronal activity and its relation to task performance by assessing traditional measures of alpha activity (power and individual alpha peak frequency) and dynamic properties of the signal measured by long-range temporal correlations (LRTC). Multichannel EEG was recorded at rest in 82 healthy male adults and compared to their cognitive performance, measured by tests involving executive functions, working memory, short- and long-term memory demands...
December 2, 2018: NeuroImage
Alisa K Zimmermann, Fiona Barnett
Accredited Exercise Physiologists (AEPs) prescribe exercise and physical activity interventions for people living with type 2 diabetes mellitus (T2DM). During initial consultations, AEPs face the challenge of collecting enough information to facilitate behaviour change and adherence to treatment recommendations. The objective of this research is to explore the initial consultation practices of AEPs with clients living with T2DM and resultant recommendations provided to clients to promote long-term adherence...
December 6, 2018: Australian Journal of Primary Health
Maryse Arendt, Annelies Allain
Annelies Allain has been at the forefront of global efforts to support and promote breastfeeding for more than 30 years. Her accomplishments continue to affect all of us who work with breastfeeding families. Born in the Netherlands in 1945, Annelies Allain-van Elk received a scholarship and completed a BA from the University of Minnesota, Duluth, USA. Back in Europe, she obtained a BA in French language and literature (University of Geneva, Switzerland) as well as a translator's diploma. After 4 years working in West Africa and visits to South America, she returned to Geneva to obtain an MA in development studies...
December 5, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
I Allayarov, S Upendar, M A Schmidt, T Weiss
Based on the resonant-state expansion with analytic mode normalization, we derive a general master equation for the nonlinear pulse propagation in waveguide geometries that is valid for bound and leaky modes. In the single-mode approximation, this equation transforms into the well-known nonlinear Schrödinger equation with a closed expression for the Kerr nonlinearity parameter. The expression for the Kerr nonlinearity parameter can be calculated on the minimal spatial domain that spans only across the regions of spatial inhomogeneities...
November 23, 2018: Physical Review Letters
José Bernabéu, Alejandro Segarra
We prove that, in any flavor transition, neutrino oscillation CP-violating asymmetries in matter have two disentangled components: (i) a CPT-odd T-invariant term, non-vanishing iff there are interactions with matter, and (ii) a T-odd CPT-invariant term, non-vanishing iff there is genuine CP violation. As function of the baseline, these two terms are distinct L-even and L-odd observables to separately test (i) matter effects sensitive to the neutrino hierarchy and (ii) genuine CP violation in the neutrino sector...
November 23, 2018: Physical Review Letters
B Kamala Latha, V S S Sastry
The presence of stable topological defects in a two-dimensional (d=2) liquid crystal model allowing molecular reorientations in three dimensions (n=3) was largely believed to induce a defect-mediated Berzenskii-Kosterlitz-Thouless-type transition to a low temperature phase with quasi-long-range order. However, earlier Monte Carlo (MC) simulations could not establish certain essential signatures of the transition, suggesting further investigations. We study this model by computing its equilibrium properties through MC simulations, based on the determination of the density of states of the system...
November 23, 2018: Physical Review Letters
Young Je Lee, Soo-Jung Kim, Matthew B Amrofell, Tae Seok Moon
Recent advances in our understanding of RNA folding and functions have facilitated the use of regulatory RNAs such as synthetic antisense RNAs (asRNAs) to modulate gene expression. However, despite the simple and universal complementarity rule, predictable asRNA-mediated repression is still challenging due to the intrinsic complexity of native asRNA-mediated gene regulation. To address this issue, we present a multivariate model, based on the change in free energy of complex formation (ΔGCF) and percent mismatch of the target binding region, which can predict synthetic asRNA-mediated repression efficiency in diverse contexts...
December 5, 2018: ACS Synthetic Biology
Daniele Moscheni, Federica Bertolotti, Laura Piveteau, Loredana Protesescu, Dmitry N Dirin, Maksym V Kovalenko, Antonio Cervellino, Jan Skov Pedersen, Norberto Masciocchi, Antonietta Guagliardi
Surface chemistry and core defects are known to play a prominent role in governing the photophysical properties of nanocrystalline semiconductors. Nevertheless, investigating them in small nanocrystals remains a complex task. Here, by combining X-ray scattering techniques in the wide- and small-angle regions and using the Debye Scattering Equation (DSE) method of analysis, we unveil a high density of planar defects in oleate-terminated zincblende (ZB) CdSe colloidal quantum dots (QDs) and size-dependent faceting within a square-cuboid morphology...
