keyword
https://read.qxmd.com/read/37957369/machado-joseph-disease-in-a-sudanese-family-links-east-africa-to-portuguese-families-and-allows-reestimation-of-ancestral-age-of-the-machado-lineage
#1
JOURNAL ARTICLE
Sandra Martins, Ashraf Yahia, Inês P D Costa, Hassab E Siddig, Rayan Abubaker, Mahmoud Koko, Marc Corral-Juan, Antoni Matilla-Dueñas, Alexis Brice, Alexandra Durr, Eric Leguern, Laura P W Ranum, António Amorim, Liena E O Elsayed, Giovanni Stevanin, Jorge Sequeiros
Machado-Joseph disease (MJD/SCA3) is the most frequent dominant ataxia worldwide. It is caused by a (CAG)n expansion. MJD has two major ancestral backgrounds: the Machado lineage, found mainly in Portuguese families; and the Joseph lineage, present in all five continents, probably originating in Asia. MJD has been described in a few African and African-American families, but here we report the first diagnosed in Sudan to our knowledge. The proband presented with gait ataxia at age 24; followed by muscle cramps and spasticity, and dysarthria, by age 26; he was wheel-chair bound at 29 years of age...
November 14, 2023: Human Genetics
https://read.qxmd.com/read/37881026/first-description-and-phylogenetic-analysis-of-coxsackie-virus-a-non-polio-enteroviruses-and-parechoviruses-a-in-south-sudanese-children
#2
JOURNAL ARTICLE
Karen Couderé, Kimberley Benschop, Astrid van Steen, Jaco J Verweij, Suzan Pas, Jeroen Cremer, Arthur W D Edridge, Gasim O E Abd-Elfarag, Michaël B van Hensbroek, Dasja Pajkrt, Jean-Luc Murk, Katja C Wolthers
Enteroviruses (EV) and parechoviruses A (PeV-A) are commonly circulating viruses able to cause severe disease. Surveillance studies from sub-Saharan Africa are limited and show high but variable infection rates and a high variation in genotypes. This is the first study to describe EV and PeV-A circulation in children in South Sudan. Of the fecal samples collected, 35% and 10% were positive for EV and PeV-A, respectively. A wide range of genotypes were found, including several rarely described EV and PeV-A types...
October 2023: Journal of Medical Virology
https://read.qxmd.com/read/37723449/tracking-the-geographical-origin-of-plasmodium-falciparum-causing-a-rare-severe-case-of-malaria-imported-into-palestine-a-zero-indigenous-case-area
#3
JOURNAL ARTICLE
Anas Al-Jawabreh, Suheir Ereqat, Amer Al-Jawabreh, Ahmed Al-Jawabreh, Hanan Al-Jawabreh, Abedelmajeed Nasereddin
BACKGROUND: Malaria cases in non-endemic zero-indigenous case areas are most likely to have been imported whatever of the route of importation. In countries recently declared malaria-free and now without local transmission, imported cases remain a threat to re-introduction of the disease and a burden on the health system. CASE PRESENTATION: Three days after returning from a long trip to malaria- endemic countries; Abyei-Sudan, Chad and Uganda, a 41-year-old male resident from Jericho, Palestine, suffered paroxysms of fever, general fatigue, myalgia, arthralgia, headache, and a strong desire to vomit...
