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https://www.readbyqxmd.com/read/30309894/thermodynamic-destabilization-and-aggregation-propensity-as-the-underlying-mechanism-behind-the-genetic-association-of-apoe3-mutants-and-lipoprotein-glomerulopathy
#1
Maria Katsarou, Efstratios Stratikos, Angeliki Chroni
Lipoprotein glomerulopathy (LPG) is a rare renal disease, characterized by lipoprotein thrombi in glomerular capillaries. A series of apolipoprotein E (apoE) mutations have been associated with LPG development. We previously showed that three mutants based on apoE3 sequence, in which an arginine was substituted by proline, are thermodynamically destabilized and aggregation-prone. To examine whether other LPG-associated apoE3 mutations induce similar effects, we characterized three non-proline LPG-associated apoE3 mutations, namely the R25C (apoEKyoto), R114C (apoETsukuba) and A152D (apoELasVegas)...
October 11, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/30246448/delirium-detection-by-a-novel-bispectral-eeg-device-in-general-hospital
#2
Gen Shinozaki, Aubrey Chan, Nick Sparr, Kasra Zarei, Lindsey Gaul, Jonathan Heinzman, Julian Robles, Kumi Yuki, Theodosis Chronis, Timothy Ando, Terrence Wong, Sayeh Sabbagh, Michelle Weckmann, Sangil Lee, Thoru Yamada, Matthew Karam, Nicholas Noiseux, Eri Shinozaki, John Cromwell
AIM: Delirium is common and dangerous among elderly inpatients. Yet it is underdiagnosed and thus undertreated. This study aims to test the diagnostic characteristics of a noninvasive point-of-care device with two-channel (bispectral) electroencephalography (EEG) for the screening of delirium in the hospital. METHODS: Patients admitted to the University of Iowa Hospitals and Clinics were assessed for the presence of delirium with a clinical assessment, the Confusion Assessment Method for Intensive Care Unit and Delirium Rating Scale...
September 24, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30198579/study-of-the-involvement-of-phosphatidic-acid-formation-in-the-expression-of-wound-responsive-genes-in-cotton
#3
Angeliki Bourtsala, Ioannis Dafnis, Angeliki Chroni, Theodora Farmaki, Dia Galanopoulou
Plants use phospholipase D (PLD, EC 3.1.4.4)/phosphatidic acid (PtdOH) for the transduction of environmental signals including those coming from wounding. Based on our previous findings suggesting that wound-induced PLDα-derived PtdOH can act as a local signaling molecule in cotton (Gossypium hirsutum), we show that wounding immediately increases local NADPH oxidase (NADPHox) and cellulose synthase A (CeSA) gene expression. After developing a novel fluorimetric assay for the investigation of n-butanol inhibitory effect on PLD activity, we show that only NADPHox gene upregulation is reduced when n-butanol is applied prior to wounding...
September 10, 2018: Lipids
https://www.readbyqxmd.com/read/30092430/spontaneous-type-ia-endoleak-sealing-in-patients-undergoing-endovascular-aneurysm-repair-with-the-ovation-stent-graft
#4
Nikolaos Kontopodis, Emmanouel Tavlas, Nikolaos Galanakis, Christos Chronis, Alexandros Kafetzakis, Dimitrios Tsetis, Christos V Ioannou
BACKGROUND: Type Ia endoleak may lead to continuous sac pressurization and late rupture after endovascular aneurysm repair (EVAR). Nevertheless, there have been scarce reports suggesting that these endoleaks may occasionally present spontaneous sealing. Taking into account the original sealing mechanism of the Ovation endograft that exploits 2 polymer-filled O-rings, we hypothesize that spontaneous type Ia endoleak sealing may sometimes incur following implantation of this device. We aim to report our experience with spontaneous type Ia endoleak sealing in patients treated with the Ovation endograft...
