Jordan Z Zhou, Bihui Huang, Bo Pei, Guang Wen Sun, Michael D Pawlitz, Wei Zhang, Xinyang Li, Kati C Hokynar, Fayi Yao, Madusha L W Perera, Shanqiao Wei, Simin Zheng, Lisa A Polin, Janet M Poulik, Annamari Ranki, Kai Krohn, Charlotte Cunningham-Rundles, Naibo Yang, Ashok S Bhagwat, Kefei Yu, Pärt Peterson, Kai Kisand, Bao Q Vuong, Andrea Cerutti, Kang Chen
In response to antigens, B cells undergo affinity maturation and class switching mediated by activation-induced cytidine deaminase (AID) in germinal centers (GCs) of secondary lymphoid organs, but uncontrolled AID activity can precipitate autoimmunity and cancer. The regulation of GC antibody diversification is of fundamental importance but not well understood. We found that autoimmune regulator (AIRE), the molecule essential for T cell tolerance, is expressed in GC B cells in a CD40-dependent manner, interacts with AID and negatively regulates antibody affinity maturation and class switching by inhibiting AID function...
January 12, 2024: bioRxiv