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heart disease

Haijuan Zhi, Zhenwei Li, Yanping Deng, Peng Qi, Jinjun Hou, Wen Deng, Jinle Cheng, Wanying Wu, Dean Guo
Salvia miltiorrhiza, one of the most famous herbal medicines, is commonly used for the treatment of coronary heart diseases in China. Besides traditional decoction pieces, another relatively new product of S. miltiorrhiza, Ultrafine Granular Powder (D90 < 45 μm), is also increasingly used nowadays. In this paper, a UHPLC-LTQ-Orbitrap MS technique was developed for metabolite profile study after oral administration of Ultrafine Granular Powder (UGP) and Traditional Decoction Slices (TDS) of S. miltiorrhiza...
September 21, 2018: Biomedical Chromatography: BMC
Rosalyn O Adigun, Amber N Boler, Rekha Mankad
PURPOSE OF REVIEW: Cardiovascular disease remains the leading cause of death in women. The goal of this review is to address known disparities in cardiovascular care with regard to diagnosis and treatment of heart disease in women. RECENT FINDINGS: Gender-specific differences in regard to the incidence, treatment, and outcomes of common cardiovascular pathology are increasingly recognized. Particular attention to ischemic heart disease, arrhythmia, congestive heart failure, and structural heart disease are reviewed in this article...
September 21, 2018: Current Treatment Options in Cardiovascular Medicine
Hang-Kun Ma, Yue Liu, Bo Li, Ying Zhang, Lin-Juan Sun, Feng-Qin Xu
OBJECTIVE: To evaluate the efficacy of oral Chinese medicine (CM) in comparison with donepezil, a cholinesterase inhibitor (ChEI), for the treatment of Alzheimer's disease (AD). METHODS: Randomized controlled trials (RCTs) have been searched, and the effect of CM compared with donepezil in AD has been investigated. An electronic search of MEDLINE, Excerpta Medica Database (EMBASE), Cochrane Library, Chinese Biological Medicine Database (CBMdisc), and China National Knowledge Infrastructure (CNKI) to identify articles in English and Chinese from the inception of the database until October 18, 2015...
September 22, 2018: Chinese Journal of Integrative Medicine
Matthew Cauldwell, Philip Steer, Monique Sterrenburg, Suzanne Wallace, Gemma Malin, Gemma Ulivi, Thomas Everett, Adam Daniel Jakes, Catherine E G Head, Aarthi R Mohan, Sophie Haynes, Margaret Simpson, Janet Brennand, Mark R Johnson
OBJECTIVE: To assess median and percentile birthweight distribution in women with various groups of heart disease relative to a contemporaneous comparison group. METHODS: Data on birth weight and gestational age were collected from 1321 pregnancies ≥24 weeks' gestation in 1053 women with heart disease from seven UK maternity units. Women were assigned to one of 16 groups according to their cardiac lesion. In units where it was possible, data on two births, one delivering before and one after index cases, were collected, giving 2307 comparators...
September 21, 2018: Heart: Official Journal of the British Cardiac Society
Joshua C Peterson, Mary Chughtai, Lambertus J Wisse, Adriana C Gittenberger-de Groot, Qingping Feng, Marie-José T H Goumans, J Conny VanMunsteren, Monique R M Jongbloed, Marco C DeRuiter
The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV and impact cardiovascular outflow tract development.Detailed 3D reconstructions, immunohistochemistry and morphometrics determined that during valvulogenesis the non-coronary leaflet separates from the parietal outflow tract cushion instead of originating from an intercalated cushion...
September 20, 2018: Disease Models & Mechanisms
Zheng Wang, Lu Gao, Lili Xiao, Lingyao Kong, Huiting Shi, Xinyu Tian, Luosha Zhao
Bakuchiol, a monoterpene phenol isolated from the seeds of Psoralea corylifolia, has been widely used to treat a large variety of diseases in both Indian and Chinese folkloric medicine. However, the effects of bakuchiol on cardiac hypertrophy remain unclear. Therefore, this study was designed to determine whether bakuchiol could alleviate cardiac hypertrophy. Mice were subjected to aortic banding to induce cardiac hypertrophy model. 1 ml/100 g body weight Bakuchiol was given by oral gavage once a day from 1 week till 8 weeks after surgery...
September 21, 2018: Bioscience Reports
Sergio Susmallian, Royi Barnea, Yossi Weiss, Asnat Raziel
BACKGROUND: People are living longer than they were expected to 2 decades ago. Increased life expectancy and reduced mortality encompasses a simultaneous increase in the number of older adults with obesity that entails an increase of co-morbidities, such as diabetes, hypertension, cancer, and many other diseases. The aim of our study was to compare the outcomes of bariatric surgery in patients age ≥65 in comparison with younger patients. METHODS: This retrospective study compares bariatric surgeries performed in a private institution between the years 2013 and 2015...
