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Human papilloma virus treatment

M C Barros-Filho, L A Reis-Rosa, M Hatakeyama, F A Marchi, T Chulam, C Scapulatempo-Neto, U R Nicolau, A L Carvalho, C A L Pinto, S A Drigo, L P Kowalski, S R Rogatto
OBJECTIVES: To identify potential molecular drivers associated with prognosis and response to treatment in advanced oropharyngeal squamous cell carcinomas (OPSCC). MATERIALS AND METHODS: Thirty-three OPSCC biopsies from untreated Brazilian patients were evaluated for human papilloma virus genotyping, genome wide copy number alterations and gene expression profiling. Data were integrated using CONEXIC algorithm. Validation with TCGA dataset and confirmation by RT-qPCR of candidate genes were performed...
August 2018: Oral Oncology
Sharon D'souza, Veeranjaneyulu Addepalli
Worldwide oral cancer is creating an alarming situation and it's a matter of global concern as it is the 11th most common carcinoma around the globe. After cardiovascular ailments, cancer is the next biggest killer. Approximately 90% of the total oral malignancies are squamous cell carcinomas. The etiological base of oral cancer is tobacco intake, smoking, smokeless tobacco (snuff or chewing tobacco), alcohol and areca nut intake, excessive sunlight exposure, reverse end smoking and Human Papilloma Virus (HPV)...
August 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate and adaptive immune responses and are a new class of cancer immunotherapy agents tested in multiple clinical trials. However, STING is commonly silenced in cancer cells via unclear mechanisms, limiting the application of these agonists. Here, we report that the expression of STING is epigenetically suppressed by the histone H3K4 lysine demethylases KDM5B and KDM5C and is activated by the opposing H3K4 methyltransferases...
August 6, 2018: PLoS Biology
Maurice A Recanati, Katherine J Kramer, John J Maggio, Conrad R Chao
Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Patients treated with cantharidin healed with less scarring than those treated with TCA (P<0.034), had less pain during treatment (P<0.01), and required fewer treatments to eradicate warts (P<0...
2018: Clinical and Experimental Obstetrics & Gynecology
Lilly Y W Bourguignon, Christine Earle, Marisa Shiina
Head and neck squamous cell carcinoma (HNSCC) is a malignancy that often involves the oral cavity, pharynx, larynx, or paranasal sinuses. There is a compelling evidence of the human papilloma virus including HPV16 E6 oncogene drives cell transformation and oncogenic processes of HPV positive (HVP+) HNSCC [in particular, Oropharyngeal Squamous Cell Carcinoma (OPSCC)]. In this study, we determined that human OPSCC-derived, HPV16 E6+ cells (UMSCC-104 and UMSCC-47 cell lines) express CD44 and a regulatory transcription factor, c-Jun...
August 2, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Vanessa Kaplum, Anelise C Ramos, Marcia E L Consolaro, Maria A Fernandez, Tânia Ueda-Nakamura, Benedito P Dias-Filho, Sueli de Oliveira Silva, João C P de Mello, Celso V Nakamura
Cervical cancer is the fourth most common cancer that affects women, mainly through human papilloma virus (HPV) infection with high-risk HPV16 and HPV18. The present study investigated the in vitro anticancer activity and mechanism of action of a proanthocyanidin polymer-rich fraction of Stryphnodendron adstringens (F2) in cervical cancer cell lines, including HeLa (HPV18-positive), SiHa (HPV16-positive), and C33A (HPV-negative) cells, and also evaluated in vivo anticancer activity. In vitro , cell viability was determined by the MTT assay...
2018: Frontiers in Pharmacology
Katri Aro, Leif Bäck, Antti Mäkitie, Laura Tapiovaara
BACKGROUND: Various detection methods to identify the primary in head and neck cancer of unknown primary (HN-CUP) require evaluation to improve and standardize management. OBJECTIVES: To evaluate the use of different diagnostic methods, which aim at decreasing the incidence of HN-CUP. MATERIAL AND METHODS: We conducted a retrospective analysis of patients with HN-CUP at the Helsinki University Hospital during 1995-2011. We evaluated clinical assessment, definitive treatment, histopathology, and follow up...
