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https://www.readbyqxmd.com/read/28528855/patterns-of-recent-national-institutes-of-health-nih-funding-to-diagnostic-radiology-departments-analysis-using-the-nih-reporter-system
#1
Ana M Franceschi, Andrew B Rosenkrantz
RATIONALE AND OBJECTIVES: This study aimed to characterize recent National Institutes of Health (NIH) funding for diagnostic radiology departments at US medical schools. MATERIALS AND METHODS: This retrospective study did not use private identifiable information and thus did not constitute human subjects research. The public NIH Research Portfolio Online Reporting Tools Expenditure and Results system was used to extract information regarding 887 NIH awards in 2015 to departments of "Radiation-Diagnostic/Oncology...
May 18, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28509682/new-neurosurgical-approaches-for-tremor-and-parkinson-s-disease
#2
Alfonso Fasano, Andres M Lozano, Esther Cubo
PURPOSE OF REVIEW: The objective of this review is to gather the newest advances in the surgical treatment of tremor and Parkinson's disease. We will briefly discuss the potential applications of the new technologies of deep brain stimulation (DBS), and we will focus on MRI-guided focused ultrasound (MRgFUS). RECENT FINDINGS: Novel DBS devices are being progressively adopted, particularly electrodes allowing a longer stimulating surface (suitable for multiple targets stimulation) and current radial steering (to minimize side effects of stimulation)...
May 13, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28508825/abcs-of-rhogtpases-indicating-potential-role-as-oncotargets
#3
REVIEW
Indira Bora, Neeta Shrivastava
RhoGTPases also known as molecular switches represent a family of GTP-binding proteins. They shuttle between "On" and "Off" states. In the "On" state, they activate plethora of molecules. These proteins perform a wide variety of functions involving cytoskeletal modeling, cell motility, migration, and mitosis. Members of this family are referred as master regulators of many cellular activities. Due to wide variety of portfolios attributed to RhoGTPases, their misbehavior leads to initiation and also progression of metastatic cancers...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28508742/caep-2016-academic-symposium-how-to-have-an-impact-as-an-emergency-medicine-educator-and-scholar
#4
Jason R Frank, Warren J Cheung, Jonathan Sherbino, Robert Primavesi, Robert A Woods, Glen Bandiera, Constance LeBlanc
BACKGROUND: In a time of major medical education transformation, emergency medicine (EM) needs to nurture education scholars who will influence EM education practice. However, the essential ingredients to ensure a career with impact in EM education are not clear. OBJECTIVE: To describe how to prepare EM educators for a high-impact career. METHODS: The Canadian Association of Emergency Physicians (CAEP) Academic Section commissioned an "Education Impact" working group (IWG) to guide the creation of consensus recommendations from the EM community...
May 2017: CJEM
https://www.readbyqxmd.com/read/28500775/vaccines-against-malaria-still-a-long-way-to-go
#5
REVIEW
Kai Matuschewski
Several species of Plasmodium cause a broad spectrum of human disease that range from nausea and fever to severe anemia, cerebral malaria, and multi-organ failure. In malaria-endemic countries continuous exposure to Plasmodium sporozoite inoculations and subsequent blood infections elicit only partial and short-lived immunity, which gradually develops over many years of parasite exposure and multiple clinical episodes. The ambitious goal of malaria vaccinology over the past 70 years has been to develop an immunization strategy that mounts protection superior to naturally acquired immunity...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28500039/selected-probiotic-lactobacilli-have-the-capacity-to-hydrolyze-gluten-peptides-during-simulated-gastro-intestinal-digestion
#6
Ruggiero Francavilla, Maria De Angelis, Carlo Giuseppe Rizzello, Noemi Cavallo, Fabio Dal Bello, Marco Gobbetti
The aim of this study was to demonstrate the capacity of probiotic lactobacilli to hydrolyze immunogenic gluten peptides. Eighteen commercial strains of probiotic lactobacilli with highly variable peptidase activity (i.e., aminopeptidase N, iminopeptidase, prolyl endopeptidyl peptidase, tripeptidase, prolidase, prolinase and dipeptidase), including towards Pro-rich peptides, were tested in this study. Ten probiotic strains were selected based on their specific enzyme activity. When pooled, these ten strains provide the peptidase portfolio that is required to completely degrade the immunogenic gluten peptides involved in celiac disease (CD)...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28498738/biogas-production-from-anaerobic-digestion-of-food-waste-and-relevant-air-quality-implications
#7
Jeff Kuo, Jason Dow
Biopower can diversify energy supply and improve energy resiliency. Increases in biopower production from sustainable biomass can provide many economic and environmental benefits. For example, increasing biogas production through anaerobic digestion of food waste would increase the use of renewable fuels throughout California and add to its renewables portfolio. Although a biopower project will produce renewable energy, the process of producing bioenergy should harmonize with the goal of protecting public health...