September 18, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37528970/development-of-indels-markers-for-the-identification-of-cytoplasmic-male-sterility-in-sorghum-by-complete-chloroplast-genome-sequences-analysis
#4
JOURNAL ARTICLE
Myeong-Eun Choe, Ji-Young Kim, Rizwana Begum Syed Nabi, Sang-Ik Han, Kwang-Soo Cho
Cytoplasmic male sterility (CMS) is predominantly used for F1 hybrid breeding and seed production in Sorghum . DNA markers to distinguish between normal fertile (CMS-N) and sterile (CMS-S) male cytoplasm can facilitate F1 hybrid cultivar development in Sorghum breeding programs. In this study, the complete chloroplast (cp) genome sequences of CMS-S and Korean Sorghum cultivars were obtained using next-generation sequencing. The de novo assembled genome size of ATx623, the CMS-S line of the chloroplast, was 140,644bp...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/36912984/a-chromosome-scale-genome-sequence-of-sudangrass-sorghum-sudanense-highlights-the-genome-evolution-and-regulation-of-dhurrin-biosynthesis
#5
JOURNAL ARTICLE
Jieqin Li, Lihua Wang, Paul W Bible, Wenmiao Tu, Jian Zheng, Peng Jin, Yanlong Liu, Junli Du, Jiacheng Zheng, Yi-Hong Wang, Qiuwen Zhan
Sudangrass is more similar to US commercial sorghums than to cultivated sorghums from Africa sequence-wise and contain significantly lower dhurrin than sorghums. CYP79A1 is linked to dhurrin content in sorghum. Sudangrass [Sorghum sudanense (Piper) Stapf] is a hybrid between grain sorghum and its wild relative S. bicolor ssp. verticilliflorum and is grown as a forage crop due to its high biomass production and low dhurrin content compared to sorghum. In this study, we sequenced the sudangrass genome and showed that the assembled genome was 715...
March 13, 2023: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://read.qxmd.com/read/36736695/north-and-east-african-mitochondrial-genetic-variation-needs-further-characterization-towards-precision-medicine
#6
JOURNAL ARTICLE
Anke Fähnrich, Isabel Stephan, Misa Hirose, Franziska Haarich, Mosab Ali Awadelkareem, Saleh Ibrahim, Hauke Busch, Inken Wohlers
INTRODUCTION: Mitochondria are maternally inherited cell organelles with their own genome, and perform various functions in eukaryotic cells such as energy production and cellular homeostasis. Due to their inheritance and manifold biological roles in health and disease, mitochondrial genetics serves a dual purpose of tracing the history as well as disease susceptibility of human populations across the globe. This work requires a comprehensive catalogue of commonly observed genetic variations in the mitochondrial DNAs for all regions throughout the world...
January 31, 2023: Journal of Advanced Research
https://read.qxmd.com/read/36376846/molecular-characterization-and-genotyping-of-hepatitis-c-virus-from-sudanese-end-stage-renal-disease-patients-on-haemodialysis
#7
JOURNAL ARTICLE
Trodia Zitha, Chien-Yu Chen, Hatim Mudawi, Waleed Hussein, Maowia Mukhtar, Mazin Shigidi, Mohamed Elamin Awad Yousif, Mohammed Ahmed Ali, Dieter Glebe, Anna Kramvis
BACKGROUND: Hepatitis C virus (HCV) is a global public health problem, with ~ 11 million people in Africa infected. There is incomplete information on HCV in Sudan, particularly in haemodialysis patients, who have a higher prevalence compared to the general population. Thus, our objectives were to genotype and molecularly characterize HCV isolated from end-stage renal disease haemodialysis patients. METHODS: A total of 541 patients were recruited from eight haemodialysis centres in Khartoum and screened for anti-HCV...
November 14, 2022: BMC Infectious Diseases
https://read.qxmd.com/read/36290124/shedding-light-on-the-origin-of-egyptian-sheep-breeds-by-evolutionary-comparison-of-mitochondrial-d-loop
#8
JOURNAL ARTICLE
Agnès Germot, Muhammad Gamal Khodary, Othman El-Mahdy Othman, Daniel Petit
(1) Background: It has been recognized that the origin of fat-tailed sheep occurred within coarse wool breeds and that this character was introgressed several times into thin-tailed populations. However, no study has investigated this idea for Egyptian breeds using mtDNA analyses. (2) Methods: Using new sequences of the control region, we constructed a database of 467 sequences representing 37 breeds including fat- and thin-tailed ones with 80 Egyptian individuals belonging to six local breeds (Barki, Fallahi, Ossimi, Rahmani, Saidi, Sohagi)...