July 17, 2018: Acta Oto-laryngologica
Megan Swanson, Saduma Ibrahim, Cinthia Blat, Sandra Oketch, Easter Olwanda, May Maloba, Megan J Huchko
BACKGROUND: The incidence of cervical cancer in Kenya is among the highest in the world. Few Kenyan women are able to access screening, thus fueling the high cervical cancer burden. Self-collected human papilloma Virus (HPV) tests, administered during community-health campaigns in rural areas may be a way to expand access to screening. METHODS: In December 2015, we carried out a four-day community health campaign (CHC) to educate participants about cervical cancer prevention and offer self-administered HPV screening...
July 3, 2018: BMC Women's Health
Martin W von Websky, Paul C Wesselmann, Carolynne Schwarze-Zander, Tim Oliver Vilz, Burkhard Stoffels, Christoph Boesecke, Jürgen Rockstroh, Jörg C Kalff, Dimitrios Pantelis
OBJECTIVES: In HIV+ -patients, routine proctological assessment is warranted due to the high incidence of human papilloma virus (HPV) infection-related anogenital lesions, such as Condylomata acuminata (C. ac.), anal intraepithelial dysplasia (AIN) and anal cancer. For C. ac. and AIN, surgical resection and topical therapy with imiquimod have been discussed as treatment options. BACKGROUND: In this study, we contrasted surgical resection and topical imiquimod therapy of HPV-associated anal lesions in HIV+ -patients, with a focus on healing rates and clinical outcome...
July 3, 2018: Zentralblatt Für Chirurgie
Mihir R Patel, Patricia A Hudgins, Jonathan J Beitler, Kelly R Magliocca, Christopher C Griffith, Yuan Liu, Kristen Bougnon, Mark El-Deiry, Nabil F Saba, Ashley H Aiken
BACKGROUND: Radiographic concern for lymphatic extranodal extension (ENE) impacts upfront management decisions for patients with human papilloma virus (HPV) oropharyngeal squamous cell carcinoma (OPSCC). Therefore, we set out to evaluate the accuracy of preoperative contrast-enhanced computed tomography (CECT) to predict major ENE (> 2 mm). METHODS: Twenty-seven consecutive patients with HPV-associated OPSCC who presented at our institutional multidisciplinary tumor board were staged radiographically with positron emission tomography (PET/CT) and CECT, and underwent primary transoral robotic resection and neck dissection...
July 3, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Pooja H Rambhia, Kord Honda, Joshua Arbesman
Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic melanoma that was treated with PD-1 inhibitor, and subsequently developed inflammation of existing seborrheic keratosis lesions and new verrucous keratoses, a cutaneous side effect that has not been previously reported to our knowledge...
June 29, 2018: Melanoma Research
Jonathan D Schoenfeld, Evisa Gjini, Scott J Rodig, Roy B Tishler, Bhupendra Rawal, Paul J Catalano, Ravindra Uppaluri, Robert I Haddad, Glenn J Hanna, Nicole G Chau, Guilherme Rabinowits, Jochen Lorch, Vickie Y Jo, Jeffrey F Krane, Laura A Goguen, Donald J Annino, Sara Abdelrahman, Mikel Lipschitz, Danielle N Margalit
PURPOSE: Programmed death-1 (PD-1) inhibitors are approved for the treatment of patients with recurrent and metastatic squamous cell carcinoma of the head and neck (SCCHN). Ongoing and planned randomized phase 3 trials are testing the benefit of combining PD-1/programmed death-ligand 1 (PD-L1) inhibitors with chemoradiation for patients with locoregionally confined SCCHN. Few studies have investigated relationships among potential predictive pathologic biomarkers such as PD-L1, PD-L2, and PD-1 in this population and associations between these markers and clinical characteristics...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
Chiara Di Tucci, Michele Carlo Schiavi, Pierangelo Faiano, Ottavia D'Oria, Giovanni Prata, Valentina Sciuga, Andrea Giannini, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Treatments for gynecological cancer include surgery, chemotherapy, and radiation. However, overall survival is not improved, and novel approaches are needed. Immunotherapy has been proven efficacious in various types of cancers and multiple approaches have been recently developed. Since numerous gynecological cancers are associated to human papilloma virus (HPV) infections, therapeutic vaccines, targeting HPV epitopes, have been developed. The advancing understanding of the immune system, regulatory pathways and tumor microenvironment have produced a major interest in immune checkpoint blockade, Indeed, immune checkpoint molecules are important clinical targets in a wide variety of tumors, including gynecological...
