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extracellular matrix in ovarian follicular development and

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https://www.readbyqxmd.com/read/29604127/interactions-between-different-media-and-follicle-stimulating-hormone-supplementation-on-in-vitro-culture-of-preantral-follicles-enclosed-in-ovarian-tissue-derived-from-collared-peccaries-pecari-tajacu-linneaus-1758
#1
G L Lima, V B Luz, L F Lima, Rmp Rocha, S V Castro, T S Castelo, Apr Rodrigues, J R Figueiredo, A R Silva
The aim was to verify the effect of follicle-stimulating hormone (FSH) supplementation to α-MEM+ or TCM199+ media on the in vitro development of ovarian preantral follicles (PFs) derived from collared peccaries. Ovaries (n = 5 pairs) were collected and divided into fragments destined to control group (non-cultured) or treatments that were cultured for 7 days. The PFs morphology, growth and activation were evaluated by classical histology. The immunohistochemistry markers Ag-NOR and PCNA were used for nuclear proliferation analysis, and the picrosirius red labelling was used for ovarian extracellular matrix (ECM) evaluation...
August 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27149979/protein-pathways-working-in-human-follicular-fluid-the-future-for-tailored-ivf
#2
REVIEW
Laura Bianchi, Assunta Gagliardi, Claudia Landi, Riccardo Focarelli, Vincenzo De Leo, Alice Luddi, Luca Bini, Paola Piomboni
The human follicular fluid (HFF) contains molecules and proteins that may affect follicle growth, oocyte maturation and competence acquiring. Despite the numerous studies, an integrated broad overview on biomolecular and patho/physiological processes that are proved or supposed to take place in HFF during folliculogenesis and oocyte development is still missing. In this review we report, for the first time, all the proteins unambiguously detected in HFF and, applying DAVID (Database for Annotation, Visualization and Integrated Discovery) and MetaCore bioinformatic resources, we shed new lights on their functional correlation, delineating protein patterns and pathways with reasonable potentialities for oocyte quality estimation in in vitro fertilisation (IVF) programs...
May 6, 2016: Expert Reviews in Molecular Medicine
https://www.readbyqxmd.com/read/27107035/a-comprehensive-transcriptomic-view-on-the-role-of-smad4-gene-by-rnai-mediated-knockdown-in-porcine-follicular-granulosa-cells
#3
Lifan Zhang, Xing Du, Shengjuan Wei, Dongfeng Li, Qifa Li
As a key mediator of the transforming growth factor-beta (TGF-β) signaling pathway, which plays a pivotal role in regulating mammalian reproductive performance, Sma- and Mad-related protein 4 (SMAD4) is closely associated with the development of ovarian follicular. However, current knowledge of the genome-wide view on the role of SMAD4 gene in mammalian follicular granulosa cells (GCs) is still largely unknown. In the present study, RNA-Seq was performed to investigate the effects of SMAD4 knockdown by RNA interference (SMAD4-siRNA) in porcine follicular GCs...
July 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/26123507/the-comprehensive-mechanisms-underlying-nonhierarchical-follicular-development-in-geese-anser-cygnoides
#4
Hehe Liu, Wenjie Zhang, Qingqing Li, Junying Liu, Tao Zhang, Tianyu Zhou, Liang Li, Jiwen Wang, Hengyong Xu, Hua He
The laying performance of poultry primarily depends on the growth and development of the ovarian follicles. Yet, little is known about the underlying mechanisms responsible for nonhierarchical follicular development in avian species. The aim of the present study is identify genes that are differentially expressed during nonhierarchical follicular development in geese by performing a transcriptome screen. A sequencing depth of 13.9 and 14.9 million mapped tags was obtained in pools of small white follicles (SWF) and small yellow follicles (SYF), respectively, and a total of 160 differentially expressed genes were identified...
August 2015: Animal Reproduction Science
https://www.readbyqxmd.com/read/25605128/development-of-the-follicular-basement-membrane-during-human-gametogenesis-and-early-folliculogenesis
#5
A Marijne Heeren, Liesbeth van Iperen, Daniëlle B Klootwijk, Ana de Melo Bernardo, Matthias S Roost, Maria M Gomes Fernandes, Leonie A Louwe, Carina G Hilders, Frans M Helmerhorst, Lucette A J van der Westerlaken, Susana M Chuva de Sousa Lopes
BACKGROUND: In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametogenesis and (early) folliculogenesis in vivo is necessary. Here, we have studied these processes focusing on the formation of the follicular basement membrane (BM) in vivo. RESULTS: The distribution of the main components of the extracellular matrix (ECM) collagen IV, laminin and fibronectin by week 10 of gestation (W10) in the ovarian cortex revealed the existence of ovarian cords and of a distinct mesenchymal compartment, resembling the organization in the male gonads...
