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Daiane Anzilaggo, André O'Reilly Beringhs, Bianca Ramos Pezzini, Diva Sonaglio, Hellen Karine Stulzer
The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an important role in the dissolution and absorption phenomena. However, many factors can influence the performance and success of LS. Therefore this study aimed to evaluate through a factorial design, the factors such as drug state (solution or dispersion), nonvolatile solvent and coating material that influence the increase simvastatin (BSC II drug) apparent aqueous solubility and LS flow properties...
November 22, 2018: Colloids and Surfaces. B, Biointerfaces
Junpu Li, Shaoshen Li, Lunhui Huang, Yaqiong Cui, Tiantian She, Ying Bian, Huiqiang Li
BACKGROUND: An increase in allergen-specific IgG4 (sIgG4 ), which serves as a blocking antibody, is associated with acquisition of immune tolerance after immunotherapy. In this study, we developed a rapid, sensitive, and homogeneous immunoassay based on the light-initiated chemiluminescent assay (LICA) technology for quantifying allergen sIgG4 in serum samples. METHODS: Allergen sIgG4 was measured in vitro by incubating the sample with biotinylated allergens and chemiluminescent beads coated with anti-human IgG4 antibody, followed by the addition of streptavidin-coated sensitizer beads...
December 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Rajan K Chakrabarty, William R Heinson
Black carbon (BC) aerosol, the strongest absorber of visible solar radiation in the atmosphere, contributes to a large uncertainty in direct radiative forcing estimates. A primary reason for this uncertainty is inaccurate parametrizations of the BC mass absorption cross section (MAC_{BC}) and its enhancement factor (E_{MAC_{BC}})-resulting from internal mixing with nonrefractory and nonlight absorbing materials-in climate models. Here, applying scaling theory to numerically exact electromagnetic calculations of simulated BC particles and observational data on BC light absorption, we show that MAC_{BC} and E_{MAC_{BC}} evolve with increasing internal mixing ratios in simple power-law exponents of 1/3...
November 23, 2018: Physical Review Letters
Ya You, Andrei Dolocan, Wangda Li, Arumugam Manthiram
Undesired reactions between layered sodium transition-metal oxide cathodes and air impede their utilization in practical sodium-ion batteries. Consequently, a fundamental understanding of how layered oxide cathodes degrade in air is of paramount importance, but it has not been fully understood yet. Here a comprehensive study on a model material NaNi0.7Mn0.15Co0.15O2 reveals its reaction chemistry with air and the dynamic evolution of the degradation species upon air exposure. We find that besides the extraction of Na+ ions from the crystal lattice to form NaOH, Na2CO3, and Na2CO3•H2O in contact with air, nickel ions gradually dissolve from the bulk to form NiO and accumulate on the particle surface as revealed by sub-nanometer surface sensitive time-of-flight secondary ion mass spectroscopy...
December 5, 2018: Nano Letters
Laura C Coates, Proton Rahman, Eliofotisti Psaradellis, Emmanouil Rampakakis, Brendan Osborne, Allen J Lehman, Francois Nantel
Objectives: Treat to target recommendations for PsA state that the target of treatment should be remission or, at the very least, low disease activity. Different clinical indexes have been proposed to define these disease states including the minimal disease activity criteria and the Disease Activity Index for PsA (DAPSA) scores, which have 7 and 4-5 domains, respectively. Using a Canadian cohort, the objectives were to calculate the proportion of patients achieving these criteria, their prognostic value and the overall patient impact of these disease states...
December 4, 2018: Rheumatology
Danielle Cristina Garbuio, Cristina Mara Zamarioli, Maísa Oliveira de Melo, Patrícia Maria Berardo Gonçalves Maia Campos, Emília Campos de Carvalho, Luis Alexandre Pedro de Freitas
OBJECTIVE: to evaluate the safety of a topical formulation containing chamomile microparticles coated with chitosan in the skin of healthy participants. METHOD: phase I blind, controlled, non-randomized, single-dose clinical trial with control for skin, base formulation, and formulation with microparticles. The variables analyzed were irritation and hydration by the Wilcoxon and Kruskall-Wallis tests. RESULTS: the study started with 35 participants with a mean age of 26...
November 29, 2018: Revista Latino-americana de Enfermagem
A Liebermann, J Detzer, B Stawarczyk
OBJECTIVES: The aim of this investigation was to test the tensile bond strength (TBS) between different computer-aided-design/manufacturing (CAD/CAM) ceramics after conditioning using different universal adhesive systems and resin composite cement. METHODS AND MATERIALS: Substrates of four CAD/CAM ceramics-1) VITABLOCS Mark II, 2) Initial LRF, 3) Celtra Duo, and 4) IPS e.max CAD (N=648, n=162)-were fabricated. VITABLOCS Mark II and Initial LRF were etched using 9% hydrofluoric acid for 60 seconds, Celtra Duo for 30 seconds, and IPS e...