August 2018: Critical Reviews in Oncology/hematology
Ozlen Saglam, Jose Conejo-Garcia
Programmed cell death-1 and programmed cell death ligand-1 (PD-1/PD-L1) blockage has become an important treatment modality after approval of pembrolizumab and nivolumab by Food and Drug Administration in advanced cancers. Patients with metastatic and recurrent cervical cancer have limited treatment options and usually receive palliative platinum-based chemotherapy without significant survival benefit. Recent studies provided support for usage of immune checkpoint inhibitors in advanced cervical cancer. Around 35% of cervical squamous cell carcinoma (C-SCC) and 17% of adenocarcinomas expressed PD-L1...
2018: Integrative Cancer Science and Therapeutics
Ester Orlandi, Rosalba Miceli, Gabriele Infante, Aurora Mirabile, Daniela Alterio, Maria Cossu Rocca, Nerina Denaro, Riccardo Vigna-Taglianti, Annamaria Merlotti, Antonio Schindler, Nicole Pizzorni, Carlo Fallai, Lisa Licitra, Paolo Bossi
The aim of this cross-sectional study is to evaluate the factors associated with patient-reported dysphagia in patients affected by locally advanced oropharyngeal cancer (OPC) treated with definitive intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy (CHT), with or without induction CHT. We evaluated 148 OPC patients treated with IMRT and concurrent CHT, without evidence of disease and who had completed their treatment since at least 6 months. At their planned follow-up visit, patients underwent clinical evaluation and completed the M...
June 8, 2018: Dysphagia
Sarah Rosanne Ottenhof, Rosa Sanne Djajadiningrat, Helene Hoegsbro Thygesen, Pamela Josephine Jakobs, Katarzyna Jóźwiak, Anne Marijne Heeren, Jeroen de Jong, Joyce Sanders, Simon Horenblas, Ekaterina Straschimirova Jordanova
The host's immune system plays a pivotal role in many tumor types, including squamous cell carcinomas (SCCs). We aim to identify immunological prognosticators for lymph node metastases (LNM) and disease-specific survival (DSS) in penile SCC. For this retrospective observational cohort study, penile SCC patients ( n  = 213) treated in the Netherlands Cancer Institute, were selected if sufficient formalin-fixed, paraffin-embedded tumor material was available. Analysis included previously described high-risk human papilloma virus (hrHPV) status, immunohistochemical scores for classical and non-classical human leukocyte antigen (HLA) class I, programmed death ligand-1 (PD-L1) expression, and novel data on tumor-infiltrating macrophages and cytotoxic an regulatory T-cells...
2018: Frontiers in Immunology
Alexey Surov, Hans Jonas Meyer, Anne-Kathrin Höhn, Karsten Winter, Osama Sabri, Sandra Purz
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is one of common cancers worldwide. Positron emission tomography (PET) with 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) is increasingly used for diagnosing and staging, as well as for monitoring of treatment of HNSCC. PET parameters like maximum and mean standard uptake values (SUVmax , SUVmean ) can predict the behavior of HNSCC. The purpose of this study was to analyze possible associations between these PET parameters and clinically relevant histopathological features in patients with HNSCC...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
L J Wang, Z Li, M Li, L Weng, W H Li, J DU, J Z Zhang
Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Yong-Xia Wang, Zhe-Ying Zhang, Jian-Qiang Wang, Xin-Lai Qian, Jing Cui
Breast cancer remains the leading cause of mortality worldwide. Human papilloma virus 16 (HPV16) may serve a function in the pathogenesis and development of breast cancer. However, the detection rate of HPV16 in breast carcinoma may vary by region. In the present study, the expression of HPV16 E7 in paraffin-embedded tissues from patients with breast cancer from North China was detected. Additionally, the molecular mechanisms underlying the function of HPV16 E7 in the proliferation of breast cancer cells were examined...
July 2018: Oncology Letters
Reza Yaaghubi, Mohammad Hassan Pipelzade, Mansur Amin, Mohammad Ali Shakeri Hosseinabad
Background: Wart is a common transferable skin disease that is caused by human papilloma virus. Choosing the best treatment method can vary based on age, therapeutic goal, complications, and wart place. Due to antibacterial effect of shallomin (hirtifolium Boiss extract) and since its effect has not been studied yet, it was compared to cryotherapy therapeutic methods for treating patients with plane warts. Methods: The present study was a randomized clinical trial that was carried out on 40 patients...
January 2018: Journal of Family Medicine and Primary Care
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