2015: BMC Developmental Biology
https://www.readbyqxmd.com/read/25545956/two-methods-of-vitrification-followed-by-in-vitro-culture-of-the-ovine-ovary-evaluation-of-the-follicular-development-and-ovarian-extracellular-matrix
#6
F T Bandeira, A A Carvalho, S V Castro, L F Lima, D A Viana, Jsam Evangelista, Mjs Pereira, C C Campello, J R Figueiredo, Apr Rodrigues
The aim of this study was to evaluate the influence of two vitrification techniques on the extra cellular matrix (ECM) and ovarian follicular development. The ovarian cortex was fragmented (9 mm(3)) and divided into six groups, viz. fresh control, cultured control, vitrified by the Ovarian Tissue Cryosystem (OTC) method, conventional solid surface vitrification (SSV) method, OTC/cultured and SSV/cultured. Follicles from all the fragments were analysed for morphology, development and viability. The ECM was evaluated based on the condition of collagen and reticular fibres and the immunolocalization of type I collagen and fibronectin...
April 2015: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/25300617/disrupted-hyaluronan-binding-protein-1-habp1-expression-one-of-the-key-mediator-for-ovarian-dysfunction-in-polycystic-ovary-rat
#7
Mohammed Arif, Sonu Chand Thakur, Kasturi Datta
Proper follicular development is crucial for cumulus-oocyte complex (COC) maturation, ovulation and luteinisation. All these ovarian processes are regulated by finely tuned rapid tissue remodeling that involves hyaluronan and interconnecting hyaladherins-rich extracellular matrix synthesis and its breakdown by various proteinase systems like matrix metalloproteinase (MMP). Disrupted tissue remodeling machinery can result into pathophysiologies like atretic follicular cysts formation in polycystic ovary syndrome (PCOS)...
January 2015: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/25172128/gene-expression-of-matrix-metalloproteinases-and-lh-receptors-in-mare-follicular-development
#8
H B A Bastos, N A Kretzmann, G O Santos, A T Esmeraldino, S Fiala Rechsteiner, R C Mattos, A P Neves
The period from the emergence of a dominant follicle until its formation requires tissue remodeling. Enzymes promoting collagen lysis, such as matrix metalloproteinases (MMPs), are fundamental for the process of extracellular matrix remodeling, which allows changes in ovarian tissue architecture during follicular growth. It has been suggested that the production of these enzymes may be affected by the rise in circulating concentrations of LH, which acts on the ovarian surface epithelium (OSE). The aim of this study was to determine the expression of MMP-1, MMP-2, and LH receptor (LHR) in the ovulation fossa and in the central portion of the equine ovary during follicular deviation and dominance...
November 2014: Theriogenology
https://www.readbyqxmd.com/read/24830430/transcriptome-profiling-of-the-theca-interna-in-transition-from-small-to-large-antral-ovarian-follicles
#9
Nicholas Hatzirodos, Katja Hummitzsch, Helen F Irving-Rodgers, Raymond J Rodgers
The theca interna layer of the ovarian follicle forms during the antral stage of follicle development and lies adjacent to and directly outside the follicular basal lamina. It supplies androgens and communicates with the granulosa cells and the oocyte by extracellular signaling. To better understand developmental changes in the theca interna, we undertook transcriptome profiling of the theca interna from small (3-5 mm, n = 10) and large (9-12 mm, n = 5) healthy antral bovine follicles, representing a calculated >7-fold increase in the amount of thecal tissue...
2014: PloS One
https://www.readbyqxmd.com/read/24422759/transcriptome-profiling-of-granulosa-cells-of-bovine-ovarian-follicles-during-growth-from-small-to-large-antral-sizes
#10
Nicholas Hatzirodos, Helen F Irving-Rodgers, Katja Hummitzsch, Margaret L Harland, Stephanie E Morris, Raymond J Rodgers
BACKGROUND: At later stages of folliculogenesis, the mammalian ovarian follicle contains layers of epithelial granulosa cells surrounding an antral cavity. During follicle development granulosa cells replicate, secrete hormones and support the growth of the oocyte. In cattle, the follicle needs to grow > 10 mm in diameter to allow an oocyte to ovulate, following which the granulosa cells cease dividing and differentiate into the specialised cells of the corpus luteum. To better understand the molecular basis of follicular growth and granulosa cell maturation, we undertook transcriptome profiling of granulosa cells from small (< 5 mm; n = 10) and large (> 10 mm, n = 4) healthy bovine follicles using Affymetrix microarrays (24,128 probe sets)...
