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https://www.readbyqxmd.com/read/27913563/-you-can-t-be-a-person-and-a-doctor-the-work-life-balance-of-doctors-in-training-a-qualitative-study
#1
Antonia Rich, Rowena Viney, Sarah Needleman, Ann Griffin, Katherine Woolf
OBJECTIVES: Investigate the work-life balance of doctors in training in the UK from the perspectives of trainers and trainees. DESIGN: Qualitative semistructured focus groups and interviews with trainees and trainers. SETTING: Postgraduate medical training in London, Yorkshire and Humber, Kent, Surrey and Sussex, and Wales during the junior doctor contract dispute at the end of 2015. Part of a larger General Medical Council study about the fairness of postgraduate medical training...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27912012/coast-wide-recruitment-dynamics-of-olympia-oysters-reveal-limited-synchrony-and-multiple-predictors-of-failure
#2
Kerstin Wasson, Brent B Hughes, John S Berriman, Andrew L Chang, Anna K Deck, Paul A Dinnel, Charlie Endris, Michael Espinoza, Sarah Dudas, Matthew C Ferner, Edwin D Grosholz, David Kimbro, Jennifer L Ruesink, Alan C Trimble, Dick Vander Schaaf, Chela J Zabin, Danielle C Zacherl
Recruitment of new propagules into a population can be a critical determinant of adult density. We examined recruitment dynamics in the Olympia oyster (Ostrea lurida), a species occurring almost entirely in estuaries. We investigated spatial scales of interannual synchrony across 37 sites in eight estuaries along 2,500 km of Pacific North American coastline, predicting that high vs. low recruitment years would coincide among neighboring estuaries due to shared exposure to regional oceanographic factors. Such synchrony in recruitment has been found for many marine species and some migratory estuarine species, but has never been examined across estuaries in a species that can complete its entire life cycle within the same estuary...
December 2016: Ecology
https://www.readbyqxmd.com/read/27882819/cross-cultural-adaptation-of-the-assistive-technology-device-predisposition-assessment-atd-pa-for-use-in-brazil-atd-pa-br
#3
Ana Cristina de Jesus Alves, Thelma Simões Matsukura, Marcia J Scherer
PURPOSE: The purpose of this study is to conduct a cross-cultural adaptation of the Assistive Technology Device Predisposition Assessment (ATD PA) for use in Brazil. METHOD: The selection of the Assistive Technology Device Predisposition Assessment (ATD PA) was determined by previous literature reviews of articles published in 2014 and 2016 in six databases with the terms "assistive device" or "assistive technology" or "self-help device" combined with "evidence-based practice" or "framework" or "measurement scale" or "model and outcome assessment"...
November 24, 2016: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/27881055/patents-in-nanobiotechnology-a-cross-jurisdictional-approach
#4
Padmavati Manchikanti, Shailaja Gnaneshwar, B Ramesh Kumar
BACKGROUND: Bio nanomaterials create new opportunities for advancing medical sciences and diseases treatment in relation to human health care. Innovations in the use of such nanomaterials and nanodevices can lead to significant improvements in the use of drugs/devices. OBJECTIVE: The present study attempts to analyse patenting trends in different areas and compare the patentability criteria and the disclosure norms for nanobiotechnology inventions in countries such as US, EU and India in the field of diagnostics and therapeutics...
November 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27875311/single-binding-mode-integration-of-hemicellulose-degrading-enzymes-via-adaptor-scaffoldins-in-ruminococcus-flavefaciens-cellulosome
#5
Pedro Bule, Victor Diogo Alves, André Leitão, Luis M A Ferreira, Edward A Bayer, Steven P Smith, Harry J Gilbert, Shabir Najmudin, Carlos M G A Fontes
The assembly of one of Nature most elaborate multi-enzyme complexes, the cellulosome, results from the binding of enzyme-borne dockerins to reiterated cohesin domains located in a non-catalytic primary scaffoldin. Generally, dockerins present two similar cohesin binding interfaces that support a dual binding mode. The dynamic integration of enzymes in cellulosomes, afforded by the dual binding mode, is believed to incorporate additional flexibility in highly populated multi-enzyme complexes. Ruminococcus flavefaciens, the primary degrader of plant structural carbohydrates in the rumen of mammals, uses a portfolio of more than 220 different enzymes to assemble the most intricate cellulosome known to date...
