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F Grosselin, X Navarro-Sune, M Raux, T Similowski, M Chavez
BACKGROUND: Although cardio-respiratory (CR) system is generally controlled by the autonomic nervous system, interactions between the cortex and these primary functions are receiving an increasing interest in neurosciences. NEW METHOD: In general, the timing of such internally paced events (e.g. heartbeats or respiratory cycles) may display a large variability. For the analysis of such CR event-related EEG potentials, a baseline must be correctly associated to each cycle of detected events...
August 13, 2018: Journal of Neuroscience Methods
Zi-Hui Zhang, Kangkai Tian, Chunshuang Chu, Mengqian Fang, Yonghui Zhang, Wengang Bi, Hao-Chung Kuo
This work establishes the relationship between the electron energy and the electron concentration within the multiple quantum wells (MQWs) for AlGaN based deep ultraviolet light-emitting diodes (DUV LEDs). The electron energy of different values can be obtained by modulating the Si doping concentration in the n-AlGaN layer and/or engineering the polarization induced interface charges. The modulated Si doping concentration in the n-AlGaN layer will cause the interface depletion region within which the electric field can be generated and then tunes the electron energy...
July 9, 2018: Optics Express
Brendan Lee Eck, Raymond F Muzic, Jacob Levi, Hao Wu, Rachid Fahmi, Yuemeng Li, Anas Fares, Mani Vembar, Amar Dhanantwari, Hiram G Bezerra, David L Wilson
In this work, we clarified the role of acquisition parameters and quantification methods in myocardial blood flow (MBF) estimability for myocardial perfusion imaging using CT (MPI-CT). We used a physiologic model with a CT simulator to generate time-attenuation curves across a range of imaging conditions, i.e. tube current-time product, imaging duration, and temporal sampling, and physiologic conditions, i.e. MBF and arterial input function width. We assessed MBF estimability by precision (interquartile range of MBF estimates) and bias (difference between median MBF estimate and reference MBF) for multiple quantification methods...
August 16, 2018: Physics in Medicine and Biology
Ahmed Sameh Eleshra, Woon Heo, Kwang-Hun Lee, Shin-Young Lee, Ha Lee, Suk-Won Song
We report a case of acute type I aortic dissection in which an emergency graft replacement of the ascending aorta and innominate artery was performed. We performed false lumen thrombosis through hybrid thoracic endovascular aortic repair to seal the primary entry tear, followed by false lumen obliteration at the level of the descending thoracic aorta, abdominal aorta, and right common iliac artery. Over a period of 4.5 years, we used Amplatzer vascular plugs and coils based on our computed tomography angiography follow-up protocol...
August 2018: Korean Journal of Thoracic and Cardiovascular Surgery
Christian Heinen, Patrick Dömer, Thomas Schmidt, Bettina Kewitz, Ulrike Janssen-Bienhold, Thomas Kretschmer
BACKGROUND: Clinical and electrophysiological assessments prevail in evaluation of traumatic nerve lesions and their regeneration following nerve surgery in humans. Recently, high-resolution neurosonography (HRNS) and magnetic resonance neurography have gained significant importance in peripheral nerve imaging. The use of the grey-scale-based "fascicular ratio" (FR) was established using both modalities allowing for quantitative assessment. OBJECTIVE: To find out whether FR using HRNS can assess nerve trauma and structural reorganization in correlation to postoperative clinical development...
August 9, 2018: Neurosurgery
Ji He, Yan Yang, Yongbo Wang, Dong Zeng, Zhaoying Bian, Hao Zhang, Jian Sun, Zongben Xu, Jianhua Ma
Reducing the exposure to X-ray radiation while maintaining a clinically acceptable image quality is desirable in various CT applications. To realize low-dose CT (LdCT) imaging, model-based iterative reconstruction (MBIR) algorithms are widely adopted, but they require proper prior knowledge assumptions in the sinogram and/or image domains and involve tedious manual optimization of multiple parameters. In this work, we propose a deep learning (DL)-based strategy for MBIR to simultaneously address prior knowledge design and MBIR parameter selection in one optimization framework...
