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Masaru Ishida, Shigeru Miyagawa, Atsuhiro Saito, Satsuki Fukushima, Akima Harada, Emiko Ito, Fumiya Ohashi, Tadashi Watabe, Jun Hatazawa, Katsuhisa Matsuura, Yoshiki Sawa
BACKGROUND: Somatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent SC-derived cardiomyocytes (iPS-CMs) are more effective than somatic SCs, such as skeletal myoblasts (SM) and mesenchymal (M)SCs, in promoting functional recovery upon transplantation in a porcine model of myocardial infarction (MI). METHODS: Myocardial injury was induced by ameroid ring placement in immunosuppressed female mini-pigs; after 1 month, epicardial cell transplantation was performed with iPS-CMs (n = 7), SMs (n = 7), and MSCs (n = 7)...
August 17, 2018: Transplantation
Matthew Shupler, William Godwin, Joseph Frostad, Paul Gustafson, Raphael E Arku, Michael Brauer
BACKGROUND: Exposure to household air pollution (HAP) from cooking with dirty fuels is a leading health risk factor within Asia, Africa and Central/South America. The concentration of particulate matter of diameter ≤ 2.5 μm (PM2.5 ) is an important metric to evaluate HAP risk, however epidemiological studies have demonstrated significant variation in HAP-PM2.5 concentrations at household, community and country levels. To quantify the global risk due to HAP exposure, novel estimation methods are needed, as financial and resource constraints render it difficult to monitor exposures in all relevant areas...
August 14, 2018: Environment International
Saeed Damirchi, Ahmadi-Kalateh Khooni Maliheh, Tahereh Heidari, Zarrin Es'haghi, Mahmoud Chamsaz
In this study, a simple and novel kinetic spectrophotometric method has been proposed for the sensitive and highly selective determination of Brilliant Green. The method is based on the interaction of Brilliant Green with Triton X-100 in micellar media at room temperature. As a result of this interaction, the peak wavelength (625 nm) is gradually shifted toward longer wavelength region (634 nm) and more intensive hyper chromic effect has been seen. As well as, variations in the red, blue and green (RGB) components of the images as a function of time were observed...
August 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Li Gao, Lanfang Han, Wenqi Peng, Bo Gao, Dongyu Xu, Xiaohong Wan
Source identification of trace metals in the water environment is important in understanding its environmental behavior and in the prevention and remediation of further pollution. Here, the regional geochemical baseline (RGB) and Pb isotopic ratios are combined to decipher the anthropogenic contribution rate, main anthropogenic source, and transport pathway of trace metals in sediments collected from the largest freshwater lake in northern China, Baiyangdian (BYD) Lake. The established RGB values of Cr, Ni, Cu, Zn, Cd, and Pb were 63...
August 14, 2018: Ecotoxicology and Environmental Safety
Yuanxin Cao, Kai Lei, Xuan Zhang, Ling Xu, Chunye Lin, Yining Yang
Contamination of trace metals in urban rivers is a global problem. The objective of this study was to investigate the contamination and ecological risks of trace metals in the Hai River, which receives substantial effluents from the Beijing-Tianjin region. A total of 43 surface water and sediment samples were collected and analyzed for physiochemical properties and toxic elements. The concentrations of Cd, Cr, Ni, Pb, Cu and Zn in the river water met the Chinese environmental quality grade I standards for surface water...
August 14, 2018: Ecotoxicology and Environmental Safety
Fabiola Lengfelder, Gisela Grupe, Annette Stallauer, Rudolf Huth, Frank Söllner
87 Sr/86 Sr isotopic ratios in skeletal remains of archaeological vertebrates are used for provenance analysis since long. However, the definition of the past bioavailable isotopic ratio at the site of recovery is not known beforehand and geological maps can provide no more than gross expectations. Therefore, the assessment of the "local Sr isotopic signature" is still of crucial importance. In this study, we present a tool for the prediction of such local isotopic signatures by creating a concentration weighted mixing model that links lithospheric, biospheric, and atmospheric strontium per site...
August 5, 2018: Science of the Total Environment
Li Gao, Bo Gao, Dongyu Xu, Wenqi Peng, Jin Lu
Response of trace metals to the consecutive water level fluctuation in the Three Gorges Reservoir (TGR) sediments remains unclear. Here, we evaluated the influence of consecutive stages of water level fluctuation on trace metal pollution using multiple analytical approaches. The spatio-temporal distributions of trace metals in TGR sediments were investigated for five consecutive water impoundment stages from 2015 to 2017. Anthropogenic contributions and trace metal stocks in the TGR were quantitatively estimated using a combination of a regional geochemical baseline (RGB) and annual sediment load...
