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https://www.readbyqxmd.com/read/28924686/psychosocial-impact-of-personalized-therapies-in-oncology
#1
Georgia Schilling, Frank Schulz-Kindermann
Personalized medicine is a keyword in modern oncology summarizing biomarker-driven targeted therapies. Those novel agents enhance our therapeutic portfolio and offer new options for our patients. But the term is often misleading and implicates a tailored therapy to the individual person, but it rather means a treatment stratified on genetic characteristics of the tumor. Molecular therapies raise expectations of curability or long-term treatments making former life-threatening diseases to more chronic ones but this is true only for some patients...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28922583/reluctant-entrepreneurs-musicians-and-entrepreneurship-in-the-new-music-industry
#2
Jo Haynes, Lee Marshall
Changing labour conditions in the creative industries - with celebrations of autonomy and entrepreneurialism intertwined with increasing job insecurity, portfolio careers and short-term, project-based contracts - are often interpreted as heralding changes to employment relations more broadly. The position of musicians' labour in relation to these changes is unclear, however, given that these kinds of conditions have defined musicians' working practices over much longer periods of time (though they may have intensified due to well-documented changes to the music industry brought about by digitization and disintermediation)...
September 18, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28920495/twelve-tips-on-how-to-compile-a-medical-educator-s-portfolio
#3
Claudia Lucy Dalton, Anthony Wilson, Steven Agius
Medical education is an expanding area of specialist interest for medical professionals. Whilst most doctors will be familiar with the compilation of clinical portfolios for scrutiny of their clinical practice and provision of public accountability, teaching portfolios used specifically to gather and demonstrate medical education activity remain uncommon in many non-academic settings. For aspiring and early career medical educators in particular, their value should not be underestimated. Such a medical educator's portfolio (MEP) is a unique compendium of evidence that is invaluable for appraisal, revalidation, and promotion...
September 17, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28912453/measuring-critical-transitions-in-financial-markets
#4
Jan Jurczyk, Thorsten Rehberg, Alexander Eckrot, Ingo Morgenstern
Tipping points in complex systems are structural transitions from one state to another. In financial markets these critical points are connected to systemic risks, which have led to financial crisis in the past. Due to this, researchers are studying tipping points with different methods. This paper introduces a new method which bridges the gap between real-world portfolio management and statistical facts in financial markets in order to give more insight into the mechanics of financial markets.
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911919/andrew-bush-a-broad-portfolio-in-paediatric-respirology
#5
Geoff Watts
No abstract text is available yet for this article.
September 11, 2017: Lancet
https://www.readbyqxmd.com/read/28910800/the-place-of-large-pore-membranes-in-the-treatment-portfolio-of-patients-on-hemodialysis
#6
Wim Van Biesen, Raymond Vanholder, Eva Schepers, Griet Glorieux, Annemieke Dhondt, Sunny Eloot
Cardiovascular disease is a major concern in patients with end-stage kidney disease (ESKD). Inflammation induced by retention of uremic toxins, of which a substantial fraction has a molecular weight in the middle molecular range, has been associated with increased cardiovascular risk. In an attempt to reduce inflammation and thus cardiovascular toxicity in patients with ESKD, hemodiafiltration (HDF) has been promoted to enhance the clearance of middle molecular weight substances during dialysis. However, HDF increases the technical complexity and costs, and requires ultrapure dialysis fluid...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28901856/recent-patents-and-emerging-therapeutics-on-ocular-inflammation-and-allergy
#7
Vibhuti Francisco Agrahari, Zach Aulgur, Siddhant Thukral, Nikhil Dhall, Ryan Conely, Ashim K Mitra
BACKGROUND: Ocular inflammation and allergic eye diseases range from mild to severe may disturbs visual function and affects quality of life. Since these diseases require intensive therapies, the pathophysiology and treatments of these conditions are highlighted. OBJECTIVE: The ocular diseases caused by inflammation and allergy are extensively studied in this review to provide an overview of the newer compounds, novel delivery approaches, preclinical and clinical trials for treatment of the allergic conjunctivitis, dry eye syndrome, and uveitis...