January 14, 2014: BMC Genomics
https://www.readbyqxmd.com/read/24375265/promoting-extracellular-matrix-remodeling-via-ascorbic-acid-enhances-the-survival-of-primary-ovarian-follicles-encapsulated-in-alginate-hydrogels
#11
David Tagler, Yogeshwar Makanji, Tao Tu, Beatriz Peñalver Bernabé, Raymond Lee, Jie Zhu, Ekaterina Kniazeva, Jessica E Hornick, Teresa K Woodruff, Lonnie D Shea
The in vitro growth of ovarian follicles is an emerging technology for fertility preservation. Various strategies support the culture of secondary and multilayer follicles from various species including mice, non-human primate, and human; however, the culture of early stage (primary and primordial) follicles, which are more abundant in the ovary and survive cryopreservation, has been limited. Hydrogel-encapsulating follicle culture systems that employed feeder cells, such as mouse embryonic fibroblasts (MEFs), stimulated the growth of primary follicles (70-80 µm); yet, survival was low and smaller follicles (<70 µm) rapidly lost structure and degenerated...
July 2014: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/24026057/involvement-of-androgens-in-ovarian-health-and-disease
#12
REVIEW
M Lebbe, T K Woodruff
In women, ovary and adrenal gland produce androgens. Androgens are essential drivers of the primordial to antral follicle development, prior to serving as substrate for estrogen production in the later stages of folliculogenesis. Androgens play a crucial role in the follicular-stromal intertalk by fine tuning the extracellular matrix and vessel content of the ovarian stroma. Local auto-and paracrine factors regulate androgen synthesis in the pre-antral follicle. Androgen excess is a hallmark of polycystic ovary syndrome and is a key contributor in the exaggerated antral follicle formation, stromal hyperplasia and hypervascularity...
December 2013: Molecular Human Reproduction
https://www.readbyqxmd.com/read/23866836/three-dimensional-systems-for-in-vitro-follicular-culture-overview-of-alginate-based-matrices
#13
REVIEW
Ivina R Brito, Isadora M T Lima, Min Xu, Lonnie D Shea, Teresa K Woodruff, José R Figueiredo
The in vitro culture of ovarian follicles has provided critical insight into the biology of the follicle and its enclosed oocyte and the physical interaction and communication between the theca and granulosa cells and the oocyte that is necessary to produce meiotically competent oocytes. Various two-dimensional (2D) and three-dimensional (3D) culture systems have been developed to evaluate the effect of growth factors, hormones, extracellular matrix components and culture conditions on follicle development and oocyte growth and maturation...
August 2014: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/23608357/fibrin-promotes-development-and-function-of-macaque-primary-follicles-during-encapsulated-three-dimensional-culture
#14
J Xu, M S Lawson, R R Yeoman, T A Molskness, A Y Ting, R L Stouffer, M B Zelinski
STUDY QUESTION: Does fibrin introduced into the extracellular matrix affect the growth and maturation of individual primate follicles during encapsulated three-dimensional (3D) culture? SUMMARY ANSWER: While not altering follicle survival, fibrin-alginate (FIBRIN) improves macaque primary, but not secondary, follicle development during encapsulated 3D culture in terms of growth, steroidogenesis, anti-Müllerian hormone (AMH)/vascular endothelial growth factor (VEGF) production and oocyte maturation...
August 2013: Human Reproduction
https://www.readbyqxmd.com/read/23564726/changes-in-granulosa-cells-gene-expression-associated-with-increased-oocyte-competence-in-bovine
#15
Anne-Laure Nivet, Christian Vigneault, Patrick Blondin, Marc-André Sirard
One of the challenges in mammalian reproduction is to understand the basic physiology of oocyte quality. It is believed that the follicle status is linked to developmental competence of the enclosed oocyte. To explore the link between follicles and competence in cows, previous research at our laboratory has developed an ovarian stimulation protocol that increases and then decreases oocyte quality according to the timing of oocyte recovery post-FSH withdrawal (coasting). Using this protocol, we have obtained the granulosa cells associated with oocytes of different qualities at selected times of coasting...
