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Colon Treatment Resistance Stem like

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https://www.readbyqxmd.com/read/30005681/regorafenib-suppresses-colon-tumorigenesis-and-the-generation-of-drug-resistant-cancer-stem-like-cells-via-modulation-of-mir-34a-associated-signaling
#1
Mao-Hua Cai, Xiao-Gang Xu, Shi-Li Yan, Ze Sun, Yin Ying, Bai-Kui Wang, Yue-Xing Tu
BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and developed drug resistance has represented one of the most challenging tasks for management. The current therapeutic regimens may select and enrich cancer stem-like cells (CSCs) resulting in the increased resistance against treatment, metastatic potential and mortality. Regorafenib is a multi-kinase inhibitor, an FDA-approved last-of-line treatment for patients with chemo-refractory metastatic CRC...
July 13, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29956726/curcumin-attenuates-resistance-to-irinotecan-via-induction-of-apoptosis-of-cancer-stem-cells-in-chemoresistant-colon-cancer-cells
#2
Pengfei Su, Yong Yang, Guoxin Wang, Xiaowu Chen, Yongle Ju
Resistance to conventional chemotherapeutic agents, including irinotecan (CPT‑11), 5-fluorouracil and capecitabine is a major cause for therapeutic failure in patients with colorectal cancer (CRC). Increasing evidence has demonstrated that cancer cells exhibiting stem cell-like characteristics are associated with the development of resistance to chemotherapeutic agents. As a plant polyphenol, curcumin has been demonstrated to have the ability to ameliorate resistance of CRC to chemotherapeutic agents, but the associations among curcumin, cancer stem cells (CSCs) and chemoresistance of CRC remain unclear...
June 29, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29805588/-in-vitro-analysis-of-putative-cancer-stem-cell-populations-and-chemosensitivity-in-the-sw480-and-sw620-colon-cancer-metastasis-model
#3
Cindy Slater, Jo-Anne De La Mare, Adrienne Lesley Edkins
The cancer stem cell (CSC) theory implicates a small subpopulation of cells with stem-like properties, which is responsible for tumour initiation, development and metastasis. The unique biological and functional characteristics of CSCs, widely associated with treatment resistance, indicate an association between metastasis and stemness. It was hypothesised that metastatic cell lines may be enriched in CSCs and that this would correlate with a more resistant tumour. In the present study, the SW480 and SW620 paired cell lines derived from a colon adenocarcinoma and its lymph node metastasis, respectively were compared as an in vitro model of cancer progression...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29682512/targeting-notch-signalling-pathway-of-cancer-stem-cells
#4
REVIEW
Vandana Venkatesh, Raghu Nataraj, Gopenath S Thangaraj, Murugesan Karthikeyan, Ashok Gnanasekaran, Shanmukhappa B Kaginelli, Gobianand Kuppanna, Chandrashekrappa Gowdru Kallappa, Kanthesh M Basalingappa
Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. CSCs have been increasingly identified in blood cancer, prostate, ovarian, lung, melanoma, pancreatic, colon, brain and many more malignancies. CSCs have slow growth rate and are resistant to chemotherapy and radiotherapy that lead to the failure of traditional current therapy. Eradicating the CSCs and recurrence, is promising aspect for the cure of cancer...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29372814/bacillus-velezensis-cc09-a-potential-vaccine-for-controlling-wheat-diseases
#5
Xingxing Kang, Wanling Zhang, Xunchao Cai, Tong Zhu, Yarong Xue, Changhong Liu
Biocontrol bacteria that can act like a "vaccine", stimulating plant resistance to pathogenic diseases, are still not fully elucidated. In this study, an endophytic bacterium, Bacillus velezensis CC09, labeled with green fluorescent protein, was tested for its colonization, migration, and expression of genes encoding iturin A synthetase within wheat tissues and organs as well as for protective effects against wheat take-all and spot blotch diseases. The results showed that strain CC09 not only formed biofilm on the root surface but was also widely distributed in almost every tissue, including the epidermis, cortex, and xylem vessels, and even migrated to stems and leaves, resulting in 66...
