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Synthetic Mesh

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https://www.readbyqxmd.com/read/28102927/complex-abdominal-wall-reconstruction-in-the-setting-of-active-infection-and-contamination-a-systematic-review-of-hernia-and-fistula-recurrence-rates
#1
REVIEW
Jonathan D Hodgkinson, Yasuko Maeda, Cosimo A Leo, Janindra Warusavitarne, Carolynne J Vaizey
INTRODUCTION: Minimal evidence exists to guide the surgeon on the risk of complications when performing abdominal wall reconstruction (AWR) in the presence of active infection, contamination or enterocutaneous fistula. This study aims to establish the outcomes of contaminated complex AWR. METHODS: Analysis was conducted according to PRISMA guidelines. Systematic search of the MEDLINE, EMBASE and Pubmed databases was performed. Studies reporting exclusively on single-staged repair of contaminated complex AWR were included...
January 19, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28100492/dynamic-assembly-of-ultrasoft-colloidal-networks-enables-cell-invasion-within-restrictive-fibrillar-polymers
#2
Alison M Douglas, Alexandros A Fragkopoulos, Michelle K Gaines, L Andrew Lyon, Alberto Fernandez-Nieves, Thomas H Barker
In regenerative medicine, natural protein-based polymers offer enhanced endogenous bioactivity and potential for seamless integration with tissue, yet form weak hydrogels that lack the physical robustness required for surgical manipulation, making them difficult to apply in practice. The use of higher concentrations of protein, exogenous cross-linkers, and blending synthetic polymers has all been applied to form more mechanically robust networks. Each relies on generating a smaller network mesh size, which increases the elastic modulus and robustness, but critically inhibits cell spreading and migration, hampering tissue regeneration...
January 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28100051/basement-membrane-mimics-of-biofunctionalized-nanofibers-for-a-bipolar-cultured-human-primary-alveolar-capillary-barrier-model
#3
Akihiro Nishiguchi, Smriti Singh, Matthias Wessling, Charles James Kirkpatrick, Martin Moeller
In vitro reconstruction of an alveolar barrier for modeling normal lung functions and pathological events serve as reproducible, high-throughput pharmaceutical platforms for drug discovery, diagnosis, and regenerative medicine. Despite much effort, the reconstruction of organ-level alveolar barrier functions has failed due to the lack of structural similarity to the natural basement membrane, functionalization with specific ligands for alveolar cell function, the use of primary cells and biodegradability. Here we report a bipolar cultured alveolar-capillary barrier model of human primary cells supported by a basement membrane mimics of fully-synthetic bifunctional nanofibers...
January 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28093117/the-biological-prosthesis-is-a-viable-option-for-abdominal-wall-reconstruction-in-pediatric-high-risk-defects
#4
Osnat Zmora, Shannon L Castle, Stephanie Papillon, James E Stein
BACKGROUND: Our aim was to explore the indications for and outcome of biological prostheses to repair high risk abdominal wall defects in children. METHODS: A retrospective chart review was performed of all cases of abdominal wall reconstruction in a single institution between 2007 and 2015. Demographic and clinical variables, technique and complications were described and compared between prosthesis types. RESULTS: A total of 23 patients underwent abdominal wall reconstruction using a biological prosthesis including 17 neonates...
January 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28092935/alloying-strategy-in-cu-in-ga-se-quantum-dots-for-high-efficiency-quantum-dot-sensitized-solar-cells
#5
Wenxiang Peng, Jun Du, Zhenxiao Pan, Naoki Nakazawa, Jiankun Sun, Zhonglin Du, Gencai Shen, Juan Yu, Jin-Song Hu, Qing Shen, Xinhua Zhong
I-III-VI2 group "green" quantum dots (QDs) are attracting increasing attentions in photoelectronic conversion applications. Herein, based on the "simultaneous nucleation and growth" approach, Cu-In-Ga-Se (CIGSe) QDs with light harvesting range about 1000 nm were synthetized and used as sensitizer to construct quantum dot sensitized solar cells (QDSCs). Inductively coupled plasma-atomic emission spectrometry (ICP-AES), wild-angle X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyses demonstrate that the Ga element was alloyed in the Cu-In-Se (CISe) host...