December 5, 2018: ACS Nano
Paolo Armando Gagliardi, Luca Primo
Activation of Rho-associated protein kinase 1 (ROCK1) and myotonic dystrophy kinase-related CDC42-binding kinase alpha (MRCKα) by caspases during apoptosis in vertebrates represents a prototypical example of co-option of kinases by proteases. How caspases acquired the ability to control these proteins during evolution of vertebrates is still unknown. Here, we report a phylogenetic and molecular study on the acquisition of caspase-cleavage sites in the family of Rho-activated kinases (RaKs). We demonstrate that the acquisition of such sites has more frequently occurred in identifiable intrinsically disordered regions (IDRs) within or flanking the coiled-coil domain...
December 4, 2018: Molecular Biology and Evolution
Neelanjan Mukherjee, Hans-Hermann Wessels, Svetlana Lebedeva, Marcin Sajek, Mahsa Ghanbari, Aitor Garzia, Alina Munteanu, Dilmurat Yusuf, Thalia Farazi, Jessica I Hoell, Kemal M Akat, Altuna Akalin, Thomas Tuschl, Uwe Ohler
RNA-binding proteins (RBPs) control and coordinate each stage in the life cycle of RNAs. Although in vivo binding sites of RBPs can now be determined genome-wide, most studies typically focused on individual RBPs. Here, we examined a large compendium of 114 high-quality transcriptome-wide in vivo RBP-RNA cross-linking interaction datasets generated by the same protocol in the same cell line and representing 64 distinct RBPs. Comparative analysis of categories of target RNA binding preference, sequence preference, and transcript region specificity was performed, and identified potential posttranscriptional regulatory modules, i...
December 5, 2018: Nucleic Acids Research
Arthur R Gorter de Vries, Lucas G F Couwenberg, Marcel van den Broek, Pilar de la Torre Cortés, Jolanda Ter Horst, Jack T Pronk, Jean-Marc G Daran
Targeted DNA double-strand breaks (DSBs) with CRISPR-Cas9 have revolutionized genetic modification by enabling efficient genome editing in a broad range of eukaryotic systems. Accurate gene editing is possible with near-perfect efficiency in haploid or (predominantly) homozygous genomes. However, genomes exhibiting polyploidy and/or high degrees of heterozygosity are less amenable to genetic modification. Here, we report an up to 99-fold lower gene editing efficiency when editing individual heterozygous loci in the yeast genome...
December 5, 2018: Nucleic Acids Research
Daniel O'Reilly, Zachary J Kartje, Eman A Ageely, Elise Malek-Adamian, Maryam Habibian, Annabelle Schofield, Christopher L Barkau, Kushal J Rohilla, Lauren B DeRossett, Austin T Weigle, Masad J Damha, Keith T Gagnon
CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofactors to guide catalysis. Therefore, chemical modification of the guide RNA can be used to characterize structure-activity relationships within CRISPR ribonucleoprotein (RNP) enzymes and identify compatible chemistries for controlling activity...
December 4, 2018: Nucleic Acids Research
Lijun Zhao, Jianzhong Cao, Kexin Hu, Penghui Wang, Guodong Li, Xiaodong He, Tanjun Tong, Limin Han
Although several studies indicate that RNA-binding proteins (RBPs) contribute to key steps in a variety of physiological processes and cancer, the detailed biological functions and mechanisms remain to be determined. By performing bioinformatics analysis using well-established hepatocellular carcinoma (HCC) datasets, we identified a set of HCC progression-associated RBPs (HPARBPs) and found that the global expression of HPARBPs was significantly correlated with patient prognosis. Among the 42 HPARBPs, human ribosomal protein S3 (RPS3) was one of the most abundant genes whose role remains uncharacterized in HCC...
December 4, 2018: Nucleic Acids Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"