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https://www.readbyqxmd.com/read/29929207/heart-protective-effects-of-echinodorus-grandiflorus-in-rabbits-that-are-fed-a-high-cholesterol-diet
#1
Francielly Mourão Gasparotto, Francislaine Aparecida Dos Reis Lívero, Rhanany Allan Caloi Palozi, Maria Leticia Ames, Bruna Nunes, Guilherme Donadel, Rita de Cassia Lima Ribeiro, Emerson Luiz Botelho Lourenço, Cândida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior
Excess weight and dyslipidemia are among the most serious health problems in Western societies. These conditions enhance the risk of cardiac disease and have been linked with a higher prevalence of cardiac arrhythmias and sudden death. The present study investigated the cardioprotective effects of Echinodorus grandiflorus on ventricular remodeling in rabbits that were fed a 1% cholesterol-rich diet. We first obtained an ethanol-soluble fraction of E. grandiflorus and performed a detailed phytochemical study by liquid chromatography-DAD/ESI-MS...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929022/risk-factors-for-surgical-site-infection-following-operative-treatment-of-ankle-fractures-a-systematic-review-and-meta-analysis
#2
REVIEW
Jiashen Shao, Huixin Zhang, Bing Yin, Jia Li, Yanbin Zhu, Yingze Zhang
BACKGROUND: This study aims to quantitatively summarize risk factors associated with surgical site infection after open reduction and internal fixation of ankle fractures. METHODS: Relevant original studies were searched in Medline, Embase, China National Knowledge Infrastructure, Wanfang database and Cochrane central database (all through April 2018). Studies eligible had to meet the quality assessment criteria by Newcastle-Ottawa Scale and to evaluate the risk factors for surgical site infection after open reduction and internal fixation of ankle fractures...
June 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29928990/asymmetric-dimethylarginine-adma-as-an-important-risk-factor-for-the-increased-cardiovascular-diseases-and-heart-failure-in-chronic-kidney-disease
#3
REVIEW
Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen
Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. Increased plasma ADMA and/or L-NMMA are strong and independent risk factor for chronic kidney disease, and various cardiovascular diseases such as hypertension, coronary artery disease, atherosclerosis, diabetes, and heart failure...
June 18, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29928977/the-melas-mutation-m-3243a-g-promotes-reactivation-of-fetal-cardiac-genes-and-an-epithelial-mesenchymal-transition-like-program-via-dysregulation-of-mirnas
#4
Salvador Meseguer, Joaquin Panadero, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Giacomo Pietro Comi, M-Eugenia Armengod
The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is mostly caused by mutation m.3243A>G in mitochondrial tRNALeu(UUR) gene...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928807/prevalence-and-determinants-of-smoking-and-secondhand-smoke-exposure-in-a-rural-population-of-central-greece-a-cross-sectional-study
#5
Chrysovalantis Stafylis, George Rachiotis, Antonis Katsioulis, Varvara A Mouchtouri, Christos Hadjichristodoulou
INTRODUCTION: Smoking is one of the most important risk factors for heart and lung disease and is responsible for many forms of cancer. The resulting morbidity and mortality weigh heavily upon countries with high prevalence, such as Greece. According to the Global Adult Tobacco Survey (GATS) Greece, 38.2% of Greeks aged ≥15 years, namely 51.2% of men and 25.7% of women, are smokers. Smoking is also common among the young and people of high education. Despite laws prohibiting smoking at indoor places, exposure to environmental tobacco is very high both in private and public places...
June 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29928786/antitumor-perspectives-of-oleuropein-and-its-metabolite-hydroxytyrosol-recent-updates
#6
REVIEW
Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Shaista Khan, Muhammad Wasim Sajid, Rai Muhammad Amir
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis...