May 12, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28498003/a-novel-approach-to-assessing-professionalism-in-preclinical-medical-students-using-multisource-feedback-through-paired-self-and-peer-evaluations
#8
Amanda R Emke, Steven Cheng, Ling Chen, Dajun Tian, Carolyn Dufault
Phenomenon: Professionalism is integral to the role of the physician. Most professionalism assessments in medical training are delayed until clinical rotations where multisource feedback is available. This leaves a gap in student assessment portfolios and potentially delays professional development. APPROACH: A total of 246 second-year medical students (2013-2015) completed self- and peer assessments of professional behaviors in 2 courses following a series of Team-Based Learning exercises...
May 12, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28494890/the-predictive-value-of-pre-recruitment-achievement-on-resident-performance-in-anesthesiology
#9
Fei Chen, Harendra Arora, Susan M Martinelli, Emily Teeter, David Mayer, David A Zvara, Anthony Passannante, Kathleen A Smith
STUDY OBJECTIVE: Selecting candidates for residency positions is challenging and there is little research on the correlation between commonly used selection criteria and subsequent performance in anesthesiology. This study examined the association between the selection measures and post-recruitment performance in residency. DESIGN: Retrospective review of archival data. SETTING: Anesthesiology residency program at a large academic anesthesiology department...
June 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28494809/the-ped-t-trial-protocol-the-effect-of-physical-exercise-and-dietary-therapy-compared-with-cognitive-behavior-therapy-in-treatment-of-bulimia-nervosa-and-binge-eating-disorder
#10
Therese Fostervold Mathisen, Jan H Rosenvinge, Gunn Pettersen, Oddgeir Friborg, KariAnne Vrabel, Solfrid Bratland-Sanda, Mette Svendsen, Trine Stensrud, Maria Bakland, Rolf Wynn, Jorunn Sundgot-Borgen
BACKGROUND: Sufferers from bulimia nervosa (BN) and binge eating disorder (BED) underestimate the severity risk of their illness and, therefore, postpone seeking professional help for years. Moreover, less than one in five actually seek professional help and only 50% respond to current treatments, such as cognitive behavioral therapy (CBT). The impetus for the present trial is to explore a novel combination treatment approach adapted from physical exercise- and dietary therapy (PED-t)...
May 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28492452/the-changing-landscape-of-hiv-prevention-in-the-united-states-health-department-experiences-and-local-adaptations-in-response-to-the-national-hiv-aids-strategy-and-high-impact-prevention-approach
#11
Holly H Fisher, Aba Essuon, Tamika Hoyte, Ekaterine Shapatava, Gene Shelley, Aisha Rios, Stephanie Beane, Stacey Bourgeois, Erica Dunbar, Tobey Sapiano
OBJECTIVE: HIV prevention has changed substantially in recent years due to changes in national priorities, biomedical advances, and health care reform. Starting in 2010, motivated by the National HIV/AIDS Strategy (NHAS) and the Centers for Disease Control and Prevention's (CDC's) High-Impact Prevention (HIP), health departments realigned resources so that cost-effective, evidence-based interventions were targeted to groups at risk in areas most affected by HIV. This analysis describes how health departments in diverse settings were affected by NHAS and HIP...