January 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28085989/real-world-clinical-quality-improvement-for-complex-abdominal-wall-reconstruction
#6
Bruce Ramshaw, Brandie Remi Forman, Karla Moore, Eric Heidel, Michael Fabian, Greg Mancini, Girish P Joshi
INTRODUCTION: Traditional methods of clinical research may not be adequate to improve the value of care for patients undergoing abdominal wall reconstruction (AWR). These patients are prone to high complication rates and high costs. Here, we describe a clinical quality improvement (CQI) effort to enhance outcomes for patients undergoing AWR. MATERIALS AND METHODS: CQI was applied for the entire care cycle for consecutive patients who underwent AWR from August 2011-September 2015...
January 13, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28062114/effect-of-immediate-administration-of-antibiotics-in-patients-with-sepsis-in-tertiary-care-a-systematic-review-and-meta-analysis
#7
REVIEW
Amy N B Johnston, Joon Park, Suhail A Doi, Vicki Sharman, Justin Clark, Jemma Robinson, Julia Crilly
PURPOSE: The goal of this review was to synthesize existing evidence regarding outcomes (mortality) for patients who present to the emergency department, are administered antibiotics immediately (within 1 hour) or later (>1 hour), and are diagnosed with sepsis. METHODS: A search of PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL, using the MeSH descriptors "sepsis," "systemic inflammatory response syndrome," "mortality," "emergency," and "antibiotics," was performed to identify studies reporting time to antibiotic administration and mortality outcome in patients with sepsis...
January 3, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28059914/risk-factors-for-recurrence-after-laparoscopic-ventral-rectopexy
#8
Cherylin W P Fu, Andrew R L Stevenson
BACKGROUND: Laparoscopic ventral rectopexy effectively treats posterior compartment prolapse. However, recurrence after laparoscopic ventral rectopexy is poorly understood. OBJECTIVE: This study aimed to evaluate factors contributing to recurrence after laparoscopic ventral rectopexy. DESIGN: A retrospective cohort analysis was performed of patients who underwent laparoscopic ventral rectopexy between June 2008 and June 2014. Patients presenting with full-thickness rectal prolapse were compared against the rest...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28052810/clinical-effectiveness-and-cost-effectiveness-of-surgical-options-for-the-management-of-anterior-and-or-posterior-vaginal-wall-prolapse-two-randomised-controlled-trials-within-a-comprehensive-cohort-study-results-from-the-prospect-study
#9
Cathryn Glazener, Suzanne Breeman, Andrew Elders, Christine Hemming, Kevin Cooper, Robert Freeman, Anthony Smith, Suzanne Hagen, Isobel Montgomery, Mary Kilonzo, Dwayne Boyers, Alison McDonald, Gladys McPherson, Graeme MacLennan, John Norrie
BACKGROUND: The use of mesh in prolapse surgery is controversial, leading to a number of enquiries into its safety and efficacy. OBJECTIVE: To compare synthetic non-absorbable mesh inlay, biological graft and mesh kit with a standard repair in terms of clinical effectiveness, adverse effects, quality of life (QoL), costs and cost-effectiveness. DESIGN: Two randomised controlled trials within a comprehensive cohort (CC) study. Allocation was by a remote web-based randomisation system in a 1 :1 : 1 ratio (Primary trial) or 1 : 1 : 2 ratio (Secondary trial), and was minimised on age, type of prolapse repair planned, need for a concomitant continence procedure, need for a concomitant upper vaginal prolapse procedure and surgeon...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28052048/a-biomimetic-mesh-for-treating-female-stress-urinary-incontinence
#10
Kuilin Lai, Jiazhen Zhang, Guoshuai Wang, Xin Luo, Man Liu, Xinzhi Zhang, Yuyu Yuan, Bin Liu, Tao Xu
For patients with medium to severe incontinence, sub-urethral support surgery has a high cure rate, but using synthetic meshes leads to some complications such as mesh erosion/exposure and thigh pain. Autologous or acellular extracellular matrix grafts present few complications but have a high recurrence rate. Regensling(™) is a new sling product made of a synthetic material with a biomimetic structure, aiming to provide long-term mechanical support with a lower complication rate. To assess the safety and effectiveness of Regensling(™), both in vitro and in vivo experiments were performed...
