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Yunyun Liu, Lingling Xie, Dongyan Wang, Da Li, Guocai Xu, Lijuan Wang, Hui Zhou, Yuefei Yu, Zhongqiu Lin, Huaiwu Lu
Purpose: This study was designed to explore the expression levels of Galectin-3 (Gal-3) and β-catenin in serous epithelial ovarian cancer (SEOC), the linkage between their expressions, and the clinicopathological features of SEOC patients. Patients and methods: Seventy-four SEOC patients' specimens were detected for Gal-3 and β-Catenin expressions using immunohistochemistry, and the association between β-catenin or Gal-3 protein expressions and clinicopathological features, treatment effects, and prognosis were analyzed using SPSS 19...
2018: Cancer Management and Research
Marzia Testa, Gian Luca Rosso, Cinzia Ferreri, Mauro Feola
Galectin-3 is demonstrated to be a robust independent marker of cardiovascular mid-term (18-month) outcomes in heart failure (HF) patients. The aim of this study was to analyze the value of a pre-discharged determination of galectin-3 alone and with brain natriuretic peptide (BNP) in predicting mid-term outcomes in elderly patients (>70 years old) discharged after an acute decompensated HF (ADHF) episode. METHODS: all elderly (≥70 years old) HF subjects discharged alive after an ADHF were enrolled...
September 27, 2018: Diseases (Basel)
Laura Thomas, Laura Andrea Pasquini
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD). The present review summarizes Gal-3 functions in the extracellular and intracellular space, its regulation and its internalization and secretion, with a focus on the current knowledge of Gal-3 role in central nervous system (CNS) health and disease, particularly oligodendrocyte (OLG) differentiation, myelination and remyelination in experimental models of multiple sclerosis (MS)...
2018: Frontiers in Cellular Neuroscience
Turkan Ozturk Topcu, Halil Kavgaci, Meral Gunaldi, Hakan Kocoglu, Murat Akyol, Ahmet Mentese, Serap Ozer Yaman, Asim Orem, Feyyaz Ozdemir, Fazil Aydin
Objective: Studies have investigated expression status of galectin-3 (Gal-3), but very little is known about the importance of circulating Gal-3 in patients with breast cancer (BC). The purpose of the study was to investigate the clinical significance and potential diagnostic value of plasma Gal-3 levels in patients with BC. Materials and Methods: Fifty-two patients with BC and 35 age-matched healthy controls were enrolled. Levels of Gal-3 were investigated in BC patients and healthy controls...
September 2018: Journal of Cancer Research and Therapeutics
Chang-Shuo Huang, Shye-Jye Tang, Mei-Hsuan Lee, Chien-Chih Chang Wang, Guang-Huan Sun, Kuang-Hui Sun
Although targeted therapy is usually the first-line treatment for advanced renal cell carcinoma (RCC), some patients can experience drug resistance. Cancer stem cells are tumour-initiating cells that play a vital role in drug resistance, metastasis and cancer relapse, while galectins (Gal) participate in tumour progression and drug resistance. However, the exact role of galectins in RCC stemness is yet unknown. In this study, we grew a subpopulation of RCC cells as tumour spheres with higher levels of stemness-related genes, such as Oct4, Sox2 and Nanog...
September 24, 2018: Journal of Cellular and Molecular Medicine
Mehmet Özbek, Mustafa Hitit, Nuh Yıldırım, Özge Özgenç, Emel Ergün, Levent Ergün, Feyzullah Beyaz, Nevin Kurtdede, Hikmet Altunay
Galectins are a family of lectins-binding beta-galactosides involved in a variety of extracellular and intracellular processes, thereby contributing to homeostasis, cell adhesion, cellular turnover, and immunity. This study aimed to determine the localization and expression of galectin-1 (Gal-1) and galectin-3 (Gal-3) in the testis and epididymis of rats at postnatal [(prepubertal (day 5), pubertal (day 20), postpubertal (day 50) and mature (day 70)] periods by using immunohistochemistry and Western blotting...
September 18, 2018: Acta Histochemica
P Bojarová, M R Tavares, D Laaf, L Bumba, L Petrásková, R Konefał, M Bláhová, H Pelantová, L Elling, T Etrych, P Chytil, V Křen
BACKGROUND: Galectin-3 (Gal-3) is a promising target in cancer therapy with a high therapeutic potential due to its abundant localization within the tumor tissue and its involvement in tumor development and proliferation. Potential clinical application of Gal-3-targeted inhibitors is often complicated by their insufficient selectivity or low biocompatibility. Nanomaterials based on N-(2-hydroxypropyl)methacrylamide (HPMA) nanocarrier are attractive for in vivo application due to their good water solubility and lack of toxicity and immunogenicity...