May 10, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28487005/nitrogen-gas-field-ion-source-gfis-focused-ion-beam-fib-secondary-electron-imaging-a-first-look
#12
Marek E Schmidt, Anto Yasaka, Masashi Akabori, Hiroshi Mizuta
The recent technological advance of the gas field ion source (GFIS) and its successful integration into systems has renewed the interest in the focused ion beam (FIB) technology. Due to the atomically small source size and the use of light ions, the limitations of the liquid metal ion source are solved as device dimensions are pushed further towards the single-digit nanometer size. Helium and neon ions are the most widely used, but a large portfolio of available ion species is desirable, to allow a wide range of applications...
May 10, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28481359/mutational-landscape-of-metastatic-cancer-revealed-from-prospective-clinical-sequencing-of-10-000-patients
#13
Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha, Hyunjae R Kim, Preethi Srinivasan, Jianjiong Gao, Debyani Chakravarty, Sean M Devlin, Matthew D Hellmann, David A Barron, Alison M Schram, Meera Hameed, Snjezana Dogan, Dara S Ross, Jaclyn F Hechtman, Deborah F DeLair, JinJuan Yao, Diana L Mandelker, Donavan T Cheng, Raghu Chandramohan, Abhinita S Mohanty, Ryan N Ptashkin, Gowtham Jayakumaran, Meera Prasad, Mustafa H Syed, Anoop Balakrishnan Rema, Zhen Y Liu, Khedoudja Nafa, Laetitia Borsu, Justyna Sadowska, Jacklyn Casanova, Ruben Bacares, Iwona J Kiecka, Anna Razumova, Julie B Son, Lisa Stewart, Tessara Baldi, Kerry A Mullaney, Hikmat Al-Ahmadie, Efsevia Vakiani, Adam A Abeshouse, Alexander V Penson, Philip Jonsson, Niedzica Camacho, Matthew T Chang, Helen H Won, Benjamin E Gross, Ritika Kundra, Zachary J Heins, Hsiao-Wei Chen, Sarah Phillips, Hongxin Zhang, Jiaojiao Wang, Angelica Ochoa, Jonathan Wills, Michael Eubank, Stacy B Thomas, Stuart M Gardos, Dalicia N Reales, Jesse Galle, Robert Durany, Roy Cambria, Wassim Abida, Andrea Cercek, Darren R Feldman, Mrinal M Gounder, A Ari Hakimi, James J Harding, Gopa Iyer, Yelena Y Janjigian, Emmet J Jordan, Ciara M Kelly, Maeve A Lowery, Luc G T Morris, Antonio M Omuro, Nitya Raj, Pedram Razavi, Alexander N Shoushtari, Neerav Shukla, Tara E Soumerai, Anna M Varghese, Rona Yaeger, Jonathan Coleman, Bernard Bochner, Gregory J Riely, Leonard B Saltz, Howard I Scher, Paul J Sabbatini, Mark E Robson, David S Klimstra, Barry S Taylor, Jose Baselga, Nikolaus Schultz, David M Hyman, Maria E Arcila, David B Solit, Marc Ladanyi, Michael F Berger
Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined tumor types, coupled with an expanding portfolio of molecularly targeted therapies, demands flexible and comprehensive approaches to profile clinically relevant genes across the full spectrum of cancers. We established a large-scale, prospective clinical sequencing initiative using a comprehensive assay, MSK-IMPACT, through which we have compiled tumor and matched normal sequence data from a unique cohort of more than 10,000 patients with advanced cancer and available pathological and clinical annotations...
May 8, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28480558/strategic-deployment-of-cho-expression-platforms-to-deliver-pfizer-s-monoclonal-antibody-portfolio
#14
John J Scarcelli, Tanya Q Shang, Tim Iskra, Martin J Allen, Lin Zhang
Development of stable cell lines for expression of large molecule therapeutics represents a significant portion of the time and effort required to advance a molecule to enabling regulatory toxicology studies and clinical evaluation. Our development strategy employs two different approaches for cell line development based on the needs of a particular project - a random integration approach for projects where high level expression is critical, and a site-specific integration approach for projects in which speed and reduced employee time spend is a necessity...