August 13, 2018: IEEE Transactions on Medical Imaging
Binyan Lin, Kai Zhao, Dawei Yang, Dongsheng Bai, Yan Liao, Yuxin Zhou, Zhou Yu, Xiaoxuan Yu, Qinglong Guo, Na Lu
Decreasing bone marrow (BM) microvessel density and circulating angiogenic cytokine levels are promising strategies for the treatment of relapsed and resistant acute myeloid leukemia (AML). Previous studies have reported that wogonoside could inhibit the progression of AML and suppress angiogenesis in a solid tumor, but the correlation of these two effects was ignored. In this research, we determined whether wogonoside could inhibit angiogenesis in this hematologic malignancy. We found that wogonoside could inhibit tumor growth and progression, and prolong the survival of nude mice inoculated with U937/MDR...
August 13, 2018: Journal of Cellular Physiology
P K Musale, S Kothare
BACKGROUND: Deep carious lesions in immature permanent molars with pulp necrosis pose a serious challenge to contemporary paedodontic practice. A further complex clinical scenario is an immature permanent molar with varying root formation in both roots. This case report demonstrates the successful management of an immature permanent mandibular first molar. CASE REPORT: An 8-year-old boy was referred for endodontic management of 36 by a general practitioner. After clinical and radiographic evaluation, a diagnosis of recurrent chronic periapical abscess with abrupt root closure in the mesial root and cessation of root closure in the distal root was made...
August 13, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Chih-Wei Hsia, Ming-Ping Wu, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Cheng-Lin Tsai, Chia-Yuan Hsu, Thanasekaran Jayakumar, Chi-Li Chung, Joen-Rong Sheu
Morin hydrate, a bioactive flavonoid, has been proven to prevent inflammation and apoptosis of cells. Flavonoids can reduce the risk of cardiovascular diseases, in which platelet activation plays a major role. This study investigated the effect of morin hydrate on platelet activation in vitro and in vivo. Morin hydrate markedly inhibited platelet aggregation stimulated by collagen in human platelets but not that stimulated by other agonists. In collagen-activated platelets, morin hydrate inhibited adenosine triphosphate (ATP) release; intracellular Ca2+ mobilization; P-selectin expression; and phosphorylation of phospholipase Cγ2 (PLCγ2), protein kinase C (PKC), and Akt...
August 13, 2018: International Journal of Molecular Sciences
Bei-Bei He, Xu-Liang Bu, Ting Zhou, Shu-Ming Li, Minjuan Xu, Jun Xu
Prenylated aromatic compounds are important intermediates in the biosynthesis of bioactive molecules such as secondary metabolites from plants, ubiquinone from prokaryotes and meroterpenoids from sponges. Biosynthesis of prenylated aromatic compounds using prokaryotic microorganisms has attracted increasing attention in the field of synthetic biology. In this study, we demonstrated that the production of 3-geranyl-4-hydroxybenzoic acid (GBA) and a variety of GBA analogs was feasible in a metabolically engineered E...
August 13, 2018: ACS Synthetic Biology
Hao Wu, H N Ashiqur Rahman, Yunzhou Dong, Xiaolei Liu, Yang Lee, Aiyun Wen, Kim Ht To, Li Xiao, Amy E Birsner, Lauren Bazinet, Scott Wong, Kai Song, Megan L Brophy, M Riaj Mahamud, Baojun Chang, Xiaofeng Cai, Satish Pasula, Sukyoung Kwak, Wenxia Yang, Joyce Bischoff, Jian Xu, Diane R Bielenberg, J Brandon Dixon, Robert J D'Amato, R Sathish Srinivasan, Hong Chen
Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this pathway is affected in diabetes remains poorly understood. We previously demonstrated that loss of epsins 1 and 2 in lymphatic endothelial cells (LECs) prevented VEGF-C-induced VEGFR3 from endocytosis and degradation. Here, we report that diabetes attenuated VEGF-C-induced lymphangiogenesis in corneal micropocket and Matrigel plug assays in WT mice but not in mice with inducible lymphatic-specific deficiency of epsins 1 and 2 (LEC-iDKO)...
August 13, 2018: Journal of Clinical Investigation
Cen Lin, Erwin R Stedronsky, Luke R Jordan, Nathan J Wittenberg, Steven L Regen
A plug and socket approach for tightening polyelectrolyte multilayers is introduced based on the use pendant β-cyclodextrin groups. Prototypical multilayers derived from poly(sodium 4-styrene sulfonate) and β-cyclodextrin-containing poly(4-vinylbenzyltrimethylammonium chloride) are described. Evidence for tightened multilayers has been obtained from gas permeation, swelling and quartz crystal microbalance with dissipation (QCM-D) measurements.
