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Lorenzo Domenichini, Valentina Branzi, Martina Smorti
Road traffic injuries represent a serious public health problem and are one of leading cause of death, injury and disability around the world. Road accidents are often caused by an accumulation of factors; however, drivers appear to be by far the most decisive one. The driver's behaviour is complex and depends on reflex (or involuntary) and voluntary driving actions. The first class of actions (reflex actions) are typical human reactions that remain inaccessible to awareness and refer to the direct interaction between the road user and the characteristics of the road and its surrounding environment...
December 11, 2018: Accident; Analysis and Prevention
Martina Maase, Anna Rygula, Marta Z Pacia, Bartosz Proniewski, Lukasz Mateuszuk, Magdalena Sternak, Agnieszka Kaczor, Stefan Chlopicki, Kristina Kusche-Vihrog
Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. However, direct evidence linking these parameters to each other is missing...
December 11, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Malwina Michalak, Uwe Warnken, Martina Schnölzer, Hans-Joachim Gabius, Jürgen Kopitz
Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium...
December 14, 2018: IUBMB Life
Martina C de Knegt, Morten Haugen, Jesper J Linde, Jørgen Tobias Kühl, Børge G Nordestgaard, Lars V Køber, Jens D Hove, Klaus F Kofoed
PURPOSE: Quantitative computed tomography (QCT) provides important prognostic information of coronary atherosclerosis. We investigated intraobserver and interobserver QCT reproducibility in asymptomatic individuals, patients with acute chest pain without acute coronary syndrome (ACS), and patients with acute chest pain and ACS. METHODS: Fifty patients from each cohort, scanned between 01/02/2010-14/11/2013 and matched according to age and gender, were retrospectively assessed for inclusion...
2018: PloS One
Mingxia Lu, Yee Yee Khine, Fan Chen, Cheng Cao, Christopher J Garvey, Hongxu Lu, Martina H Stenzel
Glycopolymer-coated nanoparticles have attracted significant interest over the past few years, because of their selective interaction with carbohydrate receptors found on the surface of cells. While the type of carbohydrate determines the strength of the ligand-receptor interaction, the presentation of the sugar can be highly influential as the carbohydrate needs to be accessible in order to display good binding. To shine more light on the relationship between nanoparticle structure and cell uptake, we have designed several micelles based on fructose containing block copolymers, which are selective to GLUT5 receptors found on breast cancer cell lines...
December 14, 2018: Biomacromolecules
Marina Cornacchiari, Anna Mudoni, Antonia Stasi, Bianca Visciano, Francesco Cosa, Valentina Martina, Maria Giuseppina Ponticelli, Carlo Giastoni
The aging of the uremic population, the increasingly common use of anticoagulants, antiplatelet agents e heparin, during hemodialysis, can expose our patients to a greatest risk of bleeding. Spontaneous retroperitoneal hematomas are a fairly rare and potentially fatal condition. We describe 5 clinical cases of retroperitoneal hemorrhage that we observed during 10 years in our department, focusing on modalities of symptom onset, clinical-laboratory picture and treatment modalities.
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Myroslava Lesiv, Juan Carlos Laso Bayas, Linda See, Martina Duerauer, Domian Dahlia, Neal Durando, Rubul Hazarika, Parag Kumar Sahariah, Mar'yana Vakolyuk, Volodymyr Blyshchyk, Andrii Bilous, Ana Perez-Hoyos, Sarah Gengler, Reinhard Prestele, Svitlana Bilous, Ibrar Ul Hassan Akhtar, Kuleswar Singha, Sochin Boro Choudhury, Tilok Chetri, Žiga Malek, Khangsembou Bungnamei, Anup Saikia, Dhrubajyoti Sahariah, William Narzary, Olha Danylo, Tobias Sturn, Mathias Karner, Ian McCallum, Dmitry Schepaschenko, Elena Moltchanova, Dilek Fraisl, Inian Moorthy, Steffen Fritz
There is an increasing evidence that smallholder farms contribute substantially to food production globally, yet spatially explicit data on agricultural field sizes are currently lacking. Automated field size delineation using remote sensing or the estimation of average farm size at subnational level using census data are two approaches that have been used. However, both have limitations, for example, automatic field size delineation using remote sensing has not yet been implemented at a global scale while the spatial resolution is very coarse when using census data...
