Haidi Li, Xin Chen, Jiejie Xu, Lin Zhu, Chao Li, Xiaolong Sun, Xiaofeng Li, Jianbo Guo, Juanjuan Li, Sheng Wang, Yong He, Hua Wang, Cheng Huang, Xiaoming Meng, Jun Li
BACKGROUND AIMS: The common characteristics for alcohol-associated liver injury (ALI) include abnormal liver function, infiltration of inflammatory cells, and generation of oxidative stress. The gastrin-releasing peptide receptor (GRPR) is activated by its neuropeptide ligand, gastrin-releasing peptide (GRP). GRP/GRPR appears to induce the production of cytokines in immune cells and promotes neutrophil migration. However, the effects of GRP/GRPR in ALI are unknown. APPROACH RESULTS: We found high GRPR expression in the liver of patients with alcoholic steatohepatitis and increased pro-GRP levels in peripheral blood mononuclear cells of these patients compared to that of the control...
July 5, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases