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https://www.readbyqxmd.com/read/28803630/evaluation-of-the-training-capacity-of-the-spanish-resident-book-of-otolaryngology-formir-as-an-electronic-portfolio
#1
Juan Manuel Maza Solano, Gustavo Benavente Bermudo, Francisco José Estrada Molina, Jesús Ambrosiani Fernández, Serafín Sánchez Gómez
BACKGROUND: and objectives We have evaluated the training capacity of the Spanish resident training book as an electronic portfolio to achieve the learning objectives of otorhinolaryngology (ENT) residents. METHODS: A multi-method qualitative investigation with transversal characteristics, temporal and retrospective guidance was performed on Spanish ENT residents using a structured questionnaire, a semi-structured interview, and a computer application on the FORMIR website...
August 10, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28792547/phenothiazine-linked-nucleosides-and-nucleotides-for-redox-labelling-of-dna
#2
Anna Simonova, Luděk Havran, Radek Pohl, Miroslav Fojta, Michal Hocek
Nucleosides and 2'-deoxyribonucleoside triphosphates (dNTPs) bearing phenothiazine (PT) attached to a nucleobase (cytosine or 7-deazaadenine) either directly or through an acetylene linker were prepared through Suzuki or Sonogashira cross-coupling and triphosphorylation, and were studied as building blocks for polymerase construction of modified DNA. The directly PT-substituted dNTPs were better substrates for polymerases than the alkyne-linked dNTPs but all of them were used in enzymatic synthesis of DNA using primer extension, nicking enzyme amplification, PCR or 3'-tail labelling by terminal deoxynucleotidyl transferase...
August 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28771776/developing-and-rewarding-teachers-as-educators-and-scholars-remarkable-progress-and-daunting-challenges
#3
David M Irby, Patricia S O'Sullivan
CONTEXT: This article describes the scholarly work that has addressed the fifth recommendation of the 1988 World Conference on Medical Education: 'Train teachers as educators, not content experts alone, and reward excellence in this field as fully as excellence in biomedical research or clinical practice'. PROGRESS: Over the past 30 years, scholars have defined the preparation needed for teaching and other educator roles, and created faculty development delivery systems to train teachers as educators...
August 3, 2017: Medical Education
https://www.readbyqxmd.com/read/28771514/sign-realized-jump-risk-and-the-cross-section-of-stock-returns-evidence-from-china-s-stock-market
#4
Youcong Chao, Xiaoqun Liu, Shijun Guo
Using 5-minute high frequency data from the Chinese stock market, we employ a non-parametric method to estimate Fama-French portfolio realized jumps and investigate whether the estimated positive, negative and sign realized jumps could forecast or explain the cross-sectional stock returns. The Fama-MacBeth regression results show that not only have the realized jump components and the continuous volatility been compensated with risk premium, but also that the negative jump risk, the positive jump risk and the sign jump risk, to some extent, could explain the return of the stock portfolios...
2017: PloS One
https://www.readbyqxmd.com/read/28765104/a-technological-innovation-to-reduce-prescribing-errors-based-on-implementation-intentions-the-acceptability-and-feasibility-of-myprescribe
#5
Chris Keyworth, Jo Hart, Hong Thoong, Jane Ferguson, Mary Tully
BACKGROUND: Although prescribing of medication in hospitals is rarely an error-free process, prescribers receive little feedback on their mistakes and ways to change future practices. Audit and feedback interventions may be an effective approach to modifying the clinical practice of health professionals, but these may pose logistical challenges when used in hospitals. Moreover, such interventions are often labor intensive. Consequently, there is a need to develop effective and innovative interventions to overcome these challenges and to improve the delivery of feedback on prescribing...
August 1, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28762988/defining-scholarship-in-physician-assistant-education
#6
Deborah A Opacic, Elizabeth Roessler
The goal of educational scholarship is to establish evidence that identifies excellence in teaching, curriculum design, student assessment, mentoring, advising, leadership, and administration. Our challenge as faculty is to determine what best defines this within our profession. Responsibilities of physician assistant (PA) educators include not only increasing evidence supporting quality in PA education but also outlining strategies that lead us to this success. As innovative scholars, we should focus on expanding the definition of educational scholarship by reevaluating criteria that define it...
July 28, 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28761888/program-evaluation-of-an-integrated-basic-science-medical-curriculum-in-shiraz-medical-school-using-cipp-evaluation-model
#7
Azadeh Rooholamini, Mitra Amini, Leila Bazrafkan, Mohammad Reza Dehghani, Zohreh Esmaeilzadeh, Parisa Nabeiei, Rita Rezaee, Javad Kojuri
INTRODUCTION: In recent years curriculum reform and integration was done in many medical schools. The integrated curriculum is a popular concept all over the world. In Shiraz medical school, the reform was initiated by stablishing the horizontal basic science integration model and Early Clinical Exposure (ECE) for undergraduate medical education. The purpose of this study was to provide the required data for the program evaluation of this curriculum for undergraduate medical students, using CIPP program evaluation model...
July 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28761071/phosphopredict-a-bioinformatics-tool-for-prediction-of-human-kinase-specific-phosphorylation-substrates-and-sites-by-integrating-heterogeneous-feature-selection
#8
Jiangning Song, Huilin Wang, Jiawei Wang, André Leier, Tatiana Marquez-Lago, Bingjiao Yang, Ziding Zhang, Tatsuya Akutsu, Geoffrey I Webb, Roger J Daly
Protein phosphorylation is a major form of post-translational modification (PTM) that regulates diverse cellular processes. In silico methods for phosphorylation site prediction can provide a useful and complementary strategy for complete phosphoproteome annotation. Here, we present a novel bioinformatics tool, PhosphoPredict, that combines protein sequence and functional features to predict kinase-specific substrates and their associated phosphorylation sites for 12 human kinases and kinase families, including ATM, CDKs, GSK-3, MAPKs, PKA, PKB, PKC, and SRC...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28755542/towards-an-evidence-based-approach-for-the-development-of-adjuvanted-vaccines
#9
REVIEW
Derek T O'Hagan, Leonard R Friedland, Emmanuel Hanon, Arnaud M Didierlaurent
In the last two decades, several vaccines formulated with a new generation of adjuvants have been licensed or approved to target diseases such as influenza, hepatitis B, cervical cancer, and malaria. These new generation adjuvants appear to work by delivering a localized activation signal to the innate immune system, which in turn promotes antigen-specific adaptive immunity. Advances in understanding of the innate immune system together with high-throughput discovery of synthetic immune potentiators are now expanding the portfolio of new generation adjuvants available for evaluation...
July 26, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28754742/learning-to-teach
#10
(no author information available yet)
In the third year of her PhD at Cambridge, Myfanwy Hill dipped into her skills toolbox to see what competences she has and what she still needs. So, with one eye on the newly fashionable 'portfolio career', and one eye on the unachieved goals on her bucket list, she signed up to teach undergraduate veterinary and medical students.
July 29, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28746331/need-of-the-ministry-of-health-in-federal-democratic-republic-of-nepal
#11
K Regmi, M Upadhyay, E Tarin, P B Chand, S R Uprety, S C Lekhak
The constitution of Nepal provides appointing a council of ministers both at federal and provincial levels without defining portfolios. There is a political agreement that MOH will be retained at the federal level. This article draws evidences around the world to meet health needs of Nepalese, the role of provincial ministry of health and coordinating structure at district/local level. The constitution emphasises on health and pronounced in 46 articles which provides guidance for the creation of federalized governance levels at federal, provincial and local levels...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28746240/-does-the-organization-of-plastic-surgery-units-into-independent-departments-affect-academic-productivity
#12
Scott N Loewenstein, Stephen Duquette, Nakul Valsangkar, Umakanth Avula, Neha Lad, Juan Socas, Roberto L Flores, Rajiv Sood, Leonidas G Koniaris
BACKGROUND: There is an increased push for plastic surgery units in the United States to become independent departments administered autonomously rather than as divisions of a multispecialty surgery department. The purpose of this research was to determine if there are any quantifiable differences in the academic performance of departments versus divisions. METHODS: Using a list of the plastic surgery units affiliated with The American Council of Academic Plastic Surgeons (ACAPS), unit websites were queried for departmental status and to obtain a list of affiliated faculty...
July 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28734487/clinical-nurse-preceptors-perception-of-e-portfolio-use-for-undergraduate-students
#13
Chi-Ping Chang, Ting-Ting Lee, Mary Etta Mills
Nursing schools and hospitals form partnerships to foster nursing education. Clinical nurse preceptors (CNPs) have a profound influence on nursing students' Last Mile practicum. Assisting preceptors to prepare students as future staff nurses has become a critical issue. E-portfolios utilize digital access and hyperlinks to integrate student knowledge, skills, and achievements with teaching assessment, process and evaluation. Based on the school-hospital partnership, preceptors require a teaching application to facilitate student learning...
July 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28730936/an-industry-update-what-is-the-latest-news-in-therapeutic-delivery
#14
Iain Simpson
This Industry Update covers the period from 1 through 30 April 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. Biogen expanded its portfolio of developmental drugs targeting neurological diseases by licensing a drug from Bristol-Myers Squibb which is currently under investigation for the treatment of progressive supranuclear palsy. Takeda announced a deal with NuBiyota focused on developing treatments for gastrointestinal disorders, based on the manipulation of microbes living in the gut...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28729406/tumor-evolution-as-a-therapeutic-target
#15
REVIEW
Nabil Amirouchene-Angelozzi, Charles Swanton, Alberto Bardelli
Recent technological advances in the field of molecular diagnostics (including blood-based tumor genotyping) allow the measurement of clonal evolution in patients with cancer, thus adding a new dimension to precision medicine: time. The translation of this new knowledge into clinical benefit implies rethinking therapeutic strategies. In essence, it means considering as a target not only individual oncogenes but also the evolving nature of human tumors. Here, we analyze the limitations of targeted therapies and propose approaches for treatment within an evolutionary framework...