December 5, 2018: Operative Dentistry
Lei Zhang, Xiao Yu Tian, Cecilia K W Chan, Qianqian Bai, Chak Kwong Cheng, Francis M Chen, Maggie S H Cheung, Bohan Yin, Hongrong Yang, Wing-Yin Yung, Zhong Chen, Fei Ding, Ken Cham-Fai Leung, Chuan Zhang, Yu Huang, James Y W Lau, Chung Hang Jonathan Choi
Many nanoparticle-based carriers to atherosclerotic plaques contain peptides, lipoproteins, and sugars, yet the application of DNA-based nanostructures for targeting plaques remains infrequent. In this work, we demonstrate that DNA-coated superparamagnetic iron oxide nanoparticles (DNA-SPIONs), prepared by attaching DNA oligonucleotides to poly(ethylene glycol)-coated SPIONs (PEG-SPIONs), effectively accumulate in the macrophages of atherosclerotic plaques following an intravenous injection into apolipoprotein E knockout (ApoE-/- ) mice...
December 5, 2018: ACS Applied Materials & Interfaces
Keyi Chen, Ye Zhang, Chilin Li
Metal-polysulfide batteries are attracting broad attentions as conversion reaction systems of high theoretical energy density and low cost. However, their further applications are hindered by low loading of active species, excess conductive additive and loose (nanostructured) electrode network. Herein, we propose that compact grain stacking and surface fluorination are two crucial factors for achieving high-rate and long-life pyrite (FeS2) cathode enabled by sulfurating ionic liquid wrapped open framework fluorides...
December 5, 2018: ACS Nano
Thomas P Forbes, Jennifer R Verkouteren
The trace detection and forensic analysis of black powders and black powder substitutes, directly from wipe-based sample collections was demonstrated using infrared thermal desorption (IRTD) coupled with direct analysis in real time mass spectrometry (DART-MS). Discrete 15 s heating ramps were generated, creating a thermal desorption profile that desorbed more volatile species (e.g., organic and semivolatile inorganic compounds) at lower temperatures (250 °C to 400 °C) and nonvolatile inorganic oxidizers at high temperatures (450 °C to 550 °C)...
December 5, 2018: Analytical Chemistry
Li Zhang, Xin Gu, Chunliu Yan, Shuo Zhang, Liangjun Li, Yingjie Jin, Shanlin Zhao, Haiyan Wang, Xuebo Zhao
Carbon coated SiO2/TiO2 (SiO2/TiO2@C) nanosheets consist of TiO2 nanoparticles uniformly embedded in SiO2 matrix and carbon coating layer are fabricated by using acidified titanosilicate JDF-L1 nanosheets as template and precursor. SiO2/TiO2@C has unique structural features of sheet-like nanostructure, ultrafine TiO2 nanoparticles distributed in SiO2 matrix and carbon coating, which can expedite ion diffusion and electron transfer, and relieve volume expansion efficiently, and thus the synergetic combination of these advantages significantly enhance their Li storage capability...
December 5, 2018: ACS Applied Materials & Interfaces
Emre Cevik, Mustafa Buyukharman, Huseyin Bekir Yildiz
In this study, gold electrodes (GE) were coated with conducting polymers to obtain high photocurrent using cyanobacteria from a novel bio-electrochemical fuel cell. For this purpose, an electropolymerization process was carried out by using 4- (4H-Dithieno [3,2-b: 2 ', 3'-d] pyrrol-4-yl) aniline, 5-(4H-dithieno [3,2-b:2,'3'-d]pyrol-4-yl) naphtalene-1-amine, monomers onto the gold electrodes. After that, gold nanoparticles (AuNP) were specifically modified by 2-mercaptoethane sulfonic acid and p-aminothiophenol in order attach to the electrode surface...
December 5, 2018: Biotechnology and Bioengineering
Vy T Duong, Megha H Unhelkar, John E Kelly, Suhn H Kim, Carter T Butts, Rachel W Martin
In plants, esterase/lipases perform transesterification reactions, playing an important role in the synthesis of useful molecules, such as those comprising the waxy coatings of leaf surfaces. Plant genomes and transcriptomes have provided a wealth of data about expression patterns and the circumstances under which these enzymes are upregulated, e.g. pathogen defense and response to drought; however, predicting their functional characteristics from genomic or transcriptome data is challenging due to weak sequence conservation among the diverse members of this group...
December 5, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
V Goshchynsky, O Lugoviy, P Goshchynsky, S Lugoviy, U Lugoviy
A retrospective analysis of the results of endovascular operations on the arteries of the lower extremities was performed in 209 patients, of which 45 (21.5%) were patients with chronic ischemia of the 2nd stage, category 4, 138 (66.1%) of patients with ischemia of the lower extremities of the third stag, category 5 and 26 (12.4%) of patients with IV stage, category 6 (by classification Rutherford et al., 1997) 17, 187 men, 22 women. The average age of patients was 63.7±9.3 years. Based on clinical and angiographic data, several variants of endovascular revascularization of the lower extremities were used: the vasoballoone segmentation followed by its stenting with a self-expanding stent of Terumo Misago (Japan) or a stent of Palmas Cordis (USA), one stent or two end-to-end stents (the stenting of the artery was supplemented by vasoballoone dilatation of the segment over the stents, between stents or under stents), sub intimal angioplasty was performed under the condition of Re-Entry Outback (Cordis, USA), balloon angioplasty was used using IN cylinders...