August 13, 2018: Chemical Communications: Chem Comm
Michel Wathier, Benjamin A Lakin, Benjamin G Cooper, Prashant N Bansal, Alison M Bendele, Vahid Entezari, Hideki Suzuki, Brian D Snyder, Mark W Grinstaff
Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively...
August 7, 2018: Biomaterials
Gemma L Holliday, Eyal Akiva, Elaine C Meng, Shoshana D Brown, Sara Calhoun, Ursula Pieper, Andrej Sali, Squire J Booker, Patricia C Babbitt
The radical SAM superfamily contains over 100,000 homologous enzymes that catalyze a remarkably broad range of reactions required for life, including metabolism, nucleic acid modification, and biogenesis of cofactors. While the highly conserved SAM-binding motif responsible for formation of the key 5'-deoxyadenosyl radical intermediate is a key structural feature that simplifies identification of superfamily members, our understanding of their structure-function relationships is complicated by the modular nature of their structures, which exhibit varied and complex domain architectures...
2018: Methods in Enzymology
Kim Allison, Michelle Hall, Tim V Wrigley, Yong-Hao Pua, Ben Metcalf, Kim L Bennell
BACKGROUND: Hip osteoarthritis (OA) is a significant cause of disability, with hip pain and reduced external hip moments during walking being key features of the condition. The external hip adduction moment is greater in healthy women than men, however these between-sex differences are not evident in those with end-stage hip OA. Whether sex-specific hip kinetics are associated with early-midstage hip OA has not been investigated and may be a potential target for directed treatment. METHODS: Thirty-eight women and twenty-eight men with a diagnosis of symptomatic, unilateral, mild-to-moderate hip OA (Kellegren-Lawrence Grade 2 or 3) underwent three-dimensional gait analysis of normal walking gait using Vicon motion capture...
July 31, 2018: Gait & Posture
L Trefan, C Harris, S Evans, D Nuttall, S Maguire, A M Kemp
BACKGROUND: It is standard practice to image concerning bruises in children. We aim to compare the clarity and measurements of bruises using cross polarized, infra-red (IR) and ultra-violet (UV) images to conventional images. METHODS: Children aged <11 years with incidental bruising were recruited. Demographics, skin and bruise details were recorded. Bruises were imaged by standard protocols in conventional, cross-polarized, IR and UV lights. Bruises were assessed in vivo for contrast, uniformity and diffuseness, and these characteristics were then compared across image modalities...
August 4, 2018: Journal of Forensic and Legal Medicine
Barbara Krajewska
Inducing calcium carbonate precipitation is another important function of urease in nature. The process takes advantage of the supply of carbonate ions derived from urea hydrolysis and of an increase in pH generated by the reaction, effects that in the presence of Ca2+ ions lead to the precipitation of CaCO3 . Further to its importance in nature, if performed in a biomimetic manner, the urease-aided CaCO3 mineralization offers enormous potential in innovative engineering applications as an eco-friendly technique operative under mild conditions, to be used for remediation and cementation/deposition in field applications in situ ...
September 2018: Journal of Advanced Research
Ayumi Eguchi, Mari Inohana, Misato Nakamura, Rei Nagahara, Megu Itahashi, Kota Nakajima, Toshinori Yoshida, Makoto Shibutani
A 3-year-old female Richardson's ground squirrel developed a subcutaneous mass at the left oral angle. Seven days after removal of the mass, the mass recurred and metastasized to the cervical lymph node. Histologically, the primary mass was subdivided by fibrous trabeculae into various-sized neoplastic cell lobules showing a solid growth pattern with frequent mitoses and sometimes forming intracytoplasmic lumina. Large to medium-sized lobules formed a central cyst plugged by comedo necrosis. Neoplastic cells showed infiltrative subcutaneous growth...
July 2018: Journal of Toxicologic Pathology
Grayson H Wheatley
No abstract text is available yet for this article.
July 20, 2018: Journal of Thoracic and Cardiovascular Surgery
Alice P Sowton, Sarah L Millington-Burgess, Andrew J Murray, Matthew T Harper
Platelet activation plays a key role in normal haemostasis and pathological thrombosis. Platelet activation is rapid; within minutes of stimulation, platelets generate bioactive phospholipids, secrete their granule contents, activate integrins and aggregate together to form a haemostatic plug. These events are dependent on ATP synthesis. Mitochondrial function in platelets from healthy volunteers and patients with a range of diseases indicate an important role for oxygen consumption in oxidative phosphorylation in normal and pathological function...
August 6, 2018: Biochemical and Biophysical Research Communications
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