Laura Marruecos, Joan Bertran, Yolanda Guillén, Jéssica González, Raquel Batlle, Erika López-Arribillaga, Marta Garrido, Cristina Ruiz-Herguido, Dominique Lisiero, Mónica González-Farré, Sara Arce-Gallego, Mar Iglesias, Angel R Nebreda, Shigeki Miyamoto, Anna Bigas, Lluís Espinosa
The intestinal epithelium is a paradigm of adult tissue in constant regeneration that is supported by intestinal stem cells (ISCs). The mechanisms regulating ISC homeostasis after injury are poorly understood. We previously demonstrated that IκBα, the main regulator of NF-κB, exerts alternative nuclear functions as cytokine sensor in a subset of PRC2-regulated genes. Here, we show that nuclear IκBα is present in the ISC compartment. Mice deficient for IκBα show altered intestinal cell differentiation with persistence of a fetal-like ISC phenotype, associated with aberrant PRC2 activity at specific loci...
June 4, 2020: EMBO Reports