January 2019: Global Change Biology
Alessandro Sannino, Elena Gabriele, Martina Bigatti, Sara Mulatto, Jacopo Piazzi, Jörg Scheuermann, Dario Neri, Etienne J Donckele, Florent Samain
DNA-Encoded chemical libraries are often used for the discovery of ligands against protein targets of interest. These large collections of DNA-barcoded chemical compounds are typically screened by using affinity capture methodologies followed by PCR amplification and DNA sequencing procedures. However, the performance of individual steps in the selection procedures has been scarcely investigated so far. Here, we describe a quantitative analysis of selection experiments, using three ligands with different affinity to carbonic anhydrase IX as model compounds...
December 13, 2018: Chembiochem: a European Journal of Chemical Biology
Michaela Fojtů, Jan Balvan, Martina Raudenská, Tomáš Vičar, Daniel Bouša, Zdeněk Sofer, Michal Masařík, Martin Pumera
Black phosphorus (BP) belongs to a group of 2D nanomaterials and nowadays attracts constantly increasing attention. Parallel to the growing utilization of BP nanomaterial increase also the requirements for the thorough comprehension of its potential impact on human and animal health. The aim of this study was to compare and discuss five assays commonly used for the cytotoxicity assessments of nanomaterials with a special focus on BP nanoparticles. A comprehensive survey of factors and pitfalls is provided that should be accounted for when assessing their toxicity and pointed to their inconsistency...
December 13, 2018: Chemistry: a European Journal
Azar Kariminia, Matthew Law, Mary-Ann Davies, Michael Vinikoor, Kara Wools-Kaloustian, Valeriane Leroy, Andrew Edmonds, Catherine McGowan, Rachel Vreeman, Lee Fairlie, Samuel Ayaya, Marcel Yotebieng, Elom Takassi, Jorge Pinto, Adebola Adedimeji, Karen Malateste, Daisy M Machado, Martina Penazzato, Rohan Hazra, Annette H Sohn
INTRODUCTION: We assessed mortality and losses to follow-up (LTFU) during adolescence in routine care settings in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. METHODS: Cohorts in the Asia-Pacific, the Caribbean, Central, and South America, and sub-Saharan Africa (Central, East, Southern, West) contributed data, and included adolescents living with HIV (ALHIV) enrolled from January 2003 and aged 10 to 19 years (period of adolescence) while under care up to database closure (June 2016)...
December 2018: Journal of the International AIDS Society
Annunziata Dattola, Luigi Bennardo, Martina Silvestri, Steven Paul Nisticò
Atopic dermatitis (AD) is a pruritic, chronic and inflammatory skin disease, with an usual onset in the pediatric age. Several drugs are used in the treatment of this skin disease. Drugs as steroid, calcineurin inhibitors, and moisturizing creams are widely used in the treatment of this disease but often patients are not satisfied with the obtained results. New drugs like dupilumab or crisaborole seem to be a promising option for moderate and severe forms of AD. This article analyzes the newest therapy available today for the treatment of AD...
November 22, 2018: Dermatologic Therapy
Andrea E Steuer, Justine Raeber, Christian Steuer, Martina I Boxler, Dario A Dornbierer, Oliver G Bosch, Boris B Quednow, Erich Seifritz, Thomas Kraemer
Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that occurs naturally in the mammalian brain and that is prescribed as a medication against narcolepsy or used as a drug of abuse. Particularly, its use as a knock-out drug in cases of drug facilitated crimes is of major importance in forensic toxicology. Because of its rapid metabolism and resulting narrow detection windows (<12 h in urine), detection of GHB remains challenging. Thus, there is an urgent call for new markers to improve the reliable detection of GHB use...
December 12, 2018: Drug Testing and Analysis
Andrew Smith, Vincenzo L'Imperio, Vanna Denti, Mariafrancesca Mazza, Mariia Ivanova, Martina Stella, Isabella Piga, Clizia Chinello, Elena Ajello, Federico Pieruzzi, Fabio Pagni, Fulvio Magni
MALDI-MSI technology has advanced rapidly during recent years with the development of instruments equipped with low-diameter lasers that are suitable for high spatial resolution imaging. This may provide significant advantages in certain fields of molecular pathology where more specific protein fingerprints of individual cell types are required, such as renal pathology. Here we performed MALDI-MSI analysis of a cohort of MN patients among which patients either responded favourably (R; n = 6), or unfavourably (NR; n = 4), to immunosuppressive treatment (Ponticelli Regimen), employing a 10μm laser spot diameter...
