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Object Relation

Marie-Claude Pelland-Marcotte, Jason D Pole, Ketan Kulkarni, Uma Athale, David Stammers, Christine Sabapathy, Jessica Halparin, Leonardo R Brandão, Lillian Sung
There is conflicting information about the epidemiology of thromboembolism (TE) in paediatric oncology. Objectives were to describe the incidence and risk factors of TE in children with cancer. We included all children with cancer less than 15 years of age diagnosed from 2001 to 2016, treated at one of the 12 Canadian paediatric centres outside of Ontario and entered into the Cancer in Young People-Canada database. Potential risk factors for TE were evaluated using Cox proportional hazards regression stratified by haematological malignancies versus solid tumours...
August 13, 2018: Thrombosis and Haemostasis
Céline Chauleur, Jean-Christophe Gris, Silvy Laporte, Céline Chapelle, Laurent Bertoletti, Véronique Equy, Pascal Gaucherand, Eva Bazan, Olivier Dupuis, Denis Gallot, Patrick Mismetti
BACKGROUND:  Management of pregnant women at risk of venous thromboembolism (VTE) and placental vascular complications (PVCs) remains complex. Guidelines do not definitively specify optimal strategies. OBJECTIVE:  Our objective was to evaluate the impact of employing risk score-driven prophylaxis strategies on VTE and PVC rates in at-risk pregnant women. MATERIALS AND METHODS:  This study, conducted in 21 French maternity units, compared VTE and PVC rates before and after implementation of a risk scoring system to determine prophylactic strategies...
August 13, 2018: Thrombosis and Haemostasis
Romy Técher, Magali Houde, Jonathan Verreault
Developing bird embryos may be affected by a number of thyroid disrupting chemicals through maternal transfer. However, thyroid disruption in developing embryos of wild birds remains largely unstudied, especially with respect to exposure to ubiquitous environmental contaminant classes including halogenated flame retardants (HFRs). The objective of the present study was to investigate responses of the hypothalamic-pituitary-thyroid (HPT) axis of developing birds that are exposed to elevated concentrations of HFRs in their environment...
July 31, 2018: Chemosphere
Peter Nørkjær Laursen, Lene Holmvang, Jacob Lønborg, Lars Køber, Dan E Høfsten, Steffen Helqvist, Peter Clemmensen, Henning Kelbæk, Erik Jørgensen, Jens Flensted Lassen, Frants Pedersen, Thomas Høi-Hansen, Christian Juhl Therkelsen, Hans-Henrik Tilsted, Lisette Okkels Jensen, Lars Nepper-Christensen, Golnaz Sadjadieh, Thomas Engstrøm
BACKGROUND: The objective was to compare patients with ischemic heart disease (IHD) undergoing percutaneous coronary intervention (PCI) who were included in randomized controlled trials (RCTs) (trial participants) with patients who were not included (nonparticipants) on a trial-by-trial basis and according to indication for PCI. METHODS: In this cohort study, we compared patients with IHD who were randomized in RCTs in relation to undergoing PCI in Denmark between 2011 and 2015 were considered as RCT-participants in this study...
August 10, 2018: American Heart Journal
Mikhael F El-Chami, Faisal Al-Samadi, Nicolas Clementy, Christophe Garweg, Jose Luis Martinez-Sande, Jonathan P Piccini, Saverio Iacopino, Michael Lloyd, Xavier Viñolas Prat, Michael Dilou Jacobsen, Philippe Ritter, Jens Brock Johansen, Claudio Tondo, Fang Liu, Dedra H Fagan, Alyssa K Eakley, Paul R Roberts
BACKGROUND: Early results from the Micra investigational trial (IDE) and Micra post-approval registry (PAR) demonstrated excellent safety and efficacy performance; however, intermediate-term results across a large patient population in the real-world setting have not been evaluated. OBJECTIVES: We report updated performance of the Micra transcatheter pacemaker from a worldwide PAR and compare with the IDE and transvenous historical control results. METHODS: The safety objective for the analysis was system- or procedure-related major complications through 12 months post-implant...
August 10, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Takeo Matsubara, Keisuke Suzuki, Hiroaki Fujita, Yuji Watanabe, Hirotaka Sakuramoto, Masanori Matsubara, Koichi Hirata
OBJECTIVE: The objective of this study was to investigate the prevalence of restless leg syndrome (RLS), leg motor restlessness (LMR) and RLS/LMR variants and their relationship with clinical factors in patients with Parkinson's disease (PD) and related disorders. METHODS: Sixty-three PD patients, 17 multiple system atrophy (MSA) patients and 11 progressive supranuclear palsy (PSP) patients were included in this study. Through face-to-face interviews, the patients were diagnosed with RLS/LMR, or with RLS/LMR variants in which the symptoms occur predominantly in body parts other than the legs...
