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https://www.readbyqxmd.com/read/30080930/advantages-of-patient-derived-orthotopic-mouse-models-and-genetic-reporters-for-developing-fluorescence-guided-surgery
#1
REVIEW
Thinzar M Lwin, Robert M Hoffman, Michael Bouvet
Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe evaluation and highlights the advantages of patient-derived orthotopic xenografts (PDOX) mouse models and genetic reporters to develop fluorescence-guided surgery.
August 6, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30073742/ph-reduction-dual-triggered-degradable-poly-doxorubicin-prodrug-nanoparticles-for-leakage-free-tumor-specific-self-delivery
#2
Jiagen Li, Peng Liu
Poly(doxorubicin) (PDOX) is synthesized with Mn of 1.66 × 104 and DOX content of 78% as prodrug for tumor-specific triggered release, via a facile condensation polymerization of DOX-SS-DOX and adipic dihydrazide. The PDOX nanoparticles (PDOX-NPs) could completely release DOX-SH within 1.5 days at the simulated tumor microenvironment, but no measurable leakage in the physiological media. The in vitro controlled release results show that the releasing rate is influenced by the dosage and independent of the particle size, while the solubility of the degraded products should be the main determining factor for the drug release from the PDOX-NPs...
August 3, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/30060824/doxorubicin-resistant-pleomorphic-liposarcoma-with-pdgfra-gene-amplification-is-targeted-and-regressed-by-pazopanib-in-a-patient-derived-orthotopic-xenograft-mouse-model
#3
Tasuku Kiyuna, Takashi Murakami, Yasunori Tome, Kentaro Igarashi, Kei Kawaguchi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Tara A Russell, Shree Ram Singh, Fuminori Kanaya, Fritz C Eilber, Robert M Hoffman
Pleomorphic liposarcoma (PLPS) is a heterogeneous resistant group of tumors. Complete surgical resection is the only known way to treat PLPS. PLPS is reristant to both radiation and chemotherapy. Therefore, precise individualized therapy is needed to improve outcome of advanced PLPS patients. In this study, a patient-derived orthotopic xenograft (PDOX) model of a PDGFRA-amplified PLPS was established in the biceps femoris of nude mice by surgical orthotopic implantation (SOI) in order to match the patient. The PLPS PDOX was treated with pazopanib (PAZ) which targets PDGFRA, as well as with temozolomide (TEM) and first-line therapy doxorubicin (DOX)...
August 2018: Tissue & Cell
https://www.readbyqxmd.com/read/30055076/partially-oxidized-palladium-nanodots-for-enhanced-electrocatalytic-carbon-dioxide-reduction
#4
Hui Lu, Le Zhang, Juhua Zhong, Huagui Yang
Here we report a partially oxidized palladium nanodots (Pd/PdOx) catalyst with a diameter of around 4.5 nm. In aqueous CO2-saturated 0.5 M KHCO3, the catalyst displays a Faradaic efficiency (FE) of 90% at -0.55 V vs. reversible hydrogen electrode (RHE) for carbon monoxide (CO) production and the activity can be retained for at least 24 h. The improved catalytic activity can be attributed to the strong adsorption of CO2*- intermediate on the Pd/PdOx electrode, wherein the presence of Pd2+ during the electroreduction reaction of CO2 may play an important role in accelerating the carbon dioxide reduction reaction (CO2RR)...
July 28, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/30024282/patterns-of-sensitivity-to-a-panel-of-drugs-are-highly-individualized-for-undifferentiated-unclassified-soft-tissue-sarcoma-usts-in-patient-derived-orthotopic-xenograft-pdox-nude-mouse-models
#5
Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Arun S Singh, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Michiaki Unno, Shree Ram Singh, Fritz C Eilber, Robert M Hoffman
Undifferentiated/unclassified soft tissue sarcoma (USTS) is a recalcitrant disease, therefore, precise individualized therapy is needed. Toward this goal, we previously established patient-derived orthotopic xenograft (PDOX) models of USTS in nude mice. Here, we determined the extent of uniqueness of drug response in a panel on USTS PDOX models from 5 different patients. We previously showed that 3 of the 5 patients were resistant to DOX despite DOX being first-line therapy. Two weeks after orthotopic tumor implantation, PDOX mouse models were randomized into five groups: untreated control, doxorubicin (DOX), gemcitabine/docetaxel (GEM/DOC), pazopanib (PAZ); temozolomide (TEM) and 3 PDOX cases completely resistant to DOX...