August 6, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30008420/thank-you-a-journal-is-as-good-as-its-reviewers
#5
EDITORIAL
Umberto Arena, Morton Barlaz, Pinjing He, Ing I D'Adamo, Sergi Astals, Jean E Bogner, Stephanie C Bolyard, Jorge Manuel Caliço Lopes de Brito, Paolo S Calabrò, Paolo Canu, Christina Chroni, Bill Clarke, Hervé Corvellec, Giulia Costa, Malcolm Richard Gent, Antonio Gallardo Izquierdo, Jacek A Koziel, Nuno Lapa, Bo Leckner, Lidia Lombardi, Massimiliano Materazzi, Hans Oonk, Kostyantyn Pivnenko, Krishna R Reddy, Hans van der Sloot, Jan-Olov Sundqvist, Fabio Tatàno, Timothy Townsend, David Turner, Juergen Vehlow, Tianfeng Wang, Yongjiang Wang, Jim White, Yang Zeng, Christian Zurbrügg
No abstract text is available yet for this article.
July 2018: Waste Management
https://www.readbyqxmd.com/read/29889314/infant-temperament-reactivity-and-early-maternal-caregiving-independent-and-interactive-links-to-later-childhood-attention-deficit-hyperactivity-disorder-symptoms
#6
Natalie V Miller, Kathryn A Degnan, Amie A Hane, Nathan A Fox, Andrea Chronis-Tuscano
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with origins early in life. There is growing evidence that individual differences in temperament reactivity are predictive of ADHD symptoms, yet little is known about the relations between temperament reactivity in early infancy and later ADHD symptoms or the combined effect of reactivity with early environmental factors on ADHD symptom development. Using a 9-year prospective longitudinal design, this study tested the independent and interactive contributions of infant reactivity and maternal caregiving behaviors (MCB) on parent- and teacher-reported childhood ADHD symptoms...
June 11, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29886211/has-anatomic-complexity-of-abdominal-aortic-aneurysms-undergoing-open-surgical-repair-changed-after-the-introduction-of-endovascular-treatment-systematic-review-and-meta-analysis-of-comparative-studies
#7
REVIEW
Nikolaos Kontopodis, Emmanouil Tavlas, Efstratios Georgakarakos, Nikolaos Galanakis, Christos Chronis, Dimitrios Tsetis, Christos V Ioannou
BACKGROUND: At a time when endovascular aneurysm repair (EVAR) is increasingly used to treat abdominal aortic aneurysms (AAAs), lesions undergoing open surgical repair (OSR) may present significant differences compared with those treated before wide EVAR availability. We aim to record discrepancies in AAAs surgically treated before and after the introduction of EVAR. METHODS: We conducted a systematic review of the literature and meta-analysis of comparative studies...
October 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29808926/outcome-of-patients-with-myelofibrosis-relapsing-after-allogeneic-stem-cell-transplant-a-retrospective-study-by-the-chronic-malignancies-working-party-of-ebmt
#8
Donal P McLornan, Richard Szydlo, Marie Robin, Anja van Biezen, Linda Koster, Henrik J P Blok, Maria T Van Lint, Jürgen Finke, Antonin Vitek, Kristina Carlson, Laimonas Griskevicius, Ernst Holler, Maija Itälä-Remes, Michel Schaap, Gerard Socié, Jacques-Olivier Bay, Yves Beguin, Benedetto Bruno, Jan J Cornelissen, Tobias Gedde-Dahl, Per Ljungman, Marie T Rubio, Ibrahim Yakoub-Agha, Evgeny Klyuchnikov, Eduardo Olavarria, Yves Chalandon, Nicolaus Kröger
Allogeneic Haematopoietic Stem Cell Transplant (allo-HSCT) remains the only curative approach for Myelofibrosis (MF). Scarce information exists in the literature on the outcome and, indeed, management of those MF patients who relapse following transplant. We hereby report on the management and outcome of 202 patients who relapsed post allo-HSCT for MF.
May 29, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29805195/use-of-an-end-to-end-simulator-to-analyze-cygnss
#9
Kacie E Hoover, John R Mecikalski, Timothy J Lang, Xuanli Li, Tyler J Castillo, Themis Chronis
Tropical convection during the onset of two Madden-Julian oscillation (MJO) events, in October and December of 2011, was simulated using the Weather Research and Forecasting (WRF) Model. Observations from the Dynamics of the MJO (DYNAMO) field campaign were assimilated into the WRF Model for an improved simulation of the mesoscale features of tropical convection. The WRF simulations with the assimilation of DYNAMO data produced realistic representations of mesoscale convection related to westerly wind bursts (WWBs) as well as downdraft-induced gust fronts...
January 2018: Journal of Atmospheric and Oceanic Technology
https://www.readbyqxmd.com/read/29743204/apoe-isoforms-and-carboxyl-terminal-truncated-apoe4-forms-affect-neuronal-bace1-levels-and-a%C3%AE-production-independently-of-their-cholesterol-efflux-capacity
#10
Ioannis Dafnis, Christina Raftopoulou, Christina Mountaki, Evgenia Megalou, Vassilis I Zannis, Angeliki Chroni
The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) initiates the production of amyloid-β peptide (Aβ), which is central to the pathogenesis of Alzheimer's disease (AD). Changes in brain cholesterol homeostasis have been suggested to affect Aβ metabolism. Cholesterol homeostasis is maintained in the brain by apolipoprotein E (apoE). The apoE4 isoform constitutes the major risk factor for AD. Here, we investigated the effect of apoE forms on Aβ generation and on BACE1 levels. We also examined the potential involvement in these processes of cholesterol transporters ABCG1 and ABCG4 or the lipoprotein receptor SR-BI, which are implicated in cholesterol efflux to apoE...
May 31, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29742391/loss-of-mecp2-leads-to-activation-of-p53-and-neuronal-senescence
#11
Minori Ohashi, Elena Korsakova, Denise Allen, Peiyee Lee, Kai Fu, Benni S Vargas, Jessica Cinkornpumin, Carlos Salas, Jenny C Park, Igal Germanguz, Justin Langerman, Contantinos Chronis, Edward Kuoy, Stephen Tran, Xinshu Xiao, Matteo Pellegrini, Kathrin Plath, William E Lowry
To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro. Molecular profiling uncovered neuronal-specific gene expression changes, including induction of a senescence-associated secretory phenotype (SASP) program. Patient-derived neurons made without MECP2 showed signs of stress, including induction of P53, and senescence...
May 8, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29712588/late-type-ia-endoleak-after-open-surgical-repair-of-an-aortic-aneurysm-leading-to-rupture-does-this-really-exist
#12
Nikolaos Kontopodis, Christos Chronis, George Papadopoulos, Nikolaos Daskalakis, Emmanouil Tavlas, Stella Lioudaki, Alexandra Papaioannou, Christos V Ioannou
No abstract text is available yet for this article.
April 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29681539/x-chromosome-dosage-influences-dna-methylation-dynamics-during-reprogramming-to-mouse-ipscs
#13
Vincent Pasque, Rahul Karnik, Constantinos Chronis, Paula Petrella, Justin Langerman, Giancarlo Bonora, Juan Song, Lotte Vanheer, Anupama Sadhu Dimashkie, Alexander Meissner, Kathrin Plath
A dramatic difference in global DNA methylation between male and female cells characterizes mouse embryonic stem cells (ESCs), unlike somatic cells. We analyzed DNA methylation changes during reprogramming of male and female somatic cells and in resulting induced pluripotent stem cells (iPSCs). At an intermediate reprogramming stage, somatic and pluripotency enhancers are targeted for partial methylation and demethylation. Demethylation within pluripotency enhancers often occurs at ESC binding sites of pluripotency transcription factors...
May 8, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29532752/hdl-dysfunction-caused-by-mutations-in-apoa-i-and-other-genes-that-are-critical-for-hdl-biogenesis-and-remodeling
#14
Angeliki Chroni, Dimitris Kardassis
The "HDL hypothesis" supporting that an elevation in HDL cholesterol (HDL-C) levels by drugs or by life style changes should be paralleled by a decrease in the risk for Cardiovascular Disease (CVD) has been challenged by recent epidemiological and clinical studies using HDL-raising drugs. HDL components such as proteins, lipids or small RNA molecules, but not cholesterol itself, possess various atheroprotective functions in different cell types and accumulating evidence supports the new hypothesis that HDL functionality is more important than HDL-C levels for CVD risk prediction...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29463328/bilateral-sudden-sensorineural-hearing-loss-as-a-first-symptom-of-infective-endocarditis-two-case-reports
#15
M Chroni, E Prappa, I Kokkevi
BACKGROUND: Septic emboli are an unusual cause of sudden sensorineural hearing loss, for which few reports exist in the literature. CASE REPORT: This paper presents two cases of sudden sensorineural hearing loss, initially considered as idiopathic, but which were caused by septic emboli. Hearing loss in these cases was bilateral, sequential and total. The first patient had mild fever one week prior to their presentation with sudden sensorineural hearing loss; the other patient had no additional symptoms at presentation...