August 9, 2018: Science of the Total Environment
George M Ibrahim, Alexander G Weil, Shaina Sedighim, Nathan B Schoen, Mirriam Mikhail, Priya Sharma, Magno R Guillen, Benjamin R Morgan, Simeon Wong, Iahn Cajigas, Walter J Jermakowicz, Carolina Sandoval-Garcia, Evan C Lewis, Aria Fallah, Nolan Altman, Santiago Medina, Esperanza Pacheco-Jacome, Prasanna Jayakar, Ann Hyslop, Ian Miller, John Ragheb, Sanjiv Bhatia, Byron Bernal
PURPOSE: Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) is an emerging minimally-invasive alternative to resective surgery for medically-intractable epilepsy. The precise lesioning effect produced by MRgLITT supplies opportunities to glean insights into epileptogenic regions and their interactions with functional brain networks. In this exploratory analysis, we sought to characterize associations between MRgLITT ablation zones and large-scale brain networks that portended seizure outcome using resting-state fMRI...
August 9, 2018: Seizure: the Journal of the British Epilepsy Association
Benjamin M Althouse, Stefan Flasche, Le Nhat Minh, Vu Dinh Thiem, Masahiro Hashizume, Koya Ariyoshi, Dang Duc Anh, Gail L Rodgers, Keith P Klugman, Hao Hu, Lay-Myint Yoshida
BACKGROUND: Acute respiratory infections (ARIs) are the most common causes of death in children under 5 years of age. While the etiology of most pneumonia and ARI episodes is undiagnosed, a broad range of ARI-causing viruses circulate widely in South East Asia. However, the patterns and drivers of the seasonal transmission dynamics are largely unknown. Here we identify the seasonal patterns of multiple circulating viruses associated with hospitalizations for ARIs in Nha Trang, Vietnam...
August 14, 2018: International Journal of Infectious Diseases: IJID
Nicole M Robey, Helena M Solo-Gabriele, Athena S Jones, Juniper Marini, Timothy G Townsend
A limitation to recycling wood from construction and demolition (C&D) waste is contamination of metals from the inadvertent inclusion of preservative treated wood, in particular wood treated with chromated copper arsenate (CCA) and newer copper-based formulations. To minimize contamination many regions have developed best management practices (BMPs) for separating treated from untreated wood. The objective of this study was to evaluate the fraction of preservative treated wood in recycled C&D wood after the implementation of BMPs, using Florida as a case study...
August 2, 2018: Environmental Pollution
Sundus Naila Maqbool, Haleema Saadiya Nazeer, Mehak Rafiq, Aneela Javed, Rumeza Hanif
Breast Cancer is the most common cancer among women with several genes involved in disease susceptibility. As majority of genome-wide significant variants fall outside the coding region, it is likely that some of them alter specific gene functions. GWAS database was used to interpret the regulatory functions of these genetic variants. A total of 320 SNPs for breast cancer were selected via GWAS, which were entered into the SNAP web portal tool, to determine the one's found to be in Linkage Disequilibrium (r2  < 0...
August 14, 2018: Gene
P Chellapandi, R Prathiviraj, A Prisilla
Malaria, caused by Plasmodium falciparum, continues to be one of the leading parasitic diseases to humans. It is urgent to discover novel targets for the development of antimalarial drugs. The 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) in 2-C-methyl-D-erythritol-4-phosphate pathway has been considered as a second in vivo off-target to discover novel antimalarial drugs for its essentiality in malarial parasites and devoid in mammals. Our aim is to rationalize the basis of its functional parts by studying molecular diversity, origin and evolution across malarial parasites...
August 14, 2018: Infection, Genetics and Evolution
Amara Yowang, Anastasios D Tsaousis, Tawatchai Chumphonsuk, Nontaphat Thongsin, Niwed Kullawong, Siam Popluechai, Eleni Gentekaki
Blastocystis is a common and broadly distributed microbial eukaryote inhabiting the gut of humans and other animals. The genetic diversity of Blastocystis is extremely high comprising no less than 17 subtypes in mammals and birds. Nonetheless, little is known about the prevalence and distribution of Blastocystis subtypes colonising humans in Thailand. Molecular surveys of Blastocystis remain extremely limited and usually focus on the central, urban part of the country. To address this knowledge gap, we collected stool samples from a population of Thai adults (n = 178) residing in Chiang Rai Province...