September 20, 2018: Journal of Nanobiotechnology
Raphael G Ferreira, Lilian C Rodrigues, Daniele C Nascimento, Alexandre Kanashiro, Paulo H Melo, Vanessa F Borges, Aline Gozzi, Douglas da Silva Prado, Marcos C Borges, Fernando S Ramalho, Sean R Stowell, Richard D Cummings, Marcelo Dias-Baruffi, Fernando Q Cunha, Jose C Alves-Filho
Sepsis is an overwhelming systemic inflammation resulting from an uncontrolled infection that causes extensive tissue damage, organ dysfunction and eventually death. A growing body of evidence indicates that impaired neutrophil migration to the site of infection is associated with poor outcome in sepsis. Here we show that galectin-3 (Gal-3), an endogenous glycan-binding protein, plays a critical role in sepsis outcome. We found that serum Gal-3 concentration increased in patients with septic shock and mice undergoing sepsis induced by cecal ligation and puncture (CLP)...
July 4, 2018: Journal of Infection
P Vichit, A Rungsipipat, S D Surachetpong
OBJECTIVE: This study aimed to evaluate cardiac function and compare the concentration of cardiac biomarkers including cardiac troponin I (cTnI), galectin-3 (Gal-3), and N-terminal pro B-type natriuretic peptides (NT-proBNP) in diabetic and control dogs. ANIMALS: Thirty-nine dogs were included. The diabetic and control groups consisted of 19 and 20 dogs, respectively. METHODS: Plasma cTnI, Gal-3, and NT-proBNP concentrations were measured in the diabetic and control groups...
September 11, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
D Ditgen, E M Anandarajah, A Reinhardt, A E Younis, S Witt, J Hansmann, E Lorenz, M García-Hernández, D Paclik, H Soblik, A Jolodar, P H Seeberger, E Liebau, N W Brattig
Helminths are complex pathogens that ensure their long-term survival by influencing the immune responses of their host. Excretory/secretory products (ESP) can exert immunoregulatory effects which foster parasite survival. Galectins represent a widespread group of β-galactoside-binding proteins which are involved in a multitude of biological processes operative in parasite-host interaction. We had earlier identified seven galectins in Strongyloides ratti, four of them detected in the ESP of distinct developmental stages of the parasite...
September 1, 2018: Molecular and Biochemical Parasitology
Weijie Du, Arnold Piek, E Marloes Schouten, Cees W A van de Kolk, Christian Mueller, Alexandre Mebazaa, Adriaan A Voors, Rudolf A de Boer, Herman H W Silljé
Plasma heart failure (HF) biomarkers, like natriuretic peptides, are important in diagnosis, prognosis and HF treatment. Several novel HF biomarkers have been identified, including Gal-3, GDF-15 and TIMP-1, but their clinical potential remains vague. Here we investigated plasma biomarker levels in relation to tissue expression and structural and functional cardiac changes. Methods: Cardiac remodeling, cardiac function, and plasma and tissue biomarker levels were investigated in mice after myocardial infarction induced by temporal and permanent LAD ligation (tLAD and pLAD)...
2018: Theranostics
Mauro Feola, Marzia Testa, Cinzia Ferreri, Marco Cardone, Mario Sola, Sara Ariotti, Gian Luca Rosso
BACKGROUND: The diuretic response has been shown to be a robust independent marker of cardiovascular outcomes in acute heart failure (ADHF) patients. The objectives of this clinical research, will aim are to: a) include diuresis in the formula for diuretic response (R-to-D); b) add to R-to-D the value of a pre-discharged determination of galectin-3 and BNP in predicting mid-term clinical outcome. METHODS: Consecutive patients discharged alive after an ADHF were enrolled...
April 2018: Archives of Medical Research
Jinfeng Liu, Shiguang Huang, Fangli Lu
Toxoplasmic encephalitis (TE), an opportunistic infection, is a severe health problem in immunocompromised patients. Previous studies have revealed that C57BL/6 mice are susceptible and BALB/c mice are resistant to TE. To investigate the mechanisms involved in the immunopathogenesis of TE in susceptible C57BL/6 and resistant BALB/c mice, both strains of mice were perorally infected with the Prugniuad (Pru) strain of Toxoplasma gondii . Our results showed that compared with BALB/c mice, C57BL/6 mice infected with T...
2018: Frontiers in Immunology
Marina Miletic Kovacevic, Nada Pejnovic, Slobodanka Mitrovic, Nemanja Jovicic, Ivica Petrovic, Nebojsa Arsenijevic, Miodrag L Lukic, Biljana Ljujic
Experimental autoimmune myocarditis (EAM) is a mouse model of immune-mediated myocarditis and cardiomyopathy. The role of Galectin-3 (Gal-3), a β-galactoside-binding lectin, in autoimmune myocarditis has not been studied. Therefore, the aim of this study was to delineate the role of Gal-3 in myosin peptide-induced autoimmune myocarditis in mice. EAM was induced in relatively resistant C57BL/6J mice (wild type, WT) and in mice with a targeted deletion of Gal-3 gene (Gal-3KO) by immunization with myosin peptide MyHCα334-352 ...