July 19, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/30003151/tumor-targeting-salmonella-typhimurium-a1-r-suppressed-an-imatinib-resistant-gastrointestinal-stromal-tumor-with-c-kit-exon-11-and-17-mutations
#6
Kentaro Miyake, Kei Kawaguchi, Masuyo Miyake, Ming Zhao, Tasuku Kiyuna, Kentaro Igarashi, Zhiying Zhang, Takashi Murakami, Yunfeng Li, Scott D Nelson, Michael Bouvet, Irmina Elliott, Tara A Russell, Arun S Singh, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chishima, Shree Ram Singh, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Gastrointestinal stromal tumor (GIST) is a refractory disease in need of novel efficacious therapy. The aim of our study was to evaluate the effectiveness of tumor-targeting Salmonella typhimurium A1-R ( S. typhimurium A1-R) using on a patient derived orthotopic xenograft (PDOX) model of imatinib-resistant GIST. The GIST was obtained from a patient with regional recurrence, and implanted in the anterior gastric wall of nude mice. The GIST PDOX mice were randomized into 3 groups of 6 mice each when the tumor volume reached 60 mm3 : G1, control group; G2, imatinib group (oral administration [p...
June 2018: Heliyon
https://www.readbyqxmd.com/read/29963961/tumor-targeting-salmonella-typhimurium-a1-r-in-combination-with-gemcitabine-gem-regresses-partially-gem-resistant-pancreatic-cancer-patient-derived-orthotopic-xenograft-pdox-nude-mouse-models
#7
Kei Kawaguchi, Kentaro Miyake, Ming Zhao, Tasuku Kiyuna, Kentaro Igarashi, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Michael Bouvet, Michiaki Unno, Robert M Hoffman
Gemcitabine (GEM) is first-line therapy for pancreatic cancer but has limited efficacy in most cases. Nanoparticle-albumin bound (nab)-paclitaxel is becoming first-line therapy for pancreatic cancer, but also has limited efficacy for pancreatic cancer. Our goal was to improve the treatment outcome in patient-like models of pancreatic cancer. We previously established patient-derived orthotopic xenografts (PDOX) pancreatic cancers from two patients. The pancreatic tumor was implanted orthotopically in the pancreatic tail of nude mice to establish the PDOX models...
July 2, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29932244/tumor-targeting-salmonella-typhimurium-a1-r-arrests-a-doxorubicin-resistant-pdgfra-amplified-patient-derived-orthotopic-xenograft-mouse-model-of-pleomorphic-liposarcoma
#8
Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Ming Zhao, Kentaro Miyake, Kentaro Igarashi, Kei Kawaguchi, Masuyo Miyake, Hiromichi Oshiro, Takashi Higuchi, Yunfeng Li, Sarah M Dry, Scott D Nelson, Tara A Russell, Mark A Eckardt, Arun S Singh, Fuminori Kanaya, Fritz C Eilber, Robert M Hoffman
Pleomorphic liposarcoma (PLPS) is a recalcitrant soft-tissue sarcoma (STS) subtype in need of transformative therapy. We have previously established a patient-derived orthotopic xenograft (PDOX) model, of PLPS with PDGFRA amplification, using surgical orthotopic implantation. In the current study, the PLPS PDOX model was randomized into 3 groups of 7 mice each: untreated control; doxorubicin (DOX)-treated; and treated with Salmonella typhimurium A1-R (S. typhimurium A1-R) expressing green fluorescent protein (GFP)...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29928962/oral-recombinant-methioninase-o-rmetase-is-superior-to-injectable-rmetase-and-overcomes-acquired-gemcitabine-resistance-in-pancreatic-cancer
#9
Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Tasuku Kiyuna, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Michael Bouvet, Shree Ram Singh, Michiaki Unno, Robert M Hoffman
Recombinant methioninase (rMETase) was previously administered as an injectable drug to target methionine dependence of cancer. Recently, we observed that rMETase could be administered orally (o-rMETase) in a patient-derived orthotopic xenograft (PDOX) mouse model of melanoma. Here, we determined the efficacy of o-rMETase on a pancreatic cancer PDOX model. Forty pancreatic cancer PDOX mouse models were randomized into four groups of 10 mice each. o-rMETase was significantly more effective than i.p.-rMETase, but the combination of both was significantly more effective than either alone...