November 14, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27872795/heterogeneous-autoregressive-model-with-structural-break-using-nearest-neighbor-truncation-volatility-estimators-for-dax
#6
Wen Cheong Chin, Min Cherng Lee, Grace Lee Ching Yap
High frequency financial data modelling has become one of the important research areas in the field of financial econometrics. However, the possible structural break in volatile financial time series often trigger inconsistency issue in volatility estimation. In this study, we propose a structural break heavy-tailed heterogeneous autoregressive (HAR) volatility econometric model with the enhancement of jump-robust estimators. The breakpoints in the volatility are captured by dummy variables after the detection by Bai-Perron sequential multi breakpoints procedure...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27869291/managing-innovation-to-maximize-value-along-the-discovery-translation-application-continuum
#7
S A Waldman, A Terzic
Success in pharmaceutical development led to a record 51 drugs approved in the past year, surpassing every previous year since 1950. Technology innovation enabled identification and exploitation of increasingly precise disease targets ensuring next generation diagnostic and therapeutic products for patient management. The expanding biopharmaceutical portfolio stands, however, in contradistinction to the unsustainable costs that reflect remarkable challenges of clinical development programs. This annual Therapeutic Innovations issue juxtaposes advances in translating molecular breakthroughs into transformative therapies with essential considerations for lowering attrition and improving the cost-effectiveness of the drug-development paradigm...
November 21, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27862002/distributed-data-networks-a-blueprint-for-big-data-sharing-and-healthcare-analytics
#8
Jennifer R Popovic
This paper defines the attributes of distributed data networks and outlines the data and analytic infrastructure needed to build and maintain a successful network. We use examples from one successful implementation of a large-scale, multisite, healthcare-related distributed data network, the U.S. Food and Drug Administration-sponsored Sentinel Initiative. Analytic infrastructure-development concepts are discussed from the perspective of promoting six pillars of analytic infrastructure: consistency, reusability, flexibility, scalability, transparency, and reproducibility...
November 18, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27857144/interplay-between-past-market-correlation-structure-changes-and-future-volatility-outbursts
#9
Nicoló Musmeci, Tomaso Aste, T Di Matteo
We report significant relations between past changes in the market correlation structure and future changes in the market volatility. This relation is made evident by using a measure of "correlation structure persistence" on correlation-based information filtering networks that quantifies the rate of change of the market dependence structure. We also measured changes in the correlation structure by means of a "metacorrelation" that measures a lagged correlation between correlation matrices computed over different time windows...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853396/development-of-training-related-health-care-software-by-a-team-of-clinical-educators-their-experience-from-conception-to-piloting
#10
Derfel Ap Dafydd, Ruth Williamson, Philip Blunt, Dominic M Blunt
The difficulties of producing useful, bespoke, and affordable information technology systems for large health care organizations are well publicized, following several high-profile endeavors in the UK. This article describes the experience of a small group of clinical radiologists and their collaborators in producing an information technology system - from conception to piloting. This system, called Trainee Tracker, enables automated target date recalculation of trainee milestones, depending on their work patterns and other individual circumstances...
2016: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/27846288/international-collaboration-and-spatial-dynamics-of-us-patenting-in-central-and-eastern-europe-1981-2010
#11
Balázs Lengyel, Mariann Leskó
How did post-socialist transition and a parallel shift in international labor division restructure regional innovation systems in Central and Eastern Europe? This question is increasingly important, because current EU innovation policy is combined with regional development in Smart Specialization Strategies; however, spatial trends of innovation in Central and Eastern Europe are not fully understood which might lead to less than perfectly efficient policy. In this paper we describe the spatial dynamics of inventor activity in the Czech Republic, Hungary, Poland and Slovakia between 1981 and 2010 -a period that covers both the late socialist era and the post-socialist transition...
2016: PloS One
https://www.readbyqxmd.com/read/27846229/microrna-expression-for-early-prediction-of-late-occurring-hematologic-acute-radiation-syndrome-in-baboons
#12
Matthias Port, Francis Herodin, Marco Valente, Michel Drouet, Reinhard Ullmann, Sven Doucha-Senf, Andreas Lamkowski, Matthäus Majewski, Michael Abend
For effective medical management of radiation-exposed persons after a radiological/nuclear event, blood-based screening measures in the first few days that could predict hematologic acute radiation syndrome (HARS) are needed. For HARS severity prediction, we used microRNA (miRNA) expression changes measured on days one and two after irradiation in a baboon model. Eighteen baboons underwent different patterns of partial or total body irradiation, corresponding to an equivalent dose of 2.5 or 5 Gy. According to changes in blood cell counts (BCC) the surviving baboons (n = 17) exhibited mild (H1-2, n = 4) or more severe (H2-3, n = 13) HARS...
2016: PloS One
https://www.readbyqxmd.com/read/27842786/toxicology-in-addiction-medicine
#13
REVIEW
Daniel A Schwarz, M P George, Martin H Bluth
Toxicology testing in addiction medicine varies across the spectrum, yet remains a powerful tool in monitoring addictive patients. There are many reference laboratories offering toxicology testing, and physicians should have some understanding of laboratory, methodology, testing portfolio, and customer support structure to aid them in selecting the best toxicology laboratory for their patients. Consultation with a clinical pathologist/toxicologist in conjunction with the consideration of monitoring large numbers of illicit and psychoactive drugs in the addictive patient may provide important clinical information for their treatment...