August 14, 2018: Infection, Genetics and Evolution
Liu Dou, Yang Mai, Christine M Madla, Mine Orlu, Abdul W Basit
The aim of this study was to explore the influence of food on P-gp relative expression in both male and female rats, and its effect on intestinal permeation of P-gp substrates (ranitidine and ganciclovir) and a P-gp non-substrate (metformin). The intestine of 12 male and 12 female Wistar rats were excised and segmented into the duodenum, jejunum, ileum and colon. P-gp extracted from each segment was then determined via Western-blotting. In male rats, the relative P-gp expression decreased significantly after food intake in all segments of the intestine except in the duodenum...
August 14, 2018: European Journal of Pharmaceutical Sciences
Yu Wang, Chuanqiang Wu, Chao Zhang, Zhaoqing Li, Tingting Zhu, Jinliang Chen, Yu Ren, Xudong Wang, Lun Zhang, Xuan Zhou
Aberrant signal transducer and activator of transcription 3 (STAT3) signaling is a critical factor that drives the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). However, the underlying mechanisms of STAT3 overexpression and regulation of HNSCC metastasis remain unknown. In the current study, we demonstrated that upregulated TGF-β may promote epithelial-mesenchymal transition (EMT) through STAT3 activation. In addition, we explored the contributions of STAT3 to HNSCC with a specific focus on its transcriptional regulation and its interaction with the long noncoding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (malat1)...
August 14, 2018: Cancer Letters
Jawad Laadraoui, Rachida Aboufatima, Zineb El Gabbas, Hind Ferehan, Kenza Bezza, Mehdi Ait Laaradia, Fatimazahra Marhoume, El Mehdi Wakrim, Abderrahman Chait
ETHNOPHARMACOLOGICAL RELEVANCE: Pregnant women prefer herbal medicines more than pharmaceutical drugs due to the cultural belief that herbs are more suffer during pregnancy for an accurate foetus development. Artemisia herba-alba (Asteraceae) is one of the most used plants in the Mediterranean region to treat various diseases including diabetes, hypertension, spasmodic dysphonia and some bacterial infection. AIM OF THE STUDY: The present study aimed to investigate the effect of Artemisia herba-alba consumption during pregnancy on fertility, physical and behavior developments of mice offspring from birth-to-weaning days...
August 14, 2018: Journal of Ethnopharmacology
Narjes Benameur, Enrico Gianluca Caiani, Martino Alessandrini, Younes Arous, Nejmeddine Ben Abdallah, Foued Saadaoui, Tarek Kraiem
BACKGROUND: Cardiac Magnetic Resonance Imaging (MRI) is the commonly used technique for the assessment of left ventricular (LV) function. Apart manually or semi-automatically contouring LV boundaries for quantification of By visual interpretation of cine images, assessment of regional wall motion is performed by visual interpretation of cine images, thus relying on an experience-dependent and subjective modality. OBJECTIVE: The aim of this work is to describe a novel algorithm based on the computation of the monogenic amplitude image to be utilized in conjunction with conventional cine-MRI visualization to assess LV motion abnormalities and to validate it against gold standard expert visual interpretation...
August 14, 2018: Magnetic Resonance Imaging
Angélica Torres-Berrio, Mauricio O Nava-Mesa
Cognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of posttraumatic stress disorder (PTSD) and Alzheimer's disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, stress response also involves the activation of the opioid system in brain regions associated with stress regulation and memory processing...
August 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Kai Joachim Borm, Julia Voppichler, Mathias Düsberg, Markus Oechsner, Tibor Vag, Wolfgang Weber, Stephanie Elisabeth Combs, Marciana Nona Duma
PURPOSE: The aim of this study was to localize loco-regional lymph node metastases using positron emission tomography with fluorine 18 fluorodeoxyglucose/computed tomography (FDG-PET/CT) datasets in a large cohort of patients and to evaluate the existing Radiation Therapy Oncology Group (RTOG) clinical target volume (CTV) and the European SocieTy for Radiotherapy & Oncology (ESTRO) CTV contouring guidelines. METHODS: 235 patients with 580 FDG/PET-CT positive loco-regional lymph node metastases were included in our analysis...
August 14, 2018: International Journal of Radiation Oncology, Biology, Physics
Yu Liu, Pei-Dong Wu, Dai-Zhen Zhang, Hua-Bin Zhang, Bo-Ping Tang, Qiu-Ning Liu, Li-Shang Dai
The mitochondrial genome (mitogenome) can provide important information for understanding phylogenetic analysis and thus molecular evolution. Herein, we amplified the complete mitogenome sequence of Pelteobagrus fulvidraco. The mitogenome was 16,526 bp in length and included 13 protein-coding genes (PCGs), 22 transfer RNA genes, two ribosomal RNA genes and a non-coding control region (D-loop). Both the organization and location of genes in the mitogenome were consistent with those from Siluriformes fishes previously published in GenBank...
August 14, 2018: Genomics
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