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Xiumei Chen, Jianzhong Lin, Tingting Hu, Zhiyun Ren, Linnan Li, Irbaz Hameed, Xiaoyu Zhang, Chen Men, Yan Guo, Di Xu, Yiyang Zhan
Oxidized low-density lipoprotein (Ox-LDL)-induced endothelial cell injury plays a crucial role in the pathogenesis of atherosclerosis (AS). Plasma galectin-3 (Gal-3) is elevated inside and drives diverse systemic inflammatory disorders, including cardiovascular diseases. However, the exact role of Gal-3 in ox-LDL-mediated endothelial injury remains unclear. This study explores the effects of Gal-3 on ox-LDL-induced endothelial dysfunction and the underlying molecular mechanisms. In this study, Gal-3, integrin β1, and GTP-RhoA in the blood and plaques of AS patients were examined by ELISA and western blot respectively...
December 10, 2018: Journal of Cellular Physiology
Seulki Song, Hyojin Kim, Soon-Hyun Ahn
Objectives: Immunohistochemistry (IHC) has been used for the diagnosis of indeterminate results in fine needle aspiration (FNA) of thyroid nodules. However, the role of IHC in core needle biopsy (CNB) is not clear and the efficacy of testing for molecular markers following CNB has not been evaluated. The aim of this study is to compare the role of IHC staining in CNB with that in FNA when examining thyroid nodules and to compare the sensitivity and usefulness of different molecular markers...
December 11, 2018: Clinical and Experimental Otorhinolaryngology
Jani Rahkila, Filip S Ekholm, Ana Ardá, Sandra Delgado, Johannes Savolainen, Jesús Jiménez-Barbero, Reko Leino
The quest for novel natural-like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates by proteins modulates a number of important biological processes. These molecular recognition events are, however, difficult to study by the use of naturally occurring oligosaccharides and polysaccharides owing to their intrinsic structural heterogeneity and to the many technical difficulties encountered during the isolation of sufficient quantities of pure material for detailed structural and biological studies...
November 30, 2018: Chembiochem: a European Journal of Chemical Biology
Tobias Rheude, Costanza Pellegrini, Julio Núñez, Michael Joner, Teresa Trenkwalder, N Patrick Mayr, Stefan Holdenrieder, Vicent Bodi, Wolfgang Koenig, Albert M Kasel, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
INTRODUCTION AND OBJECTIVES: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have been associated with adverse outcomes after transcatheter aortic valve implantation (TAVI). Experimental data have suggested a potential molecular interaction. Therefore, we assessed the association of Gal-3 and CA125 with prognosis after TAVI. METHODS: A total of 439 patients were enrolled. The primary endpoint was a composite of all-cause mortality or readmission for worsening heart failure after TAVI...
October 25, 2018: Revista Española de Cardiología
Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Masanori Baba
Galectin-3 (Gal-3) is involved in many biological processes and pathogenesis of diseases in part through nuclear factor (NF)-κB activation. We demonstrated that Gal-3 expression was significantly induced by tumor necrosis factor (TNF)-α or phorbol 12-myristate 13-acetate in OM-10.1 and ACH-2 cells, which are considered as a model of HIV-1 latently infected cells. The expression of Gal-3 was also associated with their viral production. However, the induction of Gal-3 by TNF-α was not observed in their uninfected parental cells...
November 24, 2018: Virus Research
Natalia Suárez-Fuentetaja, Eduardo Barge-Caballero, Antoni Bayés-Genís, Nieves Doménech, Lucía Moreda-Santamaría, María J Paniagua-Martín, Gonzalo Barge-Caballero, David Couto-Mallón, Miguel Solla-Buceta, Francisco Estévez-Cid, José J Cuenca-Castillo, Jorge Pombo-Otero, Zulaika Grille-Cancela, Paula Blanco-Canosa, Javier Muñiz, José Manuel Vázquez-Rodríguez, María G Crespo-Leiro
INTRODUCTION AND OBJECTIVES: Circulating galectin-3 (Gal-3) is elevated and significantly correlates with all-cause and cardiovascular mortality in patients with heart failure. However, the relationship between serum Gal-3 and heart transplant (HT) outcomes is unclear. The aim of this study was to describe the longitudinal trend and prognostic value of Gal-3 levels after HT. METHODS: Banked serum samples were available from 122 HT recipients, collected before transplant and at 1, 3, 6, and 12 months posttransplant...