May 8, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28480535/integrated-continuous-bioprocessing-economic-operational-and-environmental-feasibility-for-clinical-and-commercial-antibody-manufacture
#15
James Pollock, Jon Coffman, Sa V Ho, Suzanne S Farid
This paper presents a systems approach to evaluating the potential of integrated continuous bioprocessing for monoclonal antibody (mAb) manufacture across a product's lifecycle from pre-clinical to commercial manufacture. The economic, operational and environmental feasibility of alternative continuous manufacturing strategies were evaluated holistically using a prototype UCL decisional tool that integrated process economics, discrete-event simulation, environmental impact analysis, operational risk analysis and multi-attribute decision-making...
May 8, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28480055/feasibility-of-common-bibliometrics-in-evaluating-translational-science
#16
M Schneider, C M Kane, J Rainwater, L Guerrero, G Tong, S R Desai, W Trochim
INTRODUCTION: A pilot study by 6 Clinical and Translational Science Awards (CTSAs) explored how bibliometrics can be used to assess research influence. METHODS: Evaluators from 6 institutions shared data on publications (4202 total) they supported, and conducted a combined analysis with state-of-the-art tools. This paper presents selected results based on the tools from 2 widely used vendors for bibliometrics: Thomson Reuters and Elsevier. RESULTS: Both vendors located a high percentage of publications within their proprietary databases (>90%) and provided similar but not equivalent bibliometrics for estimating productivity (number of publications) and influence (citation rates, percentage of papers in the top 10% of citations, observed citations relative to expected citations)...
February 2017: J Clin Transl Sci
https://www.readbyqxmd.com/read/28472310/the-population-burden-of-cancer-research-driven-by-the-catchment-area-of-a-cancer-center
#17
Caroline G Tai, Robert A Hiatt
Cancer centers, particularly those supported by the National Cancer Institute, are charged with reducing the cancer burden in their catchment area. However, methods to define both the catchment area and the cancer burden are diverse and range in complexity often based on data availability, staff resources, or confusion about what is required. This article presents a review of the current literature identifying 4 studies that have defined various aspects of the cancer burden in a defined geographical area and highlights examples of how some cancer centers and other health institutions have defined their catchment area and characterized the cancer burden within it...
January 1, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28464480/flexible-device-applications-of-2d-semiconductors
#18
REVIEW
Li Gao
Graphene-like single- or few-layer semiconductors, such as dichalcogenides and buckled nanocrystals, possess direct and tunable bandgaps, and excellent electrical, optical, mechanical and thermal properties. This unique set of desirable properties of 2D semiconductors has triggered great interest in developing ultra-thin 2D flexible electronic devices, which ranges from realizing better material quality and simplified fabrication processes, to improving device performance and expanding the application horizon...
May 2, 2017: Small
https://www.readbyqxmd.com/read/28454867/a-review-of-cdc-s-web-based-injury-statistics-query-and-reporting-system-wisqars%C3%A2-planning-for-the-future-of-injury-surveillance
#19
Michael F Ballesteros, Kevin Webb, Roderick J McClure
INTRODUCTION: The Centers for Disease Control and Prevention (CDC) developed the Web-based Injury Statistics Query and Reporting System (WISQARS(TM)) to meet the data needs of injury practitioners. In 2015, CDC completed a Portfolio Review of this system to inform its future development. METHODS: Evaluation questions addressed utilization, technology and innovation, data sources, and tools and training. Data were collected through environmental scans, a review of peer-reviewed and grey literature, a web search, and stakeholder interviews...
June 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28454721/the-treatment-of-brain-arteriovenous-malformation-study-tobas-a-preliminary-inter-and-intra-rater-agreement-study-on-patient-management
#20
Robert Fahed, André L Batista, Tim E Darsaut, Jean-Christophe Gentric, Célina Ducroux, Chiraz Chaalala, David Roberge, Michel W Bojanowski, Alain Weill, Daniel Roy, Elsa Magro, Jean Raymond
OBJECT: The best management of brain arteriovenous malformation (bAVM) patients remains unknown. Randomized allocation may be more readily accepted when there is uncertainty and disagreement regarding the management of potential participants. In planning for a trial, we aimed to assess variability and agreement among physicians managing bAVM patients. METHODS: A portfolio composed of 35 patients was sent to 47 clinicians of various specialties managing bAVM patients...
April 25, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
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