August 11, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Yan-Yang Mao, Jun-Qiang Wang, Xiao-Xian Guo, Yun Bi, Cong-Xia Wang
The prevention and treatment of coronary heart disease (CHD) is a difficult problem to be solved. More and more studies have found that circular RNAs (circRNAs) may play important roles in the development of CHD. Here detection of vascular smooth muscle cells (VSMCs) showed that circ-SATB2 and STIM1 were up-regulated in proliferative VSMCs, while miR-939 were down-regulated. Circ-SATB2 and miR-939 did not affect the expression of each other, but circ-SATB2 could promote while miR-939 inhibited the expression of STIM1 (a target gene of miR-939)...
September 18, 2018: Biochemical and Biophysical Research Communications
Daniel T Hoagland, Webster Santos, Steven Poelzing, Robert G Gourdie
Cardiovascular disease remains the single largest cause of natural death in the United States, with a significant cause of mortality associated with cardiac arrhythmias. Presently, options for treating and preventing myocardial electrical dysfunction, including sudden cardiac death, are limited. Recent studies have indicated that conduction of electrical activation in the heart may have an ephaptic component, wherein intercellular coupling occurs via electrochemical signaling across narrow extracellular clefts between cardiomyocytes...
September 18, 2018: Progress in Biophysics and Molecular Biology
Mark Anderson, D Lynn Morris, Daniel Tang, George Batsides, Ajay Kirtane, Ivan Hanson, Perwais Meraj, Navin Kapur, William O'Neill
BACKGROUND: Right ventricular failure (RVF) after myocardial infarction, cardiotomy, or left ventricular assist device (LVAD) implantation increases morbidity and mortality. RVF also contributes to prolonged length of hospital stay and higher costs of care. The aim of this study was to evaluate the efficacy and safety of the Impella RP (Abiomed, Danvers, MA) in patients with severe RVF in these clinical settings. METHODS: This is a prospective cohort study of patients with severe RVF treated with a percutaneous right ventricular assist device (RVAD)...
August 8, 2018: Journal of Heart and Lung Transplantation
Tee K Teoh, Margaret M Hannan
The prevalence of heart failure is increasing worldwide due to an aging population and advances in therapeutic innovations for heart failure treatment resulting in increased survival. Heart failure remains a major contributor to morbidity and mortality worldwide. It is estimated that the total number of patients in the United States with heart failure is 5.1 million. Cardiac transplantation is a potential life-saving treatment for patients with end-stage disease but relies on a very limited number of suitable donors...
September 18, 2018: Infectious Disease Clinics of North America
Quanhe Yang, Julia L Durmer, Anne G Wheaton, Sandra L Jackson, Zefeng Zhang
OBJECTIVES: Insufficient sleep negatively impacts the cardiovascular system. No study has examined the association between sleep duration and heart age (person's predicted vascular age based on cardiovascular disease [CVD] risk profile). This study examines association between sleep duration and excess heart age (EHA; difference between heart age and chronological age) among US adults. DESIGN AND PARTICIPANTS: Cross-sectional 2007-2014 National Health and Nutrition Examination Survey data for respondents aged 30-74 years without CVD or stroke (n = 12,775)...
October 2018: Sleep Health
Symielle A Gaston, W Braxton Jackson, David R Williams, Chandra L Jackson
OBJECTIVES: To investigate Black-White disparities in suboptimal sleep and cardiometabolic health by government-assisted rental housing status. DESIGN: National Health Interview Survey (NHIS) pooled cross-sectional data (2004-2016). SETTING: United States. PARTICIPANTS: Black and White adult participants (n = 80,880). MEASUREMENTS: Poisson regression with robust variance was used to estimate prevalence ratios (PRs) and 95% confidence intervals for self-reported unrecommended (<6 hours), short (≤6-<7 hours), and long (>9 hours) sleep duration (each separately vs recommended (≤7-9 hours)) and sleep difficulties (eg, trouble falling/staying asleep ≥3 days/week) (yes vs no) among Blacks compared to Whites within rental housing categories (government-assisted vs unassisted), separately, for men and women...
October 2018: Sleep Health
Janett Barbaresko, Johanna Rienks, Ute Nöthlings
CONTEXT: Several studies investigated lifestyle indices to account for interrelations between lifestyle behaviors and cardiovascular disease risk. So far, no systematic review has been conducted. Thus, the aim is to summarize the evidence of associations between lifestyle indices and cardiovascular disease risk in observational prospective studies. EVIDENCE ACQUISITION: A systematic literature search was conducted in two databases in February 2018. Multivariable-adjusted risk estimates were combined using random effects models comparing the highest with the lowest healthy lifestyle score...