June 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29928688/genetic-fine-mapping-of-the-iowan-snca-gene-triplication-in-a-patient-with-parkinson-s-disease
#7
Faria Zafar, Ruksana Azhu Valappil, Sam Kim, Krisztina K Johansen, Anne Lynn S Chang, James W Tetrud, Peggy S Eis, Eli Hatchwell, J William Langston, Dennis W Dickson, Birgitt Schüle
The "Iowa kindred," a large Iowan family with autosomal-dominant Parkinson's disease, has been followed clinically since the 1920s at the Mayo Clinic. In 2003, the genetic cause was determined to be a 1.7 Mb triplication of the alpha-synuclein genomic locus. Affected individuals present with an early-onset, severe parkinsonism-dementia syndrome. Here, we present a descendant of the Iowa kindred with novel, disease-associated non-motor findings of reduced heart rate variability, complete anosmia, and a rare skin condition called colloid milium...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29928652/cardiac-responses-to-viewing-facial-emotion-differentiate-frontotemporal-dementias
#8
Charles R Marshall, Christopher J D Hardy, Micah Allen, Lucy L Russell, Camilla N Clark, Rebecca L Bond, Katrina M Dick, Emilie V Brotherhood, Jonathan D Rohrer, James M Kilner, Jason D Warren
Objective: To establish proof-of-principle for the use of heart rate responses as objective measures of degraded emotional reactivity across the frontotemporal dementia spectrum, and to demonstrate specific relationships between cardiac autonomic responses and anatomical patterns of neurodegeneration. Methods: Thirty-two patients representing all major frontotemporal dementia syndromes and 19 healthy older controls performed an emotion recognition task, viewing dynamic, naturalistic videos of facial emotions while ECG was recorded...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928642/pathophysiology-and-diagnosis-of-pulmonary-hypertension-due-to-left-heart-disease
#9
REVIEW
Athanasios Charalampopoulos, Robert Lewis, Peter Hickey, Charlotte Durrington, Charlie Elliot, Robin Condliffe, Ian Sabroe, David G Kiely
Pulmonary hypertension due to left heart disease (PH-LHD) is the most common type of pulmonary hypertension, although an accurate prevalence is challenging. PH-LHD includes PH due to systolic or diastolic left ventricular dysfunction, mitral or aortic valve disease and congenital left heart disease. In recent years a new and distinct phenotype of "combined post-capillary and pre-capillary PH," based on diastolic pulmonary gradient and pulmonary vascular resistance, has been recognized. The roles of right ventricular dysfunction and pulmonary vascular compliance in PH-LHD have also been elucidated recently and they appear to have significant clinical implications...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29928527/heart-disease-and-occupational-risk-factors-in-the-canadian-population-an-exploratory-study-using-the-canadian-community-health-survey
#10
Behdin Nowrouzi-Kia, Anson K C Li, Christine Nguyen, Jennifer Casole
Background: The objective of this study is to find temporal trends in the associations between cardiovascular disease and occupational risk factors in the context of the Canadian population. Methods: Population data were analyzed from the Canadian Community Health Survey (CCHS) collected between 2001 and 2014 for trends over time between heart disease and various occupational risk factors: hours worked, physical exertion at work, and occupation type (management/arts/education, business/finance, sales/services, trades/transportations, and primary industry/processing)...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928523/muscle-atrophy-in-chronic-obstructive-pulmonary-disease-molecular-basis-and-potential-therapeutic-targets
#11
REVIEW
Esther Barreiro, Ariel Jaitovich
Patients with chronic obstructive pulmonary disease (COPD) experience several systemic manifestations such skeletal muscle dysfunction with and without muscle mass loss. Moreover, frequent comorbidities such as nutritional abnormalities, heart failure, and pulmonary hypertension, which are frequently associated with COPD may further contribute to skeletal muscle mass loss and dysfunction. Muscle dysfunction impairs the patients' exercise capacity and quality of life as daily life activities may be hampered by this problem...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928313/-combat-approach-to-cardiogenic-shock
#12
REVIEW
Alexander G Truesdell, Behnam Tehrani, Ramesh Singh, Shashank Desai, Patricia Saulino, Scott Barnett, Stephen Lavanier, Charles Murphy
The incidence of cardiogenic shock is rising, patient complexity is increasing and patient survival has plateaued. Mirroring organisational innovations of elite military units, our multidisciplinary medical specialists at the INOVA Heart and Vascular Institute aim to combine the adaptability, agility and cohesion of small teams across our large healthcare system. We advocate for widespread adoption of our 'combat' methodology focused on: increased disease awareness, early multidisciplinary shock team activation, group decision-making, rapid initiation of mechanical circulatory support (as appropriate), haemodynamic-guided management, strict protocol adherence, complete data capture and regular after action reviews, with a goal of ending preventable death from cardiogenic shock...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29928236/progressive-decrease-in-coronary-vascular-function-associated-with-type-2-diabetic-heart-disease
#13
Rajesh Katare, James T Pearson, Jason Kar-Sheng Lew, Melanie Wei, Hirotsugu Tsuchimouchi, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Mikiyasu Shirai, Daryl O Schwenke
Background: The causal factors underpinning the onset and progression of diabetic heart disease (DHD) remain to be fully elucidated. Myocardial function is critically dependent on optimal coronary blood flow. Considering vascular disease occurs early in diabetes due to endothelial dysfunction, this study aimed to determine whether impaired coronary perfusion contributes to the origins of myocardial dysfunction in DHD, or whether coronary and cardiac dysfunction are independent pathologies associated with diabetes...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29928185/autoimmune-ascites-responding-to-mycophenolate-mofetil-a-case-report
#14
Douglas A Simonetto, Hala Fatima, Folkert Zijlstra, Michael K Zijlstra
Ascites is an abnormal accumulation of fluid within the peritoneal cavity. The most common cause of ascites in the United States population is portal hypertension secondary to cirrhosis, accounting for about 80% of the cases. Other etiologies include malignancy, heart failure, tuberculosis, and pancreatic disease. After an extensive literature review, it is to our best knowledge that there have been no cases reported on autoimmune ascites. We present an interesting case of ascites in a 67-year-old Caucasian male with symptoms of recurrent abdominal distention and significant weight gain, refractory to standard therapies...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29928151/a-rare-case-of-rem-sleep-related-bradyarrhythmia-syndrome-with-concomitant-severe-hypertension-a-case-report-and-a-review-of-literature
#15
Gabrielius Jakutis, Vytautas Juknevičius, Juratė Barysienė, Dalia Matačiūnienė, Birutė Petrauskienė, Žaneta Petrulionienė, Aleksandras Laucevičius
Introduction: Rapid eye movement (REM) sleep-related bradyarrhythmia syndrome is characterized by pathological asystoles during the REM sleep phase. It is a rare rhythm disorder, being reported only few times in the literature. Due to non-specific symptoms, REM sleep-related bradyarrhythmia might be often underdiagnosed. Other cardiac diseases associated with pathological sinus arrests must be excluded to establish the correct diagnosis of and appropriate therapy for REM sleep-related bradyarrhythmia...