November 23, 2018: Revista Española de Cardiología
Li Zhang, Yu-Mei Li, Xi-Xi Zeng, Xiao-Yan Wang, Shao-Kun Chen, Long-Xin Gui, Mo-Jun Lin
BACKGROUND/AIMS: Vascular muscularity is a key event in vessel remodeling during pulmonary artery hypertension (PAH). Endothelial-mesenchymal transdifferentiation (EndMT) has been increasingly reported to play a role in disease occurrence. Galectin-3, a carbohydrate-binding protein regulates cell proliferation, differentiation, migration and neovascularization. However, whether galectin-3 controls endothelial cell transdifferentiation during the development of PAH is unknown. METHODS: Rats were exposed to normoxic or hypoxic conditions (fraction of inspired O2 0...
2018: Cellular Physiology and Biochemistry
Demet Ozkaramanli Gur, Derya Necmiye Özaltun, Savaş Gu Zel, Banu Ayse Sarifakioglu, Aydın Akyu Z, Şeref Alpsoy, Ozge Aycicek, Derya Baykiz
OBJECTIVES: The diagnosis of cardiovascular involvement in ankylosing spondylitis (AS) is usually delayed since conventional echocardiography relies mainly on the morphological alterations. The aim of this study was to evaluate the role of echocardiographic methods such as tissue Doppler and strain imaging of left ventricle (LV) and proximal aorta; and concentrations of biomarkers of cardiac fibrosis such as galectin-3 (Gal-3) and soluble suppression-of-tumorogenicity-2 (sST2) in determining early cardiovascular impairment in AS...
November 21, 2018: Scandinavian Cardiovascular Journal: SCJ
Hong-Yan Li, Shen Yang, Jing-Chun Li, Jian-Xun Feng
Nephrotoxicity is a major toxic effect in chemotherapy, which constitutes up to 60% of hospitalized acute kidney injury (AKI). Very few treatment options exist to slow the transition from AKI to subsequent chronic kidney diseases (CKD). Here, we demonstrate that galectin-3 (Gal-3), a β-galactoside binding lectin that plays an important role in kidney fibrosis and renal failure, is one of the key factors for renal injury progression. Ectopic overexpression of Gal-3 significantly decreased the viability of HEK293, simultaneously inducing of cell cycle arrest and apoptosis...
November 19, 2018: Bioscience Reports
María F Ferrer, Emilia Scharrig, Nancy Charo, Ana L Rípodas, Ricardo Drut, Eugenio A Carrera Silva, Ariel Nagel, Jarlath E Nally, Daniela P Montes de Oca, Mirta Schattner, Ricardo M Gómez
Previous studies have suggested that macrophages may contribute to acute Leptospira dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Gal-3) on the survival, clinical course, bacterial burden, interstitial nephritis, and chronic kidney fibrosis in Leptospira interrogans serovar Copenhageni (LIC)-induced experimental murine leptospirosis. C57BL/6J mice depleted of macrophages by liposome-encapsulated clodronate treatment and infected with LIC presented a higher bacterial burden, had reduced subacute nephritis and enhanced chronic kidney fibrosis relative to untreated, infected mice...
2018: Frontiers in Cellular and Infection Microbiology
Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty, Nicolas Clementy
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces symptoms, morbidity and mortality in chronic heart failure patients with wide QRS complexes. However, approximately one third of CRT patients are non-responders. Myocardial fibrosis is known to be associated with absence of response. We sought to see whether galectin-3, a promising biomarker involved in fibrosis processes, could predict response and outcomes after CRT. METHODS: Consecutive patients eligible for implantation of a CRT device with a typical left bundle branch block ≥ 120 ms were prospectively included...
November 3, 2018: Journal of Translational Medicine
My-Nhan Nguyen, Mark Ziemann, Helen Kiriazis, Yidan Su, Daniel G Donner, Wei-Bo Zhao, Qun Lu, Haloom Rafehi, Junichi Sadoshima, Julie R McMullen, Assam El-Osta, Xiao-Jun Du
Dilated cardiomyopathy (DCM) is a major cause of heart failure without effective therapy. Fibrogenesis plays a key role in DCM development but little is known on the expression of a pro-fibrotic factor galectin-3 (Gal-3) and its role in DCM pathophysiology. In a mouse DCM model by transgenic (TG) overexpression of mammalian sterile 20-like kinase 1 (Mst1), we studied Gal-3 expression and effects of the Gal-3 inhibitor modified citrus pectin (MCP) or Gal-3 gene knockout (KO). Gal-3 deletion in TG mice (TG/KO) was achieved by cross-breeding Mst1-TG with Gal-3 KO mice...
November 2, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Francesco De Rose, Miriam Braeuer, Sten Braesch-Andersen, Angela M Otto, Katja Steiger, Sybille Reder, Sabine Mall, Stephan Nekolla, Markus Schwaiger, Wolfgang A Weber, Armando Bartolazzi, Calogero D'Alessandria
Preoperative characterization of thyroid nodules is challenging since thyroid scintigraphy fails to distinguish between benign and malignant lesions. Galectin-3 is widely expressed in the majority of well-differentiated thyroid carcinomas and in a large fraction of undifferentiated thyroid cancer types but not in normal thyrocytes and benign thyroid lesions. Herein, we aimed to validate galectin-3 targeting in thyroid orthotopic tumors otherwise not visible with conventional imaging. Methods: Papillary (BcPAP) and anaplastic (CAL62 and FRO82-1) thyroid carcinoma cells lines were characterized via WB and PCR, for galectin-3 and sodium iodide symporter (NIS) expression...