January 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28046281/th-cd-207a-03-a-surface-deformation-driven-respiratory-model-for-organ-motion-tracking-in-lung-cancer-radiotherapy
#11
H Chen, X Zhen, L Zhou, X Gu
PURPOSE: To propose and validate a novel real-time surface-mesh-based internal organ-external surface motion and deformation tracking method for lung cancer radiotherapy. METHODS: Deformation vector fields (DVFs) which characterizes the internal and external motion are obtained by registering the internal organ and tumor contours and external surface meshes to a reference phase in the 4D CT images using a recent developed local topology preserved non-rigid point matching algorithm (TOP)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034649/is-vaginal-mesh-a-stimulus-of-autoimmune-disease
#12
Bilal Chughtai, Art Sedrakyan, Jialin Mao, Karyn S Eilber, Jennifer T Anger, J Quentin Clemens
OBJECTIVE: To investigate a potential link between the development of systemic/ autoimmune disorders and synthetic polypropylene mesh repairs. METHODS: New York State Department of Health Statewide Planning and Research Cooperative System data was utilized to conduct this retrospective cohort study. Adult women undergoing surgery for pelvic organ prolapse (POP) with vaginally implanted mesh between January 2008 and December 2009 in inpatient and ambulatory surgery settings in New York State were identified...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28032164/innovative-management-of-implant-exposure-in-adm-implant-based-breast-reconstruction-with-negative-pressure-wound-therapy
#13
Antonello Accurso, Nicola Rocco, Giuseppe Accardo, Paola Reale, Carmela Salerno, Edi Mattera, Francesco D'Andrea
INTRODUCTION: One-stage implant-based breast reconstruction has been recently improved by the introduction of biological [acellular dermal matrix (ADM)] and synthetic meshes. Advantages of ADMs in implant-based breast reconstruction derive from the expansion of the space available for the direct positioning of an implant, but their use could be associated with several complications. Although the majority of complications can be easily managed, mistakes in dealing with the first clinical signs of a potential adverse event can lead to implant loss...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28032155/serratus-anterior-fascia-flap-versus-muscular-flap-for-expander-coverage-in-two-stage-breast-reconstruction-following-mastectomy-early-post-operative-outcomes
#14
Daniele Bordoni, Pierfrancesco Cadenelli, Nicola Rocco, Ariel Tessone, Giuseppe Falco, Cesare Magalotti
INTRODUCTION: The demand for reconstructive breast surgery after mastectomy is increasing among women and the two-stage option remains the most commonly performed technique. We conducted a self-controlled prospective clinical trial comparing the use of the serratus anterior fascia with the serratus anterior detached fibers to cover the inferolateral aspect of the expander in immediate two-stage breast reconstruction following conservative mastectomies as oncological or risk-reducing procedures...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28030858/reviewing-patients-following-mesh-repair-the-benefits
#15
Claudia R Kowalik, M M E Lakeman, Josephine E Oryszczyn, Jan Paul W R Roovers
BACKGROUND/AIMS: The use of synthetic mesh implants for vaginal prolapse surgery is still a subject of debate due to safety concerns. We aimed to explore long-term complications of all women treated with mesh surgery for pelvic organ prolapse (POP) in our centre. METHODS: This is a cross-sectional study of 188 women who underwent vaginal mesh surgery in a Dutch University Hospital between 2007 and 2012. The prevalence of mesh exposure, pain symptoms and patient satisfaction has been documented...
December 29, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28029620/a-tensor-b-spline-approach-for-solving-the-diffusion-pde-with-application-to-optical-diffusion-tomography
#16
Dmytro Shulga, Oleksii Morozov, Patrick Hunziker
Optical Diffusion Tomography (ODT) is a modern non-invasive medical imaging modality which requires mathematical modelling of near-infrared light propagation in tissue. Solving the ODT forward problem equation accurately and efficiently is crucial. Typically, the forward problem is represented by a Diffusion PDE and is solved using the Finite Element Method (FEM) on a mesh, which is often unstructured. Tensor B-spline signal processing has the attractive features of excellent interpolation and approximation properties, multiscale properties, fast algorithms and does not require meshing...