August 7, 2018: Journal of the Neurological Sciences
Elizabeth A Gottschlich, Kandyce Larson, BlakeSisk, Mary Pat Frintner
Objective To examine US pediatricians and US adults on three self-reported health measures (sleep, physical activity, and general health status), and to assess factors related to these measures for each group. Methods Pediatrician data were collected through a 2012 AAP Periodic Survey (response rate=64.0%). US population data originated from the 2012 National Health Interview Survey (response rate=61.2%). Analytic samples included those currently working and ≥30 years old; restricted to post-trainees (pediatricians; n=854) and those with at least a Bachelor's degree (US population; n=5,447)...
August 10, 2018: Academic Pediatrics
Jessica Royer, Caroline Blais, Isabelle Charbonneau, Karine Déry, Jessica Tardif, Brad Duchaine, Frédéric Gosselin, Daniel Fiset
Interest in using individual differences in face recognition ability to better understand the perceptual and cognitive mechanisms supporting face processing has grown substantially in recent years. The goal of this study was to determine how varying levels of face recognition ability are linked to changes in visual information extraction strategies in an identity recognition task. To address this question, fifty participants completed six tasks measuring face and object processing abilities. Using the Bubbles method (Gosselin & Schyns, 2001), we also measured each individual's use of visual information in face recognition...
August 10, 2018: Cognition
Luca Battaglini, Marcello Maniglia, Mahiko Konishi, Giulio Contemori, Ambra Coccaro, Clara Casco
Human sensitivity to speed differences is very high, and relatively high when one has to compare the speed of an object that disappears behind an occluder with a standard. Nevertheless, different speed illusions (by contrast, adaptation, dynamic visual noise) affect proper speed judgment for both visible and occluded moving objects. In the present study, we asked whether an illusion due to non-directional motion noise (random dynamic visual noise, rDVN) intervenes at the level of speed encoding, thus affecting speed discrimination, or at the level of speed decoding by non-sensory decision-making mechanisms, indexed by speed overestimation of visible and invisible motion...
August 10, 2018: Vision Research
Luca Cozzi, Tiziana Comito, Antonella Fogliata, Ciro Franzese, Stefano Tomatis, Marta Scorsetti
PURPOSE: To investigate the role of intensity modulated proton therapy (IMPT) for advanced hepatocellular carcinoma in comparison with volumetric modulated arc therapy (VMAT). METHODS: An in-silico planning study was performed on 20 patients. The prescription dose was 60Gy in 6 fractions. Patients were planned with abdominal compression. IMPT plans were optimized with or without the inclusion of CT calibration (3%) and isocenter positioning (2,4,6mm) uncertainties...
2018: PloS One
Maud Carron, Yu-Mei Chang, Kelvin Momanyi, James Akoko, John Kiiru, Judy Bettridge, Gemma Chaloner, Jonathan Rushton, Sarah O'Brien, Nicola Williams, Eric M Fèvre, Barbara Häsler
Campylobacteriosis is a leading foodborne zoonosis worldwide, and is frequently associated with handling and consumption of poultry meat. Various studies indicate that Campylobacter causes a substantial human disease burden in low to middle-income countries, but data regarding the organism's epidemiology in countries like Kenya are scarce. In sub-Saharan Africa, 3.8 million deaths of children under-5 years of age are reported annually. Of those, 25% are caused by diarrheal diseases, and Campylobacter is one of the most frequently isolated bacteria from diarrheic children...
August 13, 2018: PLoS Neglected Tropical Diseases
Belen Bolas-Colvee, Beatriz Tarazona, Vanessa Paredes-Gallardo, Santiago Arias-De Luxan
One of the main objectives of orthodontic treatment is to achieve an esthetic smile. This study set out to analyze differences in the perception of smile esthetics among patients before and after receiving orthodontic treatment. 250 Spanish patients analyzed a single photograph in which, by means of computer software, midline diastema, black triangle, gingival margin of the left central incisor, and gingival ("gummy") smile were altered. Each patient analyzed these images before and after undergoing orthodontic treatment...
2018: PloS One
Miodrag Stojanović, Goran Cvetanović, Marija Anđelković-Apostolović, Dijana Stojanović, Nataša Rančić
OBJECTIVE: Diabetes mellitus (DM) has been one of the leading chronic diseases worldwide over past decades. The objective of the study was to identify predictors associated with health-related quality of life (HRQOL) in diabetic patients. METHODS: A cross-sectional questionnaire-based study was conducted at the General Hospital of the city of Leskovac, between June and November 2015. The Short Form-36 (SF-36) questionnaire, EuroQol-5D (EQ-5D) and EuroQol-VAS (EQ-VAS) questionnaires were used...