2018: Acta Medica Lituanica
https://www.readbyqxmd.com/read/29928126/the-association-between-the-serum-level-of-vitamin-d-and-ischemic-heart-disease-a-study-from-jordan
#16
Mohamad I Jarrah, Nizar M Mhaidat, Karem H Alzoubi, Nasr Alrabadi, Enas Alsatari, Yousef Khader, Moath F Bataineh
Background: Decreased levels of vitamin D were associated with increased risk of multiple diseases, including cardiovascular diseases. However, there seem to be some discrepancies among the results obtained from different studies. The aim of the present study was to explore the importance of having sufficient serum levels of vitamin D in reducing the incidence and the progression of coronary artery stenosis and ischemic heart disease (IHD). Methods: Serum levels of vitamin D were measured using radioimmunoassay in 186 Jordanian patients who underwent investigative coronary catheterization...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29928113/atrial-natriuretic-peptide-modified-oleate-adenosine-prodrug-lipid-nanocarriers-for-the-treatment-of-myocardial-infarction-in-vitro-and-in-vivo-evaluation
#17
Jianjun Yu, Wei Li, Dongmei Yu
Purpose: Myocardial infarction is a major cause of mortality and heart failure worldwide. One of the most effective methods of this injury is direct delivery of cardioprotective drugs to ischemia-reperfusion (IR) myocardium. The aim of the present study was to fabricate an adenosine (Ade) prodrug-based, atrial natriuretic peptide (ANP)-modified nanosystem for the treatment of myocardial infarction. Materials and methods: Oleate adenosine prodrug (Ade-OA) and ANP-distearoylphosphatidylethanolamine-polyethylene glycol were synthesized...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29927887/influence-of-training-models-at-3-900-m-altitude-on-the-physiological-response-and-performance-of-a-professional-wheelchair-athlete-a-case-study
#18
Santiago Sanz-Quinto, Raúl López-Grueso, Gabriel Brizuela, Andrew A Flatt, Manuel Moya-Ramón
Sanz-Quinto, S, López-Grueso, R, Brizuela, G, Flatt, AA, and Moya-Ramón, M. Influence of training models at 3,900-m altitude on the physiological response and performance of a professional wheelchair athlete: A case study. J Strength Cond Res XX(X): 000-000, 2018-This case study compared the effects of two training camps using flexible planning (FP) vs. inflexible planning (IP) at 3,860-m altitude on physiological and performance responses of an elite marathon wheelchair athlete with Charcot-Marie-Tooth disease (CMT)...
June 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29927871/interpretation-and-reporting-of-coronary-arteries-in-transposition-of-the-great-arteries-cross-sectional-imaging-perspective
#19
Sara K Swanson, Mohamed M Sayyouh, Dianna M E Bardo, Maryam Ghadimi Mahani, Jimmy C Lu, Adam L Dorfman, Prachi P Agarwal
Knowledge of coronary artery nomenclature in transposition of the great arteries is essential, given the increasing population of adults with congenital heart disease and greater utilization of imaging in these patients. This article reviews appropriate terminology for describing coronary artery anatomy, commonly encountered coronary artery patterns, and postoperative coronary complications in the setting of transposition of the great arteries.
July 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29927412/-the-influence-of-confounders-on-the-outcome-of-ischemic-stroke
#20
I G Hovhannisyan, R A Hovhanessyan
AIM: To determine the degree of influence of the confounders on the outcome of ischemic stroke (IS). MATERIAL AND METHODS: One hundred and eight patients were included in the prospective clinical cohort study. Based on disease outcomes, two groups of patients were singled out: 1st group - survivors (n=93), 2nd group - patients with fatal outcomes (n=15). RESULTS: Concomitant diseases were found in 80 (74.1%) patients. Twenty-eight (25.9%) patients had no concomitant pathology (without taking into account atherosclerosis, arterial hypertension, diabetes mellitus and coronary heart disease)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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