June 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29180466/synthetic-lethality-of-parp-inhibitors-in-combination-with-myc-blockade-is-independent-of-brca-status-in-triple-negative-breast-cancer
#6
Jason P W Carey, Cansu Karakas, Tuyen Bui, Xian Chen, Smruthi Vijayaraghavan, Yang Zhao, Jing Wang, Keith Mikule, Jennifer K Litton, Kelly K Hunt, Khandan Keyomarsi
PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients. Several of those patients exhibit intrinsic/acquired resistance mechanisms that limit efficacy of PARPi monotherapy. Here we show how the efficacy of PARPi in triple-negative breast cancers (TNBC) can be expanded by targeting MYC-induced oncogenic addiction. In BRCA-mutant/sporadic TNBC patients, amplification of the MYC gene is correlated with increased expression of the homologous DNA recombination enzyme RAD51 and tumors overexpressing both genes are associated with worse overall survival...
February 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29053388/some-chemotherapeutics-treated-colon-cancer-cells-display-a-specific-phenotype-being-a-combination-of-stem-like-and-senescent-cell-features
#7
H Was, J Czarnecka, A Kominek, K Barszcz, T Bernas, K Piwocka, B Kaminska
Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the Northern countries. CRC can reappear a long time after treatment. Recent clinical studies demonstrated that, in response to chemotherapy, cancer cells may undergo stress-induced premature senescence (SIPS), which typically results in growth arrest. Nonetheless, these senescent cells were reported to divide in an atypical manner and thus contribute to cancer re-growth. Therefore, we examined if SIPS escape may follow treatment with chemotherapeutics used clinically: 5-fluorouracil (5-FU), oxaliplatin (OXA) and irinotecan (IRINO)...
January 2, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28974546/a-molecularly-annotated-model-of-patient-derived-colon-cancer-stem-like-cells-to-assess-genetic-and-nongenetic-mechanisms-of-resistance-to-anti-egfr-therapy
#8
Paolo Luraghi, Viola Bigatto, Elia Cipriano, Gigliola Reato, Francesca Orzan, Francesco Sassi, Francesca De Bacco, Claudio Isella, Sara E Bellomo, Enzo Medico, Paolo M Comoglio, Andrea Bertotti, Livio Trusolino, Carla Boccaccio
Purpose: Patient-derived xenografts (" xenopatients ") of colorectal cancer metastases have been essential to identify genetic determinants of resistance to the anti-EGFR antibody cetuximab and to explore new therapeutic strategies. From xenopatients, a genetically annotated collection of stem-like cultures (" xenospheres ") was generated and characterized for response to targeted therapies. Experimental Design: Xenospheres underwent exome-sequencing analysis, gene expression profile, and in vitro targeted treatments to assess genetic, biological, and pharmacologic correspondence with xenopatients, and to investigate nongenetic biomarkers of therapeutic resistance...
February 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28690641/prostate-cancer-stem-cell-markers-drive-progression-therapeutic-resistance-and-bone-metastasis
#9
REVIEW
Koran S Harris, Bethany A Kerr
Metastatic or recurrent tumors are the primary cause of cancer-related death. For prostate cancer, patients diagnosed with local disease have a 99% 5-year survival rate; however, this 5-year survival rate drops to 28% in patients with metastatic disease. This dramatic decline in survival has driven interest in discovering new markers able to identify tumors likely to recur and in developing new methods to prevent metastases from occurring. Biomarker discovery for aggressive tumor cells includes attempts to identify cancer stem cells (CSCs)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28652251/hypoxia-induced-downregulation-of-dusp-2-phosphatase-drives-colon-cancer-stemness
#10
Pei-Chi Hou, Yo-Hua Li, Shih-Chieh Lin, Shau-Chieh Lin, Jenq-Chang Lee, Bo-Wen Lin, Jing-Ping Liou, Jang-Yang Chang, Ching-Chuan Kuo, Yi-Min Liu, H Sunny Sun, Shaw-Jenq Tsai
Cancer stem-like cells (CSC) evolve to overcome the pressures of reduced oxygen, nutrients or chemically induced cell death, but the mechanisms driving this evolution are incompletely understood. Here, we report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer. Reduced expression of DUSP2 led to overproduction of COX-2-derived prostaglandin E2 , which promoted cancer stemness via the EP2/EP4 signaling pathways. Genetic and pharmacological inhibition of PGE2 biosynthesis or signal transduction ameliorated loss-of-DUSP2-induced tumor growth and cancer stemness...