October 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Suhail Al-Salam, Satwat Hashmi
BACKGROUND/AIMS: Myocardial reperfusion has the potential to salvage the ischemic myocardium after a period of coronary occlusion. Reperfusion, however, can cause a wide spectrum of deleterious effects. Galectin-3 (GAL-3), a beta galactoside binding lectin, is closely associated with myocardial infarction (MI), myocardial fibrosis and heart failure. In our study, we investigated its role in ischemia-reperfusion injuries (IR) as this phenomenon is extremely relevant to the early intervention after acute MI...
2018: Cellular Physiology and Biochemistry
Haeyon Cho, Ji-Ye Kim, Young Lyun Oh
Our aim is to explore differences in Hector Battifora mesothelial-1 (HBME-1), cytokeratin-19 (CK19), Galectin-3 (Gal-3), and CD56 expression in infiltrative follicular variants of papillary carcinoma (IFVPTC) and encapsulated follicular variants of papillary carcinoma (EFVPTC) and to provide clues for distinguishing the two subtypes preoperatively. Tissue microarrays from 100 EFVPTC (45 non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) and 55 invasive EFVPTCs), 43 IFVPTCs, and 64 follicular neoplasms (FN) were immunostained with HBME-1, CK19, Gal-3, and CD56...
November 2018: Pathology International
Moritz Wyler von Ballmoos, Donald S Likosky, Michael Rezaee, Kevin Lobdell, Shama Alam, Devin Parker, Sherry Owens, Heather Thiessen-Philbrook, Todd MacKenzie, Jeremiah R Brown
BACKGROUND: Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery. METHODS: Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007...
October 20, 2018: BMC Nephrology
Chaoyang Wei, Yu Zhang, Liang He, Junwen Cheng, Junhui Li, Wenyang Tao, Guizhu Mao, Hua Zhang, Robert J Linhardt, Xingqian Ye, Shiguo Chen
LP100R, LP10R and LP5R were isolated from peach gum by ultrafiltration. They were identified as AG II arabinogalactans composed of mannose, rhamnose, glucuronic acid, galactose, xylose and arabinose, which had a β-d-(1→6)-galactan backbone and were branched at O-3 and O-4. LP100R, LP10R and LP5R exist in a spherical conformation with the molecular weight of 8.50 × 104 g/mol, 4.77 × 104 g/mol and 2.40 × 104 g/mol, respectively. The binding affinities of LP fractions to galectin-3 (Gal-3) were 0.77 μM for LP100R, 2...
January 1, 2019: Carbohydrate Polymers
Yunyun Liu, Lingling Xie, Dongyan Wang, Da Li, Guocai Xu, Lijuan Wang, Hui Zhou, Yuefei Yu, Zhongqiu Lin, Huaiwu Lu
Purpose: This study was designed to explore the expression levels of Galectin-3 (Gal-3) and β-catenin in serous epithelial ovarian cancer (SEOC), the linkage between their expressions, and the clinicopathological features of SEOC patients. Patients and methods: Seventy-four SEOC patients' specimens were detected for Gal-3 and β-Catenin expressions using immunohistochemistry, and the association between β-catenin or Gal-3 protein expressions and clinicopathological features, treatment effects, and prognosis were analyzed using SPSS 19...
2018: Cancer Management and Research
Marzia Testa, Gian Luca Rosso, Cinzia Ferreri, Mauro Feola
Galectin-3 is demonstrated to be a robust independent marker of cardiovascular mid-term (18-month) outcomes in heart failure (HF) patients. The aim of this study was to analyze the value of a pre-discharged determination of galectin-3 alone and with brain natriuretic peptide (BNP) in predicting mid-term outcomes in elderly patients (>70 years old) discharged after an acute decompensated HF (ADHF) episode. METHODS: all elderly (≥70 years old) HF subjects discharged alive after an ADHF were enrolled...
September 27, 2018: Diseases (Basel)
Laura Thomas, Laura Andrea Pasquini
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD). The present review summarizes Gal-3 functions in the extracellular and intracellular space, its regulation and its internalization and secretion, with a focus on the current knowledge of Gal-3 role in central nervous system (CNS) health and disease, particularly oligodendrocyte (OLG) differentiation, myelination and remyelination in experimental models of multiple sclerosis (MS)...
2018: Frontiers in Cellular Neuroscience
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