September 11, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28882136/lessons-learned-on-recruitment-and-retention-in-hard-to-reach-families-in-a-phase-iii-randomised-controlled-trial-of-preparatory-information-for-children-undergoing-general-anaesthesia
#8
C Huntington, J Timothy Newton, N Donaldson, C Liossi, P A Reynolds, R Alharatani, M T Hosey
BACKGROUND: Recruitment and retention are documented as two of the most difficult elements of conducting clinical trials. These issues are even more challenging in paediatric trials, particularly when the families being recruited and retained are deemed 'hard to reach'. METHODS: Through the authors' own reflection on the conduct of the trial this paper examines recruitment and retention with hard to reach families from the perspective of a recently completed clinical trial on preparatory information for children undergoing general anaesthesia for tooth extractions in which approximately 83% of those approached and eligible agreed to participate...
September 7, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28881159/patent-trend-and-competitive-analysis-of-cancer-immunotherapy-in-the-united-states
#9
Chia-Lin Pan, Feng-Chi Chen
Immunotherapy has brought high hopes for cancer treatment, and attracted tremendous resources from the biopharmaceutical community. Here we analyze cancer immunotherapy-related patents granted by the United States Patent and Trademark Office in the past decade (2006-2016). A total of 2,229 patents were identified in 13 subfields. The growth of patent number in this field has outpaced the background rate, with cytokine-related therapies, immune checkpoint inhibitors, and natural killer cell therapies growing the most rapidly...
September 7, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28877900/gilead-buying-kite-for-11-9-billion
#10
(no author information available yet)
Gilead Sciences will buy Kite Pharma-and its autologous CAR T-cell technology-for $11.9 billion. The acquisition will help Gilead build its oncology portfolio and boost its revenues.
September 6, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28875580/silver-sulfur-hybrid-supertetrahedral-clusters-the-hitherto-missing-members-in-the-metal-chalcogenide-tetrahedral-clusters
#11
Geng-Geng Luo, Hai-Feng Su, An Xiao, Zhi Wang, Yang Zhao, Qiaoyu Wu, Jihuai Wu, Di Sun, Lansun Zheng
The synthesis of Group 11 metal chalcogenide supertetrahedral clusters (SCs) still remains a great challenge mainly due to the high tendency of metal aggregation through metallophilicity and global charge balance. Demonstrated herein are the preparation, crystallographic characterization and optical properties of two stable silver-sulfur SCs via ligand-control, one as discrete zero-dimensional (0D) V3,4-type cluster and the other as one-dimensional (1D) zigzag chain extended by alternating V3,2-type clusters...
September 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28867288/geography-of-genetics-and-genomics-research-funding-in-africa
#12
Eric Coles, George A Mensah
An estimated U.S. $300 billion is spent each year on medical research. What proportion of this goes to genomics and genetics research in Africa? Until recently, this type of question was nearly impossible to answer. The World RePORT database, sponsored by the Heads of International Research Organizations (HIRO) and managed by the National Institutes of Health (NIH), provides a first attempt at answering questions on the distribution of research funding by geography and research organization. In this journal issue on the Human Heredity and Health in Africa (H3Africa), we explore the geography of biomedical research funding in the genomics field with special emphasis on Africa...
June 2017: Global Heart
https://www.readbyqxmd.com/read/28863173/portfolio-optimization-for-seed-selection-in-diverse-weather-scenarios
#13
Oskar Marko, Sanja Brdar, Marko Panić, Isidora Šašić, Danica Despotović, Milivoje Knežević, Vladimir Crnojević
The aim of this work was to develop a method for selection of optimal soybean varieties for the American Midwest using data analytics. We extracted the knowledge about 174 varieties from the dataset, which contained information about weather, soil, yield and regional statistical parameters. Next, we predicted the yield of each variety in each of 6,490 observed subregions of the Midwest. Furthermore, yield was predicted for all the possible weather scenarios approximated by 15 historical weather instances contained in the dataset...