June 2018: Central European Journal of Public Health
Oľga Šušoliaková, Jindra Šmejkalová, Marie Bičíková, Lenka Hodačová, Andrea Málková, Zdeněk Fiala
OBJECTIVE: Early morning shifts have a negative effect on the hypothalamic-pituitary-adrenal axis. The aim of this study was to comprehensively assess the extent of occupational stress in early shift workers of the car industry by using salivary cortisol as an objective marker during a workday and on a day off. METHODS: For this cross-sectional epidemiological type of study, a survey included 55 suitable volunteers from the car industry. Five saliva samples were collected according to the following schedule: during one work day in the morning, during the morning shift from 6 a...
June 2018: Central European Journal of Public Health
Marcia Soares, Ekaterina Mirgorodskaya, Hatice Koca, Emilia Viklund, Matthew Richardson, Per M Gustafsson, Anna-Carin Olin, Salman Siddiqui
RATIONALE: Asthma is often characterised by inflammation, damage and dysfunction of the small airways, but no standardised biomarkers are available. 
 Objectives: Using a novel approach -Particles in Exhaled Air (PExA)- we sought to a) sample and analyse abundant protein biomarkers: surfactant protein A (SPA) and albumin in adult asthmatic and healthy patients and b) relate protein concentrations with physiological markers using phenotyping.
 Methods: 83 adult asthmatics and 21 healthy volunteers were recruited from a discovery cohort in Leicester, UK, and 32 adult asthmatics as replication cohort from Sweden...
August 13, 2018: Journal of Breath Research
Kiri A Sandler, Sandra A Mitchell, Ethan Basch, Ann C Raldow, Michael L Steinberg, Jamal Sharif, Ryan R Cook, Patrick A Kupelian, Susan A McCloskey
PURPOSE: To improve assessment of symptomatic toxicity in cancer clinical trials and complement clinician-based toxicity reporting, the US National Cancer Institute developed a measurement system called the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). The objective of this study was to examine the content validity of PRO-CTCAE in patients undergoing radiation therapy and to establish anatomic site-specific item sets for implementation in cancer research...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Yuma Saito, Yu Kume, Ayuto Kodama, Kotaro Sato, Megumi Yasuba
BACKGROUND: Limited information is available on the relationship between sleep disturbances during nighttime and the behavioral and psychological symptoms of dementia in older nursing-home residents. However, a few reports on the association between the circadian rest-activity rhythm and the behavioral and psychological symptoms of dementia in older residents have been published. The main objective of the present study was to examine the association among the circadian rest-activity rhythm, behavioral and psychological symptoms, and the cognitive function status among older individuals living in facilities...
August 13, 2018: Chronobiology International
Lei An, Yuchen Sun, Wei Zhang, Xiaolong Huang, Rui Xue, Youzhi Zhang, Yousheng Wang
Recently, dietary intervention has been considered as a prospective strategy in delaying age-related cognitive dysfunction and brain plasticity degeneration. This study explored the effect of walnut diets (6% and 9%, 8 weeks) on cognitive behavior, hippocampal neurogenesis and the neurotrophic signaling pathway in d-galactose (d-gal) model rats. Behavioral tests showed that walnut diets significantly reversed spatial memory loss in the Morris water test, locomotor activity deficiency in an open field test, and a recognition behavior reduction in a novel object recognition task...
August 13, 2018: Food & Function
Hiroyuki Ueda, Yoichi Miyazaki, Nobuo Tsuboi, Keita Hirano, Shinya Yokote, Emi Kobayashi, Makoto Ogura, Tetsuya Kawamura, Munekazu Ryuzaki, Takashi Yokoo
Objective This case series aimed to identify the clinical and pathological characteristics of elderly patients (≥60 years) with biopsy-proven IgA vasculitis with nephritis (IgAVN). Methods The clinical and pathological presentation and treatment outcomes were compared between two groups. Patients Patients with IgAVN who were ≥19 years old at the time of their renal biopsy were divided into elderly (≥60 years) and adult (19-59 years) groups. Results Of the 23 patients in our study, 13 were elderly. In the elderly group, the median age at the diagnosis was 68 years (range, 60-85 years), with a median follow-up period of 15 months (range, 3-80 months)...
August 10, 2018: Internal Medicine
Kallapat Tansriratanawong, Pawinee Wongwan, Hiroshi Ishikawa, Taka Nakahara, Kanet Wongravee
Calcium hydrogen phosphate with a hydroxyapatite-like surface (CHP-HA) is a novel synthesized compound designed to overcome the limitations of bioactive ceramics. It was originally applied as nano-sized HA strips covering core plates to enhance the degree of interfacial attachment. The objective of the present study was to examine the cellular attachment, proliferation, and osteogenic differentiation of periodontal ligament stem cells (PDLSCs) on a CHP-HA substrate in comparison with conventional nanohydroxyapatite (NanoHA)...
August 12, 2018: Journal of Oral Science
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