October 2018: American Journal of Preventive Medicine
Haoqiang He, Guang Chen, Jialiang Gao, Yu Liu, Chenhao Zhang, Chao Liu, Hongzheng Li, Qingyong He, Jun Li, Jie Wang
BACKGROUND: Qi stagnation and blood stasis syndrome (QS&BSS) is one of the common Zhengs in traditional Chinese medicine (TCM), which manifests as various symptoms and signs, such as distending pain or a tingling sensation in a fixed position. In recent years, a number of clinical trials have focused on the effectiveness and safety of XFZYC in patients with a QS&BSS subtype disease, such as coronary heart disease, hyperlipidaemia, ischaemic cerebrovascular disease, gastritis, dysmenorrhoea, or arthritis, in terms of the outcomes of relevant diseases...
September 21, 2018: Trials
Nanchao Hong, Erge Zhang, Qingjie Wang, Xiaoqing Zhang, Fen Li, Qihua Fu, Rang Xu, Yu Yu, Sun Chen, Yuejuan Xu, Kun Sun
BACKGROUND: Conotruncal heart defect (CTD) is a complex congenital heart disease with a complex and poorly understood etiology. The transcriptional corepressor RIPPLY3 plays a pivotal role in heart development as a negative regulator of the key cardiac transcription factor TBX1. A previous study showed that RIPPLY3 contribute to cardiac outflow tract development in mice, however, the relationship between RIPPLY3 and human cardiac malformation has not been reported. METHODS: 615 unrelated CTD Chinese Han patients were enrolled, we excluded the 22q11...
September 21, 2018: Journal of Translational Medicine
Daniela Passarella, Michel Goedert
The assembly of Tau into abundant β-sheet-rich filaments characterizes human tauopathies. A pathological pathway leading from monomeric to filamentous Tau is believed to be at the heart of these diseases. However, in Drosophila models of Tauopathy, neurodegeneration has been observed in the absence of abundant Tau filaments. Here we investigated the role of Tau assembly into β-sheets by expressing wild-type and Δ306-311 human Tau-383 in the retina and brain of Drosophila. We analyzed both lines for eye abnormalities, brain vacuolization, Tau phosphorylation and assembly, as well as climbing activity and survival...
August 3, 2018: Neurobiology of Aging
Raluca Marcu, Yoon Jung Choi, Jun Xue, Chelsea L Fortin, Yuliang Wang, Ryan J Nagao, Jin Xu, James W MacDonald, Theo K Bammler, Charles E Murry, Kimberly Muczynski, Kelly R Stevens, Jonathan Himmelfarb, Stephen M Schwartz, Ying Zheng
The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then throughout the embryo to establish circulatory networks that further acquire organ-specific properties during development to support diverse organ functions. Here, we investigated the properties of endothelial cells (ECs), isolated from four human major organs-the heart, lung, liver, and kidneys-in individual fetal tissues at three months' gestation, at gene expression, and at cellular function levels. We showed that organ-specific ECs have distinct expression patterns of gene clusters, which support their specific organ development and functions...
June 29, 2018: iScience
Sung-Ai Kim, Min-Kyung Kang, Chi Young Shim, Sak Lee, Byung-Chul Chang, Jong-Won Ha
BACKGROUND: Patients with chronic heart failure have alteration in body composition as a reduction in fat mass, lean body mass and bone mass. However, body wasting in valvular heart disease and the impact of corrective valvular surgery on body composition has not been investigated. OBJECTIVES: We hypothesized that body wasting in severe mitral valve (MV) diseases is reversible through MV surgery. METHODS: Forty eight patients who were scheduled to undergo MV surgery were consecutively enrolled after excluding patients with combined valvular heart disease, ischemic heart disease, cardiomyopathies, and diseases or who were taking medications that could affect metabolism...
2018: PloS One
Dongxia Zhang, Jingtao Ma
BACKGROUND Patients treated with 5-FU can develop rare but potentially severe cardiac effects, including cardiomyopathy, angina pectoris, ventricular tachycardia, heart failure, acute myocardial infarction, and cardiogenic shock. The specific pathologies and mechanisms are not fully understood. Research found that mitochondrial dynamics are widely detected in many angiocardiopathies. Therefore, in the present study we studied the mitochondrial damage and explored the role of mitochondrial fusion/fission proteins on myocardium of rats treated with 5-fluorouracil (5-FU)...
September 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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