December 7, 2018: Proteomics. Clinical Applications
Julien Chiquet, Guillem Rigaill, Martina Sundqvist
This chapter addresses the problem of reconstructing regulatory networks in molecular biology by integrating multiple sources of data. We consider data sets measured from diverse technologies all related to the same set of variables and individuals. This situation is becoming more and more common in molecular biology, for instance, when both proteomic and transcriptomic data related to the same set of "genes" are available on a given cohort of patients.To infer a consensus network that integrates both proteomic and transcriptomic data, we introduce a multivariate extension of Gaussian graphical models (GGM), which we refer to as multiattribute GGM...
2019: Methods in Molecular Biology
José Raul Herance, Hermenegildo García, Patricia Gutiérrez-Carcedo, Sergio Navalón, Antonio Pineda-Lucena, Martina Palomino-Schätzlein
Gold nanoparticles have high potential in the biomedical area, especially in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. To this end, in this study, we apply an experimental approach based on nuclear magnetic resonance spectroscopy to study the effect of gold nanoparticles, stabilised with cerium oxide or chitosan, on a human cancer cell model...
December 14, 2018: Analyst
Jan Hynek, Sebastian Jurík, Martina Koncošová, Jaroslav Zelenka, Ivana Křížová, Tomáš Ruml, Kaplan Kirakci, Ivo Jakubec, František Kovanda, Kamil Lang, Jan Demel
Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin...
2018: Beilstein Journal of Nanotechnology
Tiziana Triulzi, Luca Forte, Viola Regondi, Martina Di Modica, Cristina Ghirelli, Maria Luisa Carcangiu, Lucia Sfondrini, Andrea Balsari, Elda Tagliabue
Through whole-transcriptome profiling of HER2+ breast carcinomas (BCs), we previously showed that those sensitive to trastuzumab are addicted to this oncoprotein and are enriched in immune pathways, raising the hypothesis that HER2 itself regulates immune cell recruitment. In the present study we investigated the relationship between HER2 activity and the pro-trastuzumab tumor immune milieu. Gene expression profiling and immunohistochemistry analysis of 53 HER2+ BCs showed that trastuzumab-sensitive tumors expressed significantly higher levels of chemokines involved in immune cell recruitment, with higher infiltration of T cells and monocytes, and higher levels of PD-1 ligands than tumors that do not benefit from trastuzumab...
2019: Oncoimmunology
Marco Santin, Susanne Neugart, Antonella Castagna, Martina Barilari, Sabrina Sarrocco, Giovanni Vannacci, Monika Schreiner, Annamaria Ranieri
[This corrects the article DOI: 10.3389/fpls.2018.01598.].
2018: Frontiers in Plant Science
Claudia Sengler, Julian Zink, Jens Klotsche, Martina Niewerth, Ina Liedmann, Gerd Horneff, Christoph Kessel, Gerd Ganser, Angelika Thon, Johannes-Peter Haas, Anton Hospach, Frank Weller-Heinemann, Arnd Heiligenhaus, Dirk Foell, Angela Zink, Kirsten Minden
OBJECTIVE: The objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the course of JIA. METHODS: Patients ≤ 16 years of age with recently diagnosed JIA (< 12 months) were enrolled in the inception cohort of patients with newly diagnosed JIA (ICON), an ongoing prospective observational, controlled multicenter study started in 2010...
December 13, 2018: Arthritis Research & Therapy
Megan Brooke-Jones, Martina Gáliková, Heinrich Dircksen
The non-proteinogenic amino acid beta-methyl-amino-l-alanine (BMAA) is a neurotoxin produced by cyanobacteria. BMAA accumulation in the brain of animals via biomagnification along the food web can contribute to the development of neurodegenerative diseases such as Amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC), the latter being associated with a loss of dopaminergic neurons. Daphnia magna is an important microcrustacean zooplankton species that plays a key role in aquatic food webs, and BMAA-producing cyanobacteria often form part of their diet...
December 8, 2018: Toxins
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