October 12, 2022: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36233103/the-first-molecular-detection-of-aedes-albopictus-in-sudan-associates-with-increased-outbreaks-of-chikungunya-and-dengue
#9
JOURNAL ARTICLE
Ayman Ahmed, Mustafa Abubakr, Hamza Sami, Isam Mahdi, Nouh S Mohamed, Jakob Zinsstag
As part of our surveys of the invasive malaria vector Anopheles stephensi in four Sudanese states, including North and South Kordofan, Sennar, and White Nile, we collected 166 larvae. Our morphological identification confirmed that 30% of the collected mosquito samples were Anopheles species, namely An. gambiae s.l. and An. stephensi , while the 117 Aedes specimens were Ae. luteocephalus (39%), Ae. aegypti (32%), Ae. vexans (9%), Ae. vittatus (9%), Ae. africanus (6%), Ae. metalicus (3%), and Ae. albopictus (3%)...
October 5, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35840403/tunisian-camel-casein-gene-characterization-reveals-similarities-and-differences-with-sudanese-and-nigerian-populations
#10
JOURNAL ARTICLE
N Letaief, S Bedhiaf-Romdhani, W Ben Salem, A A S Mohammed, G Gaspa, A Pauciullo
Milk is a primary protein source that has always played a role in mammalian health. Despite the intensification of research projects on dromedary and the knowledge of the genetic diversity at the casein loci, the genetic structure of the Tunisian camel population still needs exploration. This study sought to determine the genetic diversity of 3 casein gene variants in 5 Tunisian camel ecotypes: c.150G>T at CSN1S1 (αS1 -casein), g.2126A>G at CSN2 (β-casein), and g.1029T>C at CSN3 (κ-casein). The obtained results were compared with data published on Sudanese and Nigerian camels to establish the level of differentiation within and between populations...
July 12, 2022: Journal of Dairy Science
https://read.qxmd.com/read/34493342/epidemiology-and-molecular-characterization-of-re-emerged-virulent-strains-of-peste-des-petits-ruminants-virus-among-sheep-in-kassala-state-eastern-sudan
#11
JOURNAL ARTICLE
Fatima A Saeed, Mohammed M Gumaa, Sana A Abdelaziz, Khalid A Enan, Selma K Ahmed, Mohammed O Hussien
BACKGROUND: Peste des Petits Ruminants (PPR) is a severe contagious viral disease, which mainly affects small ruminants. PPR is caused by a Morbillivirus that belongs to the family Paramyxoviridae. In this study 12 suspected PPR outbreaks among sheep and goats were investigated in four localities in Kassala State, Eastern Sudan, during 2015-2017. The causative agent was confirmed by a Sandwich Enzyme-Linked Immunosorbent Assay (sELISA), and a Reverse Transcription Polymerase Chain Reaction (RT-PCR) targeting a partial sequence of nucleocapsid protein gene (N- gene) and a partial sequence of fusion protein gene (F- gene)...
September 7, 2021: Irish Veterinary Journal
https://read.qxmd.com/read/34401360/the-ultra-structural-metabolomic-and-metagenomic-characterisation-of-the-sudanese-smokeless-tobacco-toombak
#12
JOURNAL ARTICLE
Amel Sami, Imad Elimairi, Dhrati Patangia, Claire Watkins, C Anthony Ryan, R Paul Ross, Catherine Stanton
Toombak is a smokeless tobacco produced from the Nicotiana rustica tobacco plant from Sudan. Pre-prepared and ready to buy Toombak samples were analysed using mass spectrometry (heavy metals), gas and liquid chromatography (metabolomics), 16S rRNA metagenomic sequencing (microbiome) and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and pH analysis. Chromium, cobalt, and copper were high in the pre-prepared form of Toombak while iron, tobacco specific nitrosamines (TSNAs), formaldehyde and acetaldehyde were high in both types...