April 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29413456/occurrence-of-bifid-median-nerve-in-healthy-and-carpal-tunnel-syndrome-patients
#16
Eftychia Trachani, Aspasia Rigopoulou, Dimitra Veltsista, Evangelia Gavanozi, Athina Chrysanthopoulou, Elisabeth Chroni
We investigated the possible association between median nerve morphology and carpal tunnel size, hand side and nerve conduction measurements. The study included a patient group (n = 58; 44 women) with idiopathic carpal tunnel syndrome (CTS) in 100 hands and a control group of healthy volunteers (n = 56, 112 hands; 44 women). The following data were recorded: (1) median and ulnar motor and sensory nerve conduction parameters (2) ultrasonographic dimensions of the carpal tunnel inlet area (CTAin ) and inlet area of the median nerve...
April 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29405747/future-directions-for-research-on-early-intervention-for-young-children-at-risk-for-social-anxiety
#17
Andrea Chronis-Tuscano, Christina M Danko, Kenneth H Rubin, Robert J Coplan, Danielle R Novick
Anxiety disorders are common among young children, with earlier onset typically associated with greater severity and persistence. A stable behaviorally inhibited (BI) temperament and subsequent shyness and social withdrawal (SW) place children at increased risk of developing anxiety disorders, particularly social anxiety. In this Future Directions article, we briefly review developmental and clinical research and theory that point to parenting and peer interactions as key moderators of both the stability of BI/SW and risk for later anxiety, and we describe existing interventions that address early BI/SW and/or anxiety disorders in young children...
July 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29387933/macroinvertebrate-and-fish-communities-in-the-watershed-of-a-re-constructed-mediterranean-water-body-link-to-the-ecological-potential
#18
D C Bobori, Ch Ntislidou, O Petriki, I Chronis, I Kagalou, M Lazaridou
The role of benthic macroinvertebrate and fish communities for assessing the ecological quality of an artificial re-constructed, after 50 years of dryness, Mediterranean water body (Karla Reservoir, Greece) is presented. Moreover, we provide knowledge on the structure of the biological communities and their functioning role, for inspiring feature actions that will contribute to biodiversity protection and ecosystem services. Water (physicochemical parameters), benthic macroinvertebrates, and fish were monitored during a 2-year survey (2013-2015) in Karla and Kalamaki reservoirs and the inflowing ditches...
February 1, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29366283/natural-human-apoa-i-mutations-l144r-a164s-and-l178p-alter-apoa-i-and-hdl-structure-and-functionality
#19
Christina Gkolfinopoulou, Faye Soukou, Efstratios Stratikos, Angeliki Chroni
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29327309/ischemia-reperfusion-injury-of-sciatic-nerve-in-rats-protective-role-of-combination-of-vitamin-c-with-e-and-tissue-plasminogen-activator
#20
Katerina Apostolopoulou, Dimitris Konstantinou, Rodoula Alataki, Ioannis Papapostolou, Dimitrios Zisimopoulos, Electra Kalaitzopoulou, Vasiliki Bravou, Ioannis Lilis, Fevronia Angelatou, Helen Papadaki, Christos D Georgiou, Elisabeth Chroni
An ischemia/reperfusion injury of rat's sciatic nerve was experimentally developed. In this model, we measured the in vivo production of superoxide radical, as a marker of oxidative stress and the occludin expression as an indicator of blood-nerve barrier function and we examined potential protective innervations against these abnormalities. Right sciatic nerves of the animals underwent 3 h of ischemia followed by 7 days of reperfusion and were divided into three groups: ischemic, pretreated with vitamin C in conjunction with vitamin E and treated with tissue plasminogen activator...
March 2018: Neurochemical Research
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