September 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29924472/outstanding-methane-oxidation-performance-of-palladium-embedded-ceria-catalysts-prepared-by-a-one-step-dry-ball-milling-method
#10
Maila Danielis, Sara Colussi, Carla de Leitenburg, Lluís Soler, Jordi Llorca, Alessandro Trovarelli
By carefully mixing Pd metal nanoparticles with CeO2 polycrystalline powder under dry conditions, an unpredicted arrangement of the Pd-O-Ce interface is obtained in which an amorphous shell containing palladium species dissolved in ceria is covering a core of CeO2 particles. The robust contact that is generated at the nanoscale, along with mechanical forces generated during mixing, promotes the redox exchange between Pd and CeO2 and creates highly reactive and stable sites constituted by PdOx embedded into CeO2 surface layers...
June 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29892358/selective-and-metal-free-epoxidation-of-terminal-alkenes-by-heterogeneous-polydioxirane-in-mild-conditions
#11
M Kazemnejadi, A Shakeri, M Nikookar, R Shademani, M Mohammadi
Polydioxirane (PDOX) was prepared by the treatment of polysalicylaldehyde with Oxone and was found as a selective, highly efficient and heterogeneous reagent for epoxidation of alkenes which can be successfully isolated. This work also introduced a simpler, safer and milder way for epoxidation of alkenes with dioxirane groups than before. PDOX can be simply recovered from the reaction mixture by plain filtration and reused for eight runs without significant reactivity loss.
May 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29857821/mek-inhibitor-trametinib-in-combination-with-gemcitabine-regresses-a-patient-derived-orthotopic-xenograft-pdox-pancreatic-cancer-nude-mouse-model
#12
Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Thinzar M Lwin, Masuyo Miyake, Tasuku Kiyuna, Ho Kyoung Hwang, Takashi Murakami, Jonathan C Delong, Shree Ram Singh, Bryan Clary, Michael Bouvet, Michiaki Unno, Robert M Hoffman
Pancreatic cancer is resistant to treatment and needs precision individualized therapy to improve the outcome of this disease. Previously, we demonstrated that trametinib (TRA), a MEK inhibitor, could inhibit a pancreatic cancer patient-derived orthotopic xenograft (PDOX). In the present study, we show that gemcitabine (GEM) in combination with TRA was more effective than TRA alone. We implanted a patient pancreatic cancer orthotopically in the pancreatic tail of nude mice to establish the PDOX model. After seven weeks of tumor growth, we divided 32 pancreatic-cancer PDOX nude mice into 4 groups of eight: untreated control; GEM (once a week for 2 weeks); TRA (14 consecutive days); GEM + TRA (GEM: once a week for 2 weeks, TRA:14 consecutive days)...
June 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29737543/temozolomide-regresses-a-doxorubicin-resistant-undifferentiated-spindle-cell-sarcoma-patient-derived-orthotopic-xenograft-pdox-precision-oncology-nude-mouse-model-matching-the-patient-with-effective-therapy
#13
Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Irmina A Elliott, Tara A Russell, Mark A Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant cancer, resistant to conventional chemotherapy. A patient with high-grade USCS from a striated muscle was implanted orthotopically in the right biceps femoris muscle of mice to establish a patient-derived orthotopic xenograft (PDOX) model. The PDOX models were randomized into the following groups when tumor volume reached 100 mm3 : G1, control without treatment; G2, doxorubicin (DOX) (3 mg/kg, intraperitoneal [i.p.] injection, weekly, for 2 weeks); G3, temozolomide (TEM) (25 mg/kg, p...
August 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29721200/recombinant-methioninase-combined-with-doxorubicin-dox-regresses-a-dox-resistant-synovial-sarcoma-in-a-patient-derived-orthotopic-xenograft-pdox-mouse-model
#14
Kentaro Igarashi, Kei Kawaguchi, Shukuan Li, Qinghong Han, Yuying Tan, Emily Gainor, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Arun S Singh, Mark A Eckardt, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Synovial sarcoma (SS) is a recalcitrant subgroup of soft tissue sarcoma (STS). A tumor from a patient with high grade SS from a lower extremity was grown orthotopically in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) mouse model. The PDOX mice were randomized into the following groups when tumor volume reached approximately 100 mm3 : G1, control without treatment; G2, doxorubicin (DOX) (3 mg/kg, intraperitoneal [i.p.] injection, weekly, for 2 weeks; G3, rMETase (100 unit/mouse, i...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713497/patient-derived-orthotopic-xenograft-models-for-cancer-of-unknown-primary-precisely-distinguish-chemotherapy-and-tumor-targeting-s-typhimurium-a1-r-is-superior-to-first-line-chemotherapy
#15
Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Kei Kawaguchi, Sang Nam Yoon, Zhiying Zhang, Kentaro Igarashi, Sahar Razmjooei, Sintawat Wangsiricharoen, Takashi Murakami, Yunfeng Li, Scott D Nelson, Tara A Russell, Arun S Singh, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chishima, Shree Ram Singh, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Cancer of unknown primary (CUP) is a recalcitrant disease with poor prognosis because it lacks standard first-line therapy. CUP consists of diverse malignancy groups, making personalized precision therapy essential. The present study aimed to identify an effective therapy for a CUP patient using a patient-derived orthotopic xenograft (PDOX) model. This paper reports the usefulness of the PDOX model to precisely identify effective and ineffective chemotherapy and to compare the efficacy of S. typhimurium A1-R with first-line chemotherapy using the CUP PDOX model...