August 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28627611/epithelial-mesenchymal-transition-and-cancer-stem-cell-like-phenotype-induced-by-twist1-contribute-to-acquired-resistance-to-irinotecan-in-colon-cancer
#11
Yong Yang, Guoxin Wang, Dajian Zhu, Yanfeng Huang, Yong Luo, Pengfei Su, Xiaowu Chen, Qian Wang
Inherent and acquired chemoresistance reduce the effectiveness of irinotecan in the treatment of metastatic colorectal cancer (CRC). However, the molecular mechanisms underlying this resistance process are still unclear. Twist1 is one of the master transcription factors of epithelial-mesenchymal transition (EMT). Our previous study indicated that Twist1 is overexpressed in colon cancer tissues, and demonstrated that Twist1 plays a crucial role in the chemoresistance of CRC. In the present study, we further investigated how Twist1 contribute to acquired resistance to irinotecan in colon cancer...
August 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28560069/the-identification-and-validation-of-trichosstatin-a-as-a-potential-inhibitor-of-colon-tumorigenesis-and-colon-cancer-stem-like-cells
#12
Tse-Hung Huang, Szu-Yuan Wu, Yan-Jiun Huang, Po-Li Wei, Alexander Th Wu, Tsu-Yi Chao
Colon cancer is one of the most prevalent cancer types in developed countries. Metastasis and drug resistance are two contributing factors to the high mortality rate. Accumulating evidence suggest that cancer stem-like cells (CSCs) represents as a major contributor to these malignant features. Here, we identified and isolated colon cancer stem-like cells using side-population (SP) method from human colon cancer cell lines. SP colon cells demonstrate cancer stem-like cell properties including enhanced sphere-forming ability and resistance towards fluorouracil (5-FU)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28196146/chemotherapy-induces-adaptive-drug-resistance-and-metastatic-potentials-via-phenotypic-cxcr4-expressing-cell-state-transition-in-ovarian-cancer
#13
Hyun Hee Lee, Vanessa Bellat, Benedict Law
Ovarian cancer (OVC) patients who receive chemotherapy often acquire drug resistance within one year. This can lead to tumor reoccurrence and metastasis, the major causes of mortality. We report a transient increase of a small distinctive CXCR4High/CD24Low cancer stem cell population (CXCR4High) in A2780 and SKOV-3 OVC cell lines in response to cisplatin, doxorubicin, and paclitaxel, treatments. The withdrawal of the drug challenges reversed this cell-state transition. CXCR4High exhibits dormancy in drug resistance and mesenchymal-like invasion, migration, colonization, and tumor formation properties...
2017: PloS One
https://www.readbyqxmd.com/read/27840990/microrna-302a-enhances-5-fluorouracil-induced-cell-death-in-human-colon-cancer-cells
#14
Na Liu, Jie Li, Zhenghao Zhao, Jia Han, Ting Jiang, Yanke Chen, Ni Hou, Chen Huang
New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR‑302a is an embryonic stem cell‑specific microRNA, studies on miR‑302a have focused on its role in human stem cells. Studies analyzing miR‑302 function in cancer are limited. In this study, we used two human colon cancer cell lines, HCT116 and HT29, and evaluated the influence of miR‑302a on 5‑fluorouracil (5‑FU)‑induced cell death and viability inhibition...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27806848/a-comparison-of-cancer-stem-cell-markers-and-nonclassical-major-histocompatibility-complex-antigens-in-colorectal-tumor-and-noncancerous-tissues
#15
COMPARATIVE STUDY
Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz
Colorectal carcinoma (CRC) is one of the most fatal types of cancer in both women and men, and, unfortunately, patients are often diagnosed at an advanced stage. Cancer stem cells (CSCs) are associated with poor prognosis, metastasis, and recurrence, as well as chemotherapy and radiotherapy resistance. Therefore, different treatment alternatives are needed to facilitate the elimination of CSCs. One such approach is immunotherapy; however, tumor cells can evade immune cells by alteration of the expression patterns of human leukocyte antigens (HLA)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27694285/apsa-awardee-submission-tumor-cancer-stem-cell-marker-doublecortin-like-kinase-1-in-liver-diseases
#16
REVIEW
Charles B Nguyen, Courtney W Houchen, Naushad Ali
Liver diseases are the fourth leading cause of mortality among adults in the United States. Patients with chronic liver diseases such as viral hepatitis, fibrosis, and cirrhosis have significantly higher risks of developing hepatocellular carcinoma (HCC). With a dismal five-year survival rate of 11%, HCC is the third most common cause of cancer-related deaths worldwide. Regardless of the underlying cause, late presentation and a lack of effective therapy are the major impediments for successful treatment of HCC...