October 2018: Georgian Medical News
Christopher D L Johnson, Debmalya Ganguly, Jonathan M Zuidema, Thomas J Cardinal, Alexis M Ziemba, Kathryn R Kearns, Simon M McCarthy, Deanna M Thompson, Ganpati Ramanath, Diana-Andra Borca-Tasciuc, Silvio Dutz, Ryan J Gilbert
Magnetic electrospun fibers are of interest to biomaterial applications that strive to provide cell guidance that can be delivered using minimally invasive techniques. Magnetic electrospun fibers can be injected then magnetically positioned in situ, and the aligned fiber scaffolds provide consistent topographical guidance to cells. We developed and tested magnetically-responsive aligned poly-L-lactic acid (PLLA) electrospun fiber scaffolds for neural applications. Incorporating oleic-acid-coated iron oxide nanoparticles significantly increased neurite outgrowth, reduced the fiber alignment, and increased the surface nanotopography of the electrospun fibers...
December 5, 2018: ACS Applied Materials & Interfaces
Paul Fassl, Simon Ternes, Vincent Lami, Yuriy Zakharko, Daniel Heimfarth, Paul Hopkinson, Fabian Paulus, Alexander Taylor, Jana Zaumseil, Yana Vaynzof
In this work, we examine the effect of microstructure on ion migration induced photoluminescence (PL) quenching in methylammonium lead iodide perovskite films. Thin films were fabricated by two methods: spin-coating, which results in randomly oriented perovskite grains, and zone-casting, which results in aligned grains. As an external bias is applied to these films, migration of ions causes a quenching of the PL signal in the vicinity of the anode. The evolution of this PL-quenched zone is less uniform in the spin-coated devices than in the zone-cast ones, suggesting that the relative orientation of the crystal grains plays a significant role in the migration of ions within polycrystalline perovskite...
December 5, 2018: ACS Applied Materials & Interfaces
Xu-Qing Wei, Xue-Peng Li, Chao-Ling Wu, Shu-Min Yi, Ke-Li Zhong, Tong Sun, Jian-Rong Li
The composite chitosan coatings were prepared and characterized to evaluate their preservation properties for silver carp fish balls, and the microstructures and physicochemical properties of the coatings were improved by in situ nano silicon oxide (SiOx) and zinc oxide/titania (ZnO/TiO2 ) nano-particles (NPs). In the chitosan coatings, when the chitosan combines with NPs by chemical bonds, the crystal lattice is slightly changed due to the modification of NPs. The chitosan coatings modified by NPs showed few cracks, among which sodium hexametaphosphate (SHMP) modified ZnO/TiO2 /SiOx-chitosan (ZTS-CS) coating is proved to be the optimal one...
December 5, 2018: Journal of Food Science
Hyunho Jung, Changhyun Han, Hanbit Kim, Kyung-Sang Cho, Young-Geun Roh, Yeonsang Park, Heonsu Jeon
We report a colloidal quantum dot (CQD) distributed feedback (DFB) laser structure containing a chirped grating. The device exhibits single-mode DFB lasing, of which the wavelength is spatially dispersed in a single chip. A period-chirped surface grating is fabricated using a modified Lloyd-type laser interference lithography setup, where a flat Lloyd's mirror is replaced with a concave one. A dense red-emitting CdSe/CdS/ZnS CQD film is prepared on a temporary substrate by spin-coating, which is subsequently released and wet-transferred onto a period-chirped quartz surface grating...
December 5, 2018: Nanoscale
Sanaz Panahandeh, Siyu Li, Roya Zandi
Understanding how highly symmetric, robust, monodisperse protein nano-cages self-assemble can have major applications in various areas of bio-nanotechnology, such as drug delivery, biomedical imaging and gene therapy. We develop a model to investigate the assembly of protein subunits into the structures with different sizes and symmetries. Using Monte Carlo simulation, we obtain global minimum energy structures. Our results suggest that the physical properties including the spontaneous curvature, flexibility and bending rigidity of coat proteins are sufficient to predict the size, symmetry and shape selectivity of the assembly products...
December 5, 2018: Nanoscale
Haochen Si, Li Sun, Yu Zhang, Yuanxing Zhang, Liqi Bai, Yihe Zhang
A carbon-coated molybdenum dioxide-reduced graphene oxide (RGO@MoO2/C) composite was synthesized as a high-performance electrode for supercapacitors via a facile hydrothermal method. In this composite, RGO not only provided high conductivity to benefit effective electron transfer, but also offered nucleation sites to load in situ formed MoO2/C nanoparticles. The MoO2@C nanoparticles interconnected with each other forming nanoclusters and were anchored uniformly on RGO sheets instead of self-agglomerating into large aggregates...
December 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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