June 2013: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/23409002/a-new-model-of-development-of-the-mammalian-ovary-and-follicles
#16
Katja Hummitzsch, Helen F Irving-Rodgers, Nicholas Hatzirodos, Wendy Bonner, Laetitia Sabatier, Dieter P Reinhardt, Yoshikazu Sado, Yoshifumi Ninomiya, Dagmar Wilhelm, Raymond J Rodgers
Ovarian follicular granulosa cells surround and nurture oocytes, and produce sex steroid hormones. It is believed that during development the ovarian surface epithelial cells penetrate into the ovary and develop into granulosa cells when associating with oogonia to form follicles. Using bovine fetal ovaries (n = 80) we identified a novel cell type, termed GREL for Gonadal Ridge Epithelial-Like. Using 26 markers for GREL and other cells and extracellular matrix we conducted immunohistochemistry and electron microscopy and chronologically tracked all somatic cell types during development...
2013: PloS One
https://www.readbyqxmd.com/read/23388061/insulin-and-insulin-like-growth-factor-signaling-increases-proliferation-and-hyperplasia-of-the-ovarian-surface-epithelium-and-decreases-follicular-integrity-through-upregulation-of-the-pi3-kinase-pathway
#17
Shelby M King, Dimple A Modi, Sharon L Eddie, Joanna E Burdette
BACKGROUND: The ovarian surface epithelium responds to cytokines and hormonal cues to initiate proliferation and migration following ovulation. Although insulin and IGF are potent proliferative factors for the ovarian surface epithelium and IGF is required for follicle development, increased insulin and IGF activity are correlated with at least two gynecologic conditions: polycystic ovary syndrome and epithelial ovarian cancer. Although insulin and IGF are often components of in vitro culture media, little is known about the effects that these growth factors may have on the ovarian surface epithelium morphology or how signaling in the ovarian surface may affect follicular health and development...
2013: Journal of Ovarian Research
https://www.readbyqxmd.com/read/23342920/expression-of-matrix-metalloproteinase-2-mrna-in-the-chicken-ovary-in-relation-to-follicle-remodelling
#18
Agnieszka Leśniak, Anna Hrabia
In the mammalian ovary, matrix metalloproteinase-2 (MMP-2) is thought to be involved in the regulated turnover of the extracellular matrix during the process of follicle development, ovulation and regression. Information concerning the role of MMP-2 in the chicken ovary is scarce. The present investigation was undertaken to determine the distribution of MMP-2 mRNA within the laying hen ovary as well as to define whether the expression of MMP-2 mRNA changes during the ovulatory cycle. Expression of MMP-2 mRNA in ovarian compartments was determined by RT-PCR analysis at two stages of the ovulatory cycle, i...
2012: Folia Biologica (Krakow)
https://www.readbyqxmd.com/read/23242557/microarray-analysis-identifies-comp-as-the-most-differentially-regulated-transcript-throughout-in-vitro-follicle-growth
#19
Robin M Skory, Beatriz Peñalver Bernabé, Eugene Galdones, Linda J Broadbelt, Lonnie D Shea, Teresa K Woodruff
In vitro follicle growth has emerged as a technology that can provide new information about folliculogenesis and serve as part of a suite of methods currently under development to assist women whose fertility is threatened by cancer treatments. Though it has been shown that in vitro-grown follicles secrete peptide and steroid hormones, much of the follicular transcriptome remains unknown. Thus, microarray analysis was performed to characterize the transcriptome and secretome of in vitro-grown follicles. One prominently regulated gene product was cartilage oligomeric matrix protein (Comp): its mRNA was upregulated during the final 4 days of culture (P < 0...
February 2013: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/23127507/role-of-interleukins-in-the-regulation-of-ovarian-functions
#20
REVIEW
K Smolikova, A Mlynarcikova, S Scsukova
UNLABELLED: Reproduction is a result of coordinated signaling network between gonads and pituitary/hypothalamus. Ovarian functions, such as follicular development, ovulation, luteinisation, luteolysis, and remodeling of the endometrium, are controlled by endocrine, paracrine and autocrine factors. Ovulation is a unique biological process by which the complex of a mature oocyte and surrounding somatic cumulus cells (CCs), named oocyte-cumulus complex (OCC), is released from the follicle into the oviduct for transport and fertilization...
October 2012: Endocrine Regulations
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