Oriol Busquets, Hanqin Li, Khaja Mohieddin Syed, Pilar Alvarez Jerez, Jesse Dunnack, Riana Lo Bu, Yogendra Verma, Gabriella R Pangilinan, Annika Martin, Jannes Straub, YuXin Du, Vivien M Simon, Steven Poser, Zipporiah Bush, Jessica Diaz, Atehsa Sahagun, Jianpu Gao, Dena G Hernandez, Kristin S Levine, Ezgi O Booth, Helen S Bateup, Donald C Rio, Dirk Hockemeyer, Cornelis Blauwendraat, Frank Soldner
Parkinson's disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer the uniique potential to advance our understanding of PD etiology by providing disease-relevant cell-types carrying patient mutations along with isogenic control cells. To facilitate this experimental approach, we generated a collection of 55 cell lines genetically engineered to harbor mutations in genes associated with monogenic PD ( SNCA A53T, SNCA A30P, PRKN Ex3del, PINK1 Q129X, DJ1/PARK7 Ex1-5del, LRRK2 G2019S, ATP13A2 FS, FBXO7 R498X/FS, DNAJC6 c...
February 13, 2024: bioRxiv