July 20, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28727487/improving-care-with-a-portfolio-of-physician-led-cancer-quality-measures-at-an-academic-center
#16
Julie Bryar Porter, Eben Lloyd Rosenthal, Marcy Winget, Andrea Segura Smith, Sridhar Belavadi Seshadri, Yohan Vetteth, Eileen F Kiamanesh, Amogh Badwe, Ranjana H Advani, Mark K Buyyounouski, Steven Coutre, Frederick Dirbas, Vasu Divi, Oliver Dorigo, Kristen N Ganjoo, Laura J Johnston, Lawrence David Recht, Joseph B Shrager, Eila C Skinner, Susan M Swetter, Brendan C Visser, Douglas W Blayney
PURPOSE: Development and implementation of robust reporting processes to systematically provide quality data to care teams in a timely manner is challenging. National cancer quality measures are useful, but the manual data collection required is resource intensive, and reporting is delayed. We designed a largely automated measurement system with our multidisciplinary cancer care programs (CCPs) to identify, measure, and improve quality metrics that were meaningful to the care teams and their patients...
August 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28716998/extended-training-to-prepare-gps-for-future-workforce-needs-a-qualitative-investigation-of-a-1-year-fellowship-in-urgent-care
#17
Jeremy Dale, Rachel Russell, Frances Harkness, Veronica Wilkie, Matthew Aiello
BACKGROUND: It has been argued that UK general practice specialist training should be extended to better prepare GPs for the challenges facing 21st-century health care. Evidence is needed to inform how this should occur. AIM: To investigate the experience of recently trained GPs undertaking a 1-year full-time fellowship programme designed to provide advanced skills training in urgent care, integrated care, leadership, and academic practice; and its impact on subsequent career development...
July 17, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28713550/a-community-proposal-to-integrate-proteomics-activities-in-elixir
#18
Juan Antonio Vizcaíno, Mathias Walzer, Rafael C Jiménez, Wout Bittremieux, David Bouyssié, Christine Carapito, Fernando Corrales, Myriam Ferro, Albert J R Heck, Peter Horvatovich, Martin Hubalek, Lydie Lane, Kris Laukens, Fredrik Levander, Frederique Lisacek, Petr Novak, Magnus Palmblad, Damiano Piovesan, Alfred Pühler, Veit Schwämmle, Dirk Valkenborg, Merlijn van Rijswijk, Jiri Vondrasek, Martin Eisenacher, Lennart Martens, Oliver Kohlbacher
Computational approaches have been major drivers behind the progress of proteomics in recent years. The aim of this white paper is to provide a framework for integrating computational proteomics into ELIXIR in the near future, and thus to broaden the portfolio of omics technologies supported by this European distributed infrastructure. This white paper is the direct result of a strategy meeting on 'The Future of Proteomics in ELIXIR' that took place in March 2017 in Tübingen (Germany), and involved representatives of eleven ELIXIR nodes...
2017: F1000Research
https://www.readbyqxmd.com/read/28711646/rural-rotations-at-core-rarefied-exposure-or-real-experience
#19
Christopher Brown, Tarig Abdelrahman, Neil Patel, Awen Iorwerth, John Pollitt, Mark Holt, Wyn G Lewis
OBJECTIVE: Surgical rotations involving rural General Hospitals (rGH) are frequently associated with recruitment challenges, partly because of adverse perceptions regarding distances from social support networks and training opportunities. The aim of this study was to determine the outcomes of core surgical training rotations involving rGHs when compared with urban hospitals in a single UK Deanery. DESIGN: Online Intercollegiate Surgical Curriculum Programme portfolios from 163 core surgical trainees (CST) were examined related to postlocation, operative experience, workplace-based assessments, and academic achievement...
July 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28707543/pet-mri-knocking-on-the-doors-of-the-rich-and-famous
#20
Thomas Beyer, Marcus Hacker, Vicky Goh
Since 2010 the portfolio of positron emission tomography (PET)-based imaging has been expanded by industry with the introduction of combined whole-body PET/MRI systems with the intent of merging PET-based molecular imaging with the strengths of MRI. PET/MRI has created a lot of hype in the scientific community but comparatively little traction in the clinic. The first years of whole-body PET/MRI were used to address inherent technical challenges; however, it is now time to make use of the full potential of this integrated imaging modality...
July 27, 2017: British Journal of Radiology
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