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27836564/defining-adaptation-measures-collaboratively-a-participatory-approach-in-the-do%C3%A3-ana-socio-ecological-system-spain
#14
Lucia De Stefano, Nuria Hernández-Mora, Ana Iglesias, Berta Sánchez
The uncertainty associated with the definition of strategies for climate change adaptation poses a challenge that cannot be faced by science alone. We present a participatory experience where, instead of having science defining solutions and eliciting stakeholders' feedback, local actors actually drove the process. While principles and methods of the approach are easily adaptable to different local contexts, this paper shows the contribution of participatory dynamics to the design of adaptation measures in the biodiversity-rich socio-ecological region surrounding the Doñana wetlands (Southern Spain)...
November 8, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27836530/the-effect-of-state-competitive-food-and-beverage-regulations-on-childhood-overweight-and-obesity
#15
Ashlesha Datar, Nancy Nicosia
PURPOSE: Policy efforts for combating childhood obesity have sought stronger state policies for regulating competitive foods and beverages (CF&Bs) available in schools. However, the evidence linking state policies to children's overall diet and body weight outcomes is limited and mixed, and experts have called for more rigorous studies that are able to address concerns about selection bias. The present study leverages a rare natural experiment where children in military families are "assigned" to different state policies, due to their military parent's periodic relocation, to examine whether state CF&B policies were associated with children's body mass index (BMI) and overweight or obesity...
November 8, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27828682/innovation-and-communicative-action-health-management-networks-and-technologies
#16
Francisco Javier Uribe Rivera, Elizabeth Artmann
This article discusses elements of a theory of innovation from the perspective of innovation networks and social construction of technology, based on Habermas' Theory of Communicative Action and authors from the Sociology of Innovation. Based on the theoretical framework of the communicative production of scientific facts, we focus on innovation management as a basic dimension that must meet some organizational and methodological requirements in order to power its results. We present and discuss instruments such as Situational Planning, Prospective Analysis, Strategic Portfolio Management, and Networks Management that can help deal with the challenge of innovation and exploration of the future...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27820786/self-directed-learning-in-physician-assistant-education-learning-portfolios-in-physician-assistant-programs
#17
Jeremy H Neal, Laura D M Neal
Self-directed learning (SDL) portfolios are underused in the educational process and should be considered by physician assistant (PA) programs. Clinicians such as PAs are responsible for self-identifying their learning needs, competencies, and ongoing educational requirements. This article introduces an outline for SDL in the PA profession, for direct use by learners and indirect use by educators. Without a plan, many professionals may lack the insight, motivation, and knowledge needed to improve their skill set and establish goals for individual lifelong learning...
December 2016: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/27818569/robust-inference-of-risks-of-large-portfolios
#18
Jianqing Fan, Fang Han, Han Liu, Byron Vickers
We propose a bootstrap-based robust high-confidence level upper bound (Robust H-CLUB) for assessing the risks of large portfolios. The proposed approach exploits rank-based and quantile-based estimators, and can be viewed as a robust extension of the H-CLUB procedure (Fan et al., 2015). Such an extension allows us to handle possibly misspecified models and heavy-tailed data, which are stylized features in financial returns. Under mixing conditions, we analyze the proposed approach and demonstrate its advantage over H-CLUB...
October 2016: Journal of Econometrics
https://www.readbyqxmd.com/read/27816862/the-utility-and-impact-of-information-communication-technology-ict-for-pre-registration-nurse-education-a-narrative-synthesis-systematic-review
#19
REVIEW
Lucy Webb, Jonathan Clough, Declan O'Reilly, Danita Wilmott, Gary Witham
OBJECTIVES: To evaluate and summarise the utility and impact of information communication technology (ICT) in enhancing student performance and the learning environment in pre-registration nursing. DESIGN: A systematic review of empirical research across a range of themes in ICT health-related education. DATA SOURCES: Science Direct, Cinahl, AMED, MEDLINE, PubMed, ASSIA, OVID and OVID SP (2008-2014). Further date parameters were imposed by theme...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27813044/-application-of-the-objective-structured-clinical-examination-osce-in-german-medical-schools-an-inventory
#20
S Müller, U Dahmen, U Settmacher
Introduction: The German medical licensing regulations, as amended by the government in 2002, now require the assessment of clinical skills in undergraduate medical education. As a result, the Objective Structured Clinical Examination (OSCE) was introduced as an assessment tool in many medical schools. This article provides a detailed inventory of the current application of the OSCE assessment in Germany. Methods: From June to September 2015, the implementation of the OSCE in all 36 German medical schools was investigated using semi-structured telephone interviews and email correspondence...
November 3, 2016: Das Gesundheitswesen
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