2021: Toxicology Reports
https://read.qxmd.com/read/34031154/a-chromosome-level-genome-of-a-kordofan-melon-illuminates-the-origin-of-domesticated-watermelons
#13
JOURNAL ARTICLE
Susanne S Renner, Shan Wu, Oscar A Pérez-Escobar, Martina V Silber, Zhangjun Fei, Guillaume Chomicki
Wild relatives or progenitors of crops are important resources for breeding and for understanding domestication. Identifying them, however, is difficult because of extinction, hybridization, and the challenge of distinguishing them from feral forms. Here, we use collection-based systematics, iconography, and resequenced accessions of Citrullus lanatus and other species of Citrullus to search for the potential progenitor of the domesticated watermelon. A Sudanese form with nonbitter whitish pulp, known as the Kordofan melon ( C...
June 8, 2021: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/33779310/the-iodide-transport-defect-causing-y348d-mutation-in-the-na-i-symporter-renders-the-protein-intrinsically-inactive-and-impairs-its-targeting-to-the-plasma-membrane
#14
JOURNAL ARTICLE
Andrea Reyna-Neyra, Lara Jung, Mayukh Chakrabarti, Mikel X Suárez, L Mario Amzel, Nancy Carrasco
Background: The sodium/iodide (Na+ /I- ) symporter (NIS) mediates active transport of I- into the thyroid gland. Mutations in the SLC5A5 gene, which encodes NIS, cause I- transport defects (ITDs)-which, if left untreated, lead to congenital hypothyroidism and consequent cognitive and developmental deficiencies. The ITD-causing NIS mutation Y348D, located in transmembrane segment (TMS) 9, was reported in three Sudanese patients. Methods: We generated cDNAs coding for Y348D NIS and mutants with other hydrophilic and hydrophobic amino acid substitutions at position 348 and transfected them into cells...
August 2021: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/33708238/capture-sequencing-to-explore-and-map-rare-casein-variants-in-goats
#15
JOURNAL ARTICLE
Siham A Rahmatalla, Danny Arends, Ammar Said Ahmed, Lubna M A Hassan, Stefan Krebs, Monika Reissmann, Gudrun A Brockmann
Genetic variations in the four casein genes CSN1S1 , CSN2 , CSN1S2 , and CSN3 have obtained substantial attention since they affect the milk protein yield, milk composition, cheese processing properties, and digestibility as well as tolerance in human nutrition. Furthermore, milk protein variants are used for breed characterization, biodiversity, and phylogenetic studies. The current study aimed at the identification of casein protein variants in five domestic goat breeds from Sudan (Nubian, Desert, Nilotic, Taggar, and Saanen) and three wild goat species [ Capra aegagrus aegagrus (Bezoar ibex), Capra nubiana (Nubian ibex), and Capra ibex (Alpine ibex)]...
2021: Frontiers in Genetics
https://read.qxmd.com/read/33642793/-g1-point-mutation-in-growth-differentiation-factor-9-gene-affects-litter-size-in-sudanese-desert-sheep
#16
JOURNAL ARTICLE
Amani Z Abdelgadir, Lutfi M A Musa, Khaleel I Jawasreh, Aubai O Saleem, Faisal El-Hag, Mohamed-Khair A Ahmed
Background and Aim: Sudanese desert sheep encompass different sheep breeds named according to the different Sudanese tribes that rear them such as the Dubasi, Shugor, and Watish sheep. The objectives of this study were to screen for G1 point mutation in the polymorphic growth differentiation factor 9 (GDF9) gene, investigate its association with litter size, and construct the phylogeny of the different tribal breeds that belong to the Sudanese Desert sheep tribal types. Materials and Methods: Genomic DNA was extracted from whole blood of three tribal Desert sheep breeds (Dubasi, Watish, and Shugor) using the guanidine chloride method...