December 19, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28012327/incarcerated-and-eventrated-abdominal-wall-hernia-reconstruction-with-autologous-double-layer-dermal-graft-in-the-field-of-purulent-peritonitis-a-case-report
#17
Gábor Martis, Máté Rózsahegyi, János Deák, László Damjanovich
INTRODUCTION: Double-layer dermal grafts are used for the management of complicated abdominal wall hernias in obese, high risk patients. The method has not yet been used in case of emergency in septic/dirty environment. CASE REPORT: A 76-year old female patient (BMI 36.7kg/m(2)) was admitted with mechanical bowel obstruction and sepsis caused by a third time recurred, incarcerated and eventrated abdominal wall hernia. During the emergency surgery perforation of the terminal ileum and the ascending colon was detected, along with a feculent peritonitis and extended abdominal wall necrosis...
December 6, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28012032/abdominal-wall-reinforcement-biologic-vs-degradable-synthetic-devices
#18
S Gruber-Blum, J Brand, C Keibl, R H Fortelny, H Redl, F Mayer, A H Petter-Puchner
BACKGROUND: New biodegradable synthetic and biologic hernia implants have been promoted for rapid integration and tissue reinforcement in challenging repairs, e.g. at the hiatus or in contaminated wound fields. Interestingly, experimental data to support or falsify this assumption is scarce. METHODS: Synthetic (BioA(®)) and biologic implants (porcine and bovine collagen matrices Strattice(®) and Veritas(®)) have been tested in experimental onlay hernia repair in rats in observation periods of 30 and 60 days...
December 23, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28010989/mesh-graft-or-standard-repair-for-women-having-primary-transvaginal-anterior-or-posterior-compartment-prolapse-surgery-two-parallel-group-multicentre-randomised-controlled-trials-prospect
#19
Cathryn Ma Glazener, Suzanne Breeman, Andrew Elders, Christine Hemming, Kevin G Cooper, Robert M Freeman, Anthony Rb Smith, Fiona Reid, Suzanne Hagen, Isobel Montgomery, Mary Kilonzo, Dwayne Boyers, Alison McDonald, Gladys McPherson, Graeme MacLennan, John Norrie
BACKGROUND: The use of transvaginal mesh and biological graft material in prolapse surgery is controversial and has led to a number of enquiries into their safety and efficacy. Existing trials of these augmentations are individually too small to be conclusive. We aimed to compare the outcomes of prolapse repair involving either synthetic mesh inlays or biological grafts against standard repair in women. METHODS: We did two pragmatic, parallel-group, multicentre, randomised controlled trials for our study (PROSPECT [PROlapse Surgery: Pragmatic Evaluation and randomised Controlled Trials]) in 35 centres (a mix of secondary and tertiary referral hospitals) in the UK...
December 20, 2016: Lancet
https://www.readbyqxmd.com/read/28009747/multicenter-prospective-longitudinal-study-of-the-recurrence-surgical-site-infection-and-quality-of-life-after-contaminated-ventral-hernia-repair-using-biosynthetic-absorbable-mesh-the-cobra-study
#20
Michael J Rosen, Joel J Bauer, Marco Harmaty, Alfredo M Carbonell, William S Cobb, Brent Matthews, Matthew I Goldblatt, Don J Selzer, Benjamin K Poulose, Bibi M E Hansson, Camiel Rosman, James J Chao, Garth R Jacobsen
OBJECTIVE: The aim of the study was to evaluate biosynthetic absorbable mesh in single-staged contaminated (Centers for Disease Control class II and III) ventral hernia (CVH) repair over 24 months. BACKGROUND: CVH has an increased risk of postoperative infection. CVH repair with synthetic or biologic meshes has reported chronic biomaterial infections and high hernia recurrence rates. METHODS: Patients with a contaminated or clean-contaminated operative field and a hernia defect at least 9 cm had a biosynthetic mesh (open, sublay, retrorectus, or intraperitoneal) repair with fascial closure (n = 104)...
January 2017: Annals of Surgery
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