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29629774/polymer-valence-isomerism-poly-dewar-o-xylylene-s
#16
Rong Zhu, Timothy M Swager
Poly( o-xylylene) (POX) has long been a challenging synthetic target despite its simple structure and potentially useful physical properties. In this report, we demonstrate a valence isomer strategy that leads to the formation of high molecular weight POX via an intermediate polymer of a unique structure, namely poly(Dewar- o-xylylene) (PDOX). We show that the free radical polymerization of highly strained Dewar- o-xylylene (DOX) monomer afforded PDOX, a material with a high density of Dewar benzene units in the backbone through ring-retaining propagation...
April 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29623758/targeting-altered-cancer-methionine-metabolism-with-recombinant-methioninase-rmetase-overcomes-partial-gemcitabine-resistance-and-regresses-a-patient-derived-orthotopic-xenograft-pdox-nude-mouse-model-of-pancreatic-cancer
#17
Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Thinzar M Lwin, Takashi Higuchi, Tasuku Kiyuna, Masuyo Miyake, Hiromichi Oshiro, Michael Bouvet, Michiaki Unno, Robert M Hoffman
Pancreatic cancer is a recalcitrant disease. Gemcitabine (GEM) is the most widely-used first-line therapy for pancreatic cancer, but most patients eventually fail. Transformative therapy is necessary to significantly improve the outcome of pancreatic cancer patients. Tumors have an elevated requirement for methionine and are susceptible to methionine restriction. The present study used a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer to determine the efficacy of recombinant methioninase (rMETase) to effect methionine restriction and thereby overcome GEM-resistance...
2018: Cell Cycle
https://www.readbyqxmd.com/read/29620859/insight-investigation-of-active-palladium-surface-sites-in-palladium-ceria-catalysts-for-no-co-reaction
#18
Ke Tang, Yuqing Ren, Wei Liu, Jingjing Wei, Jinxin Guo, Shuping Wang, Yanzhao Yang
The palladium species in ceria-based catalysts have a significant influence on their catalytic performance. In this work, the structure evolution of palladium species induced by various calcination rate was investigated and then these calcined catalysts were applied to NO + CO catalytic reaction. Systematic investigations by various measurements demonstrate that the calcination rate and catalytic process play crucial roles on the formation ways of palladium species and identify the forms of active palladium surface sites for NO + CO reaction...
April 25, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29599301/visualizing-the-tumor-microenvironment-by-color-coded-imaging-in-orthotopic-mouse-models-of-cancer
#19
REVIEW
Atsushi Suetsugu, Masahito Shimizu, Shigetoyo Saji, Hisataka Moriwaki, Robert M Hoffman
The tumor microenvironment (TME) contains stromal cells in a complex interaction with cancer cells. This relationship has become better understood with the use of fluorescent proteins for in vivo imaging, originally developed by our laboratories. Spectrally-distinct fluorescent proteins can used for color-coded imaging of the complex interaction of the tumor microenvironment in the living state using cancer cells expressing a fluorescent protein of one color and host mice expressing another-color fluorescent protein...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29595148/colloidal-lithography-nanostructured-pd-pdo-x-core-shell-sensor-for-ppb-level-h-2-s-detection
#20
Samatha Benedict, Chatdanai Lumdee, Alexandre Dmitriev, Srinivasan Anand, Navakanta Bhat
In this work we report on plasma oxidation of palladium (Pd) to form reliable palladium/palladium oxide (Pd/PdO x ) core-shell sensor for ppb level H2 S detection and its performance improvement through nanostructuring using hole-mask colloidal lithography (HCL). The plasma oxidation parameters and the sensor operating conditions are optimized to arrive at a sensor device with high sensitivity and repeatable response for H2 S. The plasma oxidized palladium/palladium oxide sensor shows a response of 43.1% at 3 ppm H2 S at the optimum operating temperature of 200 °C with response and recovery times of 24 s and 155 s, respectively...
June 22, 2018: Nanotechnology
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