2017: PloS One
https://www.readbyqxmd.com/read/28862111/how-can-we-improve-education-of-breast-surgeons-across-europe
#14
Agnieszka Kolacinska
The proposed global curriculum developed by the American Society of Surgical Oncology (SSO) and the European Society of Surgical Oncology (ESSO) and the textbook: provides a state-of- the- art of breast cancer surgery, complements the syllabus and curriculum of the Union Europeenne des Medecins Specialistes (UEMS) examination in breast surgery/ European Board of Surgery Qualification in Breast Surgery (EBSQinBS) administered by ESSO (1) Knowledge and understanding of the principles of breast cancer incidence, aetiology, risk factors, genetics, premalignant and high-risk lesions, pathology, prognostic and predictive factors, risk prediction models, screening, diagnosis and imaging, breast cancer, oncoplastic, reconstructive breast surgery, axillary surgery and future perspective for this, radiation therapy, neoadjuvant and adjuvant systemic treatment- endocrine-, immuno- and chemotherapy, side effects and toxicities of treatment, locoregional recurrence, follow-up, locally advanced breast cancer, metastatic breast cancer, breast cancer in young and elderly patients, survivor issues, lymphedema, palliative care, chroni pain, body image and sexuality, fertility issues, cognitive functions, etc...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28860689/an-optimal-consumption-and-investment-problem-with-quadratic-utility-and-negative-wealth-constraints
#15
Kum-Hwan Roh, Ji Yeoun Kim, Yong Hyun Shin
In this paper, we investigate the optimal consumption and portfolio selection problem with negative wealth constraints for an economic agent who has a quadratic utility function of consumption and receives a constant labor income. Due to the property of the quadratic utility function, we separate our problem into two cases and derive the closed-form solutions for each case. We also illustrate some numerical implications of the optimal consumption and portfolio.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28860290/the-clinical-research-network-get-involved-and-expand-your-portfolio
#16
Claire Gilbert, Margaret Ikpoh
No abstract text is available yet for this article.
September 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28858351/controlled-droplet-microfluidic-systems-for-multistep-chemical-and-biological-assays
#17
T S Kaminski, P Garstecki
Droplet microfluidics is a relatively new and rapidly evolving field of science focused on studying the hydrodynamics and properties of biphasic flows at the microscale, and on the development of systems for practical applications in chemistry, biology and materials science. Microdroplets present several unique characteristics of interest to a broader research community. The main distinguishing features include (i) large numbers of isolated compartments of tiny volumes that are ideal for single cell or single molecule assays, (ii) rapid mixing and negligible thermal inertia that all provide excellent control over reaction conditions, and (iii) the presence of two immiscible liquids and the interface between them that enables new or exotic processes (the synthesis of new functional materials and structures that are otherwise difficult to obtain, studies of the functions and properties of lipid and polymer membranes and execution of reactions at liquid-liquid interfaces)...
August 31, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28854942/the-biology-of-hepatocellular-carcinoma-implications-for-genomic-and-immune-therapies
#18
REVIEW
Galina Khemlina, Sadakatsu Ikeda, Razelle Kurzrock
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a leading cause of cancer-related death worldwide. It is highly refractory to most systemic therapies. Recently, significant progress has been made in uncovering genomic alterations in HCC, including potentially targetable aberrations. The most common molecular anomalies in this malignancy are mutations in the TERT promoter, TP53, CTNNB1, AXIN1, ARID1A, CDKN2A and CCND1 genes. PTEN loss at the protein level is also frequent. Genomic portfolios stratify by risk factors as follows: (i) CTNNB1 with alcoholic cirrhosis; and (ii) TP53 with hepatitis B virus-induced cirrhosis...
August 30, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28853373/using-bibliometrics-to-support-revalidation-requirements
#19
David Charles Benton
Bibliometrics is a method of statistically analysing written works, including books and journal articles. It can be used to measure an academic article's value, the importance of individual authors or academic research, and the productivity of authors, institutions or departments. Aim To explore how bibliometrics can assist nurse academics in providing documented evidence to meet the Nursing and Midwifery Council's (NMC's) revalidation requirements. Method The author's publication history was used to demonstrate how nurse academics can use bibliometrics to provide evidence of their continuing professional development (CPD)...
August 30, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28852501/is-any-job-better-than-no-job-at-all-studying-the-relations-between-employment-types-unemployment-and-subjective-health-in-belgium
#20
Karen Van Aerden, Sylvie Gadeyne, Christophe Vanroelen
BACKGROUND: This study focuses on the health impact of the labour market position, since recent research indicates that exposure to both unemployment and precarious employment causes serious harm to people's health and well-being. An overview of general and mental health associations of different labour market positions in Belgium is provided. A distinction is made between employment and unemployment and in addition between different types of jobs among the employed, taking into account the quality of employment...
2017: Archives of Public Health, Archives Belges de Santé Publique
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