August 2018: Immunologic Research
T Kotwica, J Relewicz, A Rojek, M Tupikowska-Marzec, M Kabaj, B Karolko, J Maj, G Bednarek-Tupikowska, W Kosmala, J C Szepietowski, M Przewlocka-Kosmala
BACKGROUND: Psoriasis has been shown to increase cardiovascular risk, and a contributor to this might be enhanced myocardial fibrosis promoted by the disease-associated pro-inflammatory milieu. OBJECTIVE: We sought to investigate the relationship of galectin-3 (Gal-3) - a recognized mediator of fibrosis with inflammatory activation and left ventricular (LV) systolic and diastolic function in patients with psoriasis. METHODS: We enrolled 102 psoriatic patients (mean age: 52...
August 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Sabrina Santarsia, Ana Sofia Grosso, Filipa Trovão, Jesús Jiménez-Barbero, Ana Luísa Carvalho, Cristina Nativi, Filipa Marcelo
Overexpression of the Thomsen-Friedenreich (TF) antigen in cell membrane proteins occurs in 90 % of adenocarcinomas. Additionally, the binding of the TF antigen to human galectin-3 (Gal-3), also frequently overexpressed in malignancy, promotes cancer progression and metastasis. In this context, structures that interfere with this specific interaction have the potential to prevent cancer metastasis. A multidisciplinary approach combining the optimized synthesis of a TF antigen mimetic with NMR, X-ray crystallography methods, and isothermal titration calorimetry assays was used to unravel the molecular structural details that govern the Gal-3/TF mimetic interaction...
August 9, 2018: ChemMedChem
Michal Halaj, Mária Matulová, Martina Šutovská, Jana Barboríková, Ivana Kazimierová, Soňa Fraňová, Pavel Přibyl, Vladislav Cepák, Jaromír Lukavský, Peter Capek
Microalgae occupy all territories and their products represent a rich source of phytochemicals for human being. Green microalga Dictyosphaerium chlorelloides was found to be a significant producer of the extracellular biopolymer. Dominant components of the biopolymer were found to be Gal (39 wt%) with its methyl derivatives (15 wt%), Rha (19 wt%) and Man (14 wt%). 2-OMe-Gal was found to be the major derivative while other sugars, namely 3-OMe-, 6-OMe- and 2,3-di-OMe-Gal, 3-OMe-Glc and 4-OMe-Xyl were in smaller amounts...
October 15, 2018: Carbohydrate Polymers
T N Enina, V A Kuznetsov, A M Soldatova, T I Petelina, D V Krinochkin, S M Dyachkov, A Y Rychkov, T Y Gorbunova
AIM: To study the relationship between levels of sex hormones and effectiveness of cardiac resynchronisation therapy (CRT) in men with chronic heart failure (CHF). MATERIALS AND METHODS: The best response to CRT (mean time, 38 [19,0;53,7] months) was identifed by a maximum decrease in left ventricular end-systolic volume (LVESV) in 58 men (mean age, 54.8±9.6) with CHF (61% IHD). Based on testosterone (TES) level, patients were divided into group 1 (n=28; 48%) - TES < median value (13...
2018: Kardiologiia
Zong-Sheng Wu, Jing-Jou Lo, Sheng-Hua Wu, Chau-Zen Wang, Rong-Fu Chen, Su-Shin Lee, Chee-Yin Chai, Shu-Hung Huang
Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley (SD) rats were randomly assigned to the following six groups ( n = 6 per group): (1) sham burn with sham HBO treatment; (2) sham burn with HBO treatment; (3) burn with one-week sham HBO treatment; (4) burn with two-week sham HBO treatment; (5) burn with one-week HBO treatment; and (6) burn with two-week HBO treatment...
July 27, 2018: International Journal of Molecular Sciences
Sefora Conti, Akiva Vexler, Lior Hagoel, Lital Kalich-Philosoph, Benjamin W Corn, Nir Honig, Natan Shtraus, Yaron Meir, Ilan Ron, Isaac Eliaz, Shahar Lev-Ari
BACKGROUND: Radiotherapy is one of the primary therapies for localized prostatic carcinoma. Therefore, there is an emerging need to sensitize prostatic cancer cells to chemotherapy/radiotherapy. Modified citrus pectin (MCP) is an effective inhibitor of galectin-3 (Gal-3), which is correlated with tumor progression, proliferation, angiogenesis, and apoptosis. PURPOSE: This study was directed to evaluate the efficacy of combining ionizing radiation (IR) with MCP on PCa cells...
July 25, 2018: Integrative Cancer Therapies
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