February 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27659530/cd133-cd24lo-defines-a-5-fluorouracil-resistant-colon-cancer-stem-cell-like-phenotype
#17
Amy V Paschall, Dafeng Yang, Chunwan Lu, Priscilla S Redd, Jeong-Hyeon Choi, Christopher M Heaton, Jeffrey R Lee, Asha Nayak-Kapoor, Kebin Liu
The chemotherapeutic agent 5-Fluorouracil (5-FU) is the most commonly used drug for patients with advanced colon cancer. However, development of resistance to 5-FU is inevitable in almost all patients. The mechanism by which colon cancer develops 5-FU resistance is still unclear. One recently proposed theory is that cancer stem-like cells underlie colon cancer 5-FU resistance, but the phenotypes of 5-FU-resistant colon cancer stem cells are still controversial. We report here that 5-FU treatment selectively enriches a subset of CD133+ colon cancer cells in vitro...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27570510/promising-druggable-target-in-head-and-neck-squamous-cell-carcinoma-wnt-signaling
#18
REVIEW
Amnani Aminuddin, Pei Yuen Ng
Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. Furthermore, the canonical Wnt signaling pathway has also been described as one of the critical signaling pathways for regulation of normal stem cells as well as cancer cells with stem cell-like features, termed cancer stem cells (CSC)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27354597/enhanced-tlr4-expression-on-colon-cancer-cells-after-chemotherapy-promotes-cell-survival-and-epithelial-mesenchymal-transition-through-phosphorylation-of-gsk3%C3%AE
#19
Yoon Hee Chung, Daejin Kim
BACKGROUND: Phosphorylation of glycogen synthase kinase 3β (GSK3β) by phosphatidyl-inositide 3-kinase (PI3K)/protein kinase B (AKT) or inhibition of GSK3β with small-molecule inhibitor attenuates cell survival and proliferation and increases apoptosis in most cancer cell lines. In this study, we investigated the role of phosphorylated GSK3β activated by enhanced toll-like receptor 4 (TLR4) expression in drug-treated colon cancer cells as a model of post-chemotherapy cancer cells. MATERIALS AND METHODS: The effect of TLR4 stimulation on metastasis and apoptosis in drug-exposed colon cancer cells was determined by real-time polymerase chain reaction (PCR) and immunoblotting...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27318801/transcriptome-profiling-reveals-novel-gene-expression-signatures-and-regulating-transcription-factors-of-tgf%C3%AE-induced-epithelial-to-mesenchymal-transition
#20
Liutao Du, Shota Yamamoto, Barry L Burnette, Danshang Huang, Kun Gao, Neema Jamshidi, Michael D Kuo
Dysregulated epithelial to mesenchymal transition (EMT) in cancer cells endows invasive and metastatic properties upon cancer cells that favor successful colonization of distal target organs and therefore play a critical role in transforming early-stage carcinomas into invasive malignancies. EMT has also been associated with tumor recurrence and drug resistance and cancer stem cell initiation. Therefore, better understanding of the mechanisms behind EMT could ultimately contribute to the development of novel prognostic approaches and individualized therapies that specifically target EMT processes...
August 2016: Cancer Medicine
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