January 2021: Veterinary World
https://read.qxmd.com/read/33614013/georeferenced-phylogenetic-analysis-of-a-global-collection-of-wild-and-cultivated-citrullus-species
#17
JOURNAL ARTICLE
Enoch G Achigan-Dako, Hervé Degbey, Iago Hale, Frank R Blattner
The geographical origin of watermelon ( Citrullus lanatus ) remains debated. While a first hypothesis suggests the center of origin to be West Africa, where the endemic sister species C. mucosospermus thrives, a second hypothesis suggests northeastern Africa where the white-fleshed Sudanese Kordophan melon is cultivated. In this study, we infer biogeographical and haplotype genealogy for C. lanatus, C. mucosospermus, C. amarus , and C. colocynthis using noncoding cpDNA sequences ( trn T- trn L and ndh F -rpl 32 regions) from a global collection of 135 accessions...
February 2021: Ecology and Evolution
https://read.qxmd.com/read/33178282/molecular-phylogenetic-analysis-of-16s-rrna-sequences-identified-two-lineages-of-helicobacter-pylori-strains-detected-from-different-regions-in-sudan-suggestive-of-differential-evolution
#18
JOURNAL ARTICLE
Abeer Babiker Idris, Hadeel Gassim Hassan, Maryam Atif Salaheldin Ali, Sulafa Mohamed Eltaher, Leena Babiker Idris, Hisham N Altayb, Amin Mohamed Abass, Mustafa Mohammed Ahmed Ibrahim, El-Amin Mohamed Ibrahim, Mohamed A Hassan
Background: Helicobacter pylori ( H. pylori ) is ubiquitous among humans and one of the best-studied examples of an intimate association between bacteria and humans. Phylogeny and Phylogeography of H. pylori strains are known to mirror human migration patterns and reflect significant demographic events in human prehistory. In this study, we analyzed the molecular evolution of H. pylori strains detected from different tribes and regions of Sudan using 16S rRNA gene and the phylogenetic approach...
2020: International Journal of Microbiology
https://read.qxmd.com/read/31280584/characterization-of-hiv-1-subtypes-among-south-sudanese-patients
#19
JOURNAL ARTICLE
Alessandra Lo Presti, Stefania Farcomeni, Lucia Fontanelli Sulekova, Stefania Grieco, Leonardo Sernicola, Michela Baesso, Maria T Maggiorella, Silvia Angeletti, Brian Foley, Massimo Ciccozzi, Gloria Taliani, Alessandra Borsetti
There is scarce data on circulation of genetic subtypes of HIV-1 in South Sudan due to decades of civil war. In this study, phylogenetic analysis of 10 strains collected from HIV-1-infected South Sudanese patients was performed. Partial pol and env viral gene analysis classified sequences as subtype C ( n  = 4), subtype D ( n  = 4), and partially unclassifiable recombinants ( n  = 2), interspersed within the phylogenetic tree with those from other African countries. These results indicate an exchange of viral strains between South Sudan and both neighboring and distant territories...
August 8, 2019: AIDS Research and Human Retroviruses
https://read.qxmd.com/read/29390990/first-molecular-characterization-of-echinococcus-granulosus-sensu-stricto-genotype-1-among-cattle-in-sudan
#20
JOURNAL ARTICLE
Mohamed E Ahmed, Bashir Salim, Martin P Grobusch, Imadeldin E Aradaib
BACKGROUND: Echinococcus granulosus sensu lato (s.l.) is the causative agent of cystic echinococcosis (CE), which is a cosmopolitan zoonotic parasitic disease infecting humans and a wide range of mammalian species including cattle. Currently, little information is available on the genetic diversity of Echinococcus species among livestock in Sudan. In the present study, fifty (n = 50) hydatid cysts were collected from cattle carcasses (one cyst sample per animal) at Al-kadarou slaughterhouse, Khartoum North, Sudan...
February 